Abstract：
OBJECTIVE:To analyze the expression of metalloprotein 11 (MMP11) in cultured fibroblasts obtained from human prostate tumors with different clinical and pathological characteristics. MATERIAL AND METHODS:For this study we analyzed samples of transrectal prostate biopsies from tumors with different characteristics, treated with or whithout androgen deprivation (AD). After optimization of the culture method, fibroblasts were isolated and cultured to perform the study (PCR) of MMP11 mRNA. RESULTS:Finally, 37 cases were studied: 5 samples of benign prostatic hyperplasia, 14 cases with localized neoplasms (7 high-risk according to the D'Amico classification), 5 with metastasic tumors (bone metastases), and 13 treated with AD therapy, of which 6 fulfilled the requirements to be defined as resistant to castration. In tumors without AD therapy, MMP11 expression was significantly higher (P=.001) in fibroblasts of higher grade tumors. A significant (P=.001) correlation was found between PSA and expression of MMP11 in fibroblast s and a significant increase of MMP11 expression in metastatic tumors. In tumors with AD therapy, a significantly greater expression of MMP11 was observed in resistant to castration patients than in those sensitive to castration (P=.003). CONCLUSION:In advanced prostate tumors or in stages of increased tumor aggressiveness, the production of MMP11 by fibroblasts is significantly greater than in non-metastatic tumors or in AD sensitive tumors.
journal_name
Actas Urol Espjournal_title
Actas urologicas espanolasauthors
Fernandez-Gomez JM,Eiro N,García-Rodríguez JJ,Quintás-Blanco A,Gonzalez-Ruiz de León C,Perez de Haro ML,Vizoso-Piñero Fdoi
10.1016/j.acuro.2016.12.001subject
Has Abstractpub_date
2017-01-01 00:00:00pages
376-382issue
6eissn
0210-4806issn
1699-7980pii
S0210-4806(16)30207-8journal_volume
41pub_type
杂志文章abstract：:Presentation of one case of seminal vesicle cyst with no associated anomalies. Review of diagnostic procedures useful in this type of disease, illustrating the relevance of transrectal ultrasound scanning due to its high specificity and low morbidity. Comments on the therapeutical options for this entity. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：INTRODUCTION:The prostate cancer is an important cause of men's mortality in our society. PURPOSE:To know the time of delay in to realise the surgical treatment of the prostate cancer. MATERIALS AND METHODS:Analysis of 30 cases of patients treated with radical prostatectomy, cuantifying the time of delay in all the p...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/s0210-4806(03)72922-2
更新日期：2003-04-01 00:00:00
abstract：:Contribution of a new case of vesical haemangioma in a 65-year old male. This is a benign and very rare tumour with not even 90 cases described in the urology literature to date. Haematuria was reported in all cases. This paper presents a review of the literature and a discussion of clinical and pathological features ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：
更新日期：1997-05-01 00:00:00
abstract：INTRODUCTION:The association between testosterone and prostate cancer badly is understood. The testosterone levels are not conclusive to distinguish benign prostate processes of malignant. The objective of our work is to determine the relation between levels of serum testosterone and prostate cancer. MATERIAL AND METH...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:To study the influence, in terms of prognosis, of the finding of seminal vesicle involvement in patients with prostate adenocarcinoma treated with radical prostatectomy. MATERIAL AND METHOD:We reviewed a series of patients with seminal vesicle involvement with clinically localized prostate adenocarcinoma who...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2014.05.009
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:The incidence of upper urinary tract tumors is currently unknown. The aim of this study is to determine the real incidence of upper tract urothelial carcinoma (UTUC) in Spain. MATERIAL AND METHODS:A descriptive, prospective and multicenter epidemiological study was conducted in 31 Spanish f...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2020.03.007
更新日期：2020-09-01 00:00:00
abstract：RATIONALE:To investigate whether, in the same way incidence is affected, biological aggressiveness of bladder cancer at diagnosis is greater in men than in women. METHOD:Using data from a retrospective study on urothelial cancer of the bladder between 1975 and 1991 in La Rioja (Spain), an estimate was made of total Re...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:We have performed experimental vasectomies in dogs in order to study effects of vas deferens ligature with close technique, on the testicular ultrastructure. We point out the existence of alterations: structural changes of the seminiferous epithelium, great extracellular spaces which are generated for the premature ex...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:Penile fracture with urethral laceration usually presents with pain and haematoma, detumescence, erectile failure and blood loss through urethral meatus. We describe the third published case of urethrocavernous fistula following blunt penile trauma sustained durind sexual intercourse. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(08)73987-1
更新日期：2008-11-01 00:00:00
abstract：:Benign prostatic hypertrophy (BPH) is a common urological disease with a standard surgical approach, transurethral resection (TUR) or open adenectomy (OA), but the flowmetric clinical results are controversial. Fifty-five patients were evaluated; in 23 of them TUR was performed and 32 underwent OA. The Boyarsky clinic...
journal_title：Actas urologicas espanolas
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：:Paratesticular vascular lesions are very uncommon. One of them, the epithelioid hemangioendothelioma, is a vascular tumour which grows around a vessel and in characterized for presenting epithelioid endothelial cells. Is very rare and it has good prognosis. This paper reports one case of paratesticular epithelioid hem...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:Patient treated by dialysis for end-stage renal disease are at increased risk of many cancers, especially those of kidney and urinary tract. A 56 years old man who undergoing chronic dialysis, presented in ultrasonography a 2 cm complex cystic mass in the left kidney what was confirmed by computed tomography and magne...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(08)73884-1
更新日期：2008-05-01 00:00:00
abstract：:The influence of renal and hepatic functioning on serum levels of prostate specific antigen has been studied by examining its behaviour in a control group (CG) of 178 healthy male, a group of 48 patients with end-stage renal failure (ESRF) 22 of which had pre- and post-dialysis PSA measurements and a group of 48 patie...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Lymphoma involving the prostate is rare, both as a primary and as a secondary presenting. Usually the prognosis remains poor. The clinical presentation is similar to that of other lower urinary tract obstructions, in fact prostatic lymphoma must be considered in patients with these symptoms, particularly in patients w...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/s0210-4806(02)72807-6
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVES:To evaluate the possible effects of Tribulus terrestris herbal medicine in the erectile dysfunction treatment and to quantify its potential impact on serum testosterone levels. DESIGN AND METHODS:Prospective, randomized, double-blind and placebo-controlled study including thirty healthy men selected from 10...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.acuro.2013.09.014
更新日期：2014-05-01 00:00:00
abstract：:Granulomatous orchitis is an inflammatory change of the testis. This is a rare lesion of unknown etiology. Usually are unilateral. The clinical appearance varies, and it is difficult to differentiate from testicular cancer. The diagnosis usually being made on histological examination after orchiectomy. Our paper repor...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(00)72526-5
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:To evaluate the effect of a humidity detector device on the quality of life of patients with urinary incontinence IU. METHOD:Quasi-experimental study: a series of ten cases followed for a month. The devices were placed and the questionnaires filled in before and after using it for at least ten hours a day d...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(03)72964-7
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:The increasing number of ultrasonographically detected asymptomatic, renal dilations have caused a lot of explorations to be performed in these patients. The Society of Fetal Urology proposed a four grades classification of echographic renal dilations and renographic studies are recommended in grades II to IV. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(01)72568-5
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:To value if the increase in the number of cylinders in the prostate's biopsy raise the diagnostic performance of this test. MATERIAL AND METHOD:In March 2005 we initiate this prospective study with patients who are subject to a first prostate Biopsy by a PSA between 4 and 10 ng/ml and negative rectal touch. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(07)73587-8
更新日期：2007-01-01 00:00:00
abstract：:Focal acute bacterial nephritis is an uncommon form of renal acute infection with a clinical presentation that, although similar to other acute infections of the renal parenchyma, must be taken into account in order to reach a correct differential diagnosis with other processes which have very similar radiological ima...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Transrectal ultrasound is a dynamic imaging diagnostic technique for the study of stress urinary incontinence (SUI). The highest efficiency is obtained in the study of failed corrective surgery of SUI. Our group studied 23 patients reporting clinical SUI after undergoing corrective surgery, 23.3% patients with transre...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:The surveillance of non-muscle-invasive bladder cancer (NMIBC) is usually performed by cystoscopy and cytology. Until today, no effective urinary biomarker has been used to reduce the morbidity and cost associated with these procedures. OBJECTIVE:To describe the performance of urinary biomarkers in the surv...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/j.acuro.2019.03.001
更新日期：2019-10-01 00:00:00
abstract：:Instrumentation of lower urinary tract is a predisposing factor for the development of urinary infection. Incidence of infective complications following urethrocystoscopy has been evaluated in a multicenter, prospective, comparative and randomized study in 2,284 patients, who had a previous negative urine culture. Pat...
journal_title：Actas urologicas espanolas
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1993-03-01 00:00:00
abstract：INTRODUCTION:Pyeloureteral duplication is often associated to ureterocele and ectopic ureter. Therapeutic approach of ureterocele is actually a debated subject because of the differences treatments. There is controversy about the classic heminefrectomy with ureterocele aspiration and the minimal invasive endoscopic app...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(01)72709-x
更新日期：2001-11-01 00:00:00
abstract：CONTEXT:Bladder carcinoma (BC), due its high morbidity and relapsing course, generates significant economic and health care costs. Accordingly, review the environmental nonoccupational risk factors (RF), more or less evidence-based, in the etiology and pathogenesis of BC, because the involvement of urologists is essent...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/j.acuro.2013.02.004
更新日期：2013-10-01 00:00:00
abstract：:Report of a 32-year old male patient with an injury of the posterior urethra caused by firearm. Initial examination only revealed fracture of the femoral vein. Absence of spontaneous micturition during the immediate post-operative made necessary to undertake retrograde urethrography, in which a fracture of the posteri...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：CONTEXT:Cervical cancer is the second most common tumor in women worldwide and due to diagnostic and therapeutic advances, the overall survival rates at 5 years is approaching 70%. Disorders in micturition, defecation, sexuality and quality of life have been described, frequently caused by different treatments. Address...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/j.acuro.2012.03.008
更新日期：2013-01-01 00:00:00
abstract：:Penoscrotal lymphedema is a rare disease in the developed countries, although it is relatively frequent in tropical countries. The most common cause is filariasis, although in our practice usually is associate to neoplasic and inflammatory processes, surgery, radiotherapy, hidroelectrolitic disbalances and idiopathic....
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(05)73285-x
更新日期：2005-05-01 00:00:00
abstract：AIMS:The aim of this study was to describe outcomes of laparoscopic living donor right nephrectomy (LLDRN) and study factors affecting the length of right renal vein from the donors. MATERIAL AND METHODS:This study was conducted in 60 donors (48 males and 12 females) from January 2016 to December 2017. We performed a ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2019.05.005
更新日期：2019-12-01 00:00:00
abstract：UNLABELLED:Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). OBJECTIVE:To determine and compare selenium plasma levels in patients with different prostatic pathologies. MATERIAL AND METHODS:It is a transversal, descriptive and comparative stud...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
