Avian and simian malaria: do they have a cancer connection?

Abstract:

:It has been claimed that infectious agents transmitted by mosquitoes (Diptera: Culicidae) may have a greater connection to cancer then hitherto supposed and that the immune system struggles to recognize and fight some of these infectious agents. One of the claims made is that there is a connection between human malaria and brain cancers in the USA. However, the USA declared itself free of human malaria in the last century, yet cancer incidences remain high, suggesting any overall cancer connection is slight. Two fundamental questions arise from the possible mosquito-cancer connection. Firstly, if mosquitoes are able to vector some pathogens and parasites linked with cancer pathogenesis, why has the fact not been discovered decades ago? Secondly, if there is a connection (other than in relation to Burkett's lymphoma), what is its extent? The answers may well lie with the various types of malarias known to exist. The discovery in humans of the simian malaria, caused by Plasmodium knowlesi, suggests that other forms of simian or even avian malaria may be capable of survival in humans, albeit at low levels of parasitemia, and humans may be a dead-end host. Other carcinogenic infectious agents transmitted by mosquitoes may also go undetected because either no one is looking for them, or they are looking in wrong anatomical locations and/or with inadequate tools. Research on false negative test results with respect to many infectious agents is sadly lacking, so its extent is unknown. However, electronic and other media provide numerous instances of patients failing to be diagnosed for both human malaria and Lyme's disease, to take just two examples. This review suggests that to shed light on a potential mosquito-cancer connection, more research is required to establish whether other simian and avian forms of malaria play a part. If so, then they potentially provide unique markers for early cancer detection.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Ward M,Benelli G

doi

10.1007/s00436-016-5352-3

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

839-845

issue

3

eissn

0932-0113

issn

1432-1955

pii

10.1007/s00436-016-5352-3

journal_volume

116

pub_type

杂志文章,评审
  • In silico cloning and B/T cell epitope prediction of triosephosphate isomerase from Echinococcus granulosus.

    abstract::Cystic echinococcosis is a worldwide zoonosis caused by Echinococcus granulosus. Because the methods of diagnosis and treatment for cystic echinococcosis were limited, it is still necessary to screen target proteins for the development of new anti-hydatidosis vaccine. In this study, the triosephosphate isomerase gene ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-016-5166-3

    authors: Wang F,Ye B

    更新日期:2016-10-01 00:00:00

  • Mosquitocidal essential oils: are they safe against non-target aquatic organisms?

    abstract::In latest years, the importance of the Melaleuca alternifolia essential oil (EO) has been greatly empathised due to its anti-microbial and anti-inflammatory effects, as well as to its toxic properties towards many arthropods of great medical and veterinary importance. In this research, the EO extracted from aerial par...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-013-3651-5

    authors: Conti B,Flamini G,Cioni PL,Ceccarini L,Macchia M,Benelli G

    更新日期:2014-01-01 00:00:00

  • Status and origin of Haemonchinae (Nematoda: Trichostrongylidae) in deer: a survey conducted in France from 1985 to 1998.

    abstract::During our investigations on helminthofauna in roe deer (Capreolus capreolus) and red deer (Cervus elaphus) in France (1985-1998) we isolated nematodes not only of the genus Haemonchus Cobb, 1898 but also of the genus Ashworthius Le Roux 1930, both of which belong to the same subfamily of Haemonchinae. The prevalence ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/pl00008534

    authors: Ferté H,Cléva D,Depaquit J,Gobert S,Léger N

    更新日期:2000-07-01 00:00:00

  • Scanning electron microscopy of rediae, cercariae, metacercariae and adults of Mesorchis denticulatus (Rudolphi, 1802) (Trematoda, Echinostomatidae).

    abstract::A detailed study of the surface topography of the echinostome digenean Mesorchis denticulatus (Rudolphi 1802) Dietz 1909 was carried out using the scanning electron microscope. The surface area of the redia is increased by microvilli, and ciliate sensory structures are common around the mouth. The cannibalistic behavi...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/BF00536336

    authors: Køie M

    更新日期:1987-01-01 00:00:00

  • Ultrastructural aspects of spermatogenesis, testes, and vas deferens in the parthenogenetic tapeworm Atractolytocestus huronensis Anthony, 1958 (Cestoda: Caryophyllidea), a carp parasite from Slovakia.

    abstract::Spermatogenesis, testes, and vas deferens in the parthenogenetic monozoic tapeworm Atractolytocestus huronensis Anthony, 1958 (Cestoda: Caryophyllidea) from Slovakia, parasitizing the carp Cyprinus carpio L., have been investigated by means of transmission electron microscopy for the first time. The present results sh...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-010-2038-0

    authors: Bruňanská M,Nebesářová J,Oros M

    更新日期:2011-01-01 00:00:00

  • Prevalence, intensity and seasonality of gastrointestinal parasites in abattoir horses in Germany.

    abstract::Prevalence and intensity of gastrointestinal parasites were studied through a longitudinal survey in 400 horses over a 17-month period in an abattoir in Germany. Three hundred and ten horses (77.5 %) were demonstrated harbouring endoparasites either by direct recovery of parasites from the digestive tract and/or in te...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-012-3150-0

    authors: Rehbein S,Visser M,Winter R

    更新日期:2013-01-01 00:00:00

  • Enzyme-linked immunosorbent assays for the detection of equine antibodies specific to a recombinant Fasciola hepatica surface antigen in an endemic area.

    abstract::The utility of an enzyme-linked immunosorbent assay to determine the sensitization against the trematode Fasciola hepatica in horses from an endemic area (NW Spain) was assessed. Blood samples were collected from 536 horses and tested against a 2.9-kDa recombinant surface protein (FhrAPS) to estimate the presence of I...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-011-2587-x

    authors: Arias MS,Piñeiro P,Hillyer GV,Francisco I,Cazapal-Monteiro CF,Suárez JL,Morrondo P,Sánchez-Andrade R,Paz-Silva A

    更新日期:2012-02-01 00:00:00

  • Assessment of the role of small mammals in the transmission cycle of tegumentary leishmaniasis and first report of natural infection with Leishmania braziliensis in two sigmodontines in northeastern Argentina.

    abstract::To contribute to the knowledge of the role of small mammals in the transmission cycle of tegumentary leishmaniasis caused by Leishmania braziliensis, we studied the small mammal community and its temporal and spatial association with phlebotominae, as well as small mammal infection by Leishmania spp. by PCR-RFLP analy...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-017-5714-5

    authors: Fernández MS,Fraschina J,Acardi S,Liotta DJ,Lestani E,Giuliani M,Busch M,Salomón OD

    更新日期:2018-02-01 00:00:00

  • Prevalence of Toxoplasma gondii infection in HIV-infected patients and food animals and direct genotyping of T. gondii isolates, Southern Ghana.

    abstract::Toxoplasma gondii is of public health and veterinary importance causing severe diseases in immunocompromised individuals including HIV/AIDS patients and in congenital cases and animals. There is limited information on the epidemiology of T. gondii infection in humans, particularly HIV patients and food animals and the...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-017-5442-x

    authors: Pappoe F,Cheng W,Wang L,Li Y,Obiri-Yeboah D,Nuvor SV,Ambachew H,Hu X,Luo Q,Chu D,Xu Y,Shen J

    更新日期:2017-06-01 00:00:00

  • Taxonomy on three novel species of Sphaeromyxa Thélohan 1892 (Myxozoa, Bivalvulida, Sphaeromyxidae) with insight into the evolution of the genus.

    abstract::Three new myxosporeans of the genus Sphaeromyxa Thélohan 1892 were discovered from the coastal waters off Xiamen in the East China Sea and characterized based on morphological and SSU rDNA data. Sphaeromyxa photopectoralis sp. n. was described from Photopectoralis bindus, and Sphaeromyxa sebastisca sp. n. was describe...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-020-06656-w

    authors: Chen W,Yang C,Whipps CM,Peng Z,Zhao Y

    更新日期:2020-05-01 00:00:00

  • Molecular identification of different trypanosome species in tsetse flies caught in the wildlife reserve of Santchou in the western region of Cameroon.

    abstract::Addressing the problems linked to tsetse-transmitted trypanosomiases requires considerable data on tsetse distribution and trypanosome infections. Although efforts to map tsetse and trypanosome infections have been undertaken at continental level, published data are still rare in wildlife reserves of West and Central ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-020-06606-6

    authors: Kamdem CN,Tiofack AAZ,Mewamba EM,Ofon EA,Gomseu EBD,Simo G

    更新日期:2020-03-01 00:00:00

  • Histochemical study of Sarcocystis sp. intramuscular cysts in gastrocnemius and soleus of the cat.

    abstract::Histochemical investigations of Sarcocystis microcysts found in two hindleg muscles of cats were carried out. Genus identification was based on the reinforced cyst membrane structure and its dimensions, the structure of the sarcocysts, and an electron microscopic survey of bradyzoite characteristics. The cyst membrane...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/BF00932712

    authors: Fiori MG,Lowndes HE

    更新日期:1988-01-01 00:00:00

  • Associations between fish reproductive cycle and the dynamics of metazoan parasite infection.

    abstract::The parasite fauna of the stone loach (Barbatula barbatula) was investigated monthly from May to December 2001. Four parasite species were recorded: Gyrodactylus spp. (Monogenea), Tylodelphys clavata (Digenea), Proteocephalus sagittus (Cestoda), and Raphidascaris acus (Nematoda). The changes in the seasonal dynamics o...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-004-1261-y

    authors: Simková A,Jarkovský J,Koubková B,Barus V,Prokes M

    更新日期:2005-01-01 00:00:00

  • Serodiagnosis of fasciolosis by fast protein liquid chromatography-fractionated excretory/secretory antigens.

    abstract::In several studies, different antigenic preparations and diverse immunological tests were applied for serodiagnosis of Fasciola hepatica infections. Most of these preparations showed cross-reactivity with proteins of other parasites. Application of purified antigens might reduce these cross-reactivities. Here, we used...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-016-5049-7

    authors: Mokhtarian K,Akhlaghi L,Meamar AR,Razmjou E,Manouchehri Naeini K,Gholami S,Najafi Samei M,Falak R

    更新日期:2016-08-01 00:00:00

  • Identification of proteins interacting with Toxoplasma SRCAP by yeast two-hybrid screening.

    abstract::Toxoplasma gondii is an opportunistic protozoan parasite that differentiates into latent cysts (bradyzoite) that can be reactivated during immunosuppression. TgSRCAP (Toxoplasma gondii Snf2-related CBP activator protein) is a SWI2/SNF2 family chromatin remodeler whose expression increases during cyst development. Iden...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-004-1291-5

    authors: Nallani KC,Sullivan WJ Jr

    更新日期:2005-03-01 00:00:00

  • Molecular characterization of Echinococcus granulosus isolates from Bulgarian human cystic echinococcosis patients.

    abstract::Although cystic echinococcosis (CE) is highly endemic in Bulgaria, there is still scarce information about species and/or genotypes of the Echinococcus granulosus complex that infect humans. Our study tackled the genetic diversity of E. granulosus complex in a cohort of 30 Bulgarian CE patients. Ten animal E. granulos...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-017-5386-1

    authors: Marinova I,Spiliotis M,Wang J,Muhtarov M,Chaligiannis I,Sotiraki S,Rainova I,Gottstein B,Boubaker G

    更新日期:2017-03-01 00:00:00

  • Dose- and time-dependent functional and structural damage to the colon mucosa by Entamoeba histolytica trophozoite lysates.

    abstract::Analysis of the initial interaction between Entamoeba histolytica trophozoites and the large intestine is impossible in humans and very difficult in experimental animals. To circumvent this obstacle we treated the luminal side of full-thickness rabbit colon segments mounted in Ussing-type chambers with trophozoite lys...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/BF00931595

    authors: Navarro-García F,López-Revilla R,Tstusumi V

    更新日期:1993-01-01 00:00:00

  • Cellular and subcellular localization of SALMFamide (S1)-like immunoreactivity within the central nervous system of the nematode Ascaris suum (Nematoda, Ascaroidea).

    abstract::The localization and distribution of SALMFamide (S1)-like immunoreactivity (IR), was determined at both the cellular and subcellular level in the central nervous system (CNS) of the nematode roundworm Ascaris suum. The techniques of indirect immunofluorescence in conjunction with confocal scanning laser microscopy and...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s004360050086

    authors: Brownlee DJ,Fairweather I,Thorndyke MC,Johnston CF

    更新日期:1996-01-01 00:00:00

  • Separation of calcareous corpuscles from plerocercoids of Spirometra mansoni and their binding proteins.

    abstract::Calcareous corpuscles, known as mineral concretions in Platyhelminthes, may have special biological functions. In the present study we succeeded in the quantitative separation of calcareous corpuscles in plerocercoids of Spirometra mansoni (sparganum) using Ficoll. Purified calcareous corpuscles were reacted with crud...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s004360000241

    authors: Yang HJ

    更新日期:2000-09-01 00:00:00

  • Monitoring of alien mosquitoes of the genus Aedes (Diptera: Culicidae) in Austria.

    abstract::Systematic, continuous mosquito surveillance is considered the most reliable tool to predict the spread and establishment of alien mosquito species such as the Asian tiger mosquito (Aedes albopictus), Japanese bush mosquito (Aedes japonicus), and the transmission risk of mosquito-borne arboviruses to humans. Only sing...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-019-06287-w

    authors: Schoener E,Zittra C,Weiss S,Walder G,Barogh BS,Weiler S,Fuehrer HP

    更新日期:2019-05-01 00:00:00

  • Gastrointestinal parasites of captive European bison Bison bonasus (L.) with a sign of reduced efficacy of Haemonchus contortus to fenbendazole.

    abstract::The history of European bison Bison bonasus Linnaeus, 1758 has been stormy since its extinction in the wild after the First World War. Due to the fact that the species was restored from just 12 founders, further expansion has suffered from low genetic variability, rendering the bison vulnerable to various pathogens du...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-017-5663-z

    authors: Pyziel AM,Björck S,Wiklund R,Skarin M,Demiaszkiewicz AW,Höglund J

    更新日期:2018-01-01 00:00:00

  • Labeled probes inserted in the macrophage membrane are transferred to the parasite surface and internalized during cell invasion by Toxoplasma gondii.

    abstract::Tachyzoites of Toxoplasma gondii attach to the macrophage surface and are internalized either by a phagocytic process, which can be inhibited by cytochalasin D, or by an active process, independent of host cell actin. Previous studies have shown that parasite attachment induces the secretion of macromolecules found in...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/pl00008500

    authors: Pacheco-Soares C,De Souza W

    更新日期:2000-01-01 00:00:00

  • Antimalarial drug interactions of compounds isolated from Kigelia africana (Bignoniaceae) and their synergism with artemether, against the multidrug-resistant W2mef Plasmodium falciparum strain.

    abstract::For decades, drug resistance has been the major obstacle in the fight against malaria, and the search for new drugs together with the combination therapy constitutes the major approach in responding to this situation. The present study aims at assessing the in vitro antimalarial activity of four compounds isolated fro...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-011-2519-9

    authors: Zofou D,Tene M,Tane P,Titanji VP

    更新日期:2012-02-01 00:00:00

  • Cloning and differential expression of manganese superoxide dismutase (Mn-SOD) of Trichinella pseudospiralis.

    abstract::The complete coding sequence of manganese superoxide dismutase (Mn-SOD) of Trichinella pseudospiralis (Tp) was obtained and characterized for the first time by degenerative reverse transcription polymerase chain reaction (RT-PCR) and rapid amplification of complementary DNA ends (RACE) reactions. The open reading fram...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-007-0755-9

    authors: Wu WK,Mak CH,Ko RC

    更新日期:2008-01-01 00:00:00

  • Diversity of Taenia and Hydatigera (Cestoda: Taeniidae) in domestic dogs in Kenya.

    abstract::Taenia species of domestic dogs can cause cysticercosis and coenurosis in a wide range of intermediate hosts including humans. Most taeniids of dogs are globally distributed, but some wildlife-transmitted species can be specific for certain regions. Generally, little information exists on the species composition and f...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-020-06793-2

    authors: Mulinge E,Odongo D,Magambo J,Njenga SM,Zeyhle E,Mbae C,Kagendo D,Addy F,Ebi D,Wassermann M,Kern P,Romig T

    更新日期:2020-09-01 00:00:00

  • Stage-dependent effects of analogs of gramicidin A on the growth of Plasmodium falciparum in vitro.

    abstract::Tryptophan-N-formylated gramicidin A, a nonhemolytic derivative of the toxic peptide antibiotic gramicidin A, has previously been shown to induce potassium leakage from Plasmodium falciparum-infected erythrocytes in vitro and to inhibit the growth of the parasite. In the present study the antimalarial activities of tw...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/BF00932413

    authors: Otten-Kuipers MA,Roelofsen B,Op den Kamp JA

    更新日期:1995-01-01 00:00:00

  • Hepatozoon canis in hunting dogs from Southern Italy: distribution and risk factors.

    abstract::Hepatozoon canis is a hemoprotozoan organism that infects domestic and wild carnivores throughout much of Europe. The parasite is mainly transmitted through the ingestion of infected ticks containing mature oocysts. The aims of the present survey were to determine the prevalence of H. canis in hunting dogs living in S...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-020-06820-2

    authors: Pacifico L,Braff J,Buono F,Beall M,Neola B,Buch J,Sgroi G,Piantedosi D,Santoro M,Tyrrell P,Fioretti A,Breitschwerdt EB,Chandrashekar R,Veneziano V

    更新日期:2020-09-01 00:00:00

  • First report of typical Brazilian Toxoplasma gondii genotypes from isolates of free-range chickens (Gallus gallus domesticus) circulating in the state of Paraíba, Northeast Brazil.

    abstract::This study evaluated, for the first time, the genetic diversity of Toxoplasma gondii isolates from free-range chickens from the state of Paraíba, Northeast Brazil. Tissue samples from 33 chickens from properties in five municipalities of Paraíba (Esperança, Olho d'Água, Malta, Monteiro, and Patos) were bioassayed in m...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-017-5531-x

    authors: Feitosa TF,Vilela VLR,de Almeida-Neto JL,de Melo LRB,de Morais DF,Alves BF,Nakashima F,Gennari SM,Athayde ACR,de Jesus Pena HF

    更新日期:2017-08-01 00:00:00

  • Biological nature of Cryptosporidium sp. isolated from a cat.

    abstract::A small type of Cryptosporidium oocysts was isolated from a naturally infected cat and its biological nature was investigated. In cats experimentally inoculated with Cryptosporidium oocysts, long-lasting shedding of the oocysts occurred after a prepatent period of 8-10 days, and a number of peaks of oocyst count appea...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/BF00930864

    authors: Asahi H,Koyama T,Arai H,Funakoshi Y,Yamaura H,Shirasaka R,Okutomi K

    更新日期:1991-01-01 00:00:00

  • Electron microscopic study of Tetratrichomonas didelphidis and its interaction with a prokaryotic cell.

    abstract::Tetratrichomonas didelphidis is a flagellate protozoan found in the intestine of the opossum. The parasite lives in a hostile and stressed environment, where it interacts with microorganisms and can survive under extreme conditions for growth, involving strict anaerobiosis or equilibration with air and abundance or ab...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-003-1015-2

    authors: Tasca T,De Carli GA

    更新日期:2004-01-01 00:00:00