Abstract:
OBJECTIVE:The aim of present study was to determine the effects of conjugated linoleic acid enriched milk on alveolar bone loss, hyperglycaemia, oxidative stress and apoptosis in ligature-induced periodontal disease in diabetic rat model. METHODS:Wistar rats were divided into six experimental groups: 1; non-ligated (NL, n = 6) group, 2; ligature only (LO, n = 6) group, 3; streptozotocin only (STZ, n = 8) group, 4; STZ and ligature (STZ + L, n = 8) group, 5; ligature and conjugated linoleic acid (CLA) (L + CLA, n = 8) group, 6; STZ, ligature and CLA group (STZ + L + CLA, n = 8) group. Diabetes mellitus was induced by 60 mg/kg streptozotocin. Rats were fed with CLA enriched milk for four weeks. Silk ligatures were placed at the gingival margin of lower first molars of mandibular quadrant. The study duration was four weeks after diabetes induction and the animals were sacrificed at the end of this period. Changes in alveolar bone levels were clinically measured and tissues were histopathologically examined. Inducible nitric oxide synthase (iNOS) and Bax protein expressions, serum interleukin-1β (IL-1β), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride levels and tartrate resistant acid phosphatase (TRAP)+ osteoclast numbers were also evaluated. RESULTS:At the end of four weeks, alveolar bone loss was significantly higher in the STZ + LO group compared to the other groups (p < .05). CLA decreased alveolar bone loss in L + CLA and STZ + L + CLA groups. CLA significantly decreased TRAP + osteoclast numbers and increased osteoblastic activity compared to the STZ + L group (p < .05). Diabetes and CLA increased Bax protein levels (p < .05) however CLA had no effect on iNOS expression (p > .05). CONCLUSION:Within the limits of this study, commercial CLA product administration in addition to diet significantly reduced alveolar bone loss, increased osteoblastic activity and decreased osteoclastic activity in the diabetic Wistar rats.
journal_name
Acta Odontol Scandjournal_title
Acta odontologica Scandinavicaauthors
Balci Yuce H,Akbulut N,Ocakli S,Kayir O,Elmastas Mdoi
10.1080/00016357.2016.1244355subject
Has Abstractpub_date
2017-01-01 00:00:00pages
21-29issue
1eissn
0001-6357issn
1502-3850journal_volume
75pub_type
杂志文章abstract:OBJECTIVE:The main goal of periodontal treatment is to control infection and, thereby, curb disease progression. Recent studies have suggested that the use of a laser as an adjunct to scaling and root planing (SRP) might improve the effectiveness of conventional periodontal treatment. The aim of this study was to evalu...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章,随机对照试验
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更新日期:2014-11-01 00:00:00
abstract::The purpose of this study was to determine the sensitivity, specificity, positive and negative predictive values for Corah's Dental Anxiety Scale (DAS) and two modified versions of it (MDAS; MDAS/4). A questionnaire was mailed to a simple random sample of 1,190 25-year-old residents in the west of Norway in 1997. Half...
journal_title:Acta odontologica Scandinavica
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doi:10.1080/00016350050217091
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doi:10.3109/00016357.2012.734412
更新日期:2013-05-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章,评审
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abstract::An epidemiologic sample (n = 285) drawn from the population of Skellefteå, Sweden, was examined to evaluate the prevalence of signs and symptoms of craniomandibular disorders (CMD) at the age of 17 years. The sample was then followed up prospectively at the ages of 18 and 19 years. The year they reached 28 years of ag...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016359609003548
更新日期:1996-12-01 00:00:00
abstract::Changes in the distribution of caries in economically developed nations over the last 15-20 years include 1) an overall decline in prevalence and severity in child populations; 2) an increasingly skewed distribution, with most disease now found in a small number of children; and 3) concentration of caries in pit and f...
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pub_type: 杂志文章
doi:10.1080/000163598422956
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abstract:OBJECTIVE:Edentulousness has a great impact on the individual. Extensive tooth loss is more common among functionally impaired individuals. Such groups may have difficulties with removable prostheses. The aim of this qualitative study was to explore functionally impaired patients' experience of receiving and living wit...
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abstract::In Denmark the Public Dental Health Service (PDHS) is now in the process of evaluation and revision of oral health education programs. The purpose of the present survey was 1) to evaluate the pattern of oral health behavior among 6-year-old children in relation to family and social characteristics; 2) to describe the ...
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016359209012747
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016350500474565
更新日期:2006-06-01 00:00:00
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journal_title:Acta odontologica Scandinavica
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doi:10.3109/00016358609026566
更新日期:1986-06-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016357.2014.923110
更新日期:2014-11-01 00:00:00
abstract::Fifty-one patients (mean age, 47.3 years) with moderate to severe periodontal disease and 40 patients (mean age, 48.9 years) with symptoms related to bruxism (occlusal parafunctions such as grinding and/or clenching of the teeth) were compared with regard to periodontal conditions and signs and symptoms of mandibular ...
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pub_type: 杂志文章
doi:10.3109/00016358709097536
更新日期:1987-08-01 00:00:00
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更新日期:2020-10-07 00:00:00
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pub_type: 杂志文章
doi:10.1080/000163599429048
更新日期:1999-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1080/000163598428356
更新日期:1998-12-01 00:00:00
abstract::Oral adhesion of yeasts probably occurs by interaction between yeast cell adhesins and oral epithelial cell receptors. In Candida albicans mannoprotein, glucan, chitin, cell wall proteins, and lipids are possible adhesins. Mannoprotein appears as a fibrillar or floccular outermost layer in stationary-phase cells grown...
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pub_type: 杂志文章,评审
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更新日期:1990-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-04-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.3109/00016358709096368
更新日期:1987-12-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016358609041294
更新日期:1986-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016357509026354
更新日期:1975-01-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016350801982522
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/00016357.2013.788734
更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/00016358309162299
更新日期:1983-01-01 00:00:00
abstract::The aim of this study was to evaluate the caries-preventive effect of an oral health program for preschool children living in a multicultural, low socio-economic area. In total, 804 2-year-old children were invited and recalled every 3rd month to an outreach facility for parent education and toothbrushing instruction....
journal_title:Acta odontologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016350510019900
更新日期:2005-06-01 00:00:00