Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer.

abstract：:In densely populated urban environments, the distribution of microbes and the drivers of microbial community assemblages are not well understood. In sprawling metropolitan habitats, the "urban microbiome" may represent a mix of human-associated and environmental taxa. Here we carried out a baseline study of automated ...

journal_title：mSphere

authors： Bik HM,Maritz JM,Luong A,Shin H,Dominguez-Bello MG,Carlton JM

更新日期：2016-11-16 00:00:00

abstract：:Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota. However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metaboliz...

journal_title：mSphere

authors： Wang Z,Tauzin AS,Laville E,Tedesco P,Létisse F,Terrapon N,Lepercq P,Mercade M,Potocki-Veronese G

更新日期：2020-01-08 00:00:00

abstract：:This study was carried out to evaluate hypotheses generated by fundamental cause theory regarding the socioeconomic status (SES) gradient in colonization with Staphylococcus aureus among Hispanic and non-Hispanic adults living in a border community. Participants (n = 613) recruited in naturally occurring small groups ...

journal_title：mSphere

authors： Barger SD,Lininger MR,Trotter RT 2nd,Wayment HA,Mbegbu M,Kyman S,Pearson T

更新日期：2020-09-30 00:00:00

abstract：:The genomes of Leishmania and trypanosomes encode six paralogs of the eIF4E cap-binding protein, known in other eukaryotes to anchor the translation initiation complex. In line with the heteroxenous nature of these parasites, the different LeishIF4E paralogs vary in their biophysical features and their biological beha...

journal_title：mSphere

authors： Shrivastava R,Tupperwar N,Drory-Retwitzer M,Shapira M

更新日期：2019-09-04 00:00:00

abstract：:Replication forks must respond to changes in nutrient conditions, especially in bacterial cells. By investigating the single-molecule dynamics of replicative helicase DnaC, DNA primase DnaG, and lagging-strand polymerase DnaE in the model bacterium Bacillus subtilis, we show that proteins react differently to stress c...

journal_title：mSphere

authors： Hernández-Tamayo R,Schmitz H,Graumann PL

更新日期：2021-01-27 00:00:00

abstract：:Extracellular vesicles (EVs) are membranous compartments produced by yeast and mycelial forms of several fungal species. One of the difficulties in perceiving the role of EVs during the fungal life, and particularly in cell wall biogenesis, is caused by the presence of a thick cell wall. One alternative to have better...

journal_title：mSphere

authors： Rizzo J,Chaze T,Miranda K,Roberson RW,Gorgette O,Nimrichter L,Matondo M,Latgé JP,Beauvais A,Rodrigues ML

更新日期：2020-08-12 00:00:00

abstract：:Sepsis caused by Gram-negative bacteria is the consequence of an unrestrained infection that continuously releases lipopolysaccharide (LPS) into the bloodstream, which triggers an uncontrolled systemic inflammatory response leading to multiorgan failure and death. After scrutinizing the immune modulation exerted by a ...

journal_title：mSphere

authors： Ramos-Benitez MJ,Ruiz-Jimenez C,Rosado-Franco JJ,Ramos-Pérez WD,Mendez LB,Osuna A,Espino AM

更新日期：2018-12-19 00:00:00

abstract：:Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and are thought to modify their binding interactions with different ...

journal_title：mSphere

authors： Singh BK,Leuthold MM,Hansman GS

更新日期：2016-03-30 00:00:00

abstract：:Arginine is an important pH-elevating agent in the oral cavity. It has been incorporated in oral hygiene formulations to mitigate sensitivity and to prevent caries. In this investigation, the effects of sustained arginine dosing of dental plaque microcosms on bacteriological composition and pH were evaluated under con...

journal_title：mSphere

authors： Ledder RG,Mistry H,Sreenivasan PK,Humphreys G,McBain AJ

更新日期：2017-08-23 00:00:00

abstract：:Feedback mechanisms are fundamental to the control of physiological responses. One important example in gene regulation, termed negative autoregulation (NAR), occurs when a transcription factor (TF) inhibits its own production through transcriptional repression. This enables more-rapid homeostatic control of gene expr...

journal_title：mSphere

authors： Kozuch BC,Shaffer MG,Culyba MJ

更新日期：2020-08-19 00:00:00

abstract：:The emergence of Cryptococcus gattii, previously regarded as a predominantly tropical pathogen, in the temperate climate of the North American Pacific Northwest (PNW) in 1999 prompted several questions. The most prevalent among these was the timing of the introduction of this pathogen to this novel environment. Here, ...

journal_title：mSphere

authors： Roe CC,Bowers J,Oltean H,DeBess E,Dufresne PJ,McBurney S,Overy DP,Wanke B,Lysen C,Chiller T,Meyer W,Thompson GR 3rd,Lockhart SR,Hepp CM,Engelthaler DM

更新日期：2018-01-17 00:00:00

abstract：:The Enterobacterales order of Gram-negative bacteria includes the common nosocomial pathogens Klebsiella pneumoniae, Escherichia coli, Serratia marcescens, and Enterobacter species. Intestinal domination by some colonizing bacterial taxa is associated with subsequent infection, but 16S rRNA gene sequencing is too cost...

journal_title：mSphere

authors： Rao K,Seekatz A,Bassis C,Sun Y,Mantlo E,Bachman MA

更新日期：2020-07-22 00:00:00

abstract：:Outbreaks of infection occur more often than they are reported in most developing countries, largely due to poor diagnostic services. A Klebsiella species bacteremia outbreak in a newborn unit with high mortality was recently encountered at a location being surveilled for childhood bacteremia. These surveillance effor...

journal_title：mSphere

authors： Brinkac LM,White R,D'Souza R,Nguyen K,Obaro SK,Fouts DE

更新日期：2019-03-13 00:00:00

abstract：:Grf10, a homeodomain-containing transcription factor, regulates adenylate and one-carbon metabolism and morphogenesis in the human fungal pathogen Candida albicans Here, we identified functional domains and key residues involved in transcription factor activity using one-hybrid and mutational analyses. We localized ac...

journal_title：mSphere

authors： Wangsanut T,Tobin JM,Rolfes RJ

更新日期：2018-10-24 00:00:00

abstract：:To design immune interventions that can synergize with antiretroviral therapy (ART) to reduce the rate of HIV mother-to-child transmission (MTCT), it is essential to characterize maternal immune responses in the setting of ART during pregnancy and breastfeeding and define their effect on MTCT. Prior studies reported a...

journal_title：mSphere

authors： Hompe ED,Jacobson DL,Eudailey JA,Butler K,Edwards W,Pollara J,Brummel SS,Fouda GG,Chinula L,Kamanga M,Kinikar A,Moodley D,Owor M,Fowler MG,Permar SR

更新日期：2019-10-23 00:00:00

abstract：:Diana V. Pastrana works in the field of DNA tumor virus biology. In this mSphere of Influence article, she reflects on how the two papers "Donor origin of BKV replication after kidney transplantation" (C. Schmitt, L. Raggub, S. Linnenweber-Held, O. Adams, et al., J Clin Virol 59:120-125, 2014, https://doi.org/10.1016/...

journal_title：mSphere

authors： Pastrana DV

更新日期：2020-01-15 00:00:00

abstract：:Current in vitro techniques for the culture of microorganisms, and particularly of delicate microbial biofilms, are still mostly limited to low-density plates and manual labor and are not amenable to automation and true high-throughput (HT) applications. We have developed a novel fully automated platform for the forma...

journal_title：mSphere

authors： Srinivasan A,Torres NS,Leung KP,Lopez-Ribot JL,Ramasubramanian AK

更新日期：2017-06-28 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that causes severe health problems. Despite intensive investigation, many aspects of microbial virulence remain poorly understood. We used a high-throughput, high-content, whole-organism, phenotypic screen to identify small molecules that inhibit P. aeruginosa virule...

journal_title：mSphere

authors： Kirienko DR,Revtovich AV,Kirienko NV

更新日期：2016-08-24 00:00:00

abstract：:Clinical isolates of Pseudomonas aeruginosa from patients with cystic fibrosis (CF) are known to differ from those associated with non-CF hosts by colony morphology, drug susceptibility patterns, and genomic hypermutability. Pseudomonas aeruginosa isolates from CF patients have long been recognized for their overall r...

journal_title：mSphere

authors： Qin X,Zhou C,Zerr DM,Adler A,Addetia A,Yuan S,Greninger AL

更新日期：2018-03-14 00:00:00

abstract：:The fungal cell wall is a complex and dynamic entity essential for the development of fungi. It is composed mainly of polysaccharides that are synthetized by protein complexes. At the cell wall level, enzyme activities are involved in postsynthesis polysaccharide modifications such as cleavage, elongation, branching, ...

journal_title：mSphere

authors： Muszkieta L,Fontaine T,Beau R,Mouyna I,Vogt MS,Trow J,Cormack BP,Essen LO,Jouvion G,Latgé JP

更新日期：2019-07-31 00:00:00

abstract：:The Amazon River watershed and its associated plume comprise a vast continental and oceanic area. The microbial activities along this continuum contribute substantially to global carbon and nutrient cycling, and yet there is a dearth of information on the diversity, abundance, and possible roles of viruses in this glo...

journal_title：mSphere

authors： Silva BSO,Coutinho FH,Gregoracci GB,Leomil L,de Oliveira LS,Fróes A,Tschoeke D,Soares AC,Cabral AS,Ward ND,Richey JE,Krusche AV,Yager PL,de Rezende CE,Thompson CC,Thompson FL

更新日期：2017-10-04 00:00:00

abstract：:Candida albicans is an opportunistic human fungal pathogen that causes superficial fungal infections and lethal systemic infections. To colonize and establish infections, C. albicans coordinates the expression of virulence and metabolic genes. Previous work showed that the homeodomain transcription factor Grf10 is req...

journal_title：mSphere

authors： Wangsanut T,Ghosh AK,Metzger PG,Fonzi WA,Rolfes RJ

更新日期：2017-08-02 00:00:00

abstract：:Bacteria must sense alterations in their environment and respond with changes in function and/or structure in order to cope. Extracytoplasmic function sigma factors (ECF σs) modulate transcription in response to cellular and environmental signals. The symbiotic nitrogen-fixing alphaproteobacterium Sinorhizobium melilo...

journal_title：mSphere

authors： Lang C,Barnett MJ,Fisher RF,Smith LS,Diodati ME,Long SR

更新日期：2018-10-10 00:00:00

abstract：:Streptococcus pneumoniae (the pneumococcus) carriage is commonly used to measure effects of pneumococcal vaccines. Based on findings from culture-based studies, the World Health Organization recommends both nasopharyngeal (NP) and oropharyngeal (OP) sampling for detecting adult carriage. Given evidence of potential co...

journal_title：mSphere

authors： Boelsen LK,Dunne EM,Gould KA,Ratu FT,Vidal JE,Russell FM,Mulholland EK,Hinds J,Satzke C

更新日期：2020-07-29 00:00:00

abstract：:Malaria is a devastating illness that causes approximately 500,000 deaths annually. The malaria-causing parasite (Plasmodium genus) uses the process of translational repression to regulate its growth, development, and transmission. As poly(A)-binding proteins (PABP) have been identified as critical components of RNA m...

journal_title：mSphere

authors： Minns AM,Hart KJ,Subramanian S,Hafenstein S,Lindner SE

更新日期：2018-01-10 00:00:00

abstract：:Virulence is a microbial property that is realized only in susceptible hosts. There is no absolute measurement for virulence, and consequently it is always measured relative to a standard, usually another microbe or host. This article introduces the concept of pathogenic potential, which provides a new approach to mea...

journal_title：mSphere

authors： Casadevall A

更新日期：2017-02-22 00:00:00

abstract：:Botulinum neurotoxins (BoNTs), produced by neurotoxigenic clostridial species, are the cause of the severe disease botulism in humans and animals. Early research on BoNTs has led to their classification into seven serotypes (serotypes A to G) based upon the selective neutralization of their toxicity in mice by homolog...

journal_title：mSphere

authors： Pellett S,Tepp WH,Bradshaw M,Kalb SR,Dykes JK,Lin G,Nawrocki EM,Pier CL,Barr JR,Maslanka SE,Johnson EA

更新日期：2016-02-24 00:00:00

abstract：:Enveloped viruses require viral fusion proteins to promote fusion of the viral envelope with a target cell membrane. To drive fusion, these proteins undergo large conformational changes that must occur at the right place and at the right time. Understanding the elements which control the stability of the prefusion sta...

journal_title：mSphere

authors： Webb SR,Smith SE,Fried MG,Dutch RE

更新日期：2018-04-18 00:00:00

abstract：:CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 is a novel genome-editing system that has been successfully established in Aspergillus fumigatus. However, the current state of the technology relies heavily on DNA-based expression cassettes for delivering Cas9 and the guide RNA (gRNA) to the cell...

journal_title：mSphere

authors： Al Abdallah Q,Ge W,Fortwendel JR

更新日期：2017-11-22 00:00:00

abstract：:As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread around the world, there is an urgent need for new assay formats to characterize the humoral response to infection. Here, we present an efficient, competitive serological assay that can simultaneously determine an individual's seroreact...

journal_title：mSphere

authors： Byrnes JR,Zhou XX,Lui I,Elledge SK,Glasgow JE,Lim SA,Loudermilk RP,Chiu CY,Wang TT,Wilson MR,Leung KK,Wells JA

更新日期：2020-09-16 00:00:00