Abstract:
:One of the most famous and commonly used compounds from organophosphate (OP) family is chlorpyrifos (CP) which is widespreadly used as a powerful insecticide. Previous studies have shown that OPs induce oxidative stress, inflammation and apoptosis by generating the free radicals. The protective effects of three members of phosphodiesterase inhibitor (PDEI) family, including rolipram (RLP), milrinon (MLR) and pentoxifylline (PTX) were evaluated in the human lymphocytes against CP's toxicity. In this case, the level of oxidative stress biomarkers, the viability of the cells and the rate of apoptosis by flow cytometry were investigated. The results of this study revealed that CP makes a significant increase in the level of inflammatory and oxidative stress markers such as meyloperoxidase (MPO), lipid peroxidation (LPO), total thiol molecules (TTM) and total antioxidant potential (TAP), and also makes an enhancement in the rate of apoptosis process. On the other hand, PDEIs and specifically the combination of them restored the negative effects of CP and significantly prevented the apoptosis and oxidative stress imbalance. It is concluded that these PDEIs have positive effects in attenuation, recovery, and protection of CP-induced toxicity in the human lymphocytes.
journal_name
Pestic Biochem Physioljournal_title
Pesticide biochemistry and physiologyauthors
Jowzi N,Rahimifard M,Navaei-Nigjeh M,Baeeri M,Darvishi B,Rezvanfar MA,Abdollahi Mdoi
10.1016/j.pestbp.2015.10.005subject
Has Abstractpub_date
2016-03-01 00:00:00pages
57-62eissn
0048-3575issn
1095-9939pii
S0048-3575(15)30043-2journal_volume
128pub_type
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