Hippocampal NR3C1 DNA methylation can mediate part of preconception paternal stress effects in rat offspring.

Abstract:

:Many studies have been shown that maternal stress during pregnancy and in early life period influences offspring in the behavioral and molecular aspects in human and animal models. Recent research has indicated that the environmental condition of males before conception has effects on next generations. We evaluated whether preconception paternal stress (PPS) could influence on hippocampal glucocorticoid receptor gene (GR), (NR3C1) expression, corticosterone response and behavioral outcomes of their offspring. For this purpose, adult male rats were subjected to daily 10min session of forced swimming for 21 consecutive days. Then, two parental breeding groups were formed: stressed father (SF) and non-stressed father (NSF) or control group. 30-day-old pups were tested for anxiety-like behavior by using the elevated plus maze (EPM). Serum corticosterone level was also measured by ELISA. Hippocampal NR3C1 DNA methylation, gene and protein expression were respectively assayed by methylation sensitive restriction enzymes (Real Time PCR), Reverse Transcriptase PCR (RT-PCR) and Western-blotting in all groups. More anxiety-related behavior, serum corticosterone concentration, DNA methylation levels of NR3C1 and lower expression of this gene were significantly observed in paternally stressed pups compared to control pups. As well, molecular changes were more pronounced in male pups compared to female pups. Our results revealed that paternal stress prior to conception has a negative effect on molecular, hormonal and behavioral outcomes in their offspring.

journal_name

Behav Brain Res

authors

Niknazar S,Nahavandi A,Peyvandi AA,Peyvandi H,Roozbahany NA,Abbaszadeh HA

doi

10.1016/j.bbr.2017.02.014

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

71-76

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(16)31322-5

journal_volume

324

pub_type

杂志文章
  • Neuroimaging the temporal dynamics of human avoidance to sustained threat.

    abstract::Many forms of human psychopathology are characterized by sustained negative emotional responses to threat and chronic behavioral avoidance, implicating avoidance as a potential transdiagnostic factor. Evidence from both nonhuman neurophysiological and human neuroimaging studies suggests a distributed frontal-limbic-st...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.09.042

    authors: Schlund MW,Hudgins CD,Magee S,Dymond S

    更新日期:2013-11-15 00:00:00

  • Dopamine signaling in the medial prefrontal cortex and amygdala is required for the acquisition of fructose-conditioned flavor preferences in rats.

    abstract::Systemic administration of dopamine (DA) D1 (SCH23390: SCH) and D2 (raclopride: RAC) antagonists blocked both acquisition and expression of fructose-conditioned flavor preferences (CFP). It is unclear what brain circuits are involved in mediating these effects. The present study investigated DA signaling within the nu...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.05.004

    authors: Malkusz DC,Banakos T,Mohamed A,Vongwattanakit T,Malkusz G,Saeed S,Martinez S,Bohn T,Mahmud F,Liss C,Rozvi A,Touzani K,Sclafani A,Bodnar RJ

    更新日期:2012-08-01 00:00:00

  • Conditioned saccharin avoidance and sensitization to drugs of abuse.

    abstract::Saccharin avoidance conditioned by drugs of abuse (CSA) has been interpreted as an expression of the appetitive, dopamine-dependent, properties of the drug. Repeated exposure to these drugs induces an increase (sensitization) of their motor stimulant properties associated with differential changes in DA transmission i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.05.044

    authors: Fenu S,Cadoni C,Di Chiara G

    更新日期:2010-12-25 00:00:00

  • Barnes maze performance of Octodon degus is gender dependent.

    abstract::Gender differences in spatial navigation have been widely reported in nocturnal rodent species. Here, for the first time we report gender differences in spatial learning and memory of Octodon degus, a long-lived diurnal hystricomorph rodent. In the present study, 16 months old male and female O. degus were tested in t...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.04.005

    authors: Popović N,Madrid JA,Rol MA,Caballero-Bleda M,Popović M

    更新日期:2010-10-15 00:00:00

  • Prepulse inhibition of acoustic startle in spontaneously hypertensive rats.

    abstract::Prepulse inhibition is modulated by dopaminergic drugs and is disrupted in attention-deficit hyperactivity disorder, as well as mental illnesses such as schizophrenia. Spontaneously hypertensive rats (SHR) have been proposed as an animal model of attention-deficit hyperactivity disorder and show marked alterations of ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.02.021

    authors: van den Buuse M

    更新日期:2004-10-05 00:00:00

  • Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link.

    abstract::It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM), and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and DM is still unclear. Recently, more and more evidence has shown that glycogen synthase kinase-3β (GSK-3β) may be the potential link betwe...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2017.11.015

    authors: Zhang Y,Huang NQ,Yan F,Jin H,Zhou SY,Shi JS,Jin F

    更新日期:2018-02-26 00:00:00

  • Exposure to an enriched environment facilitates motor recovery and prevents short-term memory impairment and reduction of striatal BDNF in a progressive pharmacological model of parkinsonism in mice.

    abstract::Previous studies showed that the repeated administration with a low dose of reserpine (RES) induces a gradual appearance of motor signs and cognitive deficits compatible with parkinsonism in rodents. Environmental stimulation has neuroprotective effects in animal models of neurodegenerative damage, including acutely i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.04.028

    authors: Campêlo CLC,Santos JR,Silva AF,Dierschnabel AL,Pontes A,Cavalcante JS,Ribeiro AM,Silva RH

    更新日期:2017-06-15 00:00:00

  • Proteomic and transcriptional profiling of rat amygdala following social play.

    abstract::Social play is the most characteristic form of social interaction which is necessary for adolescents to develop proper cognitive, emotional, and social competency. The information available on neural substrates and the mechanism involved in social play is limited. This study characterized social play by proteomic and ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.112210

    authors: Alugubelly N,Mohammad AN,Edelmann MJ,Nanduri B,Sayed M,Park JW,Carr RL

    更新日期:2019-12-30 00:00:00

  • Early physical and motor development of mouse offspring exposed to valproic acid throughout intrauterine development.

    abstract::Clinical research has identified developmental delay and physical malformations in children prenatally exposed to the antiepileptic drug (AED) valproic acid (VPA). However, the early signs of neurodevelopmental deficits, their evolution during postnatal development and growth, and the dose effects of VPA are not well ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.05.023

    authors: Podgorac J,Pešić V,Pavković Ž,Martać L,Kanazir S,Filipović L,Sekulić S

    更新日期:2016-09-15 00:00:00

  • Involvement of orexinergic receptors in the nucleus accumbens, in the effect of forced swim stress on the reinstatement of morphine seeking behaviors.

    abstract::Orexinergic system is involved in primary rewards; the neural circuit of the ventral tegmental area (VTA), nucleus accumbens (NAc), prefrontal cortex and amygdala represents overlapping elements mediating the rewarding effects of drugs and stressful experiences. The NAc integrates reward-related information from the V...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.08.021

    authors: Farzinpour Z,Taslimi Z,Azizbeigi R,Karimi-Haghighi S,Haghparast A

    更新日期:2019-01-01 00:00:00

  • Persistent activation of select forebrain regions in aggressive, adolescent cocaine-treated hamsters.

    abstract::Hamsters repeatedly exposed to cocaine throughout adolescence display highly escalated offensive aggression compared to saline-treated littermates. The current study investigated whether adolescent cocaine exposure activated neurons in areas of hamster forebrain implicated in aggressive behavior by examining the expre...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.11.027

    authors: Knyshevski I,Connor DF,Harrison RJ,Ricci LA,Melloni RH Jr

    更新日期:2005-04-30 00:00:00

  • Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice.

    abstract::The ameliorating effects of the ethyl acetate fraction from Dendropanax morbifera (EFDM) on cognitive impairment in high-fat diet (HFD)-induced diabetic mice were examined by measuring its possible pharmacological activities. Administration of EFDM (20 and 50mg/kg body weight) in HFD-induced diabetic mice significantl...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.06.013

    authors: Kim JM,Park SK,Guo TJ,Kang JY,Ha JS,Lee du S,Lee U,Heo HJ

    更新日期:2016-10-01 00:00:00

  • David vs. Goliath: Serotonin modulates opponent perception between smaller and larger rivals.

    abstract::During agonistic encounters, the perception of a larger opponent through morphological signaling typically suppresses aggression in the smaller individual, preventing contest intensity escalation. However, non-morphological factors such as central serotonin (5-HT) activity can influence individual aggression, potentia...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.07.028

    authors: Bubak AN,Rieger NS,Watt MJ,Renner KJ,Swallow JG

    更新日期:2015-10-01 00:00:00

  • DSP-4, a noradrenergic neurotoxin, produces sex-specific effects on pairing and courtship behavior in zebra finches.

    abstract::Norepinephrine (NE) is involved in a variety of behaviors across vertebrate species. In songbirds, NE is involved in singing and auditory perception, fundamental components of pair formation. Mechanisms of pairing remain poorly understood in avian species. NE is likely involved given its role in vocal communication an...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.05.056

    authors: Vahaba DM,Lacey WH,Tomaszycki ML

    更新日期:2013-09-01 00:00:00

  • ZENK expression in a restricted forebrain area correlates negatively with preference for an imprinted stimulus.

    abstract::Sexual imprinting is an early learning process by which young birds acquire the characteristics of a potential sexual partner. The physiological basis of this learning process is an irreversible reduction of dendritic spines in two forebrain areas, the LNM (lateral nido-mesopallium) and the MNM (medial nido-mesopalliu...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.03.034

    authors: Huchzermeyer C,Husemann P,Lieshoff C,Bischof HJ

    更新日期:2006-07-15 00:00:00

  • Short- and long-term summation characteristics of electrical self-stimulation reward.

    abstract::Using a Y-maze preference test paradigm, we examined the characteristics of the neural networks that integrate trains of rewarding stimulation pulses. Rats compared the rewarding effectiveness of various durations of a test reinforcement to those of 3 durations of a standard reinforcement. By changing the duration of ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(85)90030-0

    authors: Mason PA,Milner PM

    更新日期:1985-12-01 00:00:00

  • Ictal stimulus processing during spike-wave discharges in genetic epileptic rats.

    abstract::In the present experiment it was investigated whether and to what extent auditory information processing is possible during the presence of spike-wave discharges in rats. To that end, WAG/Rij rats which are an animal model for absence epilepsy, were provided with cortical electrodes for the registration of the electro...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(03)00031-7

    authors: Drinkenburg WH,Schuurmans ML,Coenen AM,Vossen JM,van Luijtelaar EL

    更新日期:2003-08-14 00:00:00

  • Labyrinthine and visual involvement in the dorsal immobility response of adult rats.

    abstract::The dorsal immobility response (DIR) is typically seen in the infants of many altricial mammalian species. Lifting the animal into the air by the nape of the neck is the primary releasing stimulus. Functionally, this response appears to facilitate carrying of the infants by the adults. When grasped by the nape and lif...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(90)90105-n

    authors: Pellis SM,Teitelbaum P,Meyer ME

    更新日期:1990-07-09 00:00:00

  • Does blindness affect egocentric and allocentric frames of reference in small and large scale spaces?

    abstract::There is evidence that early deprivation of vision prompts the use of body-based, egocentric spatial representations in congenitally blind individuals, whereas previous visual experience favors the use of object-based, allocentric representations (e.g. Pasqualotto A, Spiller MJ, Jansari AS, Proulx MJ. Visual experienc...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.07.032

    authors: Iachini T,Ruggiero G,Ruotolo F

    更新日期:2014-10-15 00:00:00

  • Long-term depletion of brain histamine induced by alpha-fluoromethylhistidine increases feeding-associated locomotor activity in mice with a modulation of brain amino acid levels.

    abstract::We examined the long-term effects of administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase, on the spontaneous locomotor activity, food intake and brain contents of histamine, catecholamines, serotonin and amino acids of ICR mice. The distance of ambulation and number...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(96)00059-9

    authors: Sakai N,Sakurai E,Onodera K,Sakurai E,Asada H,Miura Y,Watanabe T

    更新日期:1995-12-14 00:00:00

  • Effects of acute restraint and unpredictable chronic mild stress on brain corticotrophin releasing factor mRNA in the elevated T-maze.

    abstract::Corticotrophin releasing factor (CRF) modulates stress/anxiety-related responses. Previous studies showed that exposure to acute restraint and unpredictable chronic mild stress (UCMS) facilitates elevated T-maze (ETM) avoidance responses, an anxiogenic-like effect. This study verified the role of CRF in the modulation...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.09.029

    authors: de Andrade JS,Céspedes IC,Abrão RO,da Silva JM,Ceneviva R,Ribeiro DA,Bittencourt JC,Viana MB

    更新日期:2018-01-30 00:00:00

  • Escape behavior under tonic inhibitory control of histamine H(2)-receptor mediated mechanisms in the midbrain tectum.

    abstract::The dorsal periaqueductal gray matter (DPAG), superior and inferior colliculus have been implicated in the control of defense reactions in the midbrain. Electrical and chemical stimulation of these structures induces escape behavior, usually accompanied by autonomic responses and antinociception. GABA, 5-HT, opioids, ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00228-5

    authors: Santos NR,Huston JP,Brandão ML

    更新日期:2001-10-15 00:00:00

  • Multiple unit activity of prefrontal cortex and dorsomedial thalamus during delayed go/no-go alternation in the rat.

    abstract::While the rat was performing a go/no-go alternation task with a 10-s delay period, neuronal activity was recorded from electrodes chronically implanted in the prefrontal cortex (PFC) and the dorsomedial thalamus (DMT). In both PFC and DMT, neuronal activity during the delay period prior to a 'go' response was differen...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(86)90229-9

    authors: Sakurai Y,Sugimoto S

    更新日期:1986-06-01 00:00:00

  • Effects of neonatal testicular hormones on preference behaviour in the rat.

    abstract::The effects of neonatal testicular hormones on preference behaviour for an oestrous female rat were investigated. A residential maze was used in which the position of the animals was registered continuously without disturbing them. Two experiments are described. In the first experiment adult male rats which had been c...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(84)90197-9

    authors: Merkx J

    更新日期:1984-04-01 00:00:00

  • Acquisition of a spatial conditioned place preference is impaired by amygdala lesions and improved by fornix lesions.

    abstract::This experiment examined the role of the lateral nucleus of the amygdala, the hippocampus and the dorsal striatum in the acquisition of a conditioned place preference (CPP). The CPP was established on a radial maze which was rotated before each daily trial so that only distal cues could be used to distinguish among lo...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(93)90122-7

    authors: White NM,McDonald RJ

    更新日期:1993-06-30 00:00:00

  • Behavioral response to novelty correlates with dopamine receptor availability in striatum of Göttingen minipigs.

    abstract::Behavioral response to novelty in rats has been linked both to dopamine transmission in the ventral striatum, and to propensity to self-administer psychostimulant drugs. In order to probe the relationship between behavioral response to novelty and dopamine systems we have developed a behavioral model for correlation w...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.06.008

    authors: Lind NM,Gjedde A,Moustgaard A,Olsen AK,Jensen SB,Jakobsen S,Arnfred SM,Hansen AK,Hemmingsen RP,Cumming P

    更新日期:2005-11-07 00:00:00

  • Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.

    abstract::Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Elements of this putative association remain unclarified, notably whether: (a) COMT variation modulates responses to acute and/or chronic stress equally; (b) acute...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.12.014

    authors: Desbonnet L,Tighe O,Karayiorgou M,Gogos JA,Waddington JL,O'Tuathaigh CM

    更新日期:2012-03-17 00:00:00

  • Remote ischemic post-conditioning improves neurological function by AQP4 down-regulation in astrocytes.

    abstract::Cerebral ischemia is a primary cause of human death and long-term disability. Previous studies have suggested that remote ischemic post-conditioning (RIPC) is a potential useful tool for cerebral ischemic treatment. However, the protective mechanism of RIPC is not very clear. This study verified the hypothesis that, i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2015.04.024

    authors: Li S,Hu X,Zhang M,Zhou F,Lin N,Xia Q,Zhou Y,Qi W,Zong Y,Yang H,Wang T

    更新日期:2015-08-01 00:00:00

  • Spatial relational learning and memory abilities do not differ between men and women in a real-world, open-field environment.

    abstract::This study assesses gender differences in spatial and non-spatial relational learning and memory in adult humans behaving freely in a real-world, open-field environment. In Experiment 1, we tested the use of proximal landmarks as conditional cues allowing subjects to predict the location of rewards hidden in one of tw...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.09.046

    authors: Banta Lavenex P,Lavenex P

    更新日期:2010-02-11 00:00:00

  • Inflammatory mechanisms contribute to microembolism-induced anxiety-like and depressive-like behaviors.

    abstract::Poor vascular health, atherosclerosis, or cardiac procedures in the elderly result in clinically silent microvascular infarcts that increase susceptibility to larger ischemic episodes and can precipitate changes in mood and cognition. Although the mechanisms that underlie ischemia-induced behavioral changes have not b...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.01.057

    authors: Nemeth CL,Miller AH,Tansey MG,Neigh GN

    更新日期:2016-04-15 00:00:00