Increased oxygen exposure alters collagen expression and tissue architecture during ligature-induced periodontitis.

abstract：:Accumulating evidence indicates that TNFalpha plays an important role in the pathogenesis of periodontitis, but the effect of TNFalpha on the degradation of the periodontal ligament is not well understood. This study used reverse transcriptase-PCR to investigate the effects of TNFalpha on matrix metalloproteinase (MMP...

journal_title：Journal of periodontal research

authors： Nishikawa M,Yamaguchi Y,Yoshitake K,Saeki Y

更新日期：2002-06-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) are essential in host defense against periodontopathic bacteria such as Porphyromonas gingivalis. The uptake of immunoglobulin G (IgG)-opsonized bacteria via IgG Fc receptors (Fc gamma R) on PMN constitutes a central defense mechanism in periodontium. Fc gamma RIIIb is the most abu...

journal_title：Journal of periodontal research

authors： Kobayashi T,van der Pol WL,van de Winkel JG,Hara K,Sugita N,Westerdaal NA,Yoshie H,Horigome T

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We recently proposed a novel mechanism linking periodontitis and systemic diseases, in which orally administered Porphyromonas gingivalis affects gut microbiota composition and subsequently leads to systemic inflammation. However, the mechanism by which P. gingivalis generates systemic effects...

journal_title：Journal of periodontal research

authors： Sato K,Yokoji M,Yamada M,Nakajima T,Yamazaki K

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Osteonecrosis of the jaw (ONJ) is associated with bisphosphonate (BP) therapy. BPs alter osteoblast production of mediators of osteoclastogenesis, including interleukin (IL)-6, RANKL and osteoprotegerin (OPG), a RANKL antagonist. This can inhibit bone turnover and lead to necrosis. There is lit...

journal_title：Journal of periodontal research

authors： Tipton DA,Seshul BA,Dabbous MKh

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cannabinoid receptor CB2, expressed in osteoblasts and osteoclasts, plays a crucial role in the regulation of bone metabolism. Since periodontal ligament (PDL) cells can differentiate into osteoblasts, this study was undertaken to investigate CB2 expression and the effect of CB2 activation on o...

journal_title：Journal of periodontal research

authors： Qian H,Zhao Y,Peng Y,Han C,Li S,Huo N,Ding Y,Duan Y,Xiong L,Sang H

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES AND BACKGROUND:Endothelin-1 (ET-1) is a 21-amino acid peptide with multifunctional regulation. ET-1 expresses in various cells during inflammation. The present study aimed to examine the ET-1 expression in oral epithelial cells after infection with the periodontal pathogen and to investigate the presence of ...

journal_title：Journal of periodontal research

authors： Yamamoto E,Awano S,Koseki T,Ansai T,Takehara T

更新日期：2003-08-01 00:00:00

abstract：:This study uses cytokeratins (CK) as markers to investigate the phenotype of the junctional epithelium (JE) in partially erupted human teeth. The gingival samples, which were clinically healthy, were carefully dissected from the teeth. Cryostat sections were cut for histological staining, immunofluorescence microscopy...

journal_title：Journal of periodontal research

authors： Feghali-Assaly M,Sawaf MH,Serres G,Forest N,Ouhayoun JP

更新日期：1994-05-01 00:00:00

abstract：:Collagenolysis in periodontitis is thought to be modulated by the expression of three genes, collagenase, tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and -2). We assessed the possible difference in TIMP-1, TIMP-2 and collagenase mRNA levels between gingival samples from patients with periodontitis and tho...

journal_title：Journal of periodontal research

authors： Nomura T,Takahashi T,Hara K

更新日期：1993-09-01 00:00:00

abstract：:Though cementum of the tooth root is critical for periodontal structure and tooth attachment and function, this tissue was not discovered and characterized on human teeth until a full century later than enamel and dentin. Early observations from the seventeenth to the nineteenth centuries by Marcello Malpighi, Antonie...

journal_title：Journal of periodontal research

authors： Foster BL

更新日期：2017-08-01 00:00:00

abstract：:This study compared a rapid, colorimetric DNA probe assay designed to be performed in a dental office within 40 min, with anaerobic culture and indirect immunofluorescence microscopy (IFM) for detection of Bacteroides forsythus and Porphyromonas gingivalis in subgingival plaque samples. The DNA probe assay used the Pe...

journal_title：Journal of periodontal research

authors： Tanner AC,Maiden MF,Zambon JJ,Thoren GS,Kent RL Jr

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:After tooth formation is complete, it is suggested that continuity exists between the epithelial cell rests of Malassez (ERM), reduced enamel epithelium (REE) and subsequently the junctional epithelium. However, the junctional epithelium was reported to differ from REE and ERM. The developmenta...

journal_title：Journal of periodontal research

authors： Li S,Ge S,Yang P

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Occlusal trauma is an important factor that influences the progression of periodontitis, but it is unclear whether occlusal trauma influences periodontal destruction at the onset of periodontitis. We established an experimental periodontitis model with both site-specific loss of attachment and ...

journal_title：Journal of periodontal research

authors： Nakatsu S,Yoshinaga Y,Kuramoto A,Nagano F,Ichimura I,Oshino K,Yoshimura A,Yano Y,Hara Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Autoimmune diseases, including atherosclerosis, diabetes mellitus and rheumatoid arthritis, can be triggered and aggravated by the pathogen-driven antigenic peptide from Porphyromonas gingivalis HSP60. P. gingivalis is the major pathogen of chronic periodontitis, which is a global epidemic prev...

journal_title：Journal of periodontal research

authors： Jeong E,Lee JY,Kim SJ,Choi J

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To study the expression and role in vigabatrin (VGB)-induced gingival enlargement of Ki-67 antigen and p27KIP1, p21WAF1, and p53, proteins that activate or inhibit cell-cycle progression. MATERIALS AND METHODS:Six patients treated with VGB for partial epileptic seizures refractory to classic anticonvulsant t...

journal_title：Journal of periodontal research

authors： Mesa F,Aguilar M,Gonzalez-Moles MA,Guerrero A,Sanchez-Alvarez JC,Del Moral RG,O'Valle F

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:During cyclosporine-induced gingival overgrowth, the homeostatic balance of gingival connective tissue is disrupted leading to fibrosis. Galectins are glycan-binding proteins that can modulate a variety of cellular processes including fibrosis in several organs. Here, we study the role of galec...

journal_title：Journal of periodontal research

authors： Smith PC,Metz C,de la Peña A,Oyanadel C,Avila P,Arancibia R,Vicuña L,Retamal C,Barake F,González A,Soza A

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To describe the periodontal conditions among 30-39- and 50-59-year-old rural Thais from the Province of Songkhla, Southern Thailand. METHODS:A total of 359 dentate persons were given a clinical examination comprising recordings of plaque and calculus in six teeth, and bleeding on probing, attachment level an...

journal_title：Journal of periodontal research

authors： Baelum V,Pisuithanakan S,Teanpaisan R,Pithpornchaiyakul W,Pongpaisal S,Papapanou PN,Dahlén G,Fejerskov O

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Enamel matrix derivative (EMD) is used clinically to promote periodontal tissue regeneration, and it has been reported that EMD can induce the formation of osteoclasts in mouse marrow cultures. In the present study, we investigated the mechanisms of EMD-induced osteoclast formation using a mous...

journal_title：Journal of periodontal research

authors： Itoh N,Kasai H,Ariyoshi W,Harada E,Yokota M,Nishihara T

更新日期：2006-08-01 00:00:00

abstract：:The immunoglobulin class distribution of antibody to human collagen type I has been examined in sera and gingival extracts from patients with adult chronic periodontitis. Tissue extracts were made either by simple washing or ultrasonication. With either method, IgG and IgA antibodies to collagen were present in higher...

journal_title：Journal of periodontal research

authors： Anusaksathien O,Singh G,Matthews N,Dolby AE

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approa...

journal_title：Journal of periodontal research

authors： Jager J,Obst K,Lohan SB,Viktorov J,Staufenbiel S,Renz H,Unbehauen M,Haag R,Hedtrich S,Teutloff C,Meinke MC,Danker K,Dommisch H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Ciclosporin A (CsA)-induced gingival overgrowth is attributed to an exaggerated accumulation of extracellular matrix, which is mainly due to an increased expression of transforming growth factor-β1 (TGF-β1). Herein, the in vitro investigation of effects of overexpression of Smad7, a TGF-β1 sign...

journal_title：Journal of periodontal research

authors： Sobral LM,Aseredo F,Agostini M,Bufalino A,Pereira MC,Graner E,Coletta RD

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Aggregatibacter actinomycetemcomitans is involved in oral and systemic infections, and is associated with, eg aggressive forms of periodontitis and with endocarditis. The cagE gene encodes a ≈39 kDa putative exotoxin expressed by A. actinomycetemcomitans. The level of conservation of cagE, and ...

journal_title：Journal of periodontal research

authors： Johansson A,Claesson R,Höglund Åberg C,Haubek D,Oscarsson J

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Treponema denticola is a key pathogen associated with periodontitis, a chronic inflammatory disease affecting tooth-supporting tissues. In the present study, we investigated the response of human macrophage-like cells to stimulation by peptidoglycan isolated from T. denticola. We also studied t...

journal_title：Journal of periodontal research

authors： Tanabe SI,Bodet C,Grenier D

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Although induction of heme oxygenase-1 by H2O2 has been reported, the protective role of heme oxygenase-1 against the cytotoxic and osteoclastogenic effects of H2O2 have not been elucidated in human periodontal ligament cells. The aim of this work was to investigate the defense mechanism of hem...

journal_title：Journal of periodontal research

authors： Pi SH,Kim SC,Kim HT,Lee HJ,Lee SK,Kim EC

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In periodontitis, matrix metalloproteinases (MMPs) are upregulated in response to locally released inflammatory cytokines, resulting in pathologic processes. Roxithromycin is a 14-membered ring macrolide antibiotic with broad-spectrum antibacterial effects against oral pathogens and immunomodul...

journal_title：Journal of periodontal research

authors： Oyama T,Matsushita K,Sakuta T,Tokuda M,Tatsuyama S,Nagaoka S,Torii M

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The association between psychosocial factors and periodontal disease has been widely reported and might be modified by smoking status. This study investigated the association of periodontal status with psychosocial factors and smoking in a community population. MATERIAL AND METHODS:A structure...

journal_title：Journal of periodontal research

authors： Chiou LJ,Yang YH,Hung HC,Tsai CC,Shieh TY,Wu YM,Wang WC,Hsu TC

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Aggregatibacter actinomycetemcomitans is one of the etiological pathogens implicated in the onset of periodontal disease. This pathogen produces cytolethal distending toxin (CDT) that acts as a genotoxin to induce cell cycle arrest and cellular distension in cultured cell lines. Therefore, CDT is a possible ...

journal_title：Journal of periodontal research

authors： Ohara M,Miyauchi M,Tsuruda K,Takata T,Sugai M

更新日期：2011-06-01 00:00:00

abstract：:We have reported recently that increased expression of membrane alkaline phosphatase (ALP) activity is a phenotypical characteristic of gingival fibroblasts located in chronic inflammatory periodontal lesions. To understand the cellular properties of these cells, we isolated ALP-positive gingival fibroblasts from pati...

journal_title：Journal of periodontal research

authors： Abe T,Hara Y,Abe Y,Aida Y,Maeda K

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Interleukin (IL)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms. The aim of this study was to investigate the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in gingival crevicular fluid (...

journal_title：Journal of periodontal research

authors： Öngöz Dede F,Gökmenoğlu C,Deveci ET,Çelen S,Avci B,Kara C,Çanakçi V

更新日期：2021-01-01 00:00:00

abstract：:Prevotella intermedia has recently been re-defined and a new species, Prevotella nigrescens has been proposed. However, there is little data available on the incidence of these new species in periodontal health or disease. Black-pigmented anaerobes isolated from diseased and healthy subgingival sites were identified b...

journal_title：Journal of periodontal research

authors： Teanpaisan R,Douglas CW,Walsh TF

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several studies have shown an association between periodontitis and cardiovascular disease (CVD). Atherosclerosis is the major cause of CVD, and a key event in the development of atherosclerosis is accumulation of lipoproteins within the arterial wall. Bacteria are the primary etiologic agents ...

journal_title：Journal of periodontal research

authors： Lönn J,Ljunggren S,Klarström-Engström K,Demirel I,Bengtsson T,Karlsson H

更新日期：2018-06-01 00:00:00