Abstract:
:Sclerosing mediastinitis (SM) is an aggressive fibroproliferative process in the mediastinum that may lead to encasement of mediastinal structures within a dense fibrotic mass. This disease may cause significant clinical complications, morbidity, and even mortality. The etiology and pathogenesis of SM is unclear and in more than one third of cases remains idiopathic. Among the known causes of SM, granulomatous infection is the commonest. Association of SM with radiation therapy has been rarely reported. Herein, we are reporting a case of postradiation sclerosing mediastinitis diagnosed in fine needle aspiration (FNA) specimen. To our knowledge, this is the first reported case of postradiation sclerosing mediastinitis with unusual striking intracytoplasmic glycogen accumulation. Having high index of suspicion and awareness of the fact that this entity may be also associated with radiation therapy, will be helpful in avoiding diagnostic pitfalls in FNA specimens and guiding proper clinical management.
journal_name
Ann Diagn Patholjournal_title
Annals of diagnostic pathologyauthors
Giorgadze T,Koizumi JH,Ronen S,Chaump M,Magro CMdoi
10.1016/j.anndiagpath.2017.01.004subject
Has Abstractpub_date
2017-04-01 00:00:00pages
43-47eissn
1092-9134issn
1532-8198pii
S1092-9134(17)30021-7journal_volume
27pub_type
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