Abstract:
:The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review applies an external bioenergetic critique to the central processes of glucose-stimulated insulin secretion, including glycolytic and mitochondrial metabolism, the cytosolic adenine nucleotide pool, and its interaction with plasma membrane ion channels. The control mechanisms responsible for the unique responsiveness of the cell to glucose availability are discussed from bioenergetic and metabolic control standpoints. The concept of coupling factor facilitation of secretion is critiqued, and an attempt is made to unravel the bioenergetic basis of the oscillatory mechanisms controlling secretion. The need to consider the physiological constraints operating in the intact cell is emphasized throughout. The aim is to provide a coherent pathway through an extensive, complex, and sometimes bewildering literature, particularly for those unfamiliar with the field.
journal_name
Physiol Revjournal_title
Physiological reviewsauthors
Nicholls DGdoi
10.1152/physrev.00009.2016subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1385-447issue
4eissn
0031-9333issn
1522-1210pii
96/4/1385journal_volume
96pub_type
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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abstract::Long-chain fatty acids and lipids serve a wide variety of functions in mammalian homeostasis, particularly in the formation and dynamic properties of biological membranes and as fuels for energy production in tissues such as heart and skeletal muscle. On the other hand, long-chain fatty acid metabolites may exert toxi...
journal_title:Physiological reviews
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journal_title:Physiological reviews
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2005-07-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
doi:10.1152/physrev.00002.2002
更新日期:2002-07-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2016-07-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Physiological reviews
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更新日期:2000-01-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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journal_title:Physiological reviews
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journal_title:Physiological reviews
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更新日期:2005-10-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
abstract::Large-conductance Ca2+- and voltage-activated K+ (BK) channels play many physiological roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion. BK channels are tetramers in which the pore-forming α subunit is coded by a single gene (Slowpoke, KCNMA1). In this review, we first highlight t...
journal_title:Physiological reviews
pub_type: 杂志文章,评审
doi:10.1152/physrev.00001.2016
更新日期:2017-01-01 00:00:00
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journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:1984-10-01 00:00:00
abstract::Mitogen-activated protein kinases (MAPK) are serine-threonine protein kinases that are activated by diverse stimuli ranging from cytokines, growth factors, neurotransmitters, hormones, cellular stress, and cell adherence. Mitogen-activated protein kinases are expressed in all eukaryotic cells. The basic assembly of MA...
journal_title:Physiological reviews
pub_type: 杂志文章,评审
doi:10.1152/physrev.1999.79.1.143
更新日期:1999-01-01 00:00:00
abstract::Research over the past century has revealed the impressive capacities of the honeybee, Apis mellifera, in relation to visual perception, flight guidance, navigation, and learning and memory. These observations, coupled with the relative ease with which these creatures can be trained, and the relative simplicity of the...
journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
abstract::Cutaneous wound healing is a complex process involving blood clotting, inflammation, new tissue formation, and finally tissue remodeling. It is well described at the histological level, but the genes that regulate skin repair have only partially been identified. Many experimental and clinical studies have demonstrated...
journal_title:Physiological reviews
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
abstract::The cardiac muscle and the coronary vasculature are in close proximity to each other, and a two-way interaction, called cross-talk, exists. Here we focus on the mechanical aspects of cross-talk including the role of the extracellular matrix. Cardiac muscle affects the coronary vasculature. In diastole, the effect of t...
journal_title:Physiological reviews
pub_type: 杂志文章,评审
doi:10.1152/physrev.00029.2005
更新日期:2006-10-01 00:00:00