Abstract：
:Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to implant success is the material's mechanical properties as this affects biocompatibility and extrusion. The aim of this study was to determine the biomechanical properties of human auricular cartilage. Auricular cartilage from fifteen cadavers was indented with displacement of 1 mm/s and load of 300 g to obtain a Young's modulus in compression. Histological analysis of the auricle was conducted according to glycoprotein, collagen, and elastin content. The compression modulus was calculated for each part of the auricle with the tragus at 1.67 ± 0.61 MPa, antitragus 1.79 ± 0.56 MPa, concha 2.08 ± 0.70 MPa, antihelix 1.71 ± 0.63 MPa, and helix 1.41 ± 0.67 MPa. The concha showed to have a significantly greater Young's Elastic Modulus than the helix in compression (p < 0.05). The histological analysis demonstrated that the auricle has a homogenous structure in terms of chondrocyte morphology, extracellular matrix and elastin content. This study provides new information on the compressive mechanical properties and histological analysis of the human auricular cartilage, allowing surgeons to have a better understanding of suitable replacements. This study has provided a reference, by which cartilage replacements should be developed for auricular reconstruction.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Griffin MF,Premakumar Y,Seifalian AM,Szarko M,Butler PEdoi
10.1007/s10439-016-1688-1subject
Has Abstractpub_date
2016-12-01 00:00:00pages
3460-3467issue
12eissn
0090-6964issn
1573-9686pii
10.1007/s10439-016-1688-1journal_volume
44pub_type
杂志文章abstract：:Pelvic floor muscle (PFM) strength measurement provides useful information for the study of pelvic floor dysfunctions. Vaginal digital palpation, intravaginal pressure measurements, and the use of a dynamometric speculum represent currently available clinical methods for evaluating PFM strength. However, none of these...
journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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更新日期：2019-06-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9902-z
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journal_title：Annals of biomedical engineering
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doi：10.1007/s10439-011-0406-2
更新日期：2012-03-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368298
更新日期：1995-01-01 00:00:00
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journal_title：Annals of biomedical engineering
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doi：10.1007/s10439-016-1780-6
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.131
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02662-2
更新日期：2020-12-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1616932
更新日期：2003-11-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02636-4
更新日期：2020-12-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-005-9008-1
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9592-y
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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pub_type： 临床试验,杂志文章
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更新日期：2016-08-01 00:00:00
