Abstract：
:Complex microbial communities within the human body, constituting the microbiome, have a broad impact on human health and disease. A growing body of research now examines the role of the microbiome in patients with critical illness, such as sepsis and acute respiratory failure. In this article, we provide an introduction to microbiome concepts and terminology and we systematically review the current evidence base of the critical-illness microbiome, including 51 studies in animal models and pediatric and adult critically ill patients. We further examine how this emerging scientific discipline may transform the way we manage infectious and inflammatory diseases in intensive care units. The evolving molecular, culture-independent techniques offer the ability to study microbial communities in unprecedented depth and detail, and in the short-term, may enable us to diagnose and treat infections in critical care more precisely and effectively. Longer term, these tools may also give us insights in the underlying pathophysiology of critical illness and reveal previously unsuspected targets for innovative, microbiome-targeted therapeutics. We finally propose a roadmap for future studies in the field for transforming critical care from its current isolated focus on the host to a more personalized paradigm addressing both human and microbial contributions to critical illness.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Kitsios GD,Morowitz MJ,Dickson RP,Huffnagle GB,McVerry BJ,Morris Adoi
10.1016/j.jcrc.2016.09.029subject
Has Abstractpub_date
2017-04-01 00:00:00pages
84-91eissn
0883-9441issn
1557-8615pii
S0883-9441(16)30300-8journal_volume
38pub_type
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-06-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2018-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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更新日期：2018-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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pub_type： 杂志文章
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