Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography.

Abstract:

:Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In this study, Janus microspheres were developed and used as a positive contrast agent for enhanced OCT imaging. Phantom and ex vivo liver tissue experiments as well as in vivo animal tests were conducted, which validated that Janus microspheres, as a novel type of OCT tracer, were very effective in improving the OCT imaging contrast. Working principle and SEM image of Janus microsphere (top). Enhanced OCT imaging (bottom) of Janus microspheres in zebrafish stomach (blue dash line) and sinusoids (green arrows) of nude liver.

journal_name

J Biophotonics

journal_title

Journal of biophotonics

authors

Zhang J,Liu J,Wang LM,Li ZY,Yuan Z

doi

10.1002/jbio.201600047

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

878-886

issue

6-7

eissn

1864-063X

issn

1864-0648

journal_volume

10

pub_type

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