Abstract：
INTRODUCTION:The EOLE cohort aimed to describe, in routine clinical practice, the characteristics and management of patients receiving bevacizumab in combination with first-line metastatic chemotherapy for advanced metastatic or recurrent non squamous non-small cell lung cancer (nsNSCLC), as well as its efficacy and safety. METHODS:A total of 423 patients were enrolled in this prospective, national, multicenter study. Data were collected every 3 months over an 18-month period. RESULTS:Amongst the 407 patients analyzed (mean age 60±10 years, male 68%, ECOG-PS≤1 88%, smokers or former smokers 87%, cardiovascular comorbidities 40%), all except for 2 patients received bevacizumab (7.5 or 15mg/kg/3 weeks in 99% of patients) in combination with doublet chemotherapy. A total of 160 (60%) patients who completed induction received bevacizumab maintenance therapy. Median progression-free survival was 6.9 months (95% CI=[6.0-7.5]). Median overall survival (12.8 months [10.4-14.7]) was longer in patients with ECOG-PS≤1 (14.4 months [12.3-15.9] versus 4.9 months [3.4-8.3] if ECOG-PS=2). A total of 131 (32%) patients experienced at least one serious adverse event (SAE), and 51 (12%) at least one bevacizumab-related SAE. CONCLUSION:EOLE confirms the efficacy and safety of bevacizumab in aNSCLC patients, in current medical practice.
journal_name
Rev Mal Respirjournal_title
Revue des maladies respiratoiresauthors
Chouaid C,Falchero L,Schott R,Bonnetain F,Taguieva-Pioger N,Bennouna Jdoi
10.1016/j.rmr.2016.05.003subject
Has Abstractpub_date
2017-01-01 00:00:00pages
36-43issue
1eissn
0761-8425issn
1776-2588pii
S0761-8425(16)30089-4journal_volume
34pub_type
杂志文章,多中心研究abstract：INTRODUCTION:The high prevalence of allergic rhinitis that occurs in elite athletes has been extensively investigated. However, data among recreational athletes practicing indoor activities remain contradictory. The aim of the present study was to determine whether taking part in gym based sporting activities constitut...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2013.02.015
更新日期：2013-09-01 00:00:00
abstract：:Chest radiographs, taken in the standing position, were reviewed in 47 hospitalised patients with chronic obstructive respiratory failure; the review was done retrospectively and the radiographs were examined for signs of left ventricular failure. Only interstitial and alveolar oedema were considered, upper lobe blood...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Static lung hyperinflation is defined as the elevation of end- expiratory lung volume above its predicted value, with no increase in end-expiratory alveolar pressure, which remains equal to atmospheric pressure. Dynamic hyperinflation is the transient increase of this volume above the relaxation volume. In patients wi...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/s0761-8425(08)75094-0
更新日期：2008-12-01 00:00:00
abstract：INTRODUCTION:Lung hyperinflation (LH) has become a major concern in the management of chronic obstructive pulmonary disease (COPD). MAIN AIM:To evaluate the role of lung volumes in the positive diagnosis of COPD and in the assessment of airway obstruction reversibility. POPULATION AND METHODS:Three hundred and sixty-...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2013.05.009
更新日期：2014-01-01 00:00:00
abstract：:A 47-year-old woman, without significant past medical history, presented an acute dyspnea with hypoxia, marked pulmonary arterial hypertension (PAH) and signs of right heart failure. Chest x-ray showed a moderate dilatation of the right heart cavities. Pulmonary embolism was suggested. After detailed questioning and c...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：INTRODUCTION:Light chain deposition disease is a rare anatomo-clinical disorder, which rarely leads to cystic lung destruction. CASE REPORT:We report the case of a 62years old female patient with a history of a monoclonal gammopathy of unknown significance who developed progressive dyspnea. Thoracic CT-scan demonstrat...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2020.01.001
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:Mandibular advancement (MA) has emerged over the last decade as an alternative solution to nasal continuous airway pressure (nCPAP) for the treatment of obstructive sleep apnea syndrome (OSAS). OBSERVATION:We report the case of a patient with history of chronic atrial fibrillation and moderate supine-depe...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(06)71821-6
更新日期：2006-11-01 00:00:00
abstract：:Thirteen patients with a tracheostomy who were undergoing artificial ventilation at home were included in a study covering 62 episodes, during a month of treatment, which was undertaken with three different humidification systems: A Puritan Bennet Cascade humidifier (C), a Swedish nose Vygon-(V) (a hydroscopic condens...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Our study aimed to assess the impact of acute respiratory failure (ARF) on survival of patients with chronic obstructive pulmonary disease (COPD) receiving long-term oxygen therapy (LTOT) plus nasal intermittent positive pressure ventilation (NIPPV). Survival was analysed retrospectively in 24 patients with severe COP...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：2000-02-01 00:00:00
abstract：:The diaphragm is the muscle most implicated in breathing. Its morphological exploration usually depends on pulmonary radiography, fluoroscopy, CT-scanning and MRI. Its function is evaluated by the classical respiratory functional tests, the measurement of maximum inspiratory and expiratory pressures, the transdiaphrag...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2017.02.005
更新日期：2017-06-01 00:00:00
abstract：:Amongst the undesirable effects of medical intervention which touch on the respiratory apparatus one can distinguish schematically those disorders which affect the "passive respiratory system" (lungs, pleura, bronchi and vessels) and those which concern the "active respiratory system (SRA)" (nerve centres, respiratory...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:This study evaluates the impact of the ash cloud emitted in February 2010 during the eruption of the Soufrière Hill volcano of the island of Montserrat (70 km from Guadeloupe), on asthma exacerbations registered by the emergency hospital services in the archipelago of Guadeloupe in February 2010. METHODS:...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/j.rmr.2012.11.002
更新日期：2013-03-01 00:00:00
abstract：:Current guidelines for referring patients with idiopathic pulmonary fibrosis (IPF) for lung transplantation, based on resting parameters, are insufficient to predict 3-year mortality. The aim of this study was to determine the prognostic value of cardio-pulmonary exercise testing (CPET) in patients with IPF. A multice...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rmr.2010.08.016
更新日期：2011-03-01 00:00:00
abstract：:Right ventricular failure (RVF) is a common cause of admission to the intensive care unit and its presence is a major prognostic factor in acute pulmonary embolism (PE) and chronic pulmonary hypertension (PH). RVF results from an incapacity of the RV to adapt to an increase in afterload so it can become critical in ac...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2019.07.012
更新日期：2020-02-01 00:00:00
abstract：:Invasive pulmonary aspergillosis is an opportunistic pneumonia which is particularly common in immuno-depressed subjects. The most frequent risk factors are the intensity and duration of leucopaenia, cytotoxic drugs and steroid therapy. In the respiratory tract, the proliferation of Aspergillus fumigatus becomes possi...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:To define the role of interventional radiology and surgery respectively, in the treatment of massive haemoptysis. GENERAL CONSIDERATIONS: For the management of massive haemoptysis in non-terminal pathologies an intensive care facility and a multi-disciplinary team are necessary. It is of paramount importance ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(05)85635-9
更新日期：2005-11-01 00:00:00
abstract：:We report seven cases of seven pulmonary varicella occurring in seven adults without any previous history of known immunological deficit. In all the cases the vesicular eruption was diffuse, occurring after contact with a child presenting with benign varicella. The respiratory signs appeared five to seven days after t...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Bronchocentric granulomatosis is a rare entity and has only recently been characterised. We report a case of a forty-three year old man presenting with multifocal bronchocentric granulomatosis which was revealed following some oto-rhino-laryngological and bronchopulmonary symptoms. The open lung biopsy confirmed the d...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Primary malignant melanoma of the lower airways is very rare. 24 cases have been collected over the past century. Our case was a patient of 52 years of age who had been discovered to have a tracheal tumour which was found to be a malignant melanoma and was treated with a Laser. The major problem is to establish that t...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Lung cancer is the most common cause of cancer-related mortality throughout the world representing around 18% of the total. There is still a male predominance but this is becoming less pronounced and in the US, lung cancer is now the most common cause of cancer-related mortality in women. In France, it had risen to se...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2010.12.015
更新日期：2011-10-01 00:00:00
abstract：:This article reports an exchange of unbiased arguments between Mr Guy Postiaux speaking in favour of respiratory physiotherapy in acute viral bronchiolitis in the newborn and Prof. Jean-Christoph Dubus arguing against. A review of the literature suggests that traditional methods of physiotherapy should be abandoned be...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：10.1016/j.rmr.2017.08.003
更新日期：2018-04-01 00:00:00
abstract：:The relationship between allergens in a domestic environment and asthma has been extensively studied and it is only recently that studies have suggested the possibility of the role of chemical pollutants in the internal environment in the genesis of asthma. The pollutants studied are oxides of nitrogen (nitrogen dioxi...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:Utilization of Diagnosis Related Groups (DRGs') for hospital payments in France. OBJECTIVES:To search the variations and the explicative factors of length of stay in a pneumologic unit, to analyse the relevance of the indicators by using the DRG's and the supplementary variables in a medical and economical ...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Communication in oncology often means communicating in difficult circumstances. Moreover, "to tell" is an essential requirement in medicine. We need to make this communication a series of realistic proposals and proceed step by step. This is probably one of the greatest challenges that we have to face in oncology. The...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：10.1016/s0761-8425(08)74410-3
更新日期：2008-10-01 00:00:00
abstract：:One in a hundred pregnant females has asthma. Pregnancy may change the course of the asthma and inversely foetal and obstetric prognosis may be affected by the illness and by the potentially deleterious effect of treatment. The maternal physiological changes which occur during pregnancy throw little light on the varia...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
abstract：:Chest radiograph and computed tomography are the most appropriate imaging tools for detecting asbestos-related pleural and parenchymal disease due to their availability and performances. The cost and irradiation delivery of conventional chest X-rays are limited. Technical parameters and reading should be standardized....
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1999-12-01 00:00:00
abstract：:Recurrence of pulmonary embolism can occur in presence of coagulation disorders or cancer. It can also develop without any of these factors. Coagulation tests should search for abnormalities such as inherited deficiencies of antithrombin, protein C, protein S, factor V mutation, variation of the prothrombin gene, hype...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:The authors report the case of chronic destructive polychondritis (PCA) with extensive and predominant laryngo-tracheal involvement. The respiratory localisation of PCA is apparent in around 50% of cases. In a quarter of patients presenting with this type of localisation, the outcome is fatal. Tracheal disorders as th...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:A young man without any past history of note had taken isotretinoin for disfiguring acne before the summer season. He presented with a severe bilateral pneumonia, associated with dyspnoea two months after the start of treatment. On the pulmonary radiography there was a bilateral ground glass appearance which was worse...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Respiratory handicap due to neurological diseases is often underestimated. Given clinical signs are either mild or absent, systematic measurement of the vital capacity is the best mean to detect in practice the restrictive syndrome. The onset of home mechanical ventilatory support should be decided at steady state, ap...
journal_title：Revue des maladies respiratoires
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
