Association Between Apolipoprotein B XbaI Polymorphism and Coronary Heart Disease in Han Chinese Population: A Meta-Analysis.

Abstract:

OBJECTIVE:To examine the association between apolipoprotein B (ApoB) XbaI polymorphisms (rs693) and coronary heart disease (CHD) risk among the Han Chinese population by systematically analyzing multiple independent studies. METHODS:The Hardy-Weinberg equilibrium test was applied to check genetic equilibrium among genotypes for the selected literatures. The quality of the studies was assessed by using the NewcastleOttawa Scale. Power analysis was performed with Power and Precision V4 software. A fixed or random effect model was used on the basis of heterogeneity. Publication bias was quantified and examined with Begg's funnel plot test and Egger's linear regression test. The meta-analysis was performed by Stata 12.0 software. RESULTS:A total of 10 eligible association studies were included in this meta-analysis, and the pooled sample consisted of 1195 CHD patients and 1178 health controls. No consistent inference regarding publication bias for the included studies was obtained by using the two above-mentioned methods. The pooled odds ratios (95% confidence intervals [CIs]) for X(-) versus X(+) allele and X(+)X(+) + X(+)X(-) versus X(-)X(-) genotype were 2.25 (1.40-3.62) and 2.21 (1.39-3.50), respectively. CONCLUSIONS:This meta-analysis indicated that ApoB XbaI allele confers a significant risk towards the development of CHD among the Han Chinese population.

authors

Chen Y,Lin M,Liang Y,Zhang N,Rao S

doi

10.1089/gtmb.2015.0126

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

304-11

issue

6

eissn

1945-0265

issn

1945-0257

journal_volume

20

pub_type

杂志文章,meta分析
  • Prevalence of human papillomavirus infection in a Kashmiri ethnic female population.

    abstract::Human papillomavirus (HPV) infection is estimated to be the most common sexually transmitted infection and is one of the causal factors in cervical cancer. Understanding the epidemiology of this infection is an important step toward developing strategies for its prevention. Cervical samples from 210 healthy women with...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2011.0354

    authors: Asiaf A,Ahmad ST,Zargar MA,Mufti SM,Mir SH

    更新日期:2012-08-01 00:00:00

  • Hypothesizing an ancient Greek origin of the GJB2 35delG mutation: can science meet history?

    abstract::One specific mutation of the GJB2 gene that encodes the connexin 26 protein, the 35delG mutation, has become a major interest among scientists who focus on the genetics of nonsyndromic hearing loss. The mutation accounts for the majority of GJB2 mutations detected in Caucasian populations and represents one of the mos...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 历史文章,杂志文章

    doi:10.1089/gtmb.2009.0146

    authors: Kokotas H,Grigoriadou M,Villamar M,Giannoulia-Karantana A,del Castillo I,Petersen MB

    更新日期:2010-04-01 00:00:00

  • Molecular Prognostic Value of Circulating Epstein-Barr Viral DNA in Nasopharyngeal Carcinoma: A Meta-Analysis of 27,235 Cases in the Endemic Area of Southeast Asia.

    abstract:: Aims: This meta-analysis evaluated the value of using Epstein-Barr virus (EBV) DNA titers as a predictive factor in assessing the clinical course of nasopharyngeal carcinoma (NPC) patients in Southeast Asia. Methods: A systemat...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,meta分析

    doi:10.1089/gtmb.2018.0304

    authors: Xie X,Ren Y,Wang K,Yi B

    更新日期:2019-07-01 00:00:00

  • Association of androgen receptor, prostate-specific antigen, and CYP19 gene polymorphisms with prostate carcinoma and benign prostatic hyperplasia in a north Indian population.

    abstract::The genes involved in androgen pathway and metabolism have been reported to contribute considerably to prostate carcinoma (CaP) risk. The present study investigated the association of androgen receptor (AR), prostate-specific antigen (PSA or KLK3), and cytochrome P450 (CYP19) gene polymorphisms in CaP (n=105) and beni...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2011.0322

    authors: Soni A,Bansal A,Mishra AK,Batra J,Singh LC,Chakraborty A,Yadav DS,Mohanty NK,Saxena S

    更新日期:2012-08-01 00:00:00

  • Genetic Polymorphism of the Serotonin Transporter Gene, SLC6A4 rs16965628, Is Associated with Obsessive Compulsive Disorder.

    abstract::Obsessive compulsive disorder (OCD) is a psychiatric disorder characterized by obsessive ideas and compulsive behaviors. Genetic studies have centered on candidate genes involved in OCD etiology related to serotonergic and dopaminergic systems. In this study, the relationship between cathechol-O-methyltransferase (COM...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2014.0319

    authors: Cengiz M,Okutan SN,Bayoglu B,Sakalli Kani A,Bayar R,Kocabasoglu N

    更新日期:2015-05-01 00:00:00

  • DEFB4A Promoter Polymorphism Is Associated with Chronic Periodontitis: A Case-Control Study.

    abstract:: Background: Human β-defensin-2 is an antimicrobial peptide with antibiotic properties secreted by the oral cavity to protect the host against microbial attack. The inter-individual differences in defensin expression profiles due to genetic variation might be partly respons...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2019.0218

    authors: Kurt-Bayrakdar S,Ozturk A,Kara N

    更新日期:2020-03-01 00:00:00

  • Companion diagnostic testing for targeted cancer therapies: an overview.

    abstract::Genes and their products involved in the biological pathways of human cancers have been studied as either targets of new therapies, or predictive markers for the sensitivity of or resistance to the therapies. Companion diagnostic testing on biological markers for targeted cancer therapies has become a vital component ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,评审

    doi:10.1089/gtmb.2012.0510

    authors: Fan YS

    更新日期:2013-07-01 00:00:00

  • Transforming growth factor-beta3 gene polymorphisms and nonsyndromic cleft lip and palate risk: a meta-analysis.

    abstract:AIMS:To investigate the association between transforming growth factor-beta3 (TGF-β3) genetic polymorphisms and nonsyndromic cleft lip and palate (NSCLP) risk. METHODS:An extensive literature search for relevant studies was conducted on PubMed, Embase, Web of Science, Cochrane Library, and CBM databases from their inc...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,meta分析,评审

    doi:10.1089/gtmb.2013.0334

    authors: Tang M,Wang Y,Han S,Guo S,Wang D

    更新日期:2013-12-01 00:00:00

  • Results of genetic testing in 855 consecutive unrelated patients referred for long QT syndrome in a clinical laboratory.

    abstract:AIM:Our aim was to examine the diagnostic yield of genetic testing in 855 consecutive unrelated cases referred for Long QT syndrome (LQTS). RESULTS:Eight hundred fifty five consecutive patients with a mean age at testing of 27.5±18.6 years, were referred for LQTS genetic testing and had accompanying clinical informati...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2012.0118

    authors: Lieve KV,Williams L,Daly A,Richard G,Bale S,Macaya D,Chung WK

    更新日期:2013-07-01 00:00:00

  • Lack of association between essential hypertension and GSTO1 uncommon genetic variants in Italian patients.

    abstract:BACKGROUND AND OBJECTIVE:Essential hypertension (EH) is a complex phenotype that is affected by multiple genetic and environmental factors. Some authors have explored the role of genetic variability of the glutathione S-transferase (GST) enzymes in EH risk with contrasting results. In particular, our previous study inv...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2011.0310

    authors: Polimanti R,Piacentini S,Lazzarin N,Re MA,Manfellotto D,Fuciarelli M

    更新日期:2012-06-01 00:00:00

  • Genetic polymorphisms of platelet receptors in patients with acute myocardial infarction and resistance to antiplatelet therapy.

    abstract:METHODS:The studied group comprises 124 patients with acute myocardial infarction on dual antiplatelet therapy with acetylsalicylic acid (ASA) and thienopyridines. Antiplatelet therapy was monitored by platelet-rich plasma light transmittance aggregometry (LTA) using the APACT 4004 analyzer (Helena Laboratories) and by...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2014.0077

    authors: Ulehlova J,Slavik L,Kucerova J,Krcova V,Vaclavik J,Indrak K

    更新日期:2014-09-01 00:00:00

  • A Comparative Study of ARHI Imprinted Gene Detection and Fine-Needle Aspiration Cytology in the Differential Diagnosis of Benign and Malignant Thyroid Nodules.

    abstract:: Aims: To compare fine-needle aspiration cytology (FNAC) with imprinted gene detection in the differential diagnosis of benign and malignant thyroid nodules. Methods: A total of 34 patients (35 cases of thyroid nodules) were exa...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2019.0028

    authors: Zou D,Wu C,Miao J,Shao Q,Huang W,Huang J,Wu G,Zhang Q

    更新日期:2019-09-01 00:00:00

  • Identification of a Novel Nonsense ASPM Mutation in a Large Consanguineous Pakistani Family Using Targeted Next-Generation Sequencing.

    abstract:AIMS:To identify the pathogenic mutation underlying microcephaly primary hereditary (MCPH) in a large consanguineous Pakistani family. METHODS:A five-generation family with an autosomal recessive transmission of MCPH was recruited. Targeted next-generation DNA sequencing was carried out to analyze the genomic DNA samp...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2017.0229

    authors: Khan A,Wang R,Han S,Ahmad W,Zhang X

    更新日期:2018-03-01 00:00:00

  • Synergistic Association of Genetic Variants with Environmental Risk Factors in Susceptibility to Essential Hypertension.

    abstract:AIMS:Essential hypertension (EH) is a disease in which both environment and genes have an important role. This study was designed to identify the interaction model between genetic variants and environmental risk factors that most highly potentiates EH development. METHODS:We performed a case-control study with 1641 pa...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2017.0048

    authors: Sousa AC,Mendonça MI,Pereira A,Gouveia S,Freitas AI,Guerra G,Rodrigues M,Henriques E,Freitas S,Borges S,Pereira D,Brehm A,Palma Dos Reis R

    更新日期:2017-10-01 00:00:00

  • Effect of estrogen receptor β A1730G polymorphism on ABCA1 gene expression response to postmenopausal hormone replacement therapy.

    abstract::The estrogen receptor β (ERβ) mediates the action of estrogen on metabolism of lipids and lipoprotein. Therefore, its gene is a promising candidate gene for cardiovascular disease. The aim of the present study was to investigate whether the ERβ A1730G polymorphism modifies the metabolic response to hormone replacement...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2010.0106

    authors: Darabi M,Ani M,Panjehpour M,Rabbani M,Movahedian A,Zarean E

    更新日期:2011-01-01 00:00:00

  • Evaluation of MYOC, ACAN, HGF, and MET as candidate genes for high myopia in a Han Chinese population.

    abstract:AIM:To investigate the association between high myopia (HM) and single nucleotide polymorphisms (SNPs) in the myocilin (MYOC), hepatocyte growth factor (HGF), hepatocyte growth factor receptor (MET), and aggrecan (ACAN) genes in a Han Chinese population. METHODS:Sixteen SNPs were genotyped by the SNaPshot method in a ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2013.0479

    authors: Yang X,Liu X,Peng J,Zheng H,Lu F,Gong B,Zhao G,Meng Y,Guan H,Ning M,Yang Z,Shi Y

    更新日期:2014-06-01 00:00:00

  • The role of plasminogen activator inhibitor-1 and angiotensin-converting enzyme gene polymorphisms in bronchopulmonary dysplasia.

    abstract:BACKGROUND:Bronchopulmonary dysplasia (BPD) is a multifactorial disease of preterm infants that is characterized by airway injury, inflammation, and parencymal remodeling. Activation of the coagulation cascade leads to intraalveolar fibrin deposition in many inflammatory pulmonary disorders. Increased fibrin formation ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2010.0072

    authors: Ince DA,Atac FB,Ozkiraz S,Dilmen U,Gulcan H,Tarcan A,Ozbek N

    更新日期:2010-10-01 00:00:00

  • Genetic and Functional Analyses of Two Missense Mutations in the Transcription Factor FOXL2 in Two Chinese Families with Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome.

    abstract:BACKGROUND:Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal-dominant inherited disease. This study was carried out to investigate the genetic and functional changes within the FOXL2 gene in two Chinese families with BPES. MATERIALS AND METHODS:DNA was extracted from the peripheral blood ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2018.0064

    authors: Li H,Gu Y

    更新日期:2018-10-01 00:00:00

  • Association between polymorphisms in MTHFR and APOA5 and metabolic syndrome in the Greek population.

    abstract::Impaired energy homeostasis and low-grade inflammation have been related to components of the metabolic syndrome (MetS) such as dyslipidemia, obesity, and insulin resistance. Single-nucleotide polymorphisms in the genes encoding for IL-6 (g.-634G>C; c.174G>C), TNFα (g.-308G>A), methylenetetrahydrofolate reductase (MTH...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2010.0256

    authors: Vasilopoulos Y,Sarafidou T,Bagiatis V,Skriapa L,Goutzelas Y,Pervanidou P,Lazopoulou N,Chrousos GP,Mamuris Z

    更新日期:2011-09-01 00:00:00

  • Validation of an unlabeled probe melting analysis assay combined with high-throughput extractions for genotyping of the most common variants in HFE-associated hereditary hemochromatosis, C282Y, H63D, and S65C.

    abstract::Hereditary hemochromatosis is an inherited disorder of iron metabolism, characterized by high absorption of iron by the gastrointestinal tract leading to a toxic accumulation of iron in various organs and impaired organ function. Three variants in the HFE gene (p.C282Y, p.H63D, and p.S65C) are commonly associated with...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2011.0204

    authors: Sumner K,Hubley L,Pont-Kingdon G,Mitchell S,Wayman T,Wilson A,Meadows C,Elenitoba-Johnson K,Pattison D,Dobrowolski S,Best H,Lyon E

    更新日期:2012-07-01 00:00:00

  • Analysis of Polymorphisms in the MATN3 and DOT1L Genes and CTX-II Urinary Levels in Patients with Knee Osteoarthritis in a Northeast Mexican-Mestizo Population.

    abstract:: Aims: To investigate the possible roles of the single nucleotide polymorphisms (SNPs) MATN3 (rs77245812) and DOT1L (rs12982744) with susceptibility to knee osteoarthritis (KOA) among mestizos from the northeast region of Mexico. In addition, we analyzed the relationship of...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 临床试验,杂志文章

    doi:10.1089/gtmb.2019.0179

    authors: García-Alvarado FJ,Delgado-Aguirre HA,Rosales-González M,González-Martínez MDR,Ruiz-Flores P,González-Galarza FF,Arellano Perez Vertti RD

    更新日期:2020-02-01 00:00:00

  • Characteristics of dystrophin gene mutations among Chinese patients as revealed by multiplex ligation-dependent probe amplification.

    abstract:AIMS:To verify whether dystrophin gene mutations among Chinese patients feature different types and frequencies from other populations. METHODS:Multiplex ligation-dependent probe amplification (MLPA) in combination with multiplex PCR (mPCR) and/or short tandem repeat (STR)-based linkage analysis were applied in a larg...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2008.0059

    authors: Wang Q,Li-Ling J,Lin C,Wu Y,Sun K,Ma H,Jin C

    更新日期:2009-02-01 00:00:00

  • A genomic insight into the peopling of Manipur, India.

    abstract:INTRODUCTION:manipur, one of the northeastern states of India, lies on the ancient silk route and serves as a meeting point between the Southeast Asia and South Asia. AIMS:this study was conducted to understand and estimate the genomic diversity among various population groups of Manipur, with a major goal of getting ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2010.0078

    authors: Meitei KS,Meitei SY,Asghar M,Achoubi N,Murry B,Mondal PR,Sachdeva MP,Saraswathy KN

    更新日期:2010-12-01 00:00:00

  • Increased T-allele frequency of 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene in differentiated thyroid carcinoma.

    abstract:BACKGROUND:Epigenetic alterations in the global DNA methylation status may be associated with an increased risk of some cancer types in humans. The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic acid metabolism and plays an essential role in inherited DNA methylation profiles. The common 677 C>T ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2011.0347

    authors: Ozdemir S,Silan F,Hasbek Z,Uludag A,Atik S,Erselcan T,Ozdemir O

    更新日期:2012-07-01 00:00:00

  • DNA repair genes XRCC1 and ERCC1 polymorphisms and the risk of sporadic breast cancer in Han women in the Gansu Province of China.

    abstract:AIMS:Polymorphisms in DNA damage repair genes may affect DNA repair capacity and modulate breast cancer susceptibility. In this study, we aimed to analyze two polymorphisms for each of the DNA repair genes X-ray repair cross-complementing group 1 (XRCC1) rs25487 and rs1799782 and excision repair cross-complementing gro...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2015.0001

    authors: Zhu G,Wang L,Guo H,Lu L,Yang S,Wang T,Guo H,Wang H,Min J,Yang K,Chen X,Liu Y,Wang Z,Su H

    更新日期:2015-07-01 00:00:00

  • Improvement of a Rapid and Highly Sensitive Method for the Diagnosis of the Mitochondrial m.1555A>G Mutation Based on a Single-Stranded Tag Hybridization Chromatographic Printed-Array Strip.

    abstract:: Aims: Pathogenic variants in mitochondrial DNA are known to be associated with sensorineural hearing loss (SNHL) and aminoglycoside-induced HL. Among them, the m.1555A>G mutation is the most common. Thus, a rapid and easy companion diagnostic method for this mutation would...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/gtmb.2020.0105

    authors: Isaka Y,Nishio SY,Hishinuma E,Hiratsuka M,Usami SI

    更新日期:2021-01-01 00:00:00

  • Using Cost-Effectiveness Analysis to Quantify the Value of Genomic-Based Diagnostic Tests: Recommendations for Practice and Research.

    abstract:AIMS:New sequencing technologies allow increased opportunities to use genomic-based diagnostic tests (genomic tests) in routine clinical practice, which will impact healthcare budgets and patients' outcomes. This article aims to generate a list of recommendations on how the principles and methods of cost-effectiveness ...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章,评审

    doi:10.1089/gtmb.2017.0105

    authors: Spackman E,Hinde S,Bojke L,Payne K,Sculpher M

    更新日期:2017-12-01 00:00:00

  • Endothelial lipase-384A/C polymorphism is associated with acute coronary syndrome and lipid status in elderly Uygur patients in Xinjiang.

    abstract:OBJECTIVE:To explore the relationship between the endothelial lipase (EL) gene promoter -384A/C polymorphism and acute coronary syndrome (ACS) and lipid status in elderly Uygur patients in Xinjiang. METHODS:The polymerase chain reaction-restriction fragment length polymorphism method was used to detect the EL gene pro...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2014.0195

    authors: Huang D,Xie X,Ma YT,Huang Y,Ma X

    更新日期:2014-11-01 00:00:00

  • Genetic polymorphisms of p53 codon 72 and bladder cancer susceptibility: a hospital-based case-control study.

    abstract:BACKGROUND:p53 is one of the most widely investigated molecular markers in bladder cancer and its polymorphisms have been related to individual cancer risks. The objective of this study was to explore the association of p53 codon 72 polymorphism with susceptibility and clinicopathologic characteristics of bladder cance...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2010.0230

    authors: Zhang R,Chen W,Zhang W,Jiang Q,Liu C,Lin Y,Hu Z,Yu S,Xu G

    更新日期:2011-05-01 00:00:00

  • Low Expression of Long Noncoding RNA IRAIN Is Associated with Poor Prognosis in Non-M3 Acute Myeloid Leukemia Patients.

    abstract:AIMS:Deregulation of the long noncoding RNA IRAIN has been identified in several cancers. However, the expression pattern of IRAIN and its clinical implication in acute myeloid leukemia (AML) are unknown. The purpose of this study was to investigate the expression status of IRAIN and its clinical significance in non-M3...

    journal_title:Genetic testing and molecular biomarkers

    pub_type: 杂志文章

    doi:10.1089/gtmb.2017.0281

    authors: Pashaiefar H,Izadifard M,Yaghmaie M,Montazeri M,Gheisari E,Ahmadvand M,Momeny M,Ghaffari SH,Kasaeian A,Alimoghaddam K,Ghavamzadeh A

    更新日期:2018-05-01 00:00:00