当前位置： SCI文献检索 > Hormone Research in Paediatrics期刊下所有文献 > Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome.

Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome.

Abstract：

BACKGROUND/AIMS:Autoimmune hypophysitis (AH) is a rare inflammatory disease of the pituitary gland causing varying degrees of hypopituitarism and/or sellar compression. Cranial MRI remains the best noninvasive tool to diagnose AH, although a diagnosis of certainty requires pituitary biopsy. The objective of this study was to assess the utility of detecting pituitary antibodies for the diagnosis of AH. METHODS:A 15-year-old female with Turner syndrome (TS), hypothyroidism, and ovarian failure presented acutely with hypocortisolism. Laboratory studies revealed secondary adrenal insufficiency. MRI showed a hypotrophic pituitary gland and loss of the posterior pituitary bright spot. To establish an autoimmune basis for the adrenal insufficiency, serum was analyzed by double indirect immunofluorescence for the presence of pituitary autoantibodies. RESULTS:The patient's serum contained autoantibodies that recognized 36% of the adrenocorticotropic hormone-secreting cells, suggesting that these adenohypophyseal cells were targeted by autoimmunity. The serum contained antibodies that identified the majority of the gonadotropin-secreting cells (FSH 77%, LH 65%). No recognition of GH-, prolactin-, and TSH-secreting cells was found. Preabsorption experiments showed that antigenic targets of autoantibodies were not anterior pituitary hormones themselves. CONCLUSION:Demonstration of circulating pituitary antibodies expands the diagnostic options for AH. In this adolescent with TS, positive and cell-specific pituitary antibodies suggested that AH was the cause of her secondary adrenal insufficiency.

journal_name

Horm Res Paediatr

journal_title

Hormone research in paediatrics

authors

Pollock AJ,Seibert TS,Salvatori C,Caturegli P,Allen DB

doi

10.1159/000446912

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

123-129

issue

2

eissn

1663-2818

issn

1663-2826

pii

000446912

journal_volume

87

pub_type

杂志文章

相关文献

Hormone Research in Paediatrics文献大全
  • Fasting hypoglycaemia and postprandial hyperglycaemia as a prodrome of type 1 diabetes mellitus.

    abstract：:The pathophysiology of type 1 diabetes mellitus (DM) involves the selective autoimmune destruction of the pancreatic beta-cells [Pihoker et al.: Diabetes 2005;54(suppl 2):S52-S61]. The onset of type 1 DM is characterised by hyperglycaemia. Islet cell antibody (ICA), anti-insulin, anti-glutamic acid decarboxylase and t...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000337254

    authors： Rafeullah N,Cackett N,Hussain K

    更新日期：2012-01-01 00:00:00

  • Multiple factors influencing the incidence of congenital hypothyroidism detected by neonatal screening.

    abstract：BACKGROUND/AIMS:Over the years a rise in the incidence of congenital hypothyroidism (CH) has been described worldwide. The aim of our study was to investigate trends in the incidence of CH in Italy over the period 1987-2008, and to investigate which factors may have influenced the CH incidence in our country. METHODS:...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000369394

    authors： Olivieri A,Fazzini C,Medda E,Italian Study Group for Congenital Hypothyroidism.

    更新日期：2015-01-01 00:00:00

  • Continuous Glucose Monitoring Systems: Are They Useful for Evaluating Glycemic Control in Children with Hyperinsulinism?

    abstract：BACKGROUND:Effective treatment and close monitoring in children with congenital hyperinsulinism (HI) are important to prevent hypoglycemic-associated brain damage. The current monitoring approach involves measuring plasma glucose intermittently, but this does not provide a comprehensive assessment of glycemic control a...

    journal_title：Hormone research in paediatrics

    pub_type： 临床试验,杂志文章

    doi：10.1159/000506230

    authors： Rayannavar A,Elci OU,Mitteer L,De León DD

    更新日期：2019-01-01 00:00:00

  • Combined therapy with insulin and growth hormone in 17 patients with type-1 diabetes and growth disorders.

    abstract：BACKGROUND/AIM:Combined growth hormone (GH) and insulin therapy is rarely prescribed by pediatric endocrinologists. We investigated the attitude of Italian physicians to prescribing that therapy in the case of short stature and type-1 diabetes (T1DM). METHODS:A questionnaire was sent and if a patient was identified, d...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章,多中心研究

    doi：10.1159/000360856

    authors： Zucchini S,Iafusco D,Vannelli S,Rabbone I,Salzano G,Pozzobon G,Maghnie M,Cherubini V,Bizzarri C,Bonfanti R,D'Annunzio G,Lenzi L,Maggio MC,Marigliano M,Scaramuzza A,Tumini S,Iughetti L

    更新日期：2014-01-01 00:00:00

  • Identification of a novel heterozygous IGF1 splicing mutation in a large kindred with familial short stature.

    abstract：BACKGROUND/AIMS:Insulin-like growth factor (IGF)-I is critical for normal human growth. Extremely rare homozygous mutations of the IGF1 gene severely impair intrauterine growth, intellectual development and postnatal growth. CASE/METHOD: A young male presented with postnatal growth retardation (-4.0 height SDS). His se...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000337249

    authors： Fuqua JS,Derr M,Rosenfeld RG,Hwa V

    更新日期：2012-01-01 00:00:00

  • Endothelial nitric oxide synthase T(-786)C polymorphism in children and adolescents with type 1 diabetes and impaired endothelium-dependent dilatation.

    abstract：BACKGROUND/AIMS:This study aimed to investigate the association of endothelial nitric oxide synthase (eNOS) polymorphisms with impaired endothelium-dependent dilatation (EDD) in a cohort of children and adolescents with type 1 diabetes. METHODS:Ninety-seven children and adolescents with type 1 diabetes underwent ultra...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000329549

    authors： Battelino N,Sebestjen M,Keber I,Blagus R,Hovnik T,Bratina N,Battelino T

    更新日期：2011-01-01 00:00:00

  • Influence of fetal growth velocity and smallness at birth on adrenal function in adolescence.

    abstract：:The hypothalamic-pituitary-adrenal axis is susceptible to programming during fetal development and may be linked to risk of disease later in life. In a former prospective study the cohort was divided into those born appropriate for gestational age (AGA) or small for gestational age (SGA; birth weight <10 percentile). ...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000315656

    authors： Beck Jensen R,Vielwerth S,Larsen T,Hilsted L,Cohen A,Hougaard DM,Jensen LT,Greisen G,Juul A

    更新日期：2011-01-01 00:00:00

  • The Hypothalamic-Pituitary-Adrenal Axis and the Fetus.

    abstract：:Glucocorticoids (GCs), cortisol in humans, influence multiple essential maturational events during gestation. In the human fetus, fetal hypothalamic-pituitary-adrenal (HPA) axis function, fetal adrenal steroidogenesis, placental 11β- hydroxysteroid dehydrogenase type 2 activity, maternal cortisol concentrations, and e...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章,评审

    doi：10.1159/000488106

    authors： Morsi A,DeFranco D,Witchel SF

    更新日期：2018-01-01 00:00:00

  • Epidemiology of childhood type 1 diabetes mellitus: lessons from Central and Eastern European data.

    abstract：BACKGROUND:Over the past 15 years, the incidence of type 1 diabetes mellitus (T1DM) in Central and Eastern Europe has grown rapidly from an initially low rate. This growth cannot be attributed to genetic factors: it appears that changing environmental exposures are responsible, though no single environmental factor can...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000329168

    authors： Cinek O

    更新日期：2011-01-01 00:00:00

  • The predictive value of the individual components of the metabolic syndrome for insulin resistance in obese children.

    abstract：BACKGROUND/AIMS:The usefulness of the concept of the metabolic syndrome (MS) in its current form has recently been questioned, and its association with insulin resistance is unknown. We assessed whether a multivariate model based on all components of MS expressed on a continuous scale would be a better predictor of a c...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000327371

    authors： Vos RC,Houdijk EC,van der Kamp HJ,Pijl H,Wit JM

    更新日期：2011-01-01 00:00:00

  • Leptin and ghrelin levels in children before and after adenoidectomy or adenotonsillectomy.

    abstract：BACKGROUND AND AIM:Accelerated weight gain after (adeno)tonsillectomy has been reported in a number of studies. Whether (adeno)tonsillectomy is also a risk factor for development of overweight is unknown. We investigated serum leptin and plasma ghrelin levels before and 1 year after (adeno)tonsillectomy operation in ch...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000355508

    authors： Karalok ZS,Akdag M,Turhan M,Uzun G,Ozdem S,Dinc O,Bircan I

    更新日期：2014-01-01 00:00:00

  • Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study.

    abstract：BACKGROUND/AIMS:The autonomic nervous system (ANS) provides neurogenic control of inflammatory reactions. ANS changes in obesity may result in inflammation. This study sought to gain insight into cardiac autonomic dysfunction and inflammation in childhood obesity, and to gather pilot data on the potential relationship ...

    journal_title：Hormone research in paediatrics

    pub_type： 临床试验,杂志文章

    doi：10.1159/000445685

    authors： Hursh BE,Fazeli MS,Wang S,Marchant EA,Woo P,Elango R,Lavoie PM,Chanoine JP,Collet JP

    更新日期：2016-01-01 00:00:00

  • A novel GHR intronic variant, c.266+83G>T , activates a cryptic 5' splice site causing severe GHR deficiency and classical GH insensitivity syndrome.

    abstract：BACKGROUND/AIMS:Mutations in the human growth hormone receptor gene (GHR) are the most common cause of growth hormone insensitivity (GHI) syndrome and insulin-like growth factor (IGF-1) deficiency. The extracellular domain of GHR (encoded by exons 2-7 of the GHR gene) can be proteolytically cleaved to circulate as GH-b...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000355404

    authors： Feigerlova E,Swinyard M,Derr MA,Farnsworth J,Andrew SF,Rosenfeld RG,Hwa V

    更新日期：2013-01-01 00:00:00

  • Fast intraoperative testosterone assay confirms the location of an ovarian virilizing tumor in a young girl.

    abstract：:The detection of testosterone-producing ovarian tumors in childhood and adolescence by imaging techniques only can be difficult because of the tumors' radiological structure and sometimes diminutive size. We describe an 11.5-year-old girl with a 9-month history of voice deepening, mild hirsutism, minor acne, increased...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000339683

    authors： Braun R,Peter A,Warmann S,Fuchs J,Binder G

    更新日期：2013-01-01 00:00:00

  • Experience of Octreotide Therapy for Hyperinsulinemic Hypoglycemia in Neonates Born Small for Gestational Age: A Case Series.

    abstract：AIMS:Hyperinsulinemic hypoglycemia (HH) is common in small-for-gestational-age (SGA) neonates. Diazoxide is often used as the first-line medication for HH in SGA neonates. Unfortunately, diazoxide is not authorized in China. We examined the effectiveness of octreotide as an alternative therapy to treat HH in SGA neonat...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000441108

    authors： Pan S,Zhang M,Li Y

    更新日期：2015-01-01 00:00:00

  • Normative Thyroid-Stimulating Hormone Values for Healthy Nigerian Newborns.

    abstract：BACKGROUND:Congenital hypothyroidism is a common congenital endocrine disorder prevailing all over the world. No nationwide screening exists for any sub-Saharan country. We present normative cord and capillary thyroid-stimulating hormone (TSH) values for healthy Nigerian newborns. SUBJECTS AND METHODS:A cross-sectiona...

    journal_title：Hormone research in paediatrics

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1159/000441722

    authors： Yarhere IE,Jaja T,Oduwole A,Ibekwe MU,Suwaid S,Alkali Y,Adeniran K,Fetuga B,Jarrett OO,Elusiyan JB,Adesiyun O,Idris HW,Blankenstein O,Akani NA

    更新日期：2016-01-01 00:00:00

  • Impact of Endocrine Disruptors on the Thyroid Hormone System.

    abstract：:The thyroid hormone (TH) system plays a central role in central physiological processes of many species, including mammals and humans, ranging from growth and cell differentiation, energy metabolism, thermoregulation and phasing of hibernation or annual movements of migratory species, metamorphosis from larvae to adul...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章,评审

    doi：10.1159/000443501

    authors： Gutleb AC,Cambier S,Serchi T

    更新日期：2016-01-01 00:00:00

  • Hypogonadotropic Hypogonadism in Infants with Congenital Hypopituitarism: A Challenge to Diagnose at an Early Stage.

    abstract：BACKGROUND:Combined pituitary hormone deficiency (CPHD) presents a wide spectrum of pituitary gland disorders. The postnatal gonadotropic surge provides a useful period to explore the gonadotropic axis for assessing the presence of congenital hypogonadotropic hypogonadism (CHH). AIM:To explore the functioning of the h...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000439051

    authors： Braslavsky D,Grinspon RP,Ballerini MG,Bedecarrás P,Loreti N,Bastida G,Ropelato MG,Keselman A,Campo S,Rey RA,Bergadá I

    更新日期：2015-01-01 00:00:00

  • Hypercalcemia due to Milk-Alkali Syndrome and Fracture-Induced Immobilization in an Adolescent Boy with Hypoparathyroidism.

    abstract：BACKGROUND:Hypercalcemia of immobilization, while rare, may occur in adolescent boys after fracture. Although not fully understood, the mechanism appears to be related to bone turnover uncoupling, in part mediated by upregulation of RANKL. Animal studies suggest that parathyroidectomy suppresses RANKL-stimulated osteoc...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000446316

    authors： Henry RK,Gafni RI

    更新日期：2016-01-01 00:00:00

  • Prevalence of Metabolic Bone Disease in Tube-Fed Children Receiving Elemental Formula.

    abstract：BACKGROUND:Previous studies suggest normal mineral status in children receiving elemental formula. However, a recent multicenter survey described 51 children who developed hypophosphatemia and bone disease while receiving elemental formula. Our aim is to determine the prevalence of metabolic bone disease in children re...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000494726

    authors： Creo AL,Epp LM,Buchholtz JA,Tebben PJ

    更新日期：2018-01-01 00:00:00

  • A new horizon for glucose monitoring.

    abstract：:Regular self-monitoring of blood glucose is crucial for proper insulin dosing and gives a reliable foundation for reasonable glycaemic control. According to recent data, recommended values for glycated haemoglobin A1c as set by the professional associations remain out of the reach for a large proportion of the paediat...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章,评审

    doi：10.1159/000368924

    authors： Dovč K,Bratina N,Battelino T

    更新日期：2015-01-01 00:00:00

  • Adult height and epigenotype in children with Silver-Russell syndrome treated with GH.

    abstract：AIMS:To compare adult heights of GH-treated and GH-untreated patients with Silver-Russell syndrome (SRS) who were epigenotyped. METHODS:This was a nonrandomized retrospective study with matched controls at a single center. Molecular analysis of 32 out of 37 GH-treated patients (16 females) revealed IGF2-H19 epimutatio...

    journal_title：Hormone research in paediatrics

    pub_type： 临床试验,杂志文章

    doi：10.1159/000354658

    authors： Binder G,Liebl M,Woelfle J,Eggermann T,Blumenstock G,Schweizer R

    更新日期：2013-01-01 00:00:00

  • Molecular insights into the possible role of Kir4.1 and Kir5.1 in thyroid hormone biosynthesis.

    abstract：INTRODUCTION:Thyroid morphogenesis is a complex process. Inwardly rectifying potassium (Kir) genes play a role in hormone release, cell excitability, pH and K(+) homeostasis in many tissues. OBJECTIVES:To investigate the thyroid developmental expression of three members, Kir4.1, Kir4.2 and Kir5.1, in mice. To postulat...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000369251

    authors： Ramos HE,da Silva MR,Carré A,Silva JC Jr,Paninka RM,Oliveira TL,Tron E,Castanet M,Polak M

    更新日期：2015-01-01 00:00:00

  • Insulin-like growth factor I: pros and cons of a bioassay.

    abstract：BACKGROUND:Insulin-like growth factor I (IGF-I) immunoassays are primarily used to estimate IGF-I status. Recently an IGF-I-specific kinase receptor activation assay (KIRA) was developed as an alternative method for measuring IGF-I bioactivity. When compared with IGF-I immunoassays, the IGF-I KIRA has the theoretical a...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000329191

    authors： Janssen JA

    更新日期：2011-01-01 00:00:00

  • Techniques in pediatric surgery: congenital hyperinsulinism.

    abstract：:For surgery in congenital hyperinsulinism (CHI), a distinct strategy and technique is required for focal, diffuse and atypical types. In focal CHI, a confined, localized and parenchyma-sparing resection which is guided by the PET-CT is always indicated in order to cure the patient. In diffuse CHI, however, the results...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000321902

    authors： Barthlen W,Mohnike W,Mohnike K

    更新日期：2010-01-01 00:00:00

  • Effect of treatment with cyproterone acetate on uterine bleeding at the beginning of GnRH analogue therapy in girls with idiopathic central precocious puberty.

    abstract：BACKGROUND:The flare-up effect of GnRH analogues may cause transient uterine bleeding in girls affected with idiopathic central precocious puberty (ICPP). AIMS:To assess the incidence of endometrial bleeding and verify whether pretreatment with cyproterone acetate could counteract it. METHODS:Fifty-four girls affecte...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000308172

    authors： Seminara S,Nanni L,Generoso M,Mirri S,Leonardi V,Slabadzianiuk T,Vetrano ML,Buongiorno A,Losi S,Galluzzi F

    更新日期：2010-01-01 00:00:00

  • Auxological evaluation in patients with a 22q11.2 microdeletion syndrome: normal prevalence of obesity and neonatal length and gender influence on body mass index evolution.

    abstract：AIMS:To evaluate auxological parameters in children and adults with a 22q11.2 microdeletion syndrome (22q11.2 DS) and to compare prevalence of obesity to that in the French general population. METHODS:102 patients with 22q11.2 DS (49 males, 53 females) were recruited from birth to adulthood through a reference center ...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000328454

    authors： Reynaud R,Derain-Court J,Braunstein D,Veyrat M,Gaudart J,Giuliano F,Philip N

    更新日期：2011-01-01 00:00:00

  • The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected.

    abstract：AIM:The aim of this study was to investigate the cardiovascular risk of children with premature adrenarche (PA). METHODS:A total of 75 children (44 with PA and 31 control subjects) aged 6-10 years were included in the study. Their metabolic, anthropometric, and echocardiographic parameters were recorded and compared. ...

    journal_title：Hormone research in paediatrics

    pub_type： 临床试验,杂志文章

    doi：10.1159/000452445

    authors： Çelik N,Alp H,Çamtosun E,Alp E,Çelik S,Berk E

    更新日期：2017-01-01 00:00:00

  • Thyroid Ultrasound: More Sensitive than Radioactive Iodine Imaging in Detecting Recurrence of Papillary Thyroid Cancer in Two Pediatric Patients.

    abstract：BACKGROUND:Papillary thyroid cancer (PTC) is an uncommon pediatric disease with an excellent prognosis. In follow-up surveillance, neck ultrasound (US), basal and thyroid-stimulating hormone-stimulated serum thyroglobulin (Tg) levels, and diagnostic whole-body radioactive iodine scans (DxWBS) have been traditionally us...

    journal_title：Hormone research in paediatrics

    pub_type：

    doi：10.1159/000487436

    authors： Wise-Oringer BK,Goldis M,Regelmann MO,Klein M,Machac J,Kotlus Rosenberg H,Rapaport R

    更新日期：2018-01-01 00:00:00

  • IL-6, IL-8 and IL-10 levels in healthy weight and overweight children.

    abstract：BACKGROUND/AIM:In adults, studies have shown that obesity is a chronic low-grade inflammatory state characterized by altered levels of cytokines. Studies in children have mainly focused on C-reactive protein and adiponectin, and there is limited data for other inflammatory markers in healthy weight and overweight child...

    journal_title：Hormone research in paediatrics

    pub_type： 杂志文章

    doi：10.1159/000277632

    authors： Tam CS,Garnett SP,Cowell CT,Heilbronn LK,Lee JW,Wong M,Baur LA

    更新日期：2010-01-01 00:00:00