Toxicity of IL-2 and Corynebacterium parvum following direct intracranial injection.

Abstract:

:The toxicity of IL-2 and/or C. Parvum when injected directly into the mouse brain was examined by survival and histopathology using different numbers of injections, different doses of IL-2, different solvents for the IL-2, and different doses and routes of administration of C. Parvum. Two injections was found significantly to increase mortality (19%) over a single injection (4%). Mortality from two injections of 30,000 U (23%) or 60,000 U (20%) was higher than from two injections of 15,000 U (12%). The mortality from two injections with normal saline as solvent was much higher (29%) than from two injections with sterile water (19%) or D5W (9%). Two injections of IL-2 given simultaneously with C. Parvum showed a much higher mortality (26%) than other doses and routes of C. Parvum administration. Mice dying acutely (6-24 days) of toxicity showed an extensive mononuclear infiltrate at the site of injection. The brains of surviving mice (sacrificed at 30 days) showed a mild residual mononuclear cell infiltrate with the exception of mice which had received IL-2 and C. Parvum simultaneously. Brains from this latter group had an extensive residual mononuclear cell infiltrate.

journal_name

J Neurooncol

authors

Sutton RC 3rd,Kennedy J,Duncan J,Conley FK

doi

10.1007/BF00172920

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

261-7

issue

3

eissn

0167-594X

issn

1573-7373

journal_volume

7

pub_type

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