Abstract：
PURPOSE:Brimonidine is a lowering pressure agent currently used in glaucoma. This chronic degenerative condition is characterised by neuronal death, and an agent which offers neuroprotection may slow down or impede the progression of neuronal cell death. METHODS:The effects of brimonidine (BMD) on the short- and long-term survival of retinal ganglion cells (RGCs) after transient retinal ischaemia are reported here using a rat model. The fluorescent tracer Fluorogold (FG) was applied to both superior colliculi to retrogradely label RGCs. A ninety-minute period of ischaemia was induced and densities of surviving RGCs were estimated over time by counting FG-labelled RGCs in 12 standard regions of each retina. RESULTS:Seven days after inducing transient ischaemia, there was loss of approximately half of the RGC population. Topical pre-treatment with 0.1% or 0.5% BMD prevented ischaemia-induced RGC death. CONCLUSIONS:These results indicate that optimal neuroprotective effects against the early loss of RGCs are seen with 0.1% or 0.5% BMD. Ischaemia-induced RGC loss continued between day 7 and day 21 in the vehicle treated groups and amounted to approximately 25% of the RGC population. Topical pre-treatment with 0.1% or 0.5% BMD was also effective in reducing the slow loss of RGCs. Eur J Ophthalmol 2001; 11 (Suppl 2): S36-S40.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Vidal-Sanz M,Lafuente MP,Mayor-Torroglosa S,Aguilera ME,Miralles de Imperial J,Villegas-Prez MPdoi
10.5301/EJO.2008.4056subject
Has Abstractpub_date
2001-01-01 00:00:00pages
36-40issue
Suppl. 2eissn
1120-6721issn
1724-6016pii
9CA81646-3ED3-45C1-8B24-CE589F54BA75journal_volume
11pub_type
杂志文章abstract：PURPOSE:To report clinical and confocal microscopy features of late-onset Candida albicans keratitis after Descemet stripping automated keratoplasty (DSAEK). METHODS:We performed clinical and confocal scan on a patient who underwent DSAEK and phacoemulsification for Fuchs endothelial dystrophy and cataract. RESULTS:A...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2011.6228
更新日期：2011-07-01 00:00:00
abstract：PURPOSE:To describe eye health-care services provided by in patient Departments of Ophthalmology in Hungary as of 1998. METHODS:A standardised questionnaire was sent to all Hungarian in-patient ophthalmic departments. The response rate was 100%, and data from six university departments and 56 hospitals with ophthalmic...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210201200310
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:To investigate the low mesopic contrast sensitivity function (LMCSF) of patients implanted with different modern optical bifocal and trifocal designs of multifocal intraocular lenses (mfIOLs). METHODS:This prospective, comparative, nonrandomized consecutive case series included 180 eyes that underwent cataract...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000777
更新日期：2016-11-04 00:00:00
abstract：PURPOSE:To report three cases of bilateral primary choroidal melanoma treated with bilateral plaque radiotherapy. METHODS:Retrospective, single-center case series. RESULTS:Case 1: In 1981, a 50-year-old man was diagnosed with a 5-mm-thick choroidal melanoma in the right eye (OD) and treated with plaque radiotherapy. ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600619
更新日期：2006-11-01 00:00:00
abstract：PURPOSE:Increased PGE2 production by the iris and ciliary body regulate intraocular pressure (IOP) in vivo. Various cholinergic and adrenergic compounds are traditionally used as antiglaucoma drugs, and their effect on IOP reduction is antagonised by cyclooxygenase inhibitors, indicating a role for eicosanoids in their...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210301300103
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:To report a case of spontaneous extrusion of a stainless steel glaucoma drainage implant (Ex-PRESS). METHODS:An Ex-PRESS was implanted under the conjunctiva in a 76-year-old man with primary open-angle glaucoma. RESULTS:Two years after implantation, the Ex-Press extruded spontaneously. Despite this adverse ev...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:The main purpose of this prospective study was to compare the efficacy, local tolerance, and safety of topical lomefloxacin 0.3% and topical ofloxacin 0.3% in the treatment of acute bacterial conjunctivitis. PATIENTS AND METHODS:Forty patients with acute bacterial conjunctivitis were included in a randomized, ...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:To assess and investigate the relationship between diurnal variations in intraocular pressure (IOP) and biomechanical properties of cornea. METHODS:Sixty-two healthy volunteers were recruited. Corneal compensated IOP (IOPcc), Goldmann-correlated IOP (IOPg), corneal resistance factor (CRF), and corneal hysteres...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210901900518
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:To evaluate and compare the glaucoma discrimination ability of macula, macular ganglion cell complex (mGCC), and peripapillary nerve fiber layer (ppNFL) thickness in Chinese patients using Fourier-domain optical coherence tomography (FD-OCT). METHODS:A total of 64 normal subjects (N), 47 glaucoma suspects (GS)...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000131
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To compare the performance of two different microcatheter systems, iTrack™ 250A and Glaucolight, in ab externo canaloplasty in three major categories: intraocular pressure reduction, drug therapy reintroduction, and evaluation of viscodilation over distension of the inner wall of Schlemm's canal. METHODS:A tot...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119833547
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:To assess corneal tissue modifications after riboflavin-UVA-induced cross-linking of corneal collagen in patients with progressive keratoconus as well as regeneration of epithelium and subepithelial nerve plexus by in vivo HRT II system confocal microscopy in humans. METHODS:Ten patients with progressive kerat...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600405
更新日期：2006-07-01 00:00:00
abstract：PURPOSE:To compare the symptoms, signs, and results of objective tests for dry eye syndrome (DES) in type 1 diabetes mellitus (T1DM) patients and controls. METHODS:A total of 104 children with T1DM and 104 age- and sex-matched controls were compared in terms of the symptoms, signs, and results of objective tests for D...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700601
更新日期：2007-11-01 00:00:00
abstract：PURPOSE:To assess the long-term results of viscotrabeculotomy in infants with primary congenital glaucoma and to compare its outcome with conventional trabeculotomy. PATIENTS AND METHODS:A prospective randomized comparative study included infants with primary congenital glaucoma younger than 2 years. Patients were div...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120922453
更新日期：2020-05-26 00:00:00
abstract：PURPOSE:Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders. METHODS:This is a randomized, crossover, open-labele...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2004-11-01 00:00:00
abstract：:In myopia patients, Rh and acid phosphatase were typed in two groups: group 1 consisted of 214 patients with low myopia (-6 D or less); group 2 of 124 patients with high myopia (more than -6 D). Statistical analysis of the markers showed a good Hardy-Weinberg equilibrium for both groups. In the Rh system there was a s...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：PURPOSE:To assess the role of risk factors for amblyopia, such as family history and neonatal background, for the prediction of either strabismic amblyopia or refractive amblyopia. METHODS:In this retrospective case-control model, the study population included all children born at the Hospital de Braga during 1997-201...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5001036
更新日期：2018-03-01 00:00:00
abstract：:not available. ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2008.1196
更新日期：2004-01-01 00:00:00
abstract：:Retinal ganglion cells (RGCs) undergo programmed cell death (apoptosis) after axonal injury. This cell death is mediated by several mechanisms, including deprivation of neurotrophic factors, alterations in gene expression, and production of reactive oxygen species. However, death of RGCs is delayed after axonal injury...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:To conduct an observational, multicenter study to evaluate real-world clinical efficacy and safety of the 0.2 µg/day fluocinolone acetonide (FAc) implant in the treatment of patients with chronic diabetic macular edema (DME) in 3 large hospital ophthalmology departments in the United Kingdom. METHODS:Fluocinol...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.5301/ejo.5000929
更新日期：2017-05-11 00:00:00
abstract：PURPOSE:To report on the intraocular use of a steroid slow-release device in an attempt to avoid multiple intraocular triamcinolone injections in chronic sympathetic ophthalmia. METHODS:A 47-year-old patient with sympathetic ophthalmia had received 17 intravitreal triamcinolone injections to suppress the uveitis, to i...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210801800531
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:To identify a new cortical vitreous segmentation protocol for non invasive standardised investigation of Neovascularisation (NV) with detection of regression of NV activity in Proliferative Diabetic Retinopathy (PDR). DESIGN:Retrospective study. PARTICIPANTS:One hundred and eighty-six eyes of 93 consecutive d...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120944028
更新日期：2020-07-28 00:00:00
abstract：PURPOSE:To evaluate the efficacy of 3 different surgical techniques for convergence excess esotropia: augmented medial rectus recession, medial rectus recession plus Faden, and slanted medial rectus recession. METHODS:Twenty-nine patients with convergence excess esotropia were divided into 3 groups. Group A included 9...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.2010.5225
更新日期：2011-03-01 00:00:00
abstract：:Purpose. To investigate the sensitivity and specificity of machine learning classifiers (MLC) and spectral domain optical coherence tomography (SD-OCT) for the diagnosis of glaucoma. Methods. Sixty-two patients with early to moderate glaucomatous visual field damage and 48 healthy individuals were included. All subjec...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000183
更新日期：2012-06-15 00:00:00
abstract：PURPOSE:Cystoid macular edema (CME) is a severe complication and a major cause of visual loss in patients with intraocular infection. In this type of CME, therapeutic strategies remain controversial. We aimed to investigate the efficacy and tolerability of interferon (IFN)-α2a in cystoid macular edema caused by intraoc...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000591
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:To study the morphologic characteristics of the optic nerve (ON) by using an experimental model of knockout mice for the expression of the P27(Kip1) gene, mainly involved in cell cycle arrest, apoptosis control, and retinoblastoma protein phosphorylation. METHODS:Eyeballs with the retrobulbar ON attached were ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700317
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:To describe a case of intraocular lens opacification resembling pseudophakic pseudoexfoliation affecting an AkreosFit intraocular lens (IOL). METHODS:Single case analysis. RESULTS:A patient had IOL opacification resembling pseudophakic pseudoexfoliation. CONCLUSIONS:An 83-year-old woman with normal tension g...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To report a case of acute frosted branch angiitis associated with acquired toxoplasmosis in which a late peripheral chorioretinal scar developed. RESULTS:A 32-year-old man without systemic symptoms presented with sudden visual loss in his left eye. Examination demonstrated frosted branch angiitis without necro...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210301300812
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:We aimed to discuss the possible role of developmental embryologic factors in neural crest cells in the aetiology of keratoconus and Fuchs' heterochromic iridocyclitis by presenting this case. CASE REPORT:We diagnosed bilateral keratoconus and unilateral Fuchs' heterochromic iridocyclitis in a 19 year old wome...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210101100114
更新日期：2001-01-01 00:00:00
abstract：PURPOSE:Dacryocystorhinostomy (DCR) is the standard surgical treatment for adult nasolacrimal duct obstruction. There have been relatively few studies of closed nasolacrimal duct intubation in adults. The aim of this study was to determine rates of anatomic patency following this procedure. METHODS:The authors carried...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700402
更新日期：2007-07-01 00:00:00
abstract：:Copper intraocular foreign bodies (IOFB) are relatively common after penetrating eye injuries. Ocular signs and symptoms vary greatly in relation to the copper content, ranging from chronic uveitis and severe visual loss for IOFB containing more than 85% copper, to local copper deposits with no severe ocular damage fo...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
