Oocyte and somatic tyrosine tRNA genes in Xenopus laevis.

abstract：:A prominent feature of cell differentiation is the initiation and maintenance of an irreversible cell cycle arrest with the complex involvement of the retinoblastoma (RB) family (RB, p130, p107). We have isolated the HBP1 transcriptional repressor as a potential target of the RB family in differentiated cells. By homo...

journal_title：Genes & development

authors： Tevosian SG,Shih HH,Mendelson KG,Sheppard KA,Paulson KE,Yee AS

更新日期：1997-02-01 00:00:00

abstract：:Riboswitches are RNA elements that undergo a shift in structure in response to binding of a regulatory molecule. These elements are encoded within the transcript they regulate, and act in cis to control expression of the coding sequence(s) within that transcript; their function is therefore distinct from that of small...

journal_title：Genes & development

authors： Henkin TM

更新日期：2008-12-15 00:00:00

abstract：:Centromeres are maintained epigenetically by the presence of CENP-A, an evolutionarily conserved histone H3 variant, which directs kinetochore assembly and hence centromere function. To identify factors that promote assembly of CENP-A chromatin, we affinity-selected solubilized fission yeast CENP-ACnp1 chromatin. All ...

journal_title：Genes & development

authors： Singh PP,Shukla M,White SA,Lafos M,Tong P,Auchynnikava T,Spanos C,Rappsilber J,Pidoux AL,Allshire RC

更新日期：2020-02-01 00:00:00

abstract：:Keratinocyte growth factor (KGF), also known as fibroblast growth factor 7 (FGF7), is synthesized by skin fibroblasts. However, its mitogenic activity is on skin keratinocytes, where it is the most potent growth factor identified thus far. To explore KGF's function in vivo, we used embryonic stem cell technology to ge...

journal_title：Genes & development

authors： Guo L,Degenstein L,Fuchs E

更新日期：1996-01-15 00:00:00

abstract：:Transcription by RNA polymerase II (RNAPII) is a dynamic process with frequent variations in the elongation rate. However, the physiological relevance of variations in RNAPII elongation kinetics has remained unclear. Here we show in yeast that a RNAPII mutant that reduces the transcription elongation rate causes wides...

journal_title：Genes & development

authors： Yague-Sanz C,Vanrobaeys Y,Fernandez R,Duval M,Larochelle M,Beaudoin J,Berro J,Labbé S,Jacques PÉ,Bachand F

更新日期：2020-07-01 00:00:00

abstract：:Class Ia phosphatidylinositol 3 kinase (PI3K) is required for oncogenic receptor-mediated transformation; however, the individual roles of the two commonly expressed class Ia PI3K isoforms in oncogenic receptor signaling have not been elucidated in vivo. Here, we show that genetic ablation of p110α blocks tumor format...

journal_title：Genes & development

authors： Utermark T,Rao T,Cheng H,Wang Q,Lee SH,Wang ZC,Iglehart JD,Roberts TM,Muller WJ,Zhao JJ

更新日期：2012-07-15 00:00:00

abstract：:The discovery of transcription factors (TFs) controlling pathways in health and disease is of paramount interest. We designed a widely applicable method, dubbed barcorded synthetic tandem repeat promoter screening (BC-STAR-PROM), to identify signal-activated TFs without any a priori knowledge about their properties. T...

journal_title：Genes & development

authors： Gosselin P,Rando G,Fleury-Olela F,Schibler U

更新日期：2016-08-15 00:00:00

abstract：:Dosage compensation in Drosophila occurs by a twofold increase in transcription per copy of X-linked genes in males (XY) compared with females (XX). msl-1 is one of four genes that are essential for dosage compensation in males, and MSL-1 protein is associated specifically with the male X chromosome. To explore the ba...

journal_title：Genes & development

authors： Palmer MJ,Richman R,Richter L,Kuroda MI

更新日期：1994-03-15 00:00:00

abstract：:During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB retention and pericyte recruitment in vivo, suggesting a potential role for heparan sulfate (HS) in PDGF-BB function during...

journal_title：Genes & development

authors： Abramsson A,Kurup S,Busse M,Yamada S,Lindblom P,Schallmeiner E,Stenzel D,Sauvaget D,Ledin J,Ringvall M,Landegren U,Kjellén L,Bondjers G,Li JP,Lindahl U,Spillmann D,Betsholtz C,Gerhardt H

更新日期：2007-02-01 00:00:00

abstract：:Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 region and HIF-1alpha. A new p300-CH1 interacting protein, p35srj, has been identified and cloned. p35srj is an alternatively spliced isoform of ...

journal_title：Genes & development

authors： Bhattacharya S,Michels CL,Leung MK,Arany ZP,Kung AL,Livingston DM

更新日期：1999-01-01 00:00:00

abstract：:Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient inhibition of the pre-mRNA 3' processing machinery. Here we provide evidence that thi...

journal_title：Genes & development

authors： Kleiman FE,Wu-Baer F,Fonseca D,Kaneko S,Baer R,Manley JL

更新日期：2005-05-15 00:00:00

abstract：:Cell growth and differentiation are usually antagonistic. Proteins of the basic helix-loop-helix (bHLH) family bind DNA and play important roles in the differentiation of specific cell types. Id proteins heterodimerize with bHLH transcription factors, blocking their activation of lineage-specific gene expression and t...

journal_title：Genes & development

authors： Iavarone A,Garg P,Lasorella A,Hsu J,Israel MA

更新日期：1994-06-01 00:00:00

abstract：:We describe here a new murine homeo box gene, denoted Hlx, which is expressed within specific hematopoietic lineages. The cDNA sequence indicates that Hlx differs markedly from known vertebrate homeo box genes, and linkage analysis of an interspecific murine backcross showed that it resides at a novel homeo box locus ...

journal_title：Genes & development

authors： Allen JD,Lints T,Jenkins NA,Copeland NG,Strasser A,Harvey RP,Adams JM

更新日期：1991-04-01 00:00:00

abstract：:Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differenti...

journal_title：Genes & development

authors： Urbach A,Yermalovich A,Zhang J,Spina CS,Zhu H,Perez-Atayde AR,Shukrun R,Charlton J,Sebire N,Mifsud W,Dekel B,Pritchard-Jones K,Daley GQ

更新日期：2014-05-01 00:00:00

abstract：:The MMTVD/myc transgenic mice spontaneously develop oligoclonal CD4+CD8+ T-cell tumors. We used provirus insertional mutagenesis in these mice to identify putative collaborators of c-myc. We found that Notch1 was mutated in a high proportion (52%) of these tumors. Proviruses were inserted upstream of the exon coding f...

journal_title：Genes & development

authors： Girard L,Hanna Z,Beaulieu N,Hoemann CD,Simard C,Kozak CA,Jolicoeur P

更新日期：1996-08-01 00:00:00

abstract：:The HOP2 and MND1 genes are indispensable for meiotic recombination. The products of these genes associate to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of Rad51 and Dmc1. Here we conduct molecular studies to delineate the action mechanism of the Hop2-Mnd1 complex. We pr...

journal_title：Genes & development

authors： Chi P,San Filippo J,Sehorn MG,Petukhova GV,Sung P

更新日期：2007-07-15 00:00:00

abstract：:The p53 tumor suppressor activates either cell cycle arrest or apoptosis in response to cellular stress. Mouse embryo fibroblasts (MEFs) provide a powerful primary cell system to study both p53-dependent pathways. Specifically, in response to DNA damage, MEFs undergo p53-dependent G(1) arrest, whereas MEFs expressing ...

journal_title：Genes & development

authors： Attardi LD,Reczek EE,Cosmas C,Demicco EG,McCurrach ME,Lowe SW,Jacks T

更新日期：2000-03-15 00:00:00

abstract：:Medulloblastoma (MB) is the most common pediatric CNS malignancy. We identify EAG2 as an overexpressed potassium channel in MBs across different molecular and histological subgroups. EAG2 knockdown not only impairs MB cell growth in vitro, but also reduces tumor burden in vivo and enhances survival in xenograft studie...

journal_title：Genes & development

authors： Huang X,Dubuc AM,Hashizume R,Berg J,He Y,Wang J,Chiang C,Cooper MK,Northcott PA,Taylor MD,Barnes MJ,Tihan T,Chen J,Hackett CS,Weiss WA,James CD,Rowitch DH,Shuman MA,Jan YN,Jan LY

更新日期：2012-08-15 00:00:00

abstract：:Human ELAV proteins are implicated in cell growth and differentiation via regulation of mRNA expression in the cytoplasm. In human embryonic teratocarcinoma (hNT2) cells transfected with the human neuronal ELAV-like protein, Hel-N1, neurites formed, yet cells were not terminally differentiated. Cells in which neurite ...

journal_title：Genes & development

authors： Antic D,Lu N,Keene JD

更新日期：1999-02-15 00:00:00

abstract：:Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins...

journal_title：Genes & development

authors： Ingham PW

更新日期：2012-11-15 00:00:00

abstract：:RUNX1/AML1 is required for the development of definitive hematopoiesis, and its activity is altered by mutations, deletions, and chromosome translocations in human acute leukemia. RUNX1 function can be regulated by post-translational modifications and protein-protein interactions. We show that RUNX1 is arginine-methyl...

journal_title：Genes & development

authors： Zhao X,Jankovic V,Gural A,Huang G,Pardanani A,Menendez S,Zhang J,Dunne R,Xiao A,Erdjument-Bromage H,Allis CD,Tempst P,Nimer SD

更新日期：2008-03-01 00:00:00

abstract：:The Ultrabithorax (Ubx) gene of Drosophila melanogaster encodes a family of UBX proteins that are thought to specify the developmental fates of segments in the posterior thorax and anterior abdomen by controlling the expression of a set of target genes. UBX proteins bind DNA in vitro, and they activate or repress diff...

journal_title：Genes & development

authors： Johnson FB,Krasnow MA

更新日期：1990-06-01 00:00:00

abstract：:In Drosophila the function of the epidermal growth factor (EGF) receptor is modulated zygotically by three EGF-like proteins: Spitz (Spi), which is a potent activator; Vein (Vn), which is a moderate activator; and Argos (Aos), which is an inhibitor. Chimeric molecules were constructed in which the EGF domain of Vn was...

journal_title：Genes & development

authors： Schnepp B,Donaldson T,Grumbling G,Ostrowski S,Schweitzer R,Shilo BZ,Simcox A

更新日期：1998-04-01 00:00:00

abstract：:In this issue of Genes & Development, Dowen and colleagues (pp. 1515-1528) elegantly unify two previously unconnected aspects of physiology. The investigators provide significant genetic evidence to support a critical link between developmental timing decisions and the regulation of lipid mobilization at the transitio...

journal_title：Genes & development

authors： Weaver BP,Sewell AK,Han M

更新日期：2016-07-01 00:00:00

abstract：:The lysosomal storage disorder galactosialidosis results from a primary deficiency of the protective protein/cathepsin A (PPCA), which in turn affects the activities of beta-galactosidase and neuraminidase. Mice homozygous for a null mutation at the PPCA locus present with signs of the disease shortly after birth and ...

journal_title：Genes & development

authors： Zhou XY,Morreau H,Rottier R,Davis D,Bonten E,Gillemans N,Wenger D,Grosveld FG,Doherty P,Suzuki K,Grosveld GC,d'Azzo A

更新日期：1995-11-01 00:00:00

abstract：:Activated transcription by RNA polymerase II (Pol II) requires coactivators, one of which is the SRB/mediator. Whereas Srb4, an essential subunit of the SRB/mediator, is broadly required for Pol II transcription in yeast, we have shown that it is dispensable for the transcriptional activation of some genes. Here, we s...

journal_title：Genes & development

authors： Lee DK,Kim S,Lis JT

更新日期：1999-11-15 00:00:00

abstract：:Proliferation of pancreatic islet beta cells is an important mechanism for self-renewal and for adaptive islet expansion. Increased expression of the Ink4a/Arf locus, which encodes the cyclin-dependent kinase inhibitor p16(INK4a) and tumor suppressor p19(Arf), limits beta-cell regeneration in aging mice, but the basis...

journal_title：Genes & development

authors： Chen H,Gu X,Su IH,Bottino R,Contreras JL,Tarakhovsky A,Kim SK

更新日期：2009-04-15 00:00:00

abstract：:Alternative polyadenylation (APA) is widespread in neuronal development and activity-mediated neural plasticity. However, the underlying molecular mechanisms are largely unknown. We used systematic genetic studies and genome-wide surveys of the transcriptional landscape to identify a context-dependent regulatory pathw...

journal_title：Genes & development

authors： Chen F,Zhou Y,Qi YB,Khivansara V,Li H,Chun SY,Kim JK,Fu XD,Jin Y

更新日期：2015-11-15 00:00:00

abstract：:Mammalian cells mostly rely on extracellular molecules to transfer signals to other cells. However, in stress conditions, more robust mechanisms might be necessary to facilitate cell-cell communications. Cellular senescence, a stress response associated with permanent exit from the cell cycle and the development of an...

journal_title：Genes & development

authors： Biran A,Perelmutter M,Gal H,Burton DG,Ovadya Y,Vadai E,Geiger T,Krizhanovsky V

更新日期：2015-04-15 00:00:00

abstract：:In Saccharomyces cerevisiae, absence of the checkpoint kinase Mec1 (ATR) is viable upon mutations that increase the activity of the ribonucleotide reductase (RNR) complex. Whether this pathway is conserved in mammals remains unknown. Here we show that cells from mice carrying extra alleles of the RNR regulatory subuni...

journal_title：Genes & development

authors： Lopez-Contreras AJ,Specks J,Barlow JH,Ambrogio C,Desler C,Vikingsson S,Rodrigo-Perez S,Green H,Rasmussen LJ,Murga M,Nussenzweig A,Fernandez-Capetillo O

更新日期：2015-04-01 00:00:00