Update on Pyrin Functions and Mechanisms of Familial Mediterranean Fever.

Abstract:

:Mutations in the MEFV gene, which encodes the protein named pyrin (also called marenostrin or TRIM20), are associated with the autoinflammatory disease familial Mediterranean fever (FMF). Recent genetic and immunologic studies uncovered novel functions of pyrin and raised several new questions in relation to FMF pathogenesis. The disease is clinically heterogeneous reflecting the complexity and multiplicity of pyrin functions. The main functions uncovered so far include its involvement in innate immune response such as the inflammasome assemblage and, as a part of the inflammasome, sensing intracellular danger signals, activation of mediators of inflammation, and resolution of inflammation by the autophagy of regulators of innate immunity. Based on these functions, the FMF-associated versions of pyrin confer a heightened sensitivity to a variety of intracellular danger signals and postpone the resolution of innate immune responses. It remains to be demonstrated, however, what kind of selective advantage the heterozygous carriage conferred in the past to be positively selected and maintained in populations from the Mediterranean basin.

journal_name

Front Microbiol

authors

Manukyan G,Aminov R

doi

10.3389/fmicb.2016.00456

subject

Has Abstract

pub_date

2016-03-31 00:00:00

pages

456

issn

1664-302X

journal_volume

7

pub_type

杂志文章,评审
  • Estimation of Candida albicans ABC Transporter Behavior in Real-Time via Fluorescence.

    abstract::We present a fluorometric method for determining ABC transporter activity in the pathogenic fungus C. albicans during different growth phases and in response to glucose. The carbocyanine dye diS-C3(3) was previously used to monitor plasma membrane potentials and test the influence of surface-active compounds in membra...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.01382

    authors: Szczepaniak J,Łukaszewicz M,Krasowska A

    更新日期:2015-12-09 00:00:00

  • Fifteen Marseilleviruses Newly Isolated From Three Water Samples in Japan Reveal Local Diversity of Marseilleviridae.

    abstract::The family Marseilleviridae, defined as a group of icosahedral double-stranded DNA viruses with particle size of approximately 250 nm and genome size of 350-380 kbp, belongs to the nucleo-cytoplasmic family of large DNA viruses. The family Marseilleviridae is currently classified into lineages A-E. In this study, we i...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01152

    authors: Aoki K,Hagiwara R,Akashi M,Sasaki K,Murata K,Ogata H,Takemura M

    更新日期:2019-05-24 00:00:00

  • Antimicrobial Metabolites Produced by Penicillium mallochii CCH01 Isolated From the Gut of Ectropis oblique, Cultivated in the Presence of a Histone Deacetylase Inhibitor.

    abstract::Three chemical epigenetic modifiers [5-azacytidine, nicotinamide, and suberoylanilide hydroxamic acid (SAHA)] were applied to induce the metabolites of Penicillium mallochii CCH01, a fungus isolated from the gut of Ectropis oblique. Metabolite profiles of P. mallochii CCH01 were obviously changed by SAHA treatment. Fo...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02186

    authors: Zhang S,Fang H,Yin C,Wei C,Hu J,Zhang Y

    更新日期:2019-10-02 00:00:00

  • Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity.

    abstract::Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has emerged as a global pandemic worldwide. In this study, we used ARTIC primers-based amplicon sequencing to profile 225 SARS-CoV-2 genomes from India. Phylogenetic analysis of 202 high-quality assem...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.594928

    authors: Raghav S,Ghosh A,Turuk J,Kumar S,Jha A,Madhulika S,Priyadarshini M,Biswas VK,Shyamli PS,Singh B,Singh N,Singh D,Datey A,Avula K,Smita S,Sabat J,Bhattacharya D,Kshatri JS,Vasudevan D,Suryawanshi A,Dash R,Senapati

    更新日期:2020-11-23 00:00:00

  • Human Gut Microbiota: Toward an Ecology of Disease.

    abstract::Composed of trillions of individual microbes, the human gut microbiota has adapted to the uniquely diverse environments found in the human intestine. Quickly responding to the variances in the ingested food, the microbiota interacts with the host via reciprocal biochemical signaling to coordinate the exchange of nutri...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2017.01265

    authors: Selber-Hnatiw S,Rukundo B,Ahmadi M,Akoubi H,Al-Bizri H,Aliu AF,Ambeaghen TU,Avetisyan L,Bahar I,Baird A,Begum F,Ben Soussan H,Blondeau-Éthier V,Bordaries R,Bramwell H,Briggs A,Bui R,Carnevale M,Chancharoen M,Chevass

    更新日期:2017-07-17 00:00:00

  • Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution.

    abstract::Anti-retroviral therapy (ART) is crucial for controlling human immunodeficiency virus type-1 (HIV-1) infection. Recently, progress in identifying and characterizing highly potent broadly neutralizing antibodies has provided valuable templates for HIV-1 therapy and vaccine design. Nevertheless, HIV-1, like many RNA vir...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2017.00390

    authors: Harada S,Yoshimura K

    更新日期:2017-03-16 00:00:00

  • Abundance of Colistin-Resistant, OXA-23- and ArmA-Producing Acinetobacter baumannii Belonging to International Clone 2 in Greece.

    abstract::Carbapenem resistant Acinetobacter baumannii (CRAB) represents one of the most challenging pathogens in clinical settings. Colistin is routinely used for treatment of infections by this pathogen, but increasing colistin resistance has been reported. We obtained 122 CRAB isolates from nine Greek hospitals between 2015 ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00668

    authors: Palmieri M,D'Andrea MM,Pelegrin AC,Perrot N,Mirande C,Blanc B,Legakis N,Goossens H,Rossolini GM,van Belkum A

    更新日期:2020-04-15 00:00:00

  • In vitro and in vivo Effect of Exogenous Farnesol Exposure Against Candida auris.

    abstract::The spreading of multidrug-resistant Candida auris is considered as an emerging global health threat. The number of effective therapeutic regimens is strongly limited; therefore, development of novel strategies is needed. Farnesol is a quorum-sensing molecule with a potential antifungal and/or adjuvant effect; it may ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00957

    authors: Nagy F,Vitális E,Jakab Á,Borman AM,Forgács L,Tóth Z,Majoros L,Kovács R

    更新日期:2020-05-20 00:00:00

  • Occurrence of Hepatitis E Virus in Pigs and Pork Cuts and Organs at the Time of Slaughter, Spain, 2017.

    abstract::Zoonotic hepatitis E, mainly caused by hepatitis E virus (HEV) genotype (gt) 3, is a foodborne disease that has emerged in Europe in recent decades. The main animal reservoir for genotype 3 is domestic pigs. Pig liver and liver derivates are considered the major risk products, and studies focused on the presence of HE...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02990

    authors: García N,Hernández M,Gutierrez-Boada M,Valero A,Navarro A,Muñoz-Chimeno M,Fernández-Manzano A,Escobar FM,Martínez I,Bárcena C,González S,Avellón A,Eiros JM,Fongaro G,Domínguez L,Goyache J,Rodríguez-Lázaro D

    更新日期:2020-01-28 00:00:00

  • PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane.

    abstract::Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. Optimization has focused on selection of target genes and exact localization around the ribosome binding site, but surprisingly a length optimum around 10-12 nucleobases ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01032

    authors: Goltermann L,Yavari N,Zhang M,Ghosal A,Nielsen PE

    更新日期:2019-05-24 00:00:00

  • A Single-Nucleotide Deletion in the Transcription Factor Gene bcsmr1 Causes Sclerotial-Melanogenesis Deficiency in Botrytis cinerea.

    abstract::Botrytis cinerea is an important plant pathogenic fungus with a wide range of host. It usually produces black-colored sclerotia (BS) due to deposition of 1,8-dihydroxynaphthalene melanin in sclerotial melanogenesis. Our previous study (Zhou et al., 2018) reported six B. cinerea isolates producing orange-colored sclero...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02492

    authors: Zhou Y,Yang L,Wu M,Chen W,Li G,Zhang J

    更新日期:2017-12-12 00:00:00

  • Environmental and Host Effects on Skin Bacterial Community Composition in Panamanian Frogs.

    abstract::Research on the amphibian skin microbiota has focused on identifying bacterial taxa that deter a pathogenic chytrid fungus, and on describing patterns of microbiota variation. However, it remains unclear how environmental variation affects amphibian skin bacterial communities, and whether the overall functional divers...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00298

    authors: Varela BJ,Lesbarrères D,Ibáñez R,Green DM

    更新日期:2018-02-22 00:00:00

  • Marinobacter subterrani, a genetically tractable neutrophilic Fe(II)-oxidizing strain isolated from the Soudan Iron Mine.

    abstract::We report the isolation, characterization, and development of a robust genetic system for a halophilic, Fe(II)-oxidizing bacterium isolated from a vertical borehole originating 714 m below the surface located in the Soudan Iron Mine in northern Minnesota, USA. Sequence analysis of the 16S rRNA gene places the isolate ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00719

    authors: Bonis BM,Gralnick JA

    更新日期:2015-07-16 00:00:00

  • Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae From Retail Food in China.

    abstract::In this study, we characterized the β-lactamase genes and phenotypic resistance of cephalosporin-resistant Enterobacteriaceae isolated from retail foods in China. Of 1,024 Enterobacteriaceae isolates recovered from raw meat products, aquatic products, raw vegetables, retail-level ready-to-eat (RTE) foods, frozen foods...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01709

    authors: Ye Q,Wu Q,Zhang S,Zhang J,Yang G,Wang J,Xue L,Chen M

    更新日期:2018-08-08 00:00:00

  • Multi-Locus Phylogeny and Taxonomy of the Fungal Complex Associated With Rusty Root Rot of Panax ginseng in China.

    abstract::Panax ginseng rusty root rot caused by the Ilyonectria species complex is a devastating disease, and it is one of the main factors contributing to the difficulty in continual cropping. Rusty root rot occurs in all ginseng fields, but little is known about the taxonomy of the fungal pathogen complex, especially Ilyonec...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.618942

    authors: Guan YM,Ma YY,Jin Q,Wang QX,Liu N,Fu YP,Zhang YY,Li Y

    更新日期:2020-12-16 00:00:00

  • Transcriptome analyses to investigate symbiotic relationships between marine protists.

    abstract::Rhizaria are an important component of oceanic plankton communities worldwide. A number of species harbor eukaryotic microalgal symbionts, which are horizontally acquired in the environment at each generation. Although these photosymbioses are determinant for Rhizaria ability to thrive in oceanic ecosystems, the mecha...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00098

    authors: Balzano S,Corre E,Decelle J,Sierra R,Wincker P,Da Silva C,Poulain J,Pawlowski J,Not F

    更新日期:2015-03-17 00:00:00

  • Therapeutic Efficacy of a Trichinella Spiralis Paramyosin-Derived Peptide Modified With a Membrane-Targeting Signal in Mice With Antigen-Induced Arthritis.

    abstract::Helminth-derived molecules have the ability to modulate the host immune system. Our previous study identified a tetradecapeptide derived from Trichinella spiralis paramyosin (Ts-pmy) that could bind to human complement component C9 to inhibit its polymerization, making the peptide a candidate therapeutic agent for com...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.608380

    authors: Chen Y,Shao S,Huang J,Gu Y,Cheng Y,Zhu X

    更新日期:2020-12-23 00:00:00

  • A Prescription for Resistance: Management of Staphylococcal Skin Abscesses by General Practitioners in Australia.

    abstract:OBJECTIVES:We investigated the management of staphylococcal abscesses (boils) by general practitioners (GPs) in the context of rising antibiotic resistance in community strains of Staphylococcus aureus. DESIGN, SETTING, PARTICIPANTS:We analyzed patient-reported management of 66 cases of uncomplicated skin abscesses fr...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00802

    authors: Parrott C,Wood G,Bogatyreva E,Coombs GW,Johnson PD,Bennett CM

    更新日期:2016-06-06 00:00:00

  • Biosynthesis of Alkylcitric Acids in Aspergillus niger Involves Both Co-localized and Unlinked Genes.

    abstract::Filamentous fungi are an abundant source of bioactive secondary metabolites (SMs). In many cases, the biosynthetic processes of SMs are not well understood. This work focuses on a group of SMs, the alkylcitric acids, each of which contains a saturated alkyl "tail," and a citrate-derived "head." We initially identified...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01378

    authors: Palys S,Pham TTM,Tsang A

    更新日期:2020-06-30 00:00:00

  • Nutrient Composition Promotes Switching between Pellicle and Bottom Biofilm in Salmonella.

    abstract::Salmonella is one of the most frequently reported causes of foodborne illness worldwide. Non-typhoidal serovars cause gastroenteritis in humans. Salmonella can grow on surfaces forming biofilms, contributing to its persistence since biofilms are difficult to eradicate due to the high resistance to antimicrobials and d...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02160

    authors: Paytubi S,Cansado C,Madrid C,Balsalobre C

    更新日期:2017-11-07 00:00:00

  • Micronutrient Requirements and Sharing Capabilities of the Human Gut Microbiome.

    abstract::The human gut microbiome harbors a diverse array of metabolic pathways contributing to its development and homeostasis via a complex web of diet-dependent metabolic interactions within the microbial community and host. Genomics-based reconstruction and predictive modeling of these interactions would provide a framewor...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01316

    authors: Rodionov DA,Arzamasov AA,Khoroshkin MS,Iablokov SN,Leyn SA,Peterson SN,Novichkov PS,Osterman AL

    更新日期:2019-06-12 00:00:00

  • Isolation and Genomic Characterization of an Acinetobacter johnsonii Bacteriophage AJO2 From Bulking Activated Sludge.

    abstract::A novel Podoviridae lytic phage AJO2, specifically infecting Acinetobacter johnsonii, was isolated from bulking activated sludge. The one-step growth experiment showed that the latent period and burst size of AJO2 were estimated to be 30 min and 78.1 phages per infected cell, respectively. The viability test indicated...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00266

    authors: Fan N,Yang M,Jin R,Qi R

    更新日期:2019-02-20 00:00:00

  • A Recombinant Subviral Particle-Based Vaccine Protects Magpie (Pica pica) Against West Nile Virus Infection.

    abstract::The mosquito-borne West Nile virus (WNV) is a highly neurovirulent Flavivirus currently representing an emergent zoonotic concern. WNV cycles in nature between mosquito vectors and birds that act as amplifier hosts and play an essential role in virus ecology, being, thus, WNV a threat to many species. Availability of ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01133

    authors: Jiménez de Oya N,Escribano-Romero E,Camacho MC,Blazquez AB,Martín-Acebes MA,Höfle U,Saiz JC

    更新日期:2019-06-05 00:00:00

  • A Replisome's journey through the bacterial chromosome.

    abstract::Genome duplication requires the coordinated activity of a multi-component machine, the replisome. In contrast to the background of metabolic diversity across the bacterial domain, the composition and architecture of the bacterial replisome seem to have suffered few changes during evolution. This immutability underline...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2015.00562

    authors: Beattie TR,Reyes-Lamothe R

    更新日期:2015-06-05 00:00:00

  • Aspergillus fumigatus-Related Species in Clinical Practice.

    abstract::Aspergillus fumigatus is the main etiologic agent of invasive aspergillosis (IA). Other Aspergillus species belonging to the section Fumigati (A. fumigatus complex) may occasionally be the cause of IA. These strains are often misidentified, as they cannot be distinguished from A. fumigatus by conventional morphologica...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.00683

    authors: Lamoth F

    更新日期:2016-05-17 00:00:00

  • Explication of the Potential of 2-Hydroxy-4-Methoxybenzaldehyde in Hampering Uropathogenic Proteus mirabilis Crystalline Biofilm and Virulence.

    abstract::Proteus mirabilis is an important etiological agent of catheter-associated urinary tract infections (CAUTIs) owing to its efficient crystalline biofilm formation and virulence enzyme production. Hence, the present study explicated the antibiofilm and antivirulence efficacies of 2-hydroxy-4-methoxybenzaldehyde (HMB) ag...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02804

    authors: Durgadevi R,Abirami G,Alexpandi R,Nandhini K,Kumar P,Prakash S,Veera Ravi A

    更新日期:2019-12-10 00:00:00

  • The Microbiome-Metabolome Response in the Colon of Piglets Under the Status of Weaning Stress.

    abstract::Weaning is stressful for piglets involving nutritional, physiological, and psychological challenges, leading to an increase in the secretion of cortisol, changes in gut microbiome and metabolites, whereas the underlying relationships remain unclear. To elucidate this, 14 Meishan female piglets were divided into the we...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.02055

    authors: Jiang X,Lu N,Zhao H,Yuan H,Xia D,Lei H

    更新日期:2020-08-28 00:00:00

  • Enhancement of Pneumocandin B0 Production in Glarea lozoyensis by Low-Temperature Adaptive Laboratory Evolution.

    abstract::The production of pneumocandin B0 is limited by feedback inhibition. Here, low-temperature adaptive laboratory evolution (ALE) was used to improve the production capacity of Glarea lozoyensis by enhancing its membrane permeability. After 50 cycles of ALE, the pneumocandin B0 production of the endpoint strain (ALE50) r...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02788

    authors: Song P,Zhang K,Zhang S,Huang BQ,Ji XJ,Ren LJ,Gao S,Wen JP,Huang H

    更新日期:2018-11-21 00:00:00

  • GABA-Producing Natural Dairy Isolate From Artisanal Zlatar Cheese Attenuates Gut Inflammation and Strengthens Gut Epithelial Barrier in vitro.

    abstract::Probiotic bacteria are recognized for their health-promoting properties, including maintenance of gut epithelial integrity and host immune system homeostasis. Taking into account the beneficial health-promoting effects of GABA, the presence of the gadB gene, encoding glutamate decarboxylase that converts L-glutamate t...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00527

    authors: Sokovic Bajic S,Djokic J,Dinic M,Veljovic K,Golic N,Mihajlovic S,Tolinacki M

    更新日期:2019-03-18 00:00:00

  • Resistance to Biocides in Listeria monocytogenes Collected in Meat-Processing Environments.

    abstract::The emergence of microorganisms exerting resistance to biocides is a challenge to meat-processing environments. Bacteria can be intrinsically resistant to biocides but resistance can also be acquired by adaptation to their sub-lethal concentrations. Moreover, the presence of biocide resistance determinants, which is c...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01627

    authors: Conficoni D,Losasso C,Cortini E,Di Cesare A,Cibin V,Giaccone V,Corno G,Ricci A

    更新日期:2016-10-19 00:00:00