Runx2 and microRNA regulation in bone and cartilage diseases.

abstract：:The autonomic nervous system consists of sympathetic, parasympathetic, and enteric ganglia and also of a specialized neuroendocrine derivative, the adrenomedullary chromaffin cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Kalcheim C,Langley K,Unsicker K

更新日期：2002-10-01 00:00:00

abstract：:Obstructive sleep apnea is often regarded as a structural disorder causing narrowing of the airway. This article reviews the neurological aspects of obstructive sleep apnea, including the upper airway reflex, cortical arousal thresholds, and motor function as they pertain to the pathophysiology of disease. We also dis...

journal_title：Annals of the New York Academy of Sciences

authors： Broderick M,Guilleminault C

更新日期：2008-10-01 00:00:00

abstract：:Although the hippocampus expresses nicotinic acetylcholine receptors (nAChRs) and receives cholinergic innervation, the functional roles of these receptors are not completely understood. Our results indicated that presynaptic nAChRs mediated a calcium influx that enhanced the release of both glutamate and GABA. Fura-2...

journal_title：Annals of the New York Academy of Sciences

authors： Radcliffe KA,Fisher JL,Gray R,Dani JA

更新日期：1999-04-30 00:00:00

abstract：:Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

journal_title：Annals of the New York Academy of Sciences

authors： Moffat SD

更新日期：2005-12-01 00:00:00

abstract：:Stationary-phase mutation (a subset of which was previously called adaptive mutation) occurs in apparently nondividing, stationary-phase cells exposed to a nonlethal genetic selection. In one experimental system, stationary-phase reversion of an Escherichia coli F'-borne lac frameshift mutation occurs by a novel molec...

journal_title：Annals of the New York Academy of Sciences

authors： Lombardo MJ,Torkelson J,Bull HJ,McKenzie GJ,Rosenberg SM

更新日期：1999-05-18 00:00:00

abstract：:The rostral nucleus of the solitary tract (rNST) plays a key role in modulating, organizing and distributing the sensory information arriving at the central nervous system from gustatory receptors. However, except for some anatomical studies of rNST synapses, the neural circuits responsible for this first stage in syn...

journal_title：Annals of the New York Academy of Sciences

authors： Bradley RM,Grabauskas G

更新日期：1998-11-30 00:00:00

abstract：:Masting, the highly variable and synchronous production of seeds across a population of perennial plants, is an ecologically important, but still poorly understood, phenomenon. While much is known about the fitness benefits of masting and its effects on seed consumers and trophic interactions, less is understood about...

journal_title：Annals of the New York Academy of Sciences

authors： Crone EE,Rapp JM

更新日期：2014-08-01 00:00:00

abstract：:Angiogenesis is a prerequisite for tumor expansion and metastasis. The angiogenic potential of the heparin-binding growth factors acidic fibroblast growth factor (FGF) and basic FGF has been demonstrated in various publications. We studied the inhibitory effects of suramin and the polysulfated heparinoids pentosan pol...

journal_title：Annals of the New York Academy of Sciences

authors： Zugmaier G,Favoni R,Jaeger R,Rosen N,Knabbe C

更新日期：1999-01-01 00:00:00

abstract：:Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identi...

journal_title：Annals of the New York Academy of Sciences

authors： Baraniuk JN,Merck SJ

更新日期：2009-07-01 00:00:00

abstract：:The past three decades of clinical disappointments in treating stroke must compel us to rethink our strategy. Given the enormous complexity of the clinical disease, the "one size fits all" approach to stroke treatment is unlikely to succeed. The effective treatment of stroke aimed at reversing ischemic injury will req...

journal_title：Annals of the New York Academy of Sciences

authors： Joshi S,Agarwal S

更新日期：2010-06-01 00:00:00

abstract：:Previous studies in postmenopausal women have reported that estrogen treatment (ET) modulates the risk for developing Alzheimer's disease (AD). It has recently been hypothesized that there may be a "critical period" around the time of menopause during which the prescription of ET may reduce the risk of developing AD i...

journal_title：Annals of the New York Academy of Sciences

authors： Craig MC,Murphy DG

更新日期：2010-09-01 00:00:00

abstract：:The risk of cardiovascular (CV) disease increases in patients with rheumatoid arthritis (RA). This is due to a number of different triggers including traditional and disease-related factors. Among established risk factors for CV disease, smoking may exert a more dangerous effect on arterial wall in RA than in the gene...

journal_title：Annals of the New York Academy of Sciences

authors： Gerli R,Sherer Y,Bocci EB,Vaudo G,Moscatelli S,Shoenfeld Y

更新日期：2007-06-01 00:00:00

abstract：:Therapy for mitochondrial diseases is woefully inadequate. How-ever, lack of cure does not equate with lack of treatment. In this review, we consider sequentially several different therapeutic approaches. Palliative therapy is dictated by good medical practice and includes anticonvulsant medication, control of endocri...

journal_title：Annals of the New York Academy of Sciences

authors： Dimauro S,Mancuso M,Naini A

更新日期：2004-04-01 00:00:00

abstract：:One in 12 people worldwide suffers from diabetes and more than 90% of affected adult individuals are diagnosed with type 2 diabetes mellitus (T2DM). Obesity adds to the personal risk to develop T2DM, and both metabolic diseases are rampantly increasing worldwide. Over recent years, primary cilia have moved into the fo...

journal_title：Annals of the New York Academy of Sciences

authors： Volta F,Gerdes JM

更新日期：2017-03-01 00:00:00

abstract：:Increasing data indicate that polymorphic variants of nuclear loci can affect rate and quality of aging in humans. However, the mitochondrial genome is another good candidate, because of the central role played by mitochondrial genes in oxidative phosphorylation (OXPHOS) and cell metabolism. A characteristic of the mi...

journal_title：Annals of the New York Academy of Sciences

authors： de Benedictis G,Carrieri G,Varcasia O,Bonafè M,Franceschi C

更新日期：2000-06-01 00:00:00

abstract：:Familial British dementia (FBD) is a disorder characterized by the presence of amyloid deposits in cerebral blood vessels and brain parenchyma coexisting with neurofibrillary tangles in limbic areas. The amyloid subunit (ABri) is a 4 kDa fragment of a 266 amino acid type II single-spanning transmembrane precursor prot...

journal_title：Annals of the New York Academy of Sciences

authors： Ghiso J,Vidal R,Rostagno A,Miravalle L,Holton JL,Mead S,Révész T,Plant G,Frangione B

更新日期：2000-01-01 00:00:00

abstract：:There are two types of escapes in conservative dynamical systems with two degrees of freedom: escapes to infinity and escapes to certain singular points at a finite distance. In both cases the areas on a surface of section are not preserved. We consider the basins of escape to infinity in simple Hamiltonian systems. T...

journal_title：Annals of the New York Academy of Sciences

authors： Contopoulos G,Harsoula M

更新日期：2005-06-01 00:00:00

abstract：:Entomopathogenic fungi are promising alternatives to chemical acaricides in controlling tick populations; however, biological formulations are required to improve conidial performance of these pathogens in the field. This study evaluated the effect of in vitro treatment of Rhipicephalus sanguineus with conidial formul...

journal_title：Annals of the New York Academy of Sciences

authors： Reis RC,Fernandes EK,Bittencourt VR

更新日期：2008-12-01 00:00:00

abstract：:The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified seve...

journal_title：Annals of the New York Academy of Sciences

authors： Mundy NI,Kelly J,Theron E,Hawkins K

更新日期：2003-06-01 00:00:00

abstract：:Zoonoses are animal and human diseases. Q fever is primarily a zoonosis-an animal disease that can be transmitted to humans under certain conditions. Recent epidemiological studies suggest that Q fever should be considered as a public health problem in many countries where it is present, but unrecognizable due to inad...

journal_title：Annals of the New York Academy of Sciences

authors： Beslagić E,Hamzić S,Beslagić O,Zvizdić S

更新日期：2006-10-01 00:00:00

abstract：:Long-term exposure to estrogens influences the development of breast cancer in women, but the precise mechanisms involved are not clearly defined. Our working hypothesis is that estrogen modulates this process by two separate processes. One involves the binding of estradiol to estrogen receptor (ER) alpha with stimula...

journal_title：Annals of the New York Academy of Sciences

authors： Santen R,Cavalieri E,Rogan E,Russo J,Guttenplan J,Ingle J,Yue W

更新日期：2009-02-01 00:00:00

abstract：:The ocular motor system provides several advantages for studying the brain, including well-defined populations of neurons that contribute to specific eye movements. Generation of rapid eye movements (saccades) depends on excitatory burst neurons (EBN) and omnipause neurons (OPN) within the brainstem, both types of cel...

journal_title：Annals of the New York Academy of Sciences

authors： Eggers SD,Horn AK,Roeber S,Härtig W,Nair G,Reich DS,Leigh RJ

更新日期：2015-04-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) are used to treat myasthenia gravis (MG) but with little trial evidence. While a class I study provided evidence for the efficacy of IVIG treatment, the empirical support for PLEX has been less convincing until recently. In a randomized controlled single-mas...

journal_title：Annals of the New York Academy of Sciences

authors： Bril V,Barnett-Tapia C,Barth D,Katzberg HD

更新日期：2012-12-01 00:00:00

abstract：:The purpose of the present experiment was to determine if there is a factor in serum of patients with myasthenia gravis (MG) that interferes with binding of (125I)-alpha-bungarotoxin to acetylcholine receptors of normal mouse diaphragm. Diaphragms were incubated aerobically for 1 hour in either Krebs-Henseleit solutio...

journal_title：Annals of the New York Academy of Sciences

authors： Keesey J,Shaikh I,Wolfgram F,Chao LP

更新日期：1976-01-01 00:00:00

abstract：:On the basis of evidence just reviewed, the hormonal requirements during IVM of mammalian oocytes for fertilization and developmental competence may be summarized as follows: 1. Nuclear maturation occurs "spontaneously," without follicular factors or hormones, in all mammalian species. 2. Cumulus cells are necessary d...

journal_title：Annals of the New York Academy of Sciences

authors： Armstrong DT,Zhang X,Vanderhyden BC,Khamsi F

更新日期：1991-01-01 00:00:00

abstract：:Animal trials of many pharmacological neuroprotective agents have been quite successful, whereas trials in humans have been uniformly disappointing. A major difference between laboratory research in animals and clinical research in humans is the amount and/or quality of data obtained. The goal of this presentation is ...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews RJ

更新日期：2005-08-01 00:00:00

abstract：:Thymic pathology occurs in 80-90% of myasthenia gravis patients. Significant associations between different thymic alterations and clinical findings are discussed. To highlight peculiarities in thymoma-associated myasthenia gravis, we briefly review myasthenia gravis associated with thymic lymphofollicular hyperplasia...

journal_title：Annals of the New York Academy of Sciences

authors： Marx A,Müller-Hermelink HK,Ströbel P

更新日期：2003-09-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the beta cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of I...

journal_title：Annals of the New York Academy of Sciences

authors： Holm P,Luthman H,Kockum I

更新日期：2003-11-01 00:00:00

abstract：:Why does music pervade our lives and those of all known human beings living today and in the recent past? Why do we feel compelled to engage in musical activity, or at least simply enjoy listening to music even if we choose not to actively participate? I argue that this is because musicality--communication using varia...

journal_title：Annals of the New York Academy of Sciences

authors： Mithen S

更新日期：2009-07-01 00:00:00

abstract：:After the initial dramatic effects, observed in a Lewis lung carcinoma animal model, using a combination of thymosin alpha 1 (Talpha1) and interferon (IFN) after cyclophosphamide, a number of other preclinical models in mice (Friend erythroleukemia and B16 melanoma) and in rats (DHD/K12 colorectal cancer liver metasta...

journal_title：Annals of the New York Academy of Sciences

authors： Garaci E,Favalli C,Pica F,Sinibaldi Vallebona P,Palamara AT,Matteucci C,Pierimarchi P,Serafino A,Mastino A,Bistoni F,Romani L,Rasi G

更新日期：2007-09-01 00:00:00