Hepatic Adenomas in Adolescents and Young Women with Endometriosis Treated with Norethindrone Acetate.

Abstract:

BACKGROUND:Endometriosis-ectopic implantation of endometrial-like tissue-affects 10% of female adolescents and adults. First-line treatment includes progesterone only (such as norethindrone acetate [NET-A]) or combined estrogen/progestin oral contraceptive pills. Estrogen-containing contraceptives confer increased risk of hepatic adenomas, whereas the association with NET-A is very rarely reported. CASE:Three adolescents with stage I to II endometriosis managed with NET-A (up to 15 mg/d for 28-78 months) were diagnosed with hepatic adenomas at ages 17-22 years. They previously received estrogen-containing medications, which were stopped 24 months or longer before diagnosis of hepatic adenoma. SUMMARY AND CONCLUSION:NET-A in a dose greater than 10 mg/d might be associated with increased risk for hepatic adenomas, likely due to peripheral conversion to ethinyl estradiol. Use of NET-A might not be advisable in patients with known hepatic adenomas.

authors

Brady PC,Missmer SA,Laufer MR

doi

10.1016/j.jpag.2016.12.002

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

422-424

issue

3

eissn

1083-3188

issn

1873-4332

pii

S1083-3188(16)30232-7

journal_volume

30

pub_type

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