Markers of lipid oxidative damage among office workers exposed intermittently to air pollutants including nanoTiO2 particles.

Abstract:

:Nanoscale titanium dioxide (nanoTiO2) is a commercially important nanomaterial used in numerous applications. Experimental studies with nanotitania have documented lung injury and inflammation, oxidative stress, and genotoxicity. Production workers in TiO2 manufacturing with a high proportion of nanoparticles and a mixture of other air pollutants, such as gases and organic aerosols, had increased markers of oxidative stress, including DNA and protein damage, as well as lipid peroxidation in their exhaled breath condensate (EBC) compared to unexposed controls. Office workers were observed to get intermittent exposures to nanoTiO2 during their process monitoring. The aim of this study was to investigate the impact of such short-term exposures on the markers of health effects in office workers relative to production workers from the same factory. Twenty-two office employees were examined. They were occupationally exposed to (nano)TiO2 aerosol during their daily visits of the production area for an average of 14±9 min/day. Median particle number concentration in office workers while in the production area was 2.32×104/cm3. About 80% of the particles were <100 nm in diameter. A panel of biomarkers of lipid oxidation, specifically malondialdehyde (MDA), 4-hydroxy-trans-hexenal (HHE), 4-hydroxy-trans-nonenal (HNE), 8-isoprostaglandin F2α (8-isoprostane), and aldehydes C6-C12, were studied in the EBC and urine of office workers and 14 unexposed controls. Nine markers of lipid oxidation were elevated in the EBC of office employees relative to controls (p<0.05); only 8-isoprostane and C11 were not increased. Significant association was found in the multivariate analysis between their employment in the TiO2 production plant and EBC markers of lipid oxidation. No association was seen with age, lifestyle factors, or environmental air contamination. The EBC markers in office employees reached about 50% of the levels measured in production workers, and the difference between production workers and office employees was highly significant (p<0.001). None of these biomarkers were elevated in urine. The approach presented here seems to be very sensitive and useful for non-invasive monitoring of employees exposed to air pollutants, including gases, organic aerosols, and nanoTiO2, and may prove useful for routine biomonitoring purposes. Among them, aldehydes C6, C8, C9, and C10 appear to be the most sensitive markers of lipid oxidation in similar occupational cohorts. One major challenge with sensitive biomonitoring techniques, however, is their non-specificity and difficulty in interpreting the meaning of their physiological values in the context of chronic disease development and damage-repair kinetics.

journal_name

Rev Environ Health

authors

Pelclova D,Zdimal V,Kacer P,Komarc M,Fenclova Z,Vlckova S,Zikova N,Schwarz J,Makes O,Navratil T,Zakharov S,Bello D

doi

10.1515/reveh-2016-0030

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

193-200

issue

1-2

eissn

0048-7554

issn

2191-0308

pii

/j/reveh.ahead-of-print/reveh-2016-0030/reveh-2016

journal_volume

32

pub_type

杂志文章
  • Pyrethroid pesticide exposure and hematological cancer: epidemiological, biological and molecular evidence.

    abstract::Pyrethroid insecticides are commonly used worldwide. The chronic effects of these compounds are of concern given that epidemiological studies have suggested an association with hematological cancer, particularly in children. However, the biological evidence at molecular and cellular levels is limited. A review on the ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2018-0070

    authors: Navarrete-Meneses MDP,Pérez-Vera P

    更新日期:2019-06-26 00:00:00

  • Systematic review: the impact of socioeconomic factors on Aedes aegypti mosquito distribution in the mainland United States.

    abstract::Aedes aegypti mosquitoes are primary vectors of dengue, yellow fever, chikungunya and Zika viruses. Ae. aegypti is highly anthropophilic and relies nearly exclusively on human blood meals and habitats for reproduction. Socioeconomic factors may be associated with the spread of Ae. aegypti due to their close relationsh...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2020-0028

    authors: Holeva-Eklund WM,Behrens TK,Hepp CM

    更新日期:2020-08-24 00:00:00

  • Environmental victims: environmental injustice issues that threaten the health of children living in poverty.

    abstract::Children living in poverty are disproportionately at risk from and affected by environmental hazards. According to the National Center for Children in Poverty, 13 million children in America live in poverty. Thus, not only are millions of children living in poverty but are also living in environments that are hazardou...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2011.021

    authors: Cureton S

    更新日期:2011-01-01 00:00:00

  • Air exchange rates and alternative vapor entry pathways to inform vapor intrusion exposure risk assessments.

    abstract::Vapor intrusion (VI) is a term used to describe indoor air (IA) contamination that occurs due to the migration of chemical vapors in the soil and groundwater. The overall vapor transport process depends on several factors such as contaminant source characteristics, subsurface conditions, building characteristics, and ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2016-0039

    authors: Reichman R,Roghani M,Willett EJ,Shirazi E,Pennell KG

    更新日期:2017-03-01 00:00:00

  • A review of time-series studies used to evaluate the short-term effects of air pollution on human health.

    abstract::We review the methodology used in the analysis of time-series studies of ambient air pollution. Our focus is on mortality studies, in which daily counts of death are correlated with changes in air pollution. We first illustrate the methods by showing data from the 1950s, during which the effects of air pollution were ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2003.18.4.269

    authors: Goldberg MS,Burnett RT,Stieb D

    更新日期:2003-10-01 00:00:00

  • How serious are health impacts in one of the most polluted regions of Central Europe?

    abstract:BACKGROUND:The long-term exposure to pollutants in ambient air is associated with higher mortality and occurrence of respiratory and cardiopulmonary diseases. The longitudinal cross-section study focuses on the associations between long-term exposures to carcinogenic and non-carcinogenic pollutants and the prevalence a...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2016-0031

    authors: Jiřík V,Dalecká A,Vašendová V,Janoutová J,Janout V

    更新日期:2017-03-01 00:00:00

  • An evaluation of waterborne disease surveillance in the European Union.

    abstract::Surveillance systems to inform controls for waterborne disease (WBD) are important for the protection of public health. Member States of the European Union (EU) will soon be required to implement Directives and the Protocol on Water and Health for controlling WBD. The investigation reported here considers the consiste...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.2002.17.2.149

    authors: Poullis DA,Attwell RW,Powell SC

    更新日期:2002-04-01 00:00:00

  • Sensitization to nickel: etiology, epidemiology, immune reactions, prevention, and therapy.

    abstract::Nickel is a contact allergen causing Type I and Type IV hypersensitivity, mediated by reagins and allergen-specific T lymphocytes, expressing in a wide range of cutaneous eruptions following dermal or systemic exposure. As such, nickel is the most frequent cause of hypersensitivity, occupational as well as among the g...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2006.21.4.253

    authors: Hostynek JJ

    更新日期:2006-10-01 00:00:00

  • Phenotypic characterization of human pathogenic bacteria in fish from the coastal waters of South West Cameroon: public health implications.

    abstract::Increasing economic and recreational opportunities, attractive scenery and a perception of a better quality of life are luring people to the coast. Unfortunately, these activities together with the commensurate increase in population in the area inevitably result in pollution of coastal waters with excessive microorga...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.2009.24.2.147

    authors: Akoachere JF,Bughe RN,Oben BO,Ndip LM,Ndip RN

    更新日期:2009-04-01 00:00:00

  • Current management of household hazardous waste (HHW) in the Asian region.

    abstract::Background This review intends to explore the household hazardous waste (HHW) generation rates, HHW management, and people's awareness regarding HHW in Asian countries based on the economic levels using the available published articles. Methods This is a systematic review of the scientific literature based on several ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2019-0049

    authors: Manggali AA,Susanna D

    更新日期:2019-12-18 00:00:00

  • Diseases associated with poor water and sanitation: hazards, prevention, and solutions.

    abstract::This paper examines one of the most staggering challenges facing the mankind, the challenge to conquer diseases associated with poor water and sanitation. Although rapid strides have been made in the last decade of the last century to provide improved water supply and sanitation, the world is still rampant with diseas...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2003.18.1.33

    authors: Kulshrestha M,Mittal AK

    更新日期:2003-01-01 00:00:00

  • Pollutant toxicity to aquatic animals--methods of study and their applications.

    abstract::The toxicity of water pollutants to aquatic animals is reviewed, with particular emphasis on methods for measuring lethal toxicity, factors influencing toxicity, the measurement of chronic and sublethal toxicity, and the role of toxicological data in formulating water quality standards. Methods for measuring lethal to...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-1989-1-407

    authors: Abel PD

    更新日期:1989-01-01 00:00:00

  • Bayesian networks in infectious disease eco-epidemiology.

    abstract::Globally, infectious diseases are responsible for a significant burden on human health. Drivers of disease transmission depend on interactions between humans, the environment, vectors, carriers, and pathogens; transmission dynamics are therefore potentially highly complex. Research in infectious disease eco-epidemiolo...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2015-0052

    authors: Lau CL,Smith CS

    更新日期:2016-03-01 00:00:00

  • Residential environment and health: a review of methodological and conceptual issues.

    abstract::Geographic patterns of poor health and mortality risk are found in most countries. Important health effects at the neighborhood level are mortality, general health, illness and disabilities, mental health, and healthcare utilization. Awareness of the influence of social class on health has been growing during the last...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:

    authors: van Kamp I,van Loon J,Droomers M,de Hollander A

    更新日期:2004-07-01 00:00:00

  • An overview of indoor air quality and its impact on respiratory health among Malaysian school-aged children.

    abstract::The indoor environment is a major source of human exposure to pollutants. Some pollutants can have concentrations that are several times higher indoors than outdoors. Prolonged exposure may lead to adverse biologic effects, even at low concentrations. Several studies done in Malaysia had underlined the role of indoor ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2014-0065

    authors: Choo CP,Jalaludin J

    更新日期:2015-01-01 00:00:00

  • Influence of particulate matter on human health in selected African provinces: mini-review.

    abstract::Air contamination influenced the human health and environmental well-being of the ecosystem. Particulate matter is a series of issues from major air pollutants in atmosphere. The aim of the review was to analyses the influence of particulate matter on human health and estimate the number of populations exposed to air ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2020-0013

    authors: Bulto TW

    更新日期:2020-08-31 00:00:00

  • Adverse health effects of selenium in humans.

    abstract::Epidemiologic studies and case reports have shown that chronic exposure to selenium compounds is associated with several adverse health effects in humans. An early toxic effect of selenium is on endocrine function, particularly on the synthesis of thyroid hormones following dietary exposure of around 300 micrograms Se...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2001.16.4.233

    authors: Vinceti M,Wei ET,Malagoli C,Bergomi M,Vivoli G

    更新日期:2001-07-01 00:00:00

  • Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations.

    abstract::Unconventional oil and gas (UOG) operations have the potential to increase air and water pollution in communities located near UOG operations. Every stage of UOG operation from well construction to extraction, operations, transportation, and distribution can lead to air and water contamination. Hundreds of chemicals a...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2014-0057

    authors: Webb E,Bushkin-Bedient S,Cheng A,Kassotis CD,Balise V,Nagel SC

    更新日期:2014-01-01 00:00:00

  • Amyotrophic lateral sclerosis, occupational exposure to extremely low frequency magnetic fields and electric shocks: a systematic review and meta-analysis.

    abstract::Exposure to extremely low frequency magnetic fields (ELF-MF) and electric shocks occurs in many workplaces and occupations but it is unclear whether any of these exposures cause Amyotrophic lateral sclerosis (ALS). The aim of this systematic review and meta-analysis is to explore whether occupational exposure to ELF-M...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2020-0041

    authors: Jalilian H,Najafi K,Khosravi Y,Röösli M

    更新日期:2020-09-18 00:00:00

  • Electronic cigarettes in the indoor environment.

    abstract::The use of electronic cigarettes (e-cigarettes or "vaping") has seen an unprecedented increase worldwide. Vaping has been promoted as a beneficial smoking cessation tool and an alternative nicotine delivery device that contains no combustion by-products. However, nicotine is highly addictive, and the increased use of ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2019-0012

    authors: Marcham CL,Springston JP

    更新日期:2019-06-26 00:00:00

  • Solid waste management in Thailand: an overview and case study (Tha Khon Yang sub-district).

    abstract::Due to rapid urbanization, solid waste management (SWM) has become a significant issue in several developing countries including Thailand. Policies implemented by the Central Thai Government to manage SWM issues have had only limited success. This article reviews current municipal waste management plans in Thailand an...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2016-0061

    authors: Yukalang N,Clarke BD,Ross KE

    更新日期:2017-09-26 00:00:00

  • Health and environmental hazards of pesticides.

    abstract::The increase in world population and in demand for food and economic crops has put a pesticide burden on man and the environment. Pesticide residues from vector control and agricultural uses contaminate the terrestrial and aquatic surroundings and contribute to the pollution problem of the environment. Various human t...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.1991.9.1.47

    authors: Iyaniwura TT

    更新日期:1991-01-01 00:00:00

  • Virus, bats and drugs.

    abstract::Apart from SARS-Co-V-2 coronavirus, bats also host many highly virulent zoonotic pathogens. A matter of rising concern is the detrimental impact of pharmaceuticals in the environment, as they can have major impact at low concentrations. Insectivorous bats are among the wildlife animals likely to be exposed due to the ...

    journal_title:Reviews on environmental health

    pub_type: 社论

    doi:10.1515/reveh-2020-0083

    authors: Orive G,Lertxundi U

    更新日期:2020-08-24 00:00:00

  • An overview of radioactivity measurement studies in Pakistan.

    abstract::In our environment, various naturally occurring radionuclides are present (both underground and overground) in several places, which results in lifelong human exposure. The radiation dose received by human beings from the radiation emitted by these naturally occurring radionuclides is approximately 87%. Exposure to ra...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2018-0058

    authors: Muhammad W,Matiullah .,Ullah A,Tahir S,Ullah F,Khan M

    更新日期:2019-06-26 00:00:00

  • Association of DDT and heptachlor epoxide in human blood with diabetic nephropathy.

    abstract::Six organochlorine pesticides and pesticide metabolites in human blood were tested to determine their relationships with diabetic nephropathy. The data were derived from the National Health and Nutrition Examination Survey (NHANES) 1999-2004 (unweighted, n=2992, population estimate=133,088,752). The six chemicals were...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2015-0003

    authors: Everett CJ,Thompson OM

    更新日期:2015-01-01 00:00:00

  • Changing exposures in a changing world: models for reducing the burden of disease.

    abstract::Environmental exposures are changing dramatically in location, intensity, and frequency. Many developing countries are undergoing a transition in which they face the double burden of infectious diseases as well as chronic diseases. Noncommunicable diseases have emerged as the leading cause of death and disability in d...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2015-0049

    authors: Suk WA,Mishamandani S

    更新日期:2016-03-01 00:00:00

  • Cutaneous irritancy of water.

    abstract::Abstract Water is an ubiquitous irritant that exerts its irritancy through different mechanisms. Water passage and optimal water content is a highly controlled process of human skin and changes in the water gradient may lead to skin diseases. The pH, osmolarity, and temperature of water can all be attributes of water ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh-2014-0047

    authors: Wang TS,Tsai TF

    更新日期:2014-01-01 00:00:00

  • Environmental exposures to endocrine disrupting chemicals (EDCs) and their role in endometriosis: a systematic literature review.

    abstract::Purpose Endocrine-related diseases and disorders are on the rise globally. Synthetically produced environmental chemicals (endocrine-disrupting chemicals (EDCs)) mimic hormones like oestrogen and alter signalling pathways. Endometriosis is an oestrogen-dependent condition, affecting 10-15% of women of the reproductive...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh-2020-0046

    authors: Sirohi D,Al Ramadhani R,Knibbs LD

    更新日期:2020-09-09 00:00:00

  • Environmental-health aspects of pulse-modulated microwaves.

    abstract::Our theoretical model describes the potential influence of irradiation with pulse-modulated microwaves on the conformational oscillations of enzymes in living organisms. Certain values of pulse-repetition time, determined by the period of conformational oscillations of the corresponding type of enzyme, can produce the...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章

    doi:10.1515/reveh.1996.11.1-2.85

    authors: Neshev NN,Kirilova EI

    更新日期:1996-01-01 00:00:00

  • Environmental stressors and violence: lead and polychlorinated biphenyls.

    abstract::Many environmental risk factors for antisocial and violent behavior have been described. In recent years, this topic has become widely researched in the fields of environmental health, psychology, sociology, and many other disciplines. The results from a myriad of studies have shown that the etiologies of violent and ...

    journal_title:Reviews on environmental health

    pub_type: 杂志文章,评审

    doi:10.1515/reveh.2007.22.4.313

    authors: Hwang L

    更新日期:2007-10-01 00:00:00