[Stem Cells for Retina Replacement].

Abstract:

:In ophthalmology, regenerative medicine is rapidly becoming a reality. Cell based treatment strategies in end stage retinal degeneration may be of therapeutic value, whatever the mechanism of disease mechanism. However, while corneal transplantation is commonly performed with excellent results, many obstacles must be overcome before retinal transplants can become clinically useful. The major problems are the production of appropriate transplants and functional integration in situ. New technologies allow the production of autologous transplants by inducing pluripotency in adult somatic cells. Driven by this development, exciting new research has been conducted on the development of artificial retinal tissue for basic research and transplantation. This article reviews this progress and discusses its clinical utility.

journal_name

Klin Monbl Augenheilkd

authors

Seitz IP,Achberger K,Liebau S,Fischer MD

doi

10.1055/s-0042-105873

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1350-1356

issue

12

eissn

0023-2165

issn

1439-3999

journal_volume

233

pub_type

杂志文章,评审
  • [A follow-up study on the intraocular pressure response of timolol eye drops (author's transl)].

    abstract::In 22 open-angle glaucoma patients a total of 39 eyes were treated with Timolol 0.25% twice daily for an average period of 12.6 months. The relative intraocular pressure decrease at the beginning of the study was 47% of the untreated pressure level. This initial response declined to a 23% pressure decrease at the end ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Krieglstein GK

    更新日期:1979-11-01 00:00:00

  • [The Mannheim lens: a provisional cataract lens for one-eyed aphakic patients (author's transl)].

    abstract::Description of a tailor-made dressing with a built-in cataract lens which gives the one-eyed aphakic patient vision from the first postoperative day. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057599

    authors: Werner W,Martus H,Liesenhoff H

    更新日期:1980-06-01 00:00:00

  • [Treatment of retinal detachment with macular hole: scleral buckling with an absorbable fibrin sponge (author's transl)].

    abstract::In 21 patients with macular hole and retinal detachment a macular buckling procedure was performed including diathermic or cryogenic coagulation. An absorbable fibrin sponge (Fibrospum) was used as a new buckling material, which needs not to be sutured to the sclera at the posterior pole. In comparison to other proced...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Wollensak J,Engels T

    更新日期:1977-08-01 00:00:00

  • [Pressure-reducing effect of latanoprost 0.005%].

    abstract:BACKGROUND:Earlier studies in monkeys have shown that latanoprost 0.005% lowers the IOP by improving the uveoscleral Outflow. We wanted to know if this is also the case in the human eye. PATIENTS AND METHODS:We used our new aqueous humor outflow test with 2-nitrophenyl-acetate in 9 healthy human volunteers, mean age 3...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034877

    authors: Albach C,Wachsmuth ED,Velte K,Dekker P,Robert Y

    更新日期:1998-05-01 00:00:00

  • [The prevalence of bilateral malignant uveal melanoma].

    abstract:BACKGROUND:Malignant melanoma of the choroid is the most common ocular primary malignancy, but is still a rare tumour. The occurrence of bilateral uveal melanoma is exceedingly rare. The probability of any one individual developing bilateral melanoma is estimated to be 1 to 50 million. MATERIALS AND METHODS:A retrospe...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-963519

    authors: Sturm V,Richard G

    更新日期:2007-10-01 00:00:00

  • [Traction detachment in Coats disease].

    abstract::Immunocytochemical examination of a subretinal membrane removed during vitrectomy from a patient suffering from Coats' disease revealed macrophages, fibronectin, and vimentin. Vimentin is considered to be a marker of mesenchymal cells. Fibronectin may represent a guide rail and scaffold for the cellular organization o...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050247

    authors: Wiedemann P,Weller M,Heimann K

    更新日期:1988-08-01 00:00:00

  • Transepithelial short circuit currents in human and porcine isolated ciliary bodies: effect of acetazolamide and epinephrine.

    abstract:BACKGROUND:To investigate in human and porcine isolated ciliary bodies the effect of acetazolamide and epinephrine on ciliary transepithelial ionic currents (a parameter linked to aqueous humor production). MATERIAL AND METHODS:Isolated ciliary bodies were mounted in a Ussing-type chamber to measure transepithelial po...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2003-38168

    authors: Wu R,Flammer J,Haefliger I

    更新日期:2003-03-01 00:00:00

  • [Eye Drops Instead of Intravitreal Injections? The Dream of Treating Macular Diseases by Topically Administered Drugs].

    abstract::Background The introduction of VEGF inhibitors revolutionized treatment for age-related macular degeneration. However, it requires regular intravitreal (IVT) injections. Hence, replacement of IVT injections by topical, non-invasive eye drop treatment is subject to intensive research. Material and Methods Literature an...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0043-113253

    authors: Zeitz O,Joussen AM

    更新日期:2017-09-01 00:00:00

  • [Effect of a single oral dose of propranolol or metoprolol on the intraocular pressure of persons without glaucoma (author's transl)].

    abstract::Oral doses of propranolol and metoprolol were tested on 24 patients without glaucoma. The aim of this study was to compare the decrease in intraocular pressure in normal eyes following a single oral dose of propranolol or metoprolol. A statistically significant decrease in IOP was noticed, but no difference was seen b...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Merté HJ,Merkle W

    更新日期:1980-01-01 00:00:00

  • "En face" OCT in Small Pigmented Choroidal Tumors.

    abstract::Background "En face" optical coherence tomography (OCT) is an imaging technique with optic sections parallel to the retinal pigment epithelium (RPE). This study aims to define the use of this technique in the evaluation of small pigmented choroidal tumors. Patients and Methods Investigation of 27 small pigmented choro...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0042-123172

    authors: Cotting-Bodmer S,Zografos L,Schalenbourg A

    更新日期:2017-04-01 00:00:00

  • Early detection of Best's disease in childhood due to ineffective orthoptic treatment.

    abstract:BACKGROUND:A meticulous fundoscopy is an essential examination before administering an orthoptic occlusion therapy (patching), even in cases with a "clear indication" for patching. In this case of an 8-year-old hyperopic boy the subsequent fundoscopy revealed a bilateral maculopathy that explained the stagnation of the...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1027270

    authors: Jaggi GP,Wirthlin J,Eggmann A,Killer HE,Forrer A

    更新日期:2008-05-01 00:00:00

  • [Optic Disk Drusen: Historical and Up-To-Date Aspects].

    abstract::Optic disc drusen are an important differential diagnosis in the diagnostic evaluation of a prominent optic nerve head. Drusen of the optic disc occur in 0.34 to 2.4 % of human individuals and manifest themselves bilaterally in three of four cases. Drusen are found six times more often within histological sections tha...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0042-101554

    authors: Nentwich MM,Maertz J,Rudolph G

    更新日期:2016-03-01 00:00:00

  • [Intrastromal keratorhexis with the Nd:YAG laser--a possible method of refractive surgery?].

    abstract::A new method of refractive corneal surgery is presented. With the q-switched Nd:YAG-laser Visulas (Zeiss-Oberkochen) we succeed in altering the optical power of the cornea of rabbits, pigs and humans. The number of applied laser spots and the distribution pattern influence the way and the amount of change of refractio...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046315

    authors: Höh H,Becker KW

    更新日期:1990-12-01 00:00:00

  • [Biphakia congenita].

    abstract::Two separate lenses were found in the right eye of a 9-year-old boy who underwent surgery for bilateral cataracta congenita perinuclearis. No other ocular anomalies were observed. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054890

    authors: Gerkowicz K,Toczolowski J

    更新日期:1983-08-01 00:00:00

  • [Fundus changes in Zinsser-Engman-Cole syndrome (author's transl)].

    abstract::A case of Zinsser-Engman-Cole syndrome (Dyskeratosis congenita) with severe fundus changes is reported. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Roth K,Lange CE

    更新日期:1975-05-01 00:00:00

  • [Use of a new optoelectronic vision aid for highly visually handicapped patients].

    abstract:UNLABELLED:A new low vision aid (LVA)-the Low Vision Enhancement System or LVES, which were as developed at the Johns Hopkins University in Baltimore, is now commercially available. This instrument allows a magnification up to 10 times with control of contrast and luminance while the field of view is very large: 60 x 4...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035025

    authors: Rohrschneider K,Bruder I,Aust R,Blankenagel A

    更新日期:1997-02-01 00:00:00

  • [Gene therapy in corneal diseases].

    abstract::Gene therapy raised euphoric expectations in the past that have yet to be met and have even been lowered due to the absence of concrete clinical successes and the occurrence of some tragic incidents. In spite of the great future potential of gene therapy, numerous pilot studies in this field will probably be discontin...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-44610

    authors: Hoffmann F,Junghans C

    更新日期:2003-11-01 00:00:00

  • [The phenotype of heterozygotic females in congenital red-green color blindness (author's transl)].

    abstract::Varying degrees of deficient color perception along the Deutan axis within one family have been studied and presented. All seven family members exhibit manifest color blindness. The question of the phenotype among heterozygotic females is discussed on the basis of the data found by anomaloscope testing and the hue tes...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Fahrenkamp-Richner K

    更新日期:1976-01-01 00:00:00

  • [Malignant teratoid medulloepithelioma of the ciliary body and glial fibrillary acidic protein. Clinical, histochemical and immunohistochemical findings].

    abstract::In a four-year-old boy a malignant teratoid medulloepithelioma of the ciliary body was removed by means of an 11.0 X 11.0 mm "block excision". Two years later the patients visual acuity was 0.6. The lesion originates in the nonpigmented ciliary epithelium, extending along the lens equator to the pupillary zone and thr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1051036

    authors: Holbach L,Völcker HE,Naumann GO

    更新日期:1985-10-01 00:00:00

  • [About the application of a new audio video color cartridge system in ophthalmology (author's transl)].

    abstract::A report is given on an advanced color video cartridge system and its application within various disciplines of ophthalmology. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Stiegler G

    更新日期:1975-11-01 00:00:00

  • [Two patients with xerophthalmia].

    abstract:BACKGROUND:Xerophthalmia, the eye manifestation of vitamin A deficiency, is one of the main reasons of blindness in developing countries but is rare in industrial countries. PATIENTS:We report on 2 cases of night blindness and conjunctival and corneal xerosis because of hypovitaminosis A. One patient developed vitamin...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2000-10386

    authors: Horwath J,Stelzl U,Bachernegg M,Langmann A

    更新日期:2000-07-01 00:00:00

  • [Neurological disorders and glaucoma - an overview].

    abstract::Due to the anatomic location of the N. opticus to the brain and its embryological development as a "bulging part of the brain", a close connection between the opticoneuropathy and certain neurological diseases exists. Glaucoma is a chronic neurodegenerative disorder and many cellular and molecular mechanisms of the ch...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1360316

    authors: Göbel K,Erb C

    更新日期:2014-02-01 00:00:00

  • [Epibulbar osteomas (author's transl)].

    abstract::Epibulbar osteomas are benign tumors which are usually present at birth. Up to now 39 cases have been described in the literature. In the last three years 4 further cases have been found in the Freiburg, Hamburg, Marburg, and Munich University Eye Clinics. Epibulbar osteomas probably occur more often than is generally...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057467

    authors: Bujara K,Stefani FH,Strempel I,Witschel H

    更新日期:1980-03-01 00:00:00

  • [Selective thrombophilia screening of young patients with retinal vein occlusion].

    abstract:BACKGROUND:The potential impact of coagulation abnormalities on retinal vascular occlusive diseases, individually and in combination with cardiovascular risk factors, remains unclear. PATIENTS AND METHODS:In a prospective case-control study a cohort of 74 young patients with central, hemicentral or branch retinal vein...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0028-1109195

    authors: Kuhli-Hattenbach C,Scharrer I,Lüchtenberg M,Hattenbach LO

    更新日期:2009-09-01 00:00:00

  • [On the correction of posttraumatic unilateral aphakia in children and in adults with artificial intraocular lens implants (author's transl)].

    abstract::The problems of optical correction of unilateral traumatic aphakia are discussed. The treatment of choice is a combined Cataract-operation with intraocular lens implants. The operation must be done as soon as the eye is free of inflammation. Prescription of bifocal glasses in addition to pseudophakoi is necessary. Wit...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:

    authors: Oppong MC,Kern R,Schipper J,Käppeli F

    更新日期:1978-04-01 00:00:00

  • [Functional histopathology of pituitary neoplasms (author's transl)].

    abstract::The generally accepted classification of pituitary adenomas into eosinophilic, basophilic, mixed, and chromophobe types has not been very useful since no clear correlation exists between the staining character of the tumor cells and the clinical syndrome produced. The ultrastructural examination of different adenoma t...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Landolt AM

    更新日期:1977-02-01 00:00:00

  • [Intravitreal Ranibizumab Injection for the Treatment of Occult and Classic CNV in Exsudative AMD].

    abstract:BACKGROUND:Double-blind, randomised, placebo-controlled and multicentre studies have proven an increase in visual acuity in one-third of the patients receiving Ranibizumab (0.5 mg) injections, who suffer from exsudative AMD. The purpose of this study was to evaluate the early effects of intravitreal Ranibizumab therapy...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0029-1245131

    authors: Maier MM,Feucht N,Fegert C,Fiore B,Winkler von Mohrenfels C,Lohmann C

    更新日期:2011-02-01 00:00:00

  • [Cryptophthalmos solum corneae].

    abstract::The authors report on an 11-month-old child in whom subcutaneous fatty tissue covered with normal skin was found instead of a cornea. Since the lid and conjunctiva were intact this developmental anomaly may be designated cryptophthalmos solum corneae. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046162

    authors: Alberth B,el Zein G

    更新日期:1990-04-01 00:00:00

  • [A case of papillophlebitis].

    abstract::A case history of a young man with recurrent papillophlebitis. The fluorescein angiogram showed an extensive hyperfluorescence of the disk and surrounding retinal veins in the venous and late phase. The electro-ophthalmological findings were normal in both eyes, while computerized perimetry demonstrated an enlarged bl...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1055250

    authors: Wochesländer E,Bartl G

    更新日期:1982-11-01 00:00:00

  • [A report on ocusert (author's transl)].

    abstract::The fourth communication on the Ocular Therapeutic System Ocusert (Alza Corp., Palo Alto/Calif.; Federal Republic of Germany: Chemie Grünenthal, Stolberg) deals with experiences of a 24 months follow-up study as well as with the results of an omission test. From the diurnal curves carried out over 24 months, and the r...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Heilmann K

    更新日期:1977-01-01 00:00:00