Antioxidative mechanism of Lycium barbarum polysaccharides promotes repair and regeneration following cavernous nerve injury.

abstract：:The present study analyzed changes in Wnt3a expression during differentiation of adipose-derived stem cells into cholinergic neurons. Immunocytochemistry and immunofluorescence revealed significantly increased nestin, neuron-specific enolase, microtubule-associated protein 2, and choline acetyltransferase expression i...

journal_title：Neural regeneration research

authors： Liu B,Deng C,Zhang Y,Zhang J

更新日期：2012-07-05 00:00:00

abstract：:Membrane depolarization induces the release of the serine proteinase tissue-type plasminogen activator (tPA) from the presynaptic terminal of cerebral cortical neurons. Once in the synaptic cleft this tPA promotes the exocytosis and subsequent endocytic retrieval of glutamate-containing synaptic vesicles, and regulate...

journal_title：Neural regeneration research

authors： Jeanneret V,Yepes M

更新日期：2017-03-01 00:00:00

abstract：:Previous research revealed the positive activity of matrix metalloproteinase 7 (MMP7) on migration and myelin regeneration of Schwann cells (SCs). However, understanding of the molecular changes and biological activities induced by increased amounts of MMP7 in SCs remains limited. To better understand the underlying m...

journal_title：Neural regeneration research

authors： Lu PJ,Wang G,Cai XD,Zhang P,Wang HK

更新日期：2020-11-01 00:00:00

abstract：:In contrast to astrocytes in mammals, fish astrocytes promote axon regeneration after brain injury and actively participate in the regeneration process. Neurolin, a regeneration-associated, Zn8-labeled protein, is involved in the repair of damaged optic nerve in goldfish. At 1 week after unilateral eye injury, the exp...

journal_title：Neural regeneration research

authors： Pushchina EV,Varaksin AA

更新日期：2019-01-01 00:00:00

abstract：:Abnormal TAR DNA-binding protein 43 (TDP-43) inclusion bodies can be detected in the degenerative neurons of amyotrophic lateral sclerosis. In this study, we induced chronic oxidative stress injury by applying malonate to cultured mouse cortical motor neurons. In the later stages of the malonate insult, TDP-43 express...

journal_title：Neural regeneration research

authors： Zheng M,Shi Y,Fan D

更新日期：2013-12-15 00:00:00

abstract：:Fractional anisotropy values in diffusion tensor imaging can quantitatively reflect the consistency of nerve fibers after brain damage, where higher values generally indicate less damage to nerve fibers. Therefore, we hypothesized that diffusion tensor imaging could be used to evaluate the effect of mild hypothermia o...

journal_title：Neural regeneration research

authors： Jing G,Yao X,Li Y,Xie Y,Li WX,Liu K,Jing Y,Li B,Lv Y,Ma B

更新日期：2014-01-15 00:00:00

abstract：:Rho-associated kinase (ROCK) is a key regulatory protein involved in inflammatory secretion in microglia in the central nervous system. Our previous studies showed that ROCK inhibition enhances phagocytic activity in microglia through the extracellular signal-regulated kinase (ERK) signaling pathway, but its effect on...

journal_title：Neural regeneration research

authors： Fu PC,Tang RH,Yu ZY,Xie MJ,Wang W,Luo X

更新日期：2018-04-01 00:00:00

abstract：:Tau hyperphosphorylation is a main cause of neuronal loss in Alzheimer's disease, which can be caused by many factors, including oxidative stress. The multifunctional protein p62, which exists in neurofibrillary tangles and causes aggregation of hyperphosphorylated tau, not only serves as a receptor in selective autop...

journal_title：Neural regeneration research

authors： Zheng X,Wang W,Liu R,Huang H,Zhang R,Sun L

更新日期：2012-06-15 00:00:00

abstract：:Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction, but the mechanisms underlying this protection remain unclear. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, we induced a photochemical mode...

journal_title：Neural regeneration research

authors： Li S,Zhang Y,Shao G,Yang M,Niu J,Lv G,Ji X

更新日期：2013-11-05 00:00:00

abstract：:The present study recruited 193 patients with ischemic cerebrovascular disease from Inpatient and Outpatient Departments at the Affiliated Hospital of Qingdao University Medical College, China from August 2008 to May 2010, as well as 120 healthy volunteers from the Medical Examination Center at the Affiliated Hospital...

journal_title：Neural regeneration research

authors： Wang H,Song Y,Zhang C,Zhan J,Zhang R,Wang H

更新日期：2012-03-05 00:00:00

abstract：:Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone II...

journal_title：Neural regeneration research

authors： Yang YD,Yu X,Wang XM,Mu XH,He F

更新日期：2017-02-01 00:00:00

abstract：:Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after periphe...

journal_title：Neural regeneration research

authors： Pan B,Shi ZJ,Yan JY,Li JH,Feng SQ

更新日期：2017-12-01 00:00:00

abstract：:The optic nerve is a viscoelastic solid-like biomaterial. Its normal stress relaxation and creep properties enable the nerve to resist constant strain and protect it from injury. We hypothesized that stress relaxation and creep properties of the optic nerve change after injury. More-over, human brain-derived neurotrop...

journal_title：Neural regeneration research

authors： Lv XM,Liu Y,Wu F,Yuan Y,Luo M

更新日期：2016-04-01 00:00:00

abstract：:As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in th...

journal_title：Neural regeneration research

authors： Agatonovic-Kustrin S,Kustrin E,Morton DW

更新日期：2019-03-01 00:00:00

abstract：:Following spinal cord ischemia/reperfusion injury, an endogenous damage system is immediately activated and participates in a cascade reaction. It is difficult to interpret dynamic changes in these pathways, but the examination of the transcriptome may provide some information. The transcriptome reflects highly dynami...

journal_title：Neural regeneration research

authors： Qi ZP,Xia P,Hou TT,Li DY,Zheng CJ,Yang XY

更新日期：2016-03-01 00:00:00

abstract：:Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been unsuccessful in providing an effective treatment to address neur...

journal_title：Neural regeneration research

authors： Morrison BE

更新日期：2016-06-01 00:00:00

abstract：:The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...

journal_title：Neural regeneration research

authors： Yuan LY,He ZY,Li L,Wang YZ

更新日期：2019-03-01 00:00:00

abstract：:Type 2 diabetes-associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)-is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin rece...

journal_title：Neural regeneration research

authors： Tanokashira D,Fukuokaya W,Taguchi A

更新日期：2019-08-01 00:00:00

abstract：:Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbil...

journal_title：Neural regeneration research

authors： Yao L,He C,Zhao Y,Wang J,Tang M,Li J,Wu Y,Ao L,Hu X

更新日期：2013-02-15 00:00:00

abstract：:Alzheimer's disease is characterized by the extracellular accumulation of the amyloid β in the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles. Most of the Alzheimer's drugs targeting amyloid β have been failed in clinical trials...

journal_title：Neural regeneration research

authors： Mamun AA,Uddin MS,Mathew B,Ashraf GM

更新日期：2020-08-01 00:00:00

abstract：:This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence ...

journal_title：Neural regeneration research

authors： Chen M,Du ZY,Zheng X,Li DL,Zhou RP,Zhang K

更新日期：2018-04-01 00:00:00

abstract：:Olive leaves have an antioxidant capacity, and olive leaf extract can protect the blood, spleen and hippocampus in lead-poisoned mice. However, little is known about the effects of olive leaf extract on lead-induced brain injury. This study was designed to determine whether olive leaf extract can inhibit lead-induced ...

journal_title：Neural regeneration research

authors： Wang Y,Wang S,Cui W,He J,Wang Z,Yang X

更新日期：2013-08-05 00:00:00

abstract：:In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive...

journal_title：Neural regeneration research

authors： Dong S,Tong X,Li J,Huang C,Hu C,Jiao H,Gu Y

更新日期：2013-12-05 00:00:00

abstract：:Emodin, an extract of dried rhizomes and the root of the Rhizoma Polygoni Cuspidati, can protect neurons from hypoxic-ischemic brain damage. This study aimed to verify the underlying mechanism. After PC12 cells had differentiated into neuron-like cells under the induction of mouse nerve growth factor, cells were subje...

journal_title：Neural regeneration research

authors： Guo H,Shen X,Xu Y,Yuan J,Zhao D,Hu W

更新日期：2013-05-25 00:00:00

abstract：:Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rode...

journal_title：Neural regeneration research

authors： Jure I,Labombarda F

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES:PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by co...

journal_title：Neural regeneration research

authors： Fan X,Wang JZ,Lin XM,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:[This corrects the article on p. 770 in vol. 12, PMID: 28616034.]. ...

journal_title：Neural regeneration research

authors： Lu J,Guo Y,Guo CQ,Shi XM,Du NY,Zhao RL,Du WP,Liang JR,Zhu SP,Chen H

更新日期：2017-06-01 00:00:00

abstract：:Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the act...

journal_title：Neural regeneration research

authors： Yong CQY,Tang BL

更新日期：2019-04-01 00:00:00

abstract：:Myasthenia gravis is a rare and invalidating disease affecting the neuromuscular junction of voluntary muscles. The classical form of this autoimmune disease is characterized by the presence of antibodies against the most abundant protein in the neuromuscular junction, the nicotinic acetylcholine receptor. Other varia...

journal_title：Neural regeneration research

authors： Barrantes FJ

更新日期：2021-02-01 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease, often resulting in long-term neurodevelopmental disorders among surviving children. However, whether these neurodevelopmental issues can be passed to offspring remains unclear. The right common carotid artery of 7-day-old parental-generation r...

journal_title：Neural regeneration research

authors： Xue LL,Wang F,Niu RZ,Tan YX,Liu J,Jin Y,Ma Z,Zhang ZB,Jiang Y,Chen L,Xia QJ,Chen JJ,Wang TH,Xiong LL

更新日期：2020-09-01 00:00:00