Type 2 Diabetes, Hypoglycemia, and Basal Insulins: Ongoing Challenges.

abstract：:Chancroid, the third most prevalent venereal disease in Thailand, was treated with a single 2-gm dose of spectinomycin, or two tablets of co-trimoxazole (trimethoprim-sulfamethoxazole) twice daily for seven days. The differences in cure rates between the two groups were statistically significant. The chancroidal ulcer...

journal_title：Clinical therapeutics

authors： Traisupa A,Ariyarit C,Metheeprapha C,Buatiang A,Sungthong P

更新日期：1990-05-01 00:00:00

abstract：:In a multicenter, parallel-group, double-masked, randomized study, two questionnaires were administered to a clinical study population to identify which specific symptoms of seasonal allergic rhinitis patients perceived as most important to relieve (personal preferences) and to learn whether any relationship existed b...

journal_title：Clinical therapeutics

authors： Ricard N,Kind P,Christian S,Jensen M,Stewart J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Postoperative nausea and vomiting (PONV) are distressing and frequent adverse effects (AEs) in women undergoing laparoscopic gynecologic surgery. Midazolam has been reported to be effective for preventing PONV in adults undergoing middle ear surgery and children undergoing strabismus surgery or tonsillectomy...

journal_title：Clinical therapeutics

authors： Fujii Y,Itakura M

更新日期：2010-08-01 00:00:00

abstract：:Long-term safety and efficacy of feprazone (4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione), an antirheumatic drug that is well tolerated in the gastrointestinal tract, were assessed in a noncontrolled multicenter trial. Administered at a daily dosage of 600 mg for a mean duration of 114.1 days, feprazone was well tolera...

journal_title：Clinical therapeutics

authors： Bianchi G,Cerri B,Grasso S,Carazzi R,Dotti F,Ongari R,Cerrato O,Viara M

更新日期：1981-01-01 00:00:00

abstract：:The management of patients with congestive heart failure (CHF) can place a significant economic burden on managed care organizations, leading providers to seek treatments that are cost-effective. Diuretics play a significant role in the treatment of edema associated with CHF. We evaluated the use of 2 loop diuretics, ...

journal_title：Clinical therapeutics

authors： Noe LL,Vreeland MG,Pezzella SM,Trotter JP

更新日期：1999-05-01 00:00:00

abstract：:The pharmacokinetics of cimetidine were studied in three newborn infants with reflux esophagitis or stress ulcer. One infant was given 5 mg/kg intravenously (IV), one was given 10 mg/kg IV, and one was given 10 mg orally. Serum concentrations 30 minutes after administration were 1.2 micrograms/ml, 5 micrograms/ml, and...

journal_title：Clinical therapeutics

authors： Stile IL,Simon R,Hiatt IM,Hegyi T

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Postoperative emetic symptoms (nausea, retching, and vomiting) are common following total joint replacement, with an incidence as high as 83% when no prophylactic antiemetic is provided. However, most antiemetics currently used in Japan, such as antihistamines (eg, hydroxyzine), butyrophenones (eg, droperido...

journal_title：Clinical therapeutics

authors： Fujii Y,Nakayama M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:This study was conducted to estimate the prevalence of antipsychotic polypharmacy among fee-for service state Medicaid beneficiaries initiating antipsychotic drug therapy and to investigate psychiatric and demographic predictors of such polypharmacy. METHODS:This was a retrospective cohort study employing M...

journal_title：Clinical therapeutics

authors： Morrato EH,Dodd S,Oderda G,Haxby DG,Allen R,Valuck RJ

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Although the efficacy of canagliflozin has been well established in clinical trials, research regarding its use and impact on outcomes in clinical practice has been limited by the availability of data on observations up to and beyond 6 months after the initial use of canagliflozin. The purpose of this study was...

journal_title：Clinical therapeutics

authors： Bailey RA,Schwab P,Xu Y,Pasquale M,Renda A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Antimicrobial prophylaxis in select neutropenic patients has reduced fever, infection rates, hospital length of stay, and hospitalization rates. Guidelines from the Infectious Diseases Society of America recommend the consideration of prophylaxis with a fluoroquinolone in patients at high risk for infection ...

journal_title：Clinical therapeutics

authors： Wojenski DJ,Barreto JN,Wolf RC,Tosh PK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Hereditary angioedema (HAE) is a rare, potentially life-threatening autosomal dominant disease characterized by recurrent angioedema attacks that affect the skin, gastrointestinal tract, and airway, including the larynx. Pharmacologic developments in HAE treatment have culminated in the recent introduction o...

journal_title：Clinical therapeutics

authors： Riedl M

更新日期：2012-03-01 00:00:00

abstract：:A single-blind comparison was undertaken to evaluate 250 mg of cinoxacin and 100 mg of nitrofurantoin, both drugs being given four times a day, for the treatment of urinary tract infections. Complete data are available from 58 patients, most of whom were treated for 10 to 15 days. The clinical response was similar in ...

journal_title：Clinical therapeutics

authors： Schneider RE

更新日期：1982-01-01 00:00:00

abstract：:Recent pharmacotherapeutic advances in the treatment of depression have included the development of selective serotonin re-uptake inhibitors (SSRIs). The present study was designed to contrast direct health service expenditures for the treatment of depression among patients enrolled in a health maintenance organizatio...

journal_title：Clinical therapeutics

authors： Sclar DA,Robison LM,Skaer TL,Legg RF,Nemec NL,Galin RS,Hughes TE,Buesching DP

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:Rosuvastatin, a hydroxy methylglutaryl coenzyme A reductase inhibitor; telmisartan, an angiotensin receptor blocker; and amlodipine, a calcium channel inhibitor, are commonly prescribed together for the treatment of hypertension nonresponsive to monotherapy and accompanied by dyslipidemia. However, the pharmaco...

journal_title：Clinical therapeutics

authors： Son M,Guk J,Kim Y,Woo Chae D,Heo YA,Soh D,Park K

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:This study assessed the cost-effectiveness of escitalopram for the treatment of depression in the Netherlands from a societal perspective. METHODS:A decision tree model was constructed using decision analytical techniques. Data sources included published literature, clinical trials, official price/tariff lis...

journal_title：Clinical therapeutics

authors： Nuijten MJ,Brignone M,Marteau F,den Boer JA,Hoencamp E

更新日期：2012-06-01 00:00:00

abstract：:This study evaluated the efficacy, safety, and most suitable dose of omeprazole in short-term acute treatment (4 weeks) and maintenance treatment (6 months) of patients older than 60 years of age with endoscopically diagnosed gastric ulcer (GU) or duodenal ulcer (DU). This randomized, prospective study included 156 pa...

journal_title：Clinical therapeutics

authors： Pilotto A,Di Mario F,Battaglia G,Vigneri S,Leandro G,Franceschi M,De Boni M,Grasso A,Vianello F,Naccarato R

更新日期：1994-11-01 00:00:00

abstract：:This paper reviews the issues that are critical for the valuation of medical resources in the context of health economic studies. There are several points to consider when undertaking the valuation of medical resources. The perspective of the analysis should be established before determining the valuation process. Fut...

journal_title：Clinical therapeutics

authors： Copley-Merriman C,Lair TJ

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:This study evaluated the efficacy and tolerability of glimepiride in patients with type 2 diabetes mellitus that was inadequately controlled with a combination of immediate- or extended-release metformin and a thiazolidinedione. METHODS:This was a multicenter, randomized, double-blind, placebo-controlled, pa...

journal_title：Clinical therapeutics

authors： Roberts VL,Stewart J,Issa M,Lake B,Melis R

更新日期：2005-10-01 00:00:00

abstract：:Against the backdrop of the COVID pandemic, the scientific and medical communities are working with all deliberate speed with state-of-the-art technologies to develop diagnostic and therapeutic products that can identify, treat, and prevent infection with SARS-CoV-2. These activities may only be legally conducted with...

journal_title：Clinical therapeutics

authors： Beninger P

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Emergence agitation (EA) after emergence from sevoflurane anesthesia is a common phenomenon in children. The efficacy of prophylactic midazolam or clonidine in preventing EA is controversial. OBJECTIVE:We performed a meta-analysis of clinical trials of the 2 drugs to evaluate their ability to prevent EA in ...

journal_title：Clinical therapeutics

authors： Zhang C,Li J,Zhao D,Wang Y

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:During the past decade, there has been some progress in the pharmacotherapy of schizophrenia and schizoaffective disorder. Current evidence supports the use of various second-generation, or atypical, antipsychotic medications, although few of these agents have been associated with long-term efficacy and tole...

journal_title：Clinical therapeutics

authors： Stip E,Tourjman V

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Postherpetic neuralgia (PHN), which affects up to 70% of elderly persons with herpes zoster, can have debilitating effects, including physical and social disability and significant psychological distress. A variety of agents have been used, either singly or in combination, to control PHN, including topical a...

journal_title：Clinical therapeutics

authors： Stacey BR,Glanzman RL

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Systemic absorption of topical fluorouracil, although usually low, may vary as a result of the specific skin disease, product formulation, and other factors. OBJECTIVE:The present study was conducted to determine the pharmacokinetic profile and tolerability of a new topical 0.5% fluorouracil cream formulati...

journal_title：Clinical therapeutics

authors： Levy S,Furst K,Chern W

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess obese patients with hypercholesterolemia whom were prescribed a standardized diet, comparing the action of orlistat, fluvastatin, orlistat with fluvastatin, and placebo on anthropometric measurements, blood pressure (BP), and lipid profile. METHODS:This was a 1-year, rando...

journal_title：Clinical therapeutics

authors： Derosa G,Mugellini A,Ciccarelli L,Fogari R

更新日期：2003-04-01 00:00:00

abstract：:A drug surveillance study was performed to determine the tolerance and safety of quinapril in the treatment of patients with stage 1 or 2 hypertension. The trial was noncomparative, open-label, uncontrolled, and nonrandomized. Patients with secondary hypertension, heart failure, other heart diseases, and other serious...

journal_title：Clinical therapeutics

authors： Olvera S,Alcocer L,Novoa G

更新日期：1996-09-01 00:00:00

abstract：:Pregnancy creates a climate favorable to the growth of Candida albicans, and this yeast often is difficult to eradicate in pregnant women. Miconazole nitrate administered intravaginally has been found to achieve comparable therapeutic and mycological cure rates in both pregnant and nonpregnant women. A number of clini...

journal_title：Clinical therapeutics

authors： Weisberg M

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Hypersensitivity reactions consist of a variable group of clinical findings and have been described for a wide variety of chemical compounds. OBJECTIVE:This review characterizes the clinical profile of hypersensitivity to the nucleoside reverse transcriptase inhibitor abacavir sulfate. METHODS:We performed...

journal_title：Clinical therapeutics

authors： Hetherington S,McGuirk S,Powell G,Cutrell A,Naderer O,Spreen B,Lafon S,Pearce G,Steel H

更新日期：2001-10-01 00:00:00

abstract：:Oral rehydration therapy (ORT) has had a dramatic global impact. The worldwide consequences of this therapy are discussed in four categories: (1) adoption of ORT as the primary therapy for acute dehydrating diarrhea; (2) establishment of national ORT programs; (3) scientific knowledge gained from studies into intestin...

journal_title：Clinical therapeutics

authors： Banwell JG

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Communicating potential benefits and harm to patients and payers is essential for high-quality care. However, there are no published guidelines or consensuses on how to communicate potential benefits and harm to patients and payers. OBJECTIVE:The goal of this review was to identify key elements for communic...

journal_title：Clinical therapeutics

authors： Wu R,Kemp DE,Sajatovic M,Zhao J,Calabrese JR,Gao K

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Tetanus-diphtheria-acellular pertussis (Tdap) was licensed in the United States in 2005 to be given in place of tetanus-diphtheria (Td) for single use in adolescents. OBJECTIVES:This analysis was conducted to determine vaccination coverage with Td and Tdap among adolescents in the United States aged 13 to 1...

journal_title：Clinical therapeutics

authors： Jain N,Stokley S,Cohn A

更新日期：2010-08-01 00:00:00