APOE2 Is Associated with Spatial Navigational Strategies and Increased Gray Matter in the Hippocampus.

Abstract:

:The Apolipoprotein E (APOE) gene has a strong association with Alzheimer's disease (AD). The ε4 allele is a well-documented genetic risk factor of AD. In contrast, the ε2 allele of the APOE gene is known to be protective against AD. Much of the focus on the APOE gene has been on the ε4 allele in both young and older adults and few studies have looked into the cognitive and brain structure correlates of the ε2 allele, especially in young adults. In the current study, we investigated the relationship between APOE genotype, navigation behavior, and hippocampal gray matter in healthy young adults. One-hundred and twenty-four healthy young adults were genotyped and tested on the 4on8 virtual maze, a task that allows for the assessment of navigation strategy. The task assesses the spontaneous use of either a hippocampus-dependent spatial strategy or a caudate nucleus-dependent response strategy. Of the 124 participants, 37 underwent structural magnetic resonance imaging (MRI). We found that ε2 carriers use a hippocampus-dependent spatial strategy to a greater extent than ε3 homozygous individuals and ε4 carriers. We also found that APOE ε2 allele carriers have more gray matter in the hippocampus compared to ε3 homozygous individuals and ε4 carriers. Our findings suggest that the protective effects of the ε2 allele may, in part, be expressed through increased hippocampus gray matter and increased use of hippocampus-dependent spatial strategies. The current article demonstrates the relationship between brain structure, navigation behavior, and APOE genotypes in healthy young adults.

journal_name

Front Hum Neurosci

authors

Konishi K,Bhat V,Banner H,Poirier J,Joober R,Bohbot VD

doi

10.3389/fnhum.2016.00349

subject

Has Abstract

pub_date

2016-07-13 00:00:00

pages

349

issn

1662-5161

journal_volume

10

pub_type

杂志文章
  • The impact of expert visual guidance on trainee visual search strategy, visual attention and motor skills.

    abstract::Minimally invasive and robotic surgery changes the capacity for surgical mentors to guide their trainees with the control customary to open surgery. This neuroergonomic study aims to assess a "Collaborative Gaze Channel" (CGC); which detects trainer gaze-behavior and displays the point of regard to the trainee. A rand...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00526

    authors: Leff DR,James DR,Orihuela-Espina F,Kwok KW,Sun LW,Mylonas G,Athanasiou T,Darzi AW,Yang GZ

    更新日期:2015-10-14 00:00:00

  • Intertemporal Choice Behavior in Emerging Adults and Adults: Effects of Age Interact with Alcohol Use and Family History Status.

    abstract::Adults with alcohol use disorders (AUDs) show marked immediate reward selection (or "Now") bias in intertemporal choice tasks. This Now bias persists long into abstinence, suggesting an irreversible consequence of chronic alcohol abuse or a pre-existing AUD intermediate phenotype. However, some data show substantial N...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00627

    authors: Smith CT,Steel EA,Parrish MH,Kelm MK,Boettiger CA

    更新日期:2015-11-23 00:00:00

  • Dynamic Office Environments Improve Brain Activity and Attentional Performance Mediated by Increased Motor Activity.

    abstract::Current research demonstrates beneficial effects of physical activity on brain functions and cognitive performance. To date, less is known on the effects of gross motor movements that do not fall into the category of sports-related aerobic or anaerobic exercise. In previous studies, we found beneficial effects of dyna...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00121

    authors: Henz D,Schöllhorn WI

    更新日期:2019-04-12 00:00:00

  • FMRI in translation: the challenges facing real-world applications.

    abstract::Functional neuroimaging has increased our understanding of human brain function tremendously and has become a standard tool in clinical and cognitive neuroscience research. We briefly review its methodological foundations and describe remaining challenges for translational research. The application of neuroimaging res...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.063.2009

    authors: Schleim S,Roiser JP

    更新日期:2009-12-23 00:00:00

  • Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy?

    abstract::The proposal that dietary docosahexaenoic acid (DHA) enhances neurocognitive functioning in term infants is controversial. Theoretical evidence, laboratory research and human epidemiological studies have convincingly demonstrated that DHA deficiency can negatively impact neurocognitive development. However, the result...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00774

    authors: Heaton AE,Meldrum SJ,Foster JK,Prescott SL,Simmer K

    更新日期:2013-11-20 00:00:00

  • Situating emotional experience.

    abstract::Psychological construction approaches to emotion suggest that emotional experience is situated and dynamic. Fear, for example, is typically studied in a physical danger context (e.g., threatening snake), but in the real world, it often occurs in social contexts, especially those involving social evaluation (e.g., publ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00764

    authors: Wilson-Mendenhall CD,Barrett LF,Barsalou LW

    更新日期:2013-11-26 00:00:00

  • Neural correlates of grasping.

    abstract::PREHENSION, THE CAPACITY TO REACH AND GRASP OBJECTS, COMPRISES TWO MAIN COMPONENTS: reaching, i.e., moving the hand towards an object, and grasping, i.e., shaping the hand with respect to its properties. Knowledge of this topic has gained a huge advance in recent years, dramatically changing our view on how prehension...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2014.00686

    authors: Turella L,Lingnau A

    更新日期:2014-09-09 00:00:00

  • A Neurophysiological and Neuropsychological Consideration of Mindful Movement: Clinical and Research Implications.

    abstract::In this article, we present ideas related to three key aspects of mindfulness training: the regulation of attention via noradrenaline, the importance of working memory and its various components (particularly the central executive and episodic buffer), and the relationship of both of these to mind-wandering. These sam...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2015.00282

    authors: Russell TA,Arcuri SM

    更新日期:2015-05-26 00:00:00

  • More creative through positive mood? Not everyone!

    abstract::It is commonly assumed that positive mood improves human creativity and that the neurotransmitter dopamine might mediate this association. However, given the non-linear relation between dopamine and flexibility in divergent thinking (Akbari Chermahini and Hommel, 2010), the impact of mood on divergent kinds of creativ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00319

    authors: Akbari Chermahini S,Hommel B

    更新日期:2012-11-26 00:00:00

  • Parallel processing of face and house stimuli by V1 and specialized visual areas: a magnetoencephalographic (MEG) study.

    abstract::We used easily distinguishable stimuli of faces and houses constituted from straight lines, with the aim of learning whether they activate V1 on the one hand, and the specialized areas that are critical for the processing of faces and houses on the other, with similar latencies. Eighteen subjects took part in the expe...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00901

    authors: Shigihara Y,Zeki S

    更新日期:2014-11-07 00:00:00

  • Modeling Uncertainties in EEG Microstates: Analysis of Real and Imagined Motor Movements Using Probabilistic Clustering-Driven Training of Probabilistic Neural Networks.

    abstract::Part of the process of EEG microstate estimation involves clustering EEG channel data at the global field power (GFP) maxima, very commonly using a modified K-means approach. Clustering has also been done deterministically, despite there being uncertainties in multiple stages of the microstate analysis, including the ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00534

    authors: Dinov M,Leech R

    更新日期:2017-11-01 00:00:00

  • Navigating the complex path between the oxytocin receptor gene (OXTR) and cooperation: an endophenotype approach.

    abstract::Although cooperation represents a core facet of human social behavior there exists considerable variability across people in terms of the tendency to cooperate. One factor that may contribute to individual differences in cooperation is a key gene within the oxytocin (OT) system, the OT reception gene (OXTR). In this a...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00801

    authors: Haas BW,Anderson IW,Smith JM

    更新日期:2013-11-28 00:00:00

  • Relationship between Self-Administered Cues and Rehabilitation Outcomes in Individuals with Aphasia: Understanding Individual Responsiveness to a Technology-Based Rehabilitation Program.

    abstract::An advantage of rehabilitation administered on computers or tablets is that the tasks can be self-administered and the cueing required to complete the tasks can be monitored. Though there are many types of cueing, few studies have examined how participants' response to rehabilitation is influenced by self-administered...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00007

    authors: Des Roches CA,Mitko A,Kiran S

    更新日期:2017-02-01 00:00:00

  • Differential influence of levodopa on reward-based learning in Parkinson's disease.

    abstract::The mesocorticolimbic dopamine (DA) system linking the dopaminergic midbrain to the prefrontal cortex and subcortical striatum has been shown to be sensitive to reinforcement in animals and humans. Within this system, coexistent segregated striato-frontal circuits have been linked to different functions. In the presen...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00169

    authors: Graef S,Biele G,Krugel LK,Marzinzik F,Wahl M,Wotka J,Klostermann F,Heekeren HR

    更新日期:2010-10-14 00:00:00

  • Rating the Intensity of a Laser Stimulus, but Not Attending to Changes in Its Location or Intensity Modulates the Laser-Evoked Cortical Activity.

    abstract::Top-down attention towards nociceptive stimuli can be modulated by asking participants to pay attention to specific features of a stimulus, or to provide a rating about its intensity/unpleasantness. Whether and how these different top-down processes may lead to different modulations of the cortical response to nocicep...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00120

    authors: Torta DME,Ninghetto M,Ricci R,Legrain V

    更新日期:2020-03-31 00:00:00

  • Ketamine: 50 Years of Modulating the Mind.

    abstract::Ketamine was introduced into clinical practice in the 1960s and continues to be both clinically useful and scientifically fascinating. With considerably diverse molecular targets and neurophysiological properties, ketamine's effects on the central nervous system remain incompletely understood. Investigators have lever...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2016.00612

    authors: Li L,Vlisides PE

    更新日期:2016-11-29 00:00:00

  • Mindfulness-induced selflessness: a MEG neurophenomenological study.

    abstract::Contemporary philosophical and neurocognitive studies of the self have dissociated two distinct types of self-awareness: a "narrative" self-awareness (NS) weaving together episodic memory, future planning and self-evaluation into a coherent self-narrative and identity, and a "minimal" self-awareness (MS) focused on pr...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00582

    authors: Dor-Ziderman Y,Berkovich-Ohana A,Glicksohn J,Goldstein A

    更新日期:2013-09-24 00:00:00

  • Effects of cTBS on the Frequency-Following Response and Other Auditory Evoked Potentials.

    abstract::The frequency-following response (FFR) is an auditory evoked potential (AEP) that follows the periodic characteristics of a sound. Despite being a widely studied biosignal in auditory neuroscience, the neural underpinnings of the FFR are still unclear. Traditionally, FFR was associated with subcortical activity, but r...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00250

    authors: López-Caballero F,Martin-Trias P,Ribas-Prats T,Gorina-Careta N,Bartrés-Faz D,Escera C

    更新日期:2020-07-08 00:00:00

  • Functional Preservation and Reorganization of Brain during Motor Imagery in Patients with Incomplete Spinal Cord Injury: A Pilot fMRI Study.

    abstract::Motor imagery (MI) is a cognitive process involved in mentally rehearsing movement representations, and it has great potential for the rehabilitation of motor function in patients with spinal cord injuries. The aim of this study was to explore changes in the brain activation patterns in incomplete spinal cord injury (...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00046

    authors: Chen X,Wan L,Qin W,Zheng W,Qi Z,Chen N,Li K

    更新日期:2016-02-15 00:00:00

  • Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease.

    abstract::For the management of Parkinson's disease (PD), the concept of forced exercise (FE) has drawn interest. In PD subjects, the FE executed with lower limbs has been shown to lessen symptoms and to promote brain adaptive changes. Our study is aimed to investigate the effect of an upper-limb exercise, conceptually comparab...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00350

    authors: Messa LV,Ginanneschi F,Momi D,Monti L,Battisti C,Cioncoloni D,Pucci B,Santarnecchi E,Rossi A

    更新日期:2019-10-15 00:00:00

  • Hypnosis as neurophenomenology.

    abstract::Hypnosis research binds phenomenology and neuroscience. Here we show how recent evidence probing the impact of hypnosis and suggestion can inform and advance a neurophenomenological approach. In contrast to meditative practices that involve lengthy and intensive training, hypnosis induces profound alterations in subje...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00469

    authors: Lifshitz M,Cusumano EP,Raz A

    更新日期:2013-08-15 00:00:00

  • Temporal dynamics of attentional selection in adult male carriers of the fragile X premutation allele and adult controls.

    abstract::Carriers of the fragile X premutation allele (fXPCs) have an expanded CGG trinucleotide repeat size within the FMR1 gene and are at increased risk of developing fragile x-associated tremor/ataxia syndrome (FXTAS). Previous research has shown that male fXPCs with FXTAS exhibit cognitive decline, predominantly in execut...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00037

    authors: Wong LM,Tassone F,Rivera SM,Simon TJ

    更新日期:2015-02-05 00:00:00

  • Regional Changes in Cerebral Oxygenation During Repeated Passive Movement Measured by Functional Near-infrared Spectroscopy.

    abstract::The aim of this study is to investigate the influence of passive movement repetition frequency at 1.5-Hz and 1-Hz on changes in cerebral oxygenation and assess the temporal properties of these changes using functional near-infrared spectroscopy (fNIRS). No significant differences in systemic hemodynamics were observed...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00641

    authors: Sugawara K,Onishi H,Tsubaki A,Takai H,Tokunaga Y,Tamaki H

    更新日期:2015-11-25 00:00:00

  • Mapping a lateralization gradient within the ventral stream for auditory speech perception.

    abstract::Recent models on speech perception propose a dual-stream processing network, with a dorsal stream, extending from the posterior temporal lobe of the left hemisphere through inferior parietal areas into the left inferior frontal gyrus, and a ventral stream that is assumed to originate in the primary auditory cortex in ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00629

    authors: Specht K

    更新日期:2013-10-02 00:00:00

  • Brain-to-Brain Coupling in the Gamma-Band as a Marker of Shared Intentionality.

    abstract::Cooperation and competition are two ways of social interaction keys to life in society. Recent EEG-based hyperscanning studies reveal that cooperative and competitive interactions induce an increase in interbrain coupling. However, whether this interbrain coupling effect is just a reflection of inter-subject motor coo...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00295

    authors: Barraza P,Pérez A,Rodríguez E

    更新日期:2020-07-30 00:00:00

  • Expectation Gates Neural Facilitation of Emotional Words in Early Visual Areas.

    abstract::The current study examined whether emotional expectations gate attention to emotional words in early visual cortex. Color cues informed about word valence and onset latency. We observed a stimulus-preceding negativity prior to the onset of cued words that was larger for negative than for neutral words. This indicates ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00281

    authors: Trauer SM,Müller MM,Kotz SA

    更新日期:2019-08-23 00:00:00

  • Dietary fat induces sustained reward response in the human brain without primary taste cortex discrimination.

    abstract::To disentangle taste from reward responses in the human gustatory cortex, we combined high density electro-encephalography with a gustometer delivering tastant puffs to the tip of the tongue. Stimuli were pure tastants (salt solutions at two concentrations), caloric emulsions (two milk preparations identical in compos...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00036

    authors: Tzieropoulos H,Rytz A,Hudry J,le Coutre J

    更新日期:2013-02-20 00:00:00

  • Human visual cortical responses to specular and matte motion flows.

    abstract::Determining the compositional properties of surfaces in the environment is an important visual capacity. One such property is specular reflectance, which encompasses the range from matte to shiny surfaces. Visual estimation of specular reflectance can be informed by characteristic motion profiles; a surface with a spe...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00579

    authors: Kam TE,Mannion DJ,Lee SW,Doerschner K,Kersten DJ

    更新日期:2015-10-21 00:00:00

  • Corrigendum "fNIRS-based brain-computer interfaces: a review".

    abstract::[This corrects the article on p. 3 in vol. 9, PMID: 25674060.]. ...

    journal_title:Frontiers in human neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnhum.2015.00172

    authors: Naseer N,Hong KS

    更新日期:2015-03-26 00:00:00

  • Mapping the "What" and "Where" Visual Cortices and Their Atrophy in Alzheimer's Disease: Combined Activation Likelihood Estimation with Voxel-Based Morphometry.

    abstract::The human cortical regions for processing high-level visual (HLV) functions of different categories remain ambiguous, especially in terms of their conjunctions and specifications. Moreover, the neurobiology of declined HLV functions in patients with Alzheimer's disease (AD) has not been fully investigated. This study ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00333

    authors: Deng Y,Shi L,Lei Y,Liang P,Li K,Chu WC,Wang D,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2016-06-29 00:00:00