Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD.

abstract：:Infantile botulism is a recently recognized cause of acute hypotonic paresis and respiratory failure in young infants. Electrophysiological testing has proven useful in early diagnosis in suspected cases by demonstrating abnormal neuromuscular transmission as is known to occur in botulism. Twenty-five infants with bac...

journal_title：Muscle & nerve

authors： Cornblath DR,Sladky JT,Sumner AJ

更新日期：1983-07-01 00:00:00

abstract：:n-Hexane neuropathy was studied in 20 workers exposed for prolonged periods to this solvent, and with urinary 2,5-hexanedione concentrations exceeding the biological exposure index recommended by the American Conference of Governmental Industrial Hygienists (5 mg/L) with a mean of 11.02 mg/L (range 5.3-24.2 mg/L). Alt...

journal_title：Muscle & nerve

authors： Pastore C,Marhuenda D,Marti J,Cardona A

更新日期：1994-09-01 00:00:00

abstract：:Muscle fatigue occurs in many neuromuscular diseases, including the muscular dystrophies, and it contributes to a loss of functional capacity and reduced quality of life for affected patients. An improvement in fatigue resistance has been observed in diaphragm muscles of mdx mice following insulin-like growth factor-I...

journal_title：Muscle & nerve

authors： Gregorevic P,Plant DR,Lynch GS

更新日期：2004-09-01 00:00:00

abstract：:Electrical stimulation was applied daily for 20 minutes to denervated rabbit extensor digitorum longus muscle. One group was stimulated with short tetani, another with 1-Hz frequency, using isometric contractions for both. Tetanic stimulation induced severe fibrosis and is harmful to denervated muscle. One Hertz stimu...

journal_title：Muscle & nerve

authors： Nix WA,Dahm M

更新日期：1987-02-01 00:00:00

abstract：INTRODUCTION:The aim of this work was to determine the effect of chronic alcohol exposure on peripheral nerves in a nutritionally balanced rat model of alcoholism. METHODS:Three different strains of adult male rats were pair-fed for 8 weeks with isocaloric liquid diets containing 0% or 37% ethanol. Nerve conduction st...

journal_title：Muscle & nerve

authors： Mellion ML,Nguyen V,Tong M,Gilchrist J,De La Monte S

更新日期：2013-08-01 00:00:00

abstract：:In muscle of whole animals, pituitary growth hormone, the thyroid hormones, and insulin are major growth-promoting hormones, and the glucocorticoids have significant catabolic actions. At the cellular level the primary anabolic hormones for cultured myoblasts are the somatomedins (insulin-like growth factors) and fibr...

journal_title：Muscle & nerve

authors： Florini JR

更新日期：1987-09-01 00:00:00

abstract：:Action potentials of rabbit masseter motor units (n = 42) were registered at different jaw angles to examine whether the shape of the action potential is related to length of muscle fibers in motor units and depends on the intramuscular location of the motor unit. Twitches were elicited by stimulating motoneurons in t...

journal_title：Muscle & nerve

authors： Turkawski SJ,van Eijden TM

更新日期：2001-11-01 00:00:00

abstract：:We prospectively evaluated thalidomide-induced neuropathy using electrodiagnostic studies. Sixty-seven men with metastatic androgen-independent prostate cancer in an open-label trial of oral thalidomide underwent neurologic examinations and nerve conduction studies (NCS) prior to and at 3-month intervals during treatm...

journal_title：Muscle & nerve

authors： Molloy FM,Floeter MK,Syed NA,Sandbrink F,Culcea E,Steinberg SM,Dahut W,Pluda J,Kruger EA,Reed E,Figg WD

更新日期：2001-08-01 00:00:00

abstract：:The aim of this study was to investigate the fasciculation potentials (FPs) in the small-peripheral muscles of the foot and hand and the possible associated factors, in a healthy population. One hundred-twenty-two normal individuals (65 men and 57 women), aged 17-67 years (mean 39.96, SD=12.76) participated in the stu...

journal_title：Muscle & nerve

authors： Mitsikostas DD,Karandreas N,Coutsopetras P,Piperos P,Lygidakis C,Papageorgiou C

更新日期：1998-04-01 00:00:00

abstract：INTRODUCTION:Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. METHODS:We conducted a prospective, cross-s...

journal_title：Muscle & nerve

authors： Elsheikh B,Arnold WD,Gharibshahi S,Reynolds J,Freimer M,Kissel JT

更新日期：2016-01-01 00:00:00

abstract：:We have examined the clinical features of patients with femoral neuropathy and the factors that influence the prognosis. Of 80 consecutive patients referred for neurophysiological evaluations of proximal lower limb weakness, 32 fulfilled strict inclusion criteria and had adequate information, including estimates of ax...

journal_title：Muscle & nerve

authors： Kuntzer T,van Melle G,Regli F

更新日期：1997-02-01 00:00:00

abstract：:This investigation analyzes the temporal characteristics of maximal depolarization times for three waveforms: end-plate spikes, fibrillation potentials, and positive sharp waves (PSWs) to provide support for the electrode initiation hypothesis of PSW induction. The maximal depolarization times for PSWs are documented ...

journal_title：Muscle & nerve

authors： Dumitru D,Santa Maria DL

更新日期：2007-09-01 00:00:00

abstract：:Twenty-four adult albino rats were injected with tetanus toxin into the right gastrocnemius muscle and then subjected to sustained dorsiflexion of the right ankle joint for 2 to 14 days. Histologic examinations of the soleus after this procedure showed myopathic changes, characterized by variations in fiber diameters,...

journal_title：Muscle & nerve

authors： Mizuno Y,Chou SM

更新日期：1990-10-01 00:00:00

abstract：:Familial amyotrophic lateral sclerosis (ALS) with the autosomal-recessively inherited D90A CuZn-superoxide dismutase (CuZn-SOD) mutation is characterized by a stereotypic slowly progressive, distinctive phenotype and very slow central motor conduction. To determine the basis of this slowing, we assessed corticomotoneu...

journal_title：Muscle & nerve

authors： Weber M,Eisen A,Stewart HG,Andersen PM,Hirota N

更新日期：2001-01-01 00:00:00

abstract：:The clinical and neurophysiological features of multifocal motor neuropathy (MMN) indicate selective involvement of motor axons, but pathological abnormalities in sensory axons suggest a more widespread disease process. The present study was undertaken to determine whether the focal abnormalities are associated with w...

journal_title：Muscle & nerve

authors： Cappelen-Smith C,Kuwabara S,Lin CS,Burke D

更新日期：2002-12-01 00:00:00

abstract：INTRODUCTION:Previous studies have reported higher wrist ratios (WR) related to carpal tunnel syndrome (CTS) but have not assessed effect modification by obesity and may have inadequately controlled for confounders. METHODS:Baseline data of a multicenter prospective cohort study were analyzed. CTS was defined by nerve...

journal_title：Muscle & nerve

authors： Thiese MS,Merryweather A,Koric A,Ott U,Wood EM,Kapellusch J,Foster J,Garg A,Deckow-Schaefer G,Tomich S,Kendall R,Drury DL,Wertsch J,Hegmann KT,Wistah Study Team.

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Voltage-gated Kv1 potassium channel complex (VGKC) autoantibodies subtyped for leucine-rich glioma-inactivated 1 (LGI1), contactin-associated-proteinlike 2 (CASPR2), and Kv IgGs have a spectrum of neurological presentations. Painful polyneuropathy is seen in some patients, but nerve pathology descriptions ...

journal_title：Muscle & nerve

authors： Lahoria R,Pittock SJ,Gadoth A,Engelstad JK,Lennon VA,Klein CJ

更新日期：2017-04-01 00:00:00

abstract：:Three children presented at birth with axial hypotonia and symmetrical flaccid paresis limited to the upper extremities, and involving proximal and distal muscle groups. At birth, palmar flexion creases were poorly developed, and the hand muscles were atrophic. These clinical features, the muscle biopsy findings, and ...

journal_title：Muscle & nerve

authors： Darwish H,Sarnat H,Archer C,Brownell K,Kotagal S

更新日期：1981-03-01 00:00:00

abstract：:Congenital myasthenic syndromes (CMS) stem from defects in presynaptic, synaptic basal lamina, and postsynaptic proteins. The presynaptic CMS are associated with defects that curtail the evoked release of acetylcholine (ACh) quanta or ACh resynthesis. Defects in ACh resynthesis have now been traced to mutations in cho...

journal_title：Muscle & nerve

authors： Engel AG,Ohno K,Sine SM

更新日期：2003-01-01 00:00:00

abstract：:Patients with peripheral neuropathy frequently suffer from positive sensory (pain and paresthesias) and motor (muscle cramping) symptoms even in the recovery phase of the disease. To investigate the pathophysiology of increased axonal excitability in peripheral nerve regeneration, we assessed the temporal and spatial ...

journal_title：Muscle & nerve

authors： Nakata M,Baba H,Kanai K,Hoshi T,Sawai S,Hattori T,Kuwabara S

更新日期：2008-06-01 00:00:00

abstract：:L-carnitine stimulated CO2 production from 1-14C pyruvate in mitochondria from human skeletal muscle nearly twofold. A comparable increase in the pyruvate dehydrogenase complex (PDHC) activity was seen. Moreover, in the presence of L-carnitine and at pyruvate concentration greater than 0.25 mM, this effect was associa...

journal_title：Muscle & nerve

authors： Uziel G,Garavaglia B,Di Donato S

更新日期：1988-07-01 00:00:00

abstract：INTRODUCTION:Acetylcholine receptor (AChR) and striated muscle antibodies (StrAbs) are found frequently in myasthenia gravis (MG) patients with thymoma. In this study we aimed to determine the positive predictive value (PPV) and negative predictive value (NPV) of these antibodies for thymoma in patients with MG. METHO...

journal_title：Muscle & nerve

authors： Choi Decroos E,Hobson-Webb LD,Juel VC,Massey JM,Sanders DB

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to assess age- and gender-specific incidence rates (IRs) of acetylcholine receptor (AChR)-antibody-positive myasthenia gravis (MG) in South Africa, and geographical variations in incidence. METHODS:IRs were calculated from positive AChR-antibody laboratory data between 2011 and 2...

journal_title：Muscle & nerve

authors： Mombaur B,Lesosky MR,Liebenberg L,Vreede H,Heckmann JM

更新日期：2015-04-01 00:00:00

abstract：:Peripheral nerve disorders are commonly encountered in clinical practice. Electrodiagnostic studies remain the cornerstone of the evaluation of nerve disorders. More recently, ultrasound has played an increasing complementary role in the neuromuscular clinic. Ultrasound elastography is a technique that measures the el...

journal_title：Muscle & nerve

authors： Wee TC,Simon NG

更新日期：2019-11-01 00:00:00

abstract：:Calpain 3 (C3) is the only muscle-specific member of the calcium-dependent protease family. Although neither its physiological function nor its in vivo substrates are known, C3 must be an important protein for normal muscle function as mutations in the C3 gene result in limb-girdle muscular dystrophy type 2A. Previous...

journal_title：Muscle & nerve

authors： Guyon JR,Kudryashova E,Potts A,Dalkilic I,Brosius MA,Thompson TG,Beckmann JS,Kunkel LM,Spencer MJ

更新日期：2003-10-01 00:00:00

abstract：:Human normal (RCMH) and Duchenne muscular dystrophy (RCDMD) cell lines, as well as newly developed normal and dystrophic murine cell lines, were used for the study of both changes in inositol 1,4,5-trisphosphate (IP3) mass and IP3 binding to receptors. Basal levels of IP3 were increased two- to threefold in dystrophic...

journal_title：Muscle & nerve

authors： Liberona JL,Powell JA,Shenoi S,Petherbridge L,Caviedes R,Jaimovich E

更新日期：1998-07-01 00:00:00

abstract：INTRODUCTION:In this study we estimated the costs paid by U.S. health plans for treating myasthenia gravis (MG) in 2009 and determined the major cost drivers. METHODS:One hundred thirteen MG patients were matched by propensity scores with 339 non-MG patients from a comprehensive health-care insurance database. The mea...

journal_title：Muscle & nerve

authors： Guptill JT,Sharma BK,Marano A,Soucy A,Krueger A,Sanders DB

更新日期：2012-03-01 00:00:00

abstract：:Earlier studies have shown that prior denervation of muscle prevents myotonia induced by 2,4-dichlorophenoxy acetic acid (2,4-D) both in vivo and in vitro. This work studied the effect of reinnervation on 2,4-D myotonia. Twenty Sprague-Dawley rats were injected with 2,4-D at specific intervals following unilateral sci...

journal_title：Muscle & nerve

authors： Al-Sulaiman A,Al-Rajeh S,Iyer V

更新日期：1986-05-01 00:00:00

abstract：INTRODUCTION:Mutations in the guanosine diphosphate-mannose pyrophosphorylase-B gene (GMPPB) have been identified in congenital muscular dystrophies, limb-girdle muscular dystrophy (LGMD2T), and congenital myasthenic syndromes (CMSs); overall, 41 patients have been described. METHODS:Two patients presented with a myas...

journal_title：Muscle & nerve

authors： Montagnese F,Klupp E,Karampinos DC,Biskup S,Gläser D,Kirschke JS,Schoser B

更新日期：2017-08-01 00:00:00

abstract：:Metabolic costs of force generation were compared for constant-frequency and catchlike-inducing electrical stimulation. Repetitive catchlike-inducing trains consisted of 2 interpulse intervals (IPIs) at 12.5 ms, 1 IPI at 25 ms, and 5 IPIs at 50 ms. Constant-frequency trains consisted of 8 IPIs at 37.5 ms. One train wa...

journal_title：Muscle & nerve

authors： Ratkevicius A,Quistorff B

更新日期：2002-03-01 00:00:00