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Two domains in alpha interferons influence the efficacy of the antiviral response.

Abstract：

:Murine interferon-alpha 1 and murine interferon-alpha 4 share 80% of their amino acids, yet the proteins differ considerably in their ability to protect mouse or hamster cells against viral infection. With the aim of localizing areas within these proteins which influence the biological response we have constructed hybrid alpha 1 alpha 4 genes by means of homologous recombination of the parent genes. When the antiviral activities of these proteins were compared, it appeared that there are at least two domains that affect the biological response to these proteins: area A (amino acids 10-20) and area B (amino acids 55-67). These areas are presumably involved in the interaction between ligand and receptor. Most interestingly, hybrids in which area A from IFN-alpha 1 is combined with area B from alpha 4, have antiviral activities on homologous cells that are one to two orders of magnitude higher than those of the parent proteins.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zwarthoff EC,Gennissen A,Bosveld IJ,Trapman J,van Heuvel M

doi

10.1016/s0006-291x(87)80085-2

subject

Has Abstract

pub_date

1987-08-31 00:00:00

pages

47-55

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(87)80085-2

journal_volume

147

pub_type

杂志文章

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