Abstract:
OBJECTIVES:To evaluate whether preterm thrombocytopenia within 24 hours of birth is associated with delayed closure of patent ductus arteriosus (PDA) and higher proportion of hemodynamically significant PDA (Hs-PDA). METHODS:Neonates (gestation 260/7-336/7 weeks, age <24 hours) with known platelet count and PDA on echocardiogram were prospectively enrolled. Asphyxia, congenital infections, structural heart disease, major malformations and clinical sepsis were exclusions. Subjects were recruited in groups A (n = 35), B (n = 18), and C (n = 17) [platelet counts >150,000, 100,000-150,000 and <100,000 per μL respectively] and underwent daily echocardiography until first closure of PDA, death, or day 10. RESULTS:The primary outcome was time to first closure of PDA. Secondary outcomes included proportion with PDA at 72 hours and 7 days, Hs-PDA, and PDA needing treatment. In groups A, B, and C, median (first-third quartile) platelet counts (×100000/μL) were 2.28 (1.94-3.19), 1.25 (1.14-1.37), and 0.68 (0.54-0.83) and time to PDA closure was 2 (2-2), 2 (2-3), and 10 (6-10) days, respectively (log-rank test, P < .001). On Cox proportional hazard regression, platelet count (in multiples of 10 000 /μL) independently predicted time to PDA closure (adjusted hazard ratio: 1.045; 95% confidence interval: 1.019-1.07). On day 7, 47.1% neonates in group C had PDA and none in groups A and B (P < .001). CONCLUSIONS:Thrombocytopenia within 24 hours of birth independently predicts delayed PDA closure and PDA on day 7 in preterm neonates.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Kulkarni VV,Dutta S,Sundaram V,Saini SSdoi
10.1542/peds.2016-1627subject
Has Abstractpub_date
2016-10-01 00:00:00issue
4eissn
0031-4005issn
1098-4275pii
peds.2016-1627journal_volume
138pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVES:The aims of this study were to determine parent and provider knowledge and awareness of newborn screening; to gather opinions from parents, providers, and newborn screening professionals about the content and timing of newborn screening education; and to use consensus data to formulate recommendations and to...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2633M
更新日期:2006-05-01 00:00:00
abstract::Two types of waterbeds were developed to impart compensatory vestibular-proprioceptive stimulation to premature infants. Twenty-one infants ranging in gestational age from 27 to 34 weeks and birthweights from 1,050 to 1,920 gm were included in this pilot study. Assignment to experimental and control groups was made by...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVE:Late-onset sepsis (occurring after 3 days of age) is an important problem in very low birth weight (VLBW) infants. To determine the current incidence of late-onset sepsis, risk factors for disease, and the impact of late-onset sepsis on subsequent hospital course, we evaluated a cohort of 6956 VLBW (401-1500 ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.110.2.285
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:In this study we sought to evaluate the efficacy of motivational interviewing (MI) compared with structured brief advice (SBA) for adolescent smoking behavior change. METHODS:Participants (N=355) were randomly assigned to 5 sessions of either MI or SBA. The primary outcomes were attempts to reduce and to qui...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2010-2174
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To characterize neuroimaging, physical, neurobehavioral, and developmental findings in children with inflicted and noninflicted traumatic brain injury (TBI) and to identify characteristic features of inflicted TBI. METHODS AND PATIENTS:Forty children, 0 to 6 years of age, hospitalized for TBI who had no docu...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.2.300
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the association of negative stressful life events experienced over 12 months and the risk of moderate to severe immune suppression among children and youth infected with human immunodeficiency virus type 1 (HIV-1). METHODS:Longitudinal study of 618 HIV-1-infected children, baseline ages 1 to 20 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.3.540
更新日期:2000-09-01 00:00:00
abstract::Diabetic ketoacidosis (DKA) is a life-threatening condition and a major cause of morbidity and mortality in children with type 1 diabetes mellitus. The deficiency of insulin leads to metabolic decompensation, causing hyperglycemia and ketosis that resolves with the administration of insulin and fluids. However, an ind...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-0741
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City. METHODS:Forty-eight-hour personal air and/or spot urine samples were collected during the third tri...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0325
更新日期:2009-12-01 00:00:00
abstract::Splenic function in sickle hemoglobinopathy syndromes was assessed to determine the developmental pattern of splenic dysfunction. Nonvisualization of the spleen using technetium-99 metastable (99mTc) spleen scans correlated strongly with pocked (vesiculated) RBCs greater than or equal to 3.5%. Cross-sectional analysis...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurobehavioral conditions of childhood and adolescence. Despite availability of effective treatment options, initiation of treatment is variable and persistence with therapeutic regimens is poor. OBJECTIVE:We sought to better underst...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2569
更新日期:2009-08-01 00:00:00
abstract::Children who become overweight by age 2 years have significantly greater risks of long-term health problems, and children in low-income communities, where rates of low adult literacy are highest, are at increased risk of developing obesity. The objective of the Greenlight Intervention Study is to assess the effectiven...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2013-3867
更新日期:2014-06-01 00:00:00
abstract::Servocontrol of skin temperature for the critically ill premature neonate nursed on a radiant warmer bed has been assumed to be analogous to skin temperature control for infants nursed in convection-warmed incubators. There are significant differences between these two warming techniques, and no definitive data exist ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-01-01 00:00:00
abstract::Cat scratch disease is a benign, self-limited illness characterized by regional lymphadenopathy that usually occurs in association with a history of contact with a cat. Cases of cat scratch disease with skin manifestations that included erythema nodosum; erythema multiforme; erythema marginatum; and non-specific macul...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:CONTEXT:In the last few years, there has been an increasing amount of research showing the concurrent and long-term consequences of bullying and being bullied by peers. OBJECTIVE. We performed a meta-analysis to quantify the association between involvement in bullying and psychosomatic complaints in the school-aged pop...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2008-1215
更新日期:2009-03-01 00:00:00
abstract::A physician faces many challenges in making a definitive diagnosis of asthma in young children. Although there are clinical and historical features consistent with asthma, identical features are present in many other diseases. Furthermore, there is no specific test for asthma. Other diseases must always be ruled out b...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To determine hepatitis B virus (HBV) carrier and infection rates and HBV epidemiology in Honolulu students. DESIGN:Cross-sectional survey. SETTING:Honolulu public elementary, intermediate, and high schools. PATIENTS:A volunteer sample of 4936 students from 43 Honolulu schools. MAIN OUTCOME MEASURES:HBV c...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Suspension and expulsion from school are used to punish students, alert parents, and protect other students and school staff. Unintended consequences of these practices require more attention from health care professionals. Suspension and expulsion may exacerbate academic deterioration, and when students are provided ...
journal_title:Pediatrics
pub_type: 指南,杂志文章,实务指引
doi:10.1542/peds.112.5.1206
更新日期:2003-11-01 00:00:00
abstract::In 1978 in the United States, 38 children aged 5 years or younger were killed when they fell from the passenger compartments of moving motor vehicles not involved in crashes. Twenty-eight children (74%) were boys. Eighteen (47%) were 2 years old; 35 (92%) were aged 1 to 3 years. Thirty-six children fell out through do...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-10-01 00:00:00
abstract::An overview is presented of the major methods of contraception available to the sexually active adolescent. Emphasis is given to the combined birth control pill, while the literature describing absolute and relative contraindications to oral contraception is reviewed. It is noted that adolescents with chronic illness ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1980-01-01 00:00:00
abstract::Hyperphenylalaninemia due to a biopterin synthesis defect was detected in an infant with decreased biopterin and increased neopterin levels in plasma and urine. Tetrahydrobiopterin (BH4) administration normalized plasma phenylalanine levels. CSF biopterin and neurotransmitter metabolite levels were normal and with the...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract:OBJECTIVE:To develop a quantitative model to estimate the probability of neonatal early-onset bacterial infection on the basis of maternal intrapartum risk factors. METHODS:This was a nested case-control study of infants born at ≥34 weeks' gestation at 14 California and Massachusetts hospitals from 1993 to 2007. Case-...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2010-3464
更新日期:2011-11-01 00:00:00
abstract::: media-1vid110.1542/5839998266001PEDS-VA_2018-2130Video Abstract BACKGROUND: Freshman college students living in residence halls have previously been identified as being at an increased risk for meningococcal disease. In this evaluation, we assess the incidence and characteristics of meningococcal disease in college-...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2018-2130
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Respiratory infections (RIs) are an important cause of morbidity and excessive antibiotic prescriptions in children attending day care centers (DCCs). We aimed to assess the effectiveness of an educational and hand hygiene program in DCCs and homes in reducing RI incidence and antibiotic prescriptions in chi...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2018-1245
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:This population-based study investigated the psychological problems associated with daytime wetting in children. METHODS:A sample of 8213 children (age range: 7 years 6 months to 9 years 3 months) who were enrolled in the population-based Avon Longitudinal Study of Parents and Children participated in this s...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0894
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To provide reference data for ambulatory blood pressure monitoring (ABPM) and to determine the influence of age, sex, and race on these values. METHODS:ABPM was performed on 300 healthy, normotensive boys and girls between the ages of 10 and 18 years, including 160 boys and 140 girls, of whom 149 were white ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::We describe here the case of a boy who presented 2 days after birth with purpura fulminans on his feet and scalp. Laboratory investigations revealed signs of disseminated intravascular coagulation. An underlying coagulation disorder was suspected, and therapy with recombinant tissue plasminogen activator, fresh-frozen...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2009-2913
更新日期:2011-05-01 00:00:00
abstract::Approximately 1 out of 5 children worldwide suffers from childhood malnutrition or stunting and associated health conditions, including an increased susceptibility to infections and inflammation. Due to improved early interventions, most children even in low-resource settings now survive early childhood malnutrition, ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-2828I
更新日期:2017-04-01 00:00:00
abstract::Severe methemoglobinemia resulting from the use of topical benzocaine has been reported in adults as a rare complication. Here we report a case of severe acquired methemoglobinemia resulting from topical use of benzocaine spray during diagnostic upper gastrointestinal endoscopy in a 3-year-old boy with repeated episod...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2005-1952
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:We aim to describe the demographics, clinical presentation, hospital course, and severity of pediatric inpatients with coronavirus disease 2019 (COVID-19), with an emphasis on healthy, immunocompromised, and chronically ill children. METHODS:We conducted a single-center retrospective cohort study of hospita...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-003186
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Adolescent men who have sex with men (AMSM) have a high rate of HIV diagnoses. An estimated 14.5% of HIV infections in the United States are undiagnosed; but among 13- to 24-year-olds, the rate is 51.4%. We describe HIV testing rates and identifies salient individual, family, school, and health care influenc...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-2322
更新日期:2020-03-01 00:00:00