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Complementary and alternative healthcare use by participants in the PACE trial of treatments for chronic fatigue syndrome.

Abstract：

BACKGROUND:Chronic Fatigue Syndrome (CFS) is characterised by persistent fatigue, disability and a range of other symptoms. The PACE trial was randomised to compare four non-pharmacological treatments for patients with CFS in secondary care clinics. The aims of this sub study were to describe the use of complementary and alternative medicine (CAM) in the trial sample and to test whether CAM use correlated with an improved outcome. METHOD:CAM use was recorded at baseline and 52weeks. Logistic and multiple regression models explored relationships between CAM use and both patient characteristics and trial outcomes. RESULTS:At baseline, 450/640 (70%) of participants used any sort of CAM; 199/640 (31%) participants were seeing a CAM practitioner and 410/640 (64%) were taking a CAM medication. At 52weeks, those using any CAM fell to 379/589 (64%). Independent predictors of CAM use at baseline were female gender, local ME group membership, prior duration of CFS and treatment preference. At 52weeks, the associated variables were being female, local ME group membership, and not being randomised to the preferred trial arm. There were no significant associations between any CAM use and fatigue at either baseline or 52weeks. CAM use at baseline was associated with a mean (CI) difference of 4.10 (1.28, 6.91; p=0.024) increased SF36 physical function score at 52weeks, which did not reach the threshold for a clinically important difference. CONCLUSION:CAM use is common in patients with CFS. It was not associated with any clinically important trial outcomes.

journal_name

J Psychosom Res

journal_title

Journal of psychosomatic research

authors

Lewith G,Stuart B,Chalder T,McDermott C,White PD

doi

10.1016/j.jpsychores.2016.06.005

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

37-42

eissn

0022-3999

issn

1879-1360

pii

S0022-3999(16)30327-0

journal_volume

87

pub_type

杂志文章,随机对照试验

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