Abstract：
BACKGROUND:Increased cardiac troponin concentrations in acute coronary syndrome (ACS) identify patients with ongoing cardiomyocyte necrosis who are at increased risk. However, with the use of more precise assays, cardiac troponin increases are commonly noted in other cardiovascular conditions as well. This has generated interest in the use of cardiac troponin for prognostic assessment and clinical management of these patients. In this review, we have summarized the data from studies investigating the implications of cardiac troponin concentrations in various acute and chronic conditions beyond ACS, i.e., heart failure, myocarditis, Takotsubo cardiomyopathy, aortic dissection, supraventricular arrhythmias, valve disease, pulmonary arterial hypertension, stroke, and in the perioperative setting. CONTENT:Cardiac troponin concentrations are often detectable and frankly increased in non-ACS conditions, in particular when measured with high-sensitivity (hs) assays. With the exception of myocarditis and Takotsubo cardiomyopathy, cardiac troponin concentrations carry strong prognostic information, mainly with respect to mortality, or incipient and/or worsening heart failure. Studies investigating the prognostic benefit associated with cardiac troponin-guided treatments however, are almost lacking and the potential role of cardiac troponin in the management of non-ACS conditions is not defined. SUMMARY:Increased cardiac troponin indicates increased risk for adverse outcome in patients with various cardiovascular conditions beyond ACS. Routine measurement of cardiac troponin concentrations can however, not be generally recommended unless there is a suspicion of ACS. Nonetheless, any finding of an increased cardiac troponin concentration in a patient without ACS should at least prompt the search for possible underlying conditions and these should be managed meticulously according to current guidelines to improve outcome.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Eggers KM,Lindahl Bdoi
10.1373/clinchem.2016.261495subject
Has Abstractpub_date
2017-01-01 00:00:00pages
223-235issue
1eissn
0009-9147issn
1530-8561pii
clinchem.2016.261495journal_volume
63pub_type
杂志文章,评审abstract：:Serial results from an individual are often obtained using more than one method. Results should be transferable over time and locale. Every method has inherent analytical error, and goals are required to delineate the maximum allowable random (imprecision) and systematic (inaccuracy, bias) errors to facilitate optimal...
journal_title：Clinical chemistry
pub_type： 杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:Emerging technologies for rapid identification of microbes demonstrate a shift from traditional biochemical and molecular testing algorithms toward methods using mass spectrometry (MS) for the semiquantitative analysis of microbial proteins and genetic elements. This study was performed to assess the diagnos...
journal_title：Clinical chemistry
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doi：10.1373/clinchem.2011.161968
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abstract：:Distributions of concentrations of free glycerol in clinical plasma obtained for triglyceride assay were compiled to determine the frequency with which increased concentrations of free glycerol posed a potential problem for clinical interpretation of triglyceride results. Clinical histories were studied in patients wi...
journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:We used ion-exchange column chromatography and electrophoresis on polyacrylamide gel to compare the acid phosphatase isoenzymes of prostate and leukocytes. The major isoenzyme of the prostate is band 2A; only a trace of band 2B was observed. However, the major isoenzymes of leukocytes are band 4 and band 2B, and only ...
journal_title：Clinical chemistry
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doi：
更新日期：1979-07-01 00:00:00
abstract：:We developed a simple method for the analysis of bismuth (Bi) in biological tissue, using wet digestion for sample pretreatment. Bi was determined by electrothermal atomic absorption spectrometry with platinum as a matrix modifier to decrease the volatility of Bi. The furnace program included a gas stop for sensitivit...
journal_title：Clinical chemistry
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doi：
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:Genomic instability resulting in copy number variation is a hallmark of malignant transformation and may be identified through massive parallel sequencing. Tumor-specific cell free DNA (cfDNA) present in serum and plasma provides a real-time, easily accessible surrogate. METHODS:DNA was extracted from serum...
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doi：10.1373/clinchem.2014.226571
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doi：10.1373/clinchem.2016.257592
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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doi：
更新日期：1988-10-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1980-09-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：2000-12-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1988-03-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：2002-11-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1976-07-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1987-05-01 00:00:00
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doi：10.1373/clinchem.2009.134643
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journal_title：Clinical chemistry
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doi：
更新日期：1998-07-01 00:00:00
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更新日期：2014-04-01 00:00:00
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doi：
更新日期：1990-10-01 00:00:00
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更新日期：2008-12-01 00:00:00
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doi：
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journal_title：Clinical chemistry
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doi：
更新日期：1978-09-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1985-10-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1978-01-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1981-07-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1980-05-01 00:00:00
abstract：:In this simple and low-cost radioimmunoassay (RIA) procedure for thyroxin (T4), ethacridine (6,9-diamino-2-ethoxyacridine lactate; Rivanol) is used to separate antibody-bound ligand and free ligand. This acridine dye precipitates free T4 not bound to antibody. At pH 8.6, it precipitates more than 90% of 125I-labeled T...
journal_title：Clinical chemistry
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doi：
更新日期：1983-11-01 00:00:00
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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更新日期：1986-03-01 00:00:00
