Abstract:
:The inducible metalloproteinase inhibitor (IMPI) discovered in Galleria mellonella is currently the only specific inhibitor of metalloproteinases found in animals. Its role is to inhibit the activity of metalloproteinases secreted by pathogenic organisms as virulence factors to degrade immune-relevant polypeptides of the infected host. This is a good example of an evolutionary arms race between the insect hosts and their natural pathogens. In this report, we analyze the expression of a gene encoding an inducible metalloproteinase inhibitor (IMPI) in fat bodies of the greater wax moth larvae Galleria mellonella infected with an entomopathogenic fungus Beauveria bassiana. We have used a natural infection, i.e. covering larval integument with fungal aerospores, as well as injection of fungal blastospores directly into the larval hemocel. We compare the expression of IMPI with the expression of genes encoding proteins with fungicidal activity, gallerimycin and galiomycin, whose expression reflects the stimulation of Galleria mellonella defense mechanisms. Also, gene expression is analyzed in the light of survival of animals after spore injection.
journal_name
Acta Biochim Poljournal_title
Acta biochimica Polonicaauthors
Vertyporokh L,Wojda Idoi
10.18388/abp.2016_1376subject
Has Abstractpub_date
2017-01-01 00:00:00pages
273-278issue
2eissn
0001-527Xissn
1734-154Xpii
1376journal_volume
64pub_type
杂志文章abstract::Fluorescent tri-cyclic purine analogs, derivatives of isoguanine and adenine, were examined as potential substrates of purine-nucleoside phosphorylase. It was found previously that etheno- derivatives of both compounds are ribosylated in phosphate-free media, but ribosylation places in some instances differ from purin...
journal_title:Acta biochimica Polonica
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.18388/abp.2016_1369
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pub_type: 杂志文章
doi:
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journal_title:Acta biochimica Polonica
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doi:
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journal_title:Acta biochimica Polonica
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doi:10.18388/abp.2015_1022
更新日期:2016-01-01 00:00:00
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journal_title:Acta biochimica Polonica
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doi:
更新日期:2001-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2015_1068
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Acta biochimica Polonica
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doi:
更新日期:1984-01-01 00:00:00
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journal_title:Acta biochimica Polonica
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doi:
更新日期:2008-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2017_2308
更新日期:2018-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
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doi:
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
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doi:10.18388/abp.2018_2641
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doi:
更新日期:1997-01-01 00:00:00
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journal_title:Acta biochimica Polonica
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doi:
更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章,评审
doi:024903597
更新日期:2002-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:024904829
更新日期:2002-01-01 00:00:00
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journal_title:Acta biochimica Polonica
pub_type: 杂志文章
doi:10.18388/abp.2016_1364
更新日期:2017-01-01 00:00:00