Abstract:
:Tyrosine kinase inhibitors are widely used for treatment of certain oncohematological diseases. Several clinical studies have confirmed that specific BCR-ABL tyrosine kinase inhibitors alter the physiological process of bone tissue in a complex and unclearly identified manner. Since these treatments are being given to more and more patients, and the therapy takes decades or lasts even lifelong, it is justifiable to obtain more detailed knowledge of the molecular background of these mechanisms. In this article the authors summarize preliminary research results and human clinical observations on imatinib and nilotinib which are related to bone metabolism, and present the results of their own experiments in in vitro osteoblast cultures. Based on the presented results, the effects of imatinib and nilotinib on bone cells depend on the concentration of imatinib and nilotinib, the maturation stage of the cells and the distribution ratio of receptor tyrosine kinase signaling pathways. In this study the authors firstly prepared a stop-gap, comprehensive review in the Hungarian literature, regarding the effects of tyrosine kinase inhibitors on bone metabolism. In addition they firstly performed whole transcriptome analysis on osteoblasts in order to obtain a better understanding of the cellular molecular mechanisms. Orv. Hetil., 2016, 157(36), 1429-1437.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Kirschner G,Balla B,Kósa J,Horváth P,Kövesdi A,Lakatos G,Takács I,Nagy Z,Tóbiás B,Árvai K,Lakatos Pdoi
10.1556/650.2016.30525subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1429-37issue
36eissn
0030-6002issn
1788-6120journal_volume
157pub_type
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