Abstract:
:In recent years, many studies have shown that phytochemicals exert their antibacterial activity through different mechanisms of action, such as damage to the bacterial membrane and suppression of virulence factors, including inhibition of the activity of enzymes and toxins, and bacterial biofilm formation. In this review, we summarise data from the available literature regarding the antibacterial effects of the main phytochemicals belonging to different chemical classes, alkaloids, sulfur-containing phytochemicals, terpenoids, and polyphenols. Some phytochemicals, besides having direct antimicrobial activity, showed an in vitro synergistic effect when tested in combination with conventional antibiotics, modifying antibiotic resistance. Review of the literature showed that phytochemicals represent a possible source of effective, cheap and safe antimicrobial agents, though much work must still be carried out, especially in in vivo conditions to ensure the selection of effective antimicrobial substances with low side and adverse effects.
journal_name
Microbiol Resjournal_title
Microbiological researchauthors
Barbieri R,Coppo E,Marchese A,Daglia M,Sobarzo-Sánchez E,Nabavi SF,Nabavi SMdoi
10.1016/j.micres.2016.12.003subject
Has Abstractpub_date
2017-03-01 00:00:00pages
44-68eissn
0944-5013issn
1618-0623pii
S0944-5013(16)30619-Xjournal_volume
196pub_type
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