Abstract:
:The toxicity of IL-2 and/or C. Parvum when injected directly into the mouse brain was examined by survival and histopathology using different numbers of injections, different doses of IL-2, different solvents for the IL-2, and different doses and routes of administration of C. Parvum. Two injections was found significantly to increase mortality (19%) over a single injection (4%). Mortality from two injections of 30,000 U (23%) or 60,000 U (20%) was higher than from two injections of 15,000 U (12%). The mortality from two injections with normal saline as solvent was much higher (29%) than from two injections with sterile water (19%) or D5W (9%). Two injections of IL-2 given simultaneously with C. Parvum showed a much higher mortality (26%) than other doses and routes of C. Parvum administration. Mice dying acutely (6-24 days) of toxicity showed an extensive mononuclear infiltrate at the site of injection. The brains of surviving mice (sacrificed at 30 days) showed a mild residual mononuclear cell infiltrate with the exception of mice which had received IL-2 and C. Parvum simultaneously. Brains from this latter group had an extensive residual mononuclear cell infiltrate.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Sutton RC 3rd,Kennedy J,Duncan J,Conley FKdoi
10.1007/BF00172920subject
Has Abstractpub_date
1989-09-01 00:00:00pages
261-7issue
3eissn
0167-594Xissn
1573-7373journal_volume
7pub_type
杂志文章abstract::An extremely rare case of primary intracranial myxoma mimicking an intraaxial parenchymal tumour is reported. A 25 year old male presented with complaints of headache and right sided hemiparesis. A gross total resection of the tumour was achieved. Histology confirmed that the tumour was a myxoma. Investigations did no...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-008-9555-z
更新日期:2008-06-01 00:00:00
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journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-018-2959-5
更新日期:2018-11-01 00:00:00
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journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
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更新日期:1998-06-01 00:00:00
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journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-011-0630-5
更新日期:2011-12-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-012-0939-8
更新日期:2012-10-01 00:00:00
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-008-9787-y
更新日期:2009-07-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
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更新日期:2007-08-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:2018-05-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:2009-12-01 00:00:00
abstract::Once considered a "no man's land" especially when invaded by a diffuse low grade glioma (DLGG), the insula remains to this day a surgical challenge. Surgery for insular DLGG involves consideration of its hidden location under the potentially eloquent operculae, the proximity to vascular tree and high density of functi...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
doi:10.1007/s11060-016-2120-2
更新日期:2016-11-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-014-1424-3
更新日期:2014-06-01 00:00:00
abstract::Membrane-type MMPs (MT-MMPs) constitute a growing subclass of recently identified matrix metalloproteinases (MMPs). In addition to the highly conserved MMP functional domains, the MT-MMPs have additional insertion sequences (IS) that confer unique functional roles. While most of the MMPs are secreted, the MT-MMPs are ...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
doi:10.1023/a:1012213604731
更新日期:2001-06-01 00:00:00
abstract::Intraspinal location of central PNET (cPNET) is very rare. We present a case, critically review all publications of primary intraspinal cPNET occurrence and discuss tendencies in clinical presentation. In several previous attempts to summarise, authors often confused cPNET with peripheral PNET (pPNET). cPNET and pPNET...
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pub_type: 杂志文章,评审
doi:10.1007/s11060-005-9006-z
更新日期:2006-03-01 00:00:00
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journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11060-015-1845-7
更新日期:2015-09-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
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更新日期:1999-05-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-009-0090-3
更新日期:2010-07-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 历史文章,杂志文章,评审
doi:10.1023/a:1012949214960
更新日期:2001-09-01 00:00:00
abstract::In this retrospective, IRB-exempt study, we analyzed data from 68 patients diagnosed with glioblastoma (GBM) in two institutions and investigated the relationship between tumor shape, quantified using algorithmic analysis of magnetic resonance images, and survival. Each patient's Fluid Attenuated Inversion Recovery (F...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章,多中心研究
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更新日期:2017-03-01 00:00:00
abstract::Several molecular markers have been proposed as predictors of outcome in patients with high grade gliomas. We report a retrospective multicenter study of 97 consecutive adult patients with anaplastic astrocytoma (AA) treated with radiation therapy (RT) plus concomitant and adjuvant temozolomide (TMZ) between October 2...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章,多中心研究
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更新日期:2014-06-01 00:00:00