Abstract:
:Respiratory syncytial virus (RSV) is a major cause of bronchiolitis and pneumonia in infants and pneumonia virus of mice (PVM) causes similar disease. BALB/c mice are highly susceptible, while C57BL/6 mice are more resistant to PVM. IL-12 was significantly more up-regulated in response to PVM infection in BALB/c than in C57BL/6 mice. IL-12p40-deficient neonatal and adult BALB/c mice showed significantly less weight loss than wild-type mice after PVM challenge. The percentage of regulatory T cells, as well as IFN-β and IL-18 expression, was higher in the lungs of both neonatal and adult IL-12p40-/- mice. Adult IL-12p40-/- mice also showed enhanced TGF-β and IL-10 expression and reduced inflammatory responses. Furthermore, IL-12p40-/- mice showed decreased sensitization to inhaled cockroach antigen after PVM infection when compared to wild-type mice. In conclusion, these data suggest that a depressed regulatory capacity in BALB/c mice to PVM infection results in enhanced immunopathology and sensitization to allergen.
journal_name
Virologyjournal_title
Virologyauthors
Shrivastava P,Sarkar I,Atanley E,Gomis S,van Drunen Littel-van den Hurk Sdoi
10.1016/j.virol.2016.06.020subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1-10eissn
0042-6822issn
1096-0341pii
S0042-6822(16)30160-Xjournal_volume
497pub_type
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