Optimal design of upstream processes in biotransformation technologies.

Abstract:

:In this work a mathematical programming model for the optimal design of the bioreaction section of biotechnological processes is presented. Equations for the estimation of the equipment cost derived from a recent publication by the US National Renewable Energy Laboratory (NREL) are also summarized. The cost-optimal design of process units and the optimal scheduling of their operation can be obtained using the proposed formulation that has been implemented in software available from the journal web page or the corresponding author. The proposed optimization model can be used to quantify the effects of decisions taken at a lab scale on the industrial scale process economics. It is of paramount important to note that this can be achieved at the early stage of the development of a biotechnological project. Two case studies are presented that demonstrate the usefulness and potential of the proposed methodology.

journal_name

Bioresour Technol

journal_title

Bioresource technology

authors

Dheskali E,Michailidi K,de Castro AM,Koutinas AA,Kookos IK

doi

10.1016/j.biortech.2016.10.084

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

509-514

eissn

0960-8524

issn

1873-2976

pii

S0960-8524(16)31498-5

journal_volume

224

pub_type

杂志文章
  • Supercritical CO2 pretreatment of lignocellulose enhances enzymatic cellulose hydrolysis.

    abstract::The supercritical carbon dioxide (SC-CO2) pretreatment of lignocellulose for enzymatic hydrolysis of cellulose was investigated. Aspen (hardwood) and southern yellow pine (softwood) with moisture contents in the range of 0-73% (w/w) were pretreated with SC-CO2 at 3100 and 4000 psi and at 112-165 degrees C for 10-60 mi...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/s0960-8524(00)00147-4

    authors: Kim KH,Hong J

    更新日期:2001-04-01 00:00:00

  • Enhanced Coulombic efficiency in glucose-fed microbial fuel cells by reducing metabolite electron losses using dual-anode electrodes.

    abstract::Glucose-fed microbial fuel cells (MFCs) have displayed low Coulombic efficiency (CE); one reason for a low CE is metabolite generation, causing significant electron loss within MFC systems. In the present study, notable electron loss (15.83%) is observed in glucose-fed MFCs due to residual propionate, a glucose metabo...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2010.12.036

    authors: Kim KY,Chae KJ,Choi MJ,Ajayi FF,Jang A,Kim CW,Kim IS

    更新日期:2011-03-01 00:00:00

  • Production and purification of a novel exopolysaccharide from lactic acid bacterium Streptococcus phocae PI80 and its functional characteristics activity in vitro.

    abstract::Optimum culture conditions which ease the synthesis of a novel exopolysaccharide (EPS) from a potent marine strain Streptococcus phocae was proposed in this study. The strain grows well at 35 °C, pH 7.0 and NaCl (2%) with lactose and yeast extract as best carbon and nitrogen sources. The maximum yield of EPS (11.75 an...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2010.12.118

    authors: Kanmani P,Satish kumar R,Yuvaraj N,Paari KA,Pattukumar V,Arul V

    更新日期:2011-04-01 00:00:00

  • Response of humic acid formation to elevated nitrate during chicken manure composting.

    abstract::Nitrate can stimulate microbes to degrade aromatic compounds, whereas humic acid (HA) as a high molecular weight aromatic compound, its formation may be affected by elevated nitrate during composting. Therefore, this study is conducted to determine the effect of elevated nitrate on HA formation. Five tests were execut...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2018.03.056

    authors: Shi M,Wei Z,Wang L,Wu J,Zhang D,Wei D,Tang Y,Zhao Y

    更新日期:2018-06-01 00:00:00

  • Degradation mechanism of Ibuprofen via a forward osmosis membrane bioreactor.

    abstract::Ibuprofen (IBU) is a non-steroidal drug that is classified as a trace organic compound (TrOC). A forward osmosis membrane bioreactor (FOMBR) has traditionally been a favored technology for wastewater treatment. In this study, the IBU degradation mechanism was clarified using an FOMBR. The results indicated that the av...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2020.124448

    authors: Yao M,Duan L,Song Y,Hermanowicz SW

    更新日期:2021-02-01 00:00:00

  • The adsorption behavior and mechanism investigation of Pb(II) removal by flocculation using microbial flocculant GA1.

    abstract::In this work, microbial flocculant GA1 (MBFGA1) was used to remove Pb(II) ions from aqueous solution. A series of experimental parameters including initial pH, MBFGA1 dose, temperature and initial calcium ions concentration on Pb(II) uptake was evaluated. Meanwhile, the flocculation mechanism of MBFGA1 was investigate...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2013.09.011

    authors: Feng J,Yang Z,Zeng G,Huang J,Xu H,Zhang Y,Wei S,Wang L

    更新日期:2013-11-01 00:00:00

  • Activated carbon prepared from biomass as adsorbent: elimination of Ni(II) from aqueous solution.

    abstract::Activated carbon (AC) prepared from waste Parthenium was used to eliminate Ni(lI) from aqueous solution by adsorption. Batch mode adsorption experiments are carried out, by varying contact time, metal ion concentration, carbon concentration, pH and desorption to assess kinetic and equilibrium parameters. They allowed ...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/s0960-8524(01)00093-1

    authors: Kadirvelu K,Senthilkumar P,Thamaraiselvi K,Subburam V

    更新日期:2002-01-01 00:00:00

  • Agro-industrial residues as low-price feedstock for diesel-like fuel production by thermal cracking.

    abstract::Pyrolysis of industrial fatty wastes (soybean soapstock, beef tallow, and poultry industry waste) was carried out in the absence of catalysts. In all cases, organic mixtures of hydrocarbons and oxygenated compounds were obtained. These mixtures were distilled and diesel-like fractions were isolated and characterized b...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2010.02.100

    authors: Santos AL,Martins DU,Iha OK,Ribeiro RA,Quirino RL,Suarez PA

    更新日期:2010-08-01 00:00:00

  • Synergistic effect of up-flow constructed wetland and microbial fuel cell for simultaneous wastewater treatment and energy recovery.

    abstract::This study demonstrated a successful operation of up-flow constructed wetland-microbial fuel cell (UFCW-MFC) in wastewater treatment and energy recovery. The goals of this study were to investigate the effect of circuit connection, organic loading rates, and electrode spacing on the performance of wastewater treatment...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2015.12.011

    authors: Oon YL,Ong SA,Ho LN,Wong YS,Dahalan FA,Oon YS,Lehl HK,Thung WE

    更新日期:2016-03-01 00:00:00

  • Effect of organic carbon and nutrient supplementation on the digestate-grown microalga, Parachlorella kessleri.

    abstract::Digested effluents are usually deprived of the appropriate levels of organic carbon or macro- and micro-nutrients to effectively sustain microalgal growth. In this regard, Parachlorella kessleri was cultivated in an agro-waste digestate supplemented with different glucose concentrations, magnesium and trace metals and...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2019.122232

    authors: Koutra E,Kopsahelis A,Maltezou M,Grammatikopoulos G,Kornaros M

    更新日期:2019-12-01 00:00:00

  • The effects of temperature and color value on hydrochars' properties in hydrothermal carbonization.

    abstract::In order to investigate the influence of hydrothermal carbonization (HTC) on the properties of the hydrochars, sawdust with a particle size below 0.45mm was treated in an autoclave at 200-260°C. The physical and chemical characteristics of products were studied, including proximate analysis, elemental composition, fib...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2017.10.046

    authors: Li H,Wang S,Yuan X,Xi Y,Huang Z,Tan M,Li C

    更新日期:2018-02-01 00:00:00

  • Biological removal of nitrogen oxides by microalgae, a promising strategy from nitrogen oxides to protein production.

    abstract::Nitrogen oxides (NOx) are the components of fossil flue gases that give rise to serious environmental and health hazards. Among the available techniques for NOx removal, microalgae-based biological removal of NOx (BioDeNOx) is a promising and competent technology with eco-friendly path of low energy and low-cost solut...

    journal_title:Bioresource technology

    pub_type: 杂志文章,评审

    doi:10.1016/j.biortech.2019.122037

    authors: Qie F,Zhu J,Rong J,Zong B

    更新日期:2019-11-01 00:00:00

  • Evaluation of different water-washing treatments effects on wheat straw combustion properties.

    abstract::A series of experiments was conducted to explore the effects of various water-washing solid-liquid ratios (1:50 and 1:10) and the stirring on wheat straw (WS) combustion properties. Comparing different solid-liquid ratio groups, a 16% increment in the higher heating value was obtained for 1:50 groups and only 5% for 1...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2017.09.052

    authors: Ma Q,Han L,Huang G

    更新日期:2017-12-01 00:00:00

  • Stability of autotrophic nitrogen removal system under four non-steady operations.

    abstract::Stable nitrogen removal from the digester supernatant for sludge via the nitritation-anammox process under steady operations of ammonium concentration and flow rate has been often reported. In this study, the effects of four non-steady operations, intentional fluctuations of influent concentration from 890 to 650 mg-N...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2013.03.130

    authors: Kimura Y,Itokawa H,Noto K,Murakami T,Isaka K

    更新日期:2013-06-01 00:00:00

  • Anaerobic digestion of hydrothermally-pretreated lignocellulosic biomass: Influence of pretreatment temperatures, inhibitors and soluble organics on methane yield.

    abstract::Anaerobic digestion (AD) of lignocellulosic biomass has received significant attention for bioenergy production in recent years. However, hydrolysis is a rate-limiting in AD of such feedstock. In this study, effects of hydrothermal pretreatment of Napier grass, a model lignocellulosic biomass, on methane yield were ex...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2019.03.114

    authors: Phuttaro C,Sawatdeenarunat C,Surendra KC,Boonsawang P,Chaiprapat S,Khanal SK

    更新日期:2019-07-01 00:00:00

  • High-rate partial nitrification treatment of reject water as a pretreatment for anaerobic ammonium oxidation (anammox).

    abstract::In this study, a lab-scale swim-bed partial nitrification reactor was developed to treat ammonium-rich reject water to achieve an appropriate NO(2)(-)-N/NH(4)(+)-N mixture that could serve as a pretreatment for anaerobic ammonium oxidation (anammox). Strictly controlling the DO concentration was adopted as the main op...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2010.12.008

    authors: Zhang L,Yang J,Hira D,Fujii T,Furukawa K

    更新日期:2011-02-01 00:00:00

  • A study in the adsorption of Fe(2+) and NO(3)(-) on pine needles based hydrogels.

    abstract::Novel supports for use as cation and anion adsorbents were prepared from lignocellulosics using pine needles and their carboxymethylated forms by network/hydrogel formation with acrylamide and N,N-methylene bisacrylamide. The hydrogels thus prepared were further functionalized by partial alkaline hydrolysis with 0.5 N...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2007.11.044

    authors: Chauhan GS,Chauhan S,Kumar S,Kumari A

    更新日期:2008-09-01 00:00:00

  • Self-powered denitration of landfill leachate through ammonia/nitrate coupled redox fuel cell reactor.

    abstract::In order to explore the feasibility of energy-free denitrifying N-rich wastewater, a self-powered device was uniquely assembled, in which ammonia/nitrate coupled redox fuel cell (CRFC) reactor was served as removing nitrogen and harvesting electric energy simultaneously. Ammonia is oxidized at anodic compartment and n...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2015.12.009

    authors: Zhang H,Xu W,Feng D,Liu Z,Wu Z

    更新日期:2016-03-01 00:00:00

  • Vermicomposting of citronella bagasse and paper mill sludge mixture employing Eisenia fetida.

    abstract::The vermicomposting potential of Eisenia fetida on citronella bagasse and paper mill sludge mixture was studied. The experiment was carried out in pots by taking a mixture of citronella bagasse and paper mill sludge in 3:2 ratios. The physico-chemical properties such as pH, conductivity, total organic carbon, nitrogen...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2019.122147

    authors: Boruah T,Barman A,Kalita P,Lahkar J,Deka H

    更新日期:2019-12-01 00:00:00

  • Improved fucoxanthin and docosahexaenoic acid productivities of a sorted self-settling Tisochrysis lutea phenotype at pilot scale.

    abstract::This work aimed to select a Tisochrysis lutea phenotype with higher biomass and fucoxanthin productivities using fluorescence-activated cell sorting (FACS). A novel phenotype was obtained after 2 rounds of selection, based on high-fucoxanthin fluorescence. The resulting phenotype forms cell aggregates, has no flagella...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2021.124725

    authors: Gao F,Sá M,Cabanelas ITD,Wijffels RH,Barbosa MJ

    更新日期:2021-01-18 00:00:00

  • End-of-life of starch-polyvinyl alcohol biopolymers.

    abstract::This study presents a life cycle assessment (LCA) model comparing the waste management options for starch-polyvinyl alcohol (PVOH) biopolymers including landfill, anaerobic digestion (AD), industrial composting and home composting. The ranking of biological treatment routes for starch-PVOH biopolymer wastes depended o...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2012.09.093

    authors: Guo M,Stuckey DC,Murphy RJ

    更新日期:2013-01-01 00:00:00

  • Enhancement in xylonate production from hemicellulose pre-hydrolysate by powdered activated carbon treatment.

    abstract::Xylonic acid can be produced with high-yield from hemicelullosic xylose, which accounts for 25% of the total sugars in lignocellulosic material. The key barrier associated with efficient bio-oxidation of hemicellulosic xylose to xylonic acid is the serious foam formed in downstream air-aerated and agitated bioreaction...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2020.123944

    authors: Dai L,Jiang W,Zhou X,Xu Y

    更新日期:2020-11-01 00:00:00

  • A two-step process for efficient enzymatic saccharification of rice straw.

    abstract::Response surface methodology was used to optimise a two-step process of cellulase mediated saccharification of rice straw by an isolated bacterium Lysinibacillus sphaericus. CMC concentration, yeast extract, pH and incubation temperature were optimised for cellulase production using a central composite design and thei...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2014.09.101

    authors: Gupta P,Parkhey P

    更新日期:2014-12-01 00:00:00

  • Acceleration of azo dye decolorization by using quinone reductase activity of azoreductase and quinone redox mediator.

    abstract::This study demonstrated the effective application of intracellular azoreductase in mediated decolorization of azo dyes. Using the quinone reductase activity of overexpressed azoreductase AZR and quinone redox mediators, the decolorization performance of the recombinant strain Escherichia coli YB was significantly enha...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2008.12.040

    authors: Liu G,Zhou J,Wang J,Zhou M,Lu H,Jin R

    更新日期:2009-06-01 00:00:00

  • An integrated aerobic-anaerobic strategy for performance enhancement of Pseudomonas aeruginosa-inoculated microbial fuel cell.

    abstract::Microbial fuel cell (MFC) is a promising device for energy generation and organic waste treatment simultaneously by electrochemically active bacteria (EAB). In this study, an integrated aerobic-anaerobic strategy was developed to improve the performance of P. aeruginosa-inoculated MFC. With an aerobic start-up and fol...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2017.06.050

    authors: Yong XY,Yan ZY,Shen HB,Zhou J,Wu XY,Zhang LJ,Zheng T,Jiang M,Wei P,Jia HH,Yong YC

    更新日期:2017-10-01 00:00:00

  • Epoxidation of cottonseed oil by aqueous hydrogen peroxide catalysed by liquid inorganic acids.

    abstract::The kinetics of epoxidation of cottonseed oil by peroxyacetic acid generated in situ from hydrogen peroxide and glacial acetic acid in the presence of liquid inorganic acid catalysts were studied. It was possible to obtain up to 78% relative conversion to oxirane with very less oxirane cleavage by in situ technique. T...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2007.07.015

    authors: Dinda S,Patwardhan AV,Goud VV,Pradhan NC

    更新日期:2008-06-01 00:00:00

  • Direct ethanol production from cellulosic materials by the hypersaline-tolerant white-rot fungus Phlebia sp. MG-60.

    abstract::White-rot fungus Phlebia sp. MG-60 was identified as a good producer of ethanol from several cellulosic materials containing lignin. When this fungus was cultured with 20 g/L unbleached hardwood kraft pulp (UHKP), 8.4 g/L ethanol was produced after 168 h of incubation giving yields of ethanol of 0.42 g/g UHKP, 71.8% o...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2012.02.109

    authors: Kamei I,Hirota Y,Mori T,Hirai H,Meguro S,Kondo R

    更新日期:2012-05-01 00:00:00

  • The use of waste biomass of Sargassum sp. for the biosorption of copper from simulated semiconductor effluents.

    abstract::Seaweed Sargassum sp. biomass proved to be useful for the recovery of ionic copper from highly concentrated solutions simulating effluents from semiconductor production. In the case of solutions containing copper in the form of chloride, sulphate and nitrate salts, the best pH for the recovery of copper was 4.5. It wa...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2004.11.009

    authors: Padilha FP,de França FP,da Costa AC

    更新日期:2005-09-01 00:00:00

  • Thermostability, pH stability and dye degrading activity of a bacterial laccase are enhanced in the presence of Cu2O nanoparticles.

    abstract::The present study relates to a nanotechnology enabled method in which purified laccase from Escherichia coli AKL2 was supplemented with 100 μM copper oxide nanoparticles (Cu(2)O) (NP-laccase). The activity, half life and stability of NP-laccase were enhanced by 4, 42 and 36-fold respectively at high temperature (80 °C...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2012.09.087

    authors: Mukhopadhyay A,Dasgupta AK,Chakrabarti K

    更新日期:2013-01-01 00:00:00

  • Response of microbial community structure to pre-acclimation strategies in microbial fuel cells for domestic wastewater treatment.

    abstract::Microbial community structures and performance of air-cathode microbial fuel cells (MFCs) inoculated with activated sludge from domestic wastewater were investigated to evaluate the effects of three substrate pre-acclimation strategies: 1, serial pre-acclimation with acetate and glucose before supplying domestic waste...

    journal_title:Bioresource technology

    pub_type: 杂志文章

    doi:10.1016/j.biortech.2017.02.101

    authors: Park Y,Cho H,Yu J,Min B,Kim HS,Kim BG,Lee T

    更新日期:2017-06-01 00:00:00