Abstract:
:Chronic rhinosinusitis (CRS) is a prevalent condition that is heterogeneous in disease characteristics and multifactorial in cause. Although sinonasal mucosal inflammation in CRS is often either reversible or well-managed medically and surgically, a significant proportion of patients has a refractory form of CRS despite maximal therapy. Two of the several described factors thought to contribute to disease recalcitrance are genetic influences and dysfunction of the host immune system. Current evidence for a genetic basis of CRS is reviewed, as it pertains to putative abnormalities in innate and adaptive immune function. The role of systemic immunodeficiencies in refractory CRS is discussed.
journal_name
Otolaryngol Clin North Amjournal_title
Otolaryngologic clinics of North Americaauthors
Halderman A,Lane APdoi
10.1016/j.otc.2016.08.009subject
Has Abstractpub_date
2017-02-01 00:00:00pages
13-28issue
1eissn
0030-6665issn
1557-8259pii
S0030-6665(16)30167-0journal_volume
50pub_type
杂志文章,评审abstract::Various routes of immunotherapy (injection, intranasal, oral) using lyophilized, aqueous, glycerinated, and modified allergenic extracts have all produced blocking antibodies and symptomatic improvement. No single, empirical predetermined maintenance or optimal dose of allergenic extract right for every patient, can b...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1992-02-01 00:00:00
abstract::Mestizo noses have mesorrhine nasal characteristics. They have a modest osteocartilaginous framework, nasal tips that tend to be bulbous with poor projection and rotation, and skins that tend to be thick and acne prone. A structural rhinoplasty approach is performed, focusing on anatomic findings. Conservative tissue ...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2019.12.008
更新日期:2020-04-01 00:00:00
abstract::Serous otitis media is the most common health problem in children receiving nonsurgical and surgical medical treatment. Spontaneous remission frequently occurs, thus an expectant wait-and-see approach is initially appropriate. ...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract::This article details clinical reports and studies of ototoxicity associated with the administration of erythromycin and its analogues. Suspected mechanisms of ototoxicity also are discussed. Ototoxicity due to erythromycin appears to be clearly dose related. ...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1993-10-01 00:00:00
abstract::The management of major airway collapse in the pediatric age group has evolved and continues to evolve over time. Tracheobronchomalacia, either primary or secondary, is still the most frequent cause of major airway collapse. This article reviews tracheobronchomalacia and discusses several treatment options; from tradi...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0030-6665(05)70213-9
更新日期:2000-02-01 00:00:00
abstract::The authors review problems associated with prolonged intubation. Laryngeal stenosis and injuries caused by the endotracheal tube itself are described. Postintubation laryngotracheal pathology, including signs and symptoms and the management of specific lesions, is described in detail. Other injuries associated with p...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:
更新日期:1990-12-01 00:00:00
abstract::This article presents the anatomy and physiology of the balance system focusing on the daily use of the system in normal individuals to accomplish the major goals of the system. These goals include perceptions of movement and orientation, control of eye movements for clear visualization of the world, and control of up...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0030-6665(05)70220-6
更新日期:2000-06-01 00:00:00
abstract::The actinic keratotic lesion appearing on the sun-exposed skin of the middle-aged and elderly is a common premalignant lesion that infrequently becomes squamous cell carcinoma. Generally, superficially destructive measures provide adequate therapy for this epidermal dysplastic growth. Because of the rare threat of squ...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Information on the genetic basis of and testing for disorders with hearing loss is increasing rapidly. In this review, the authors explain genetic terminology, the principles of inheritance, and the types of genetic variation and the genetic basis of selected disorders of hearing loss. The authors also review how info...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2011.08.015
更新日期:2012-02-01 00:00:00
abstract::Noninflammatory, non-neoplastic diseases comprise a diverse group of disorders that can present in a variety of ways. In general, a careful history will sharply focus the diagnostic possibilities. Although the diagnosis usually will be certain following the physical examination, additional testing may be needed to fac...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0030-6665(05)70176-6
更新日期:1999-10-01 00:00:00
abstract::Oral mucous membranes and the surrounding structures are largely composed of stratified squamous epithelium that is supported by a fibrous connective tissue lamina propria and a submucosa of fibroadipose tissue. Minor salivary glands, nerves, and capillaries course abundantly throughout the supporting collagen and fib...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2005.11.002
更新日期:2006-04-01 00:00:00
abstract::Lymphatic malformations (LMs) occur in 2.8 to 5 per 100,000 live births. Most involve the head and neck and they are equally common in men and women. They are developmental anomalies of unknown cause, although recent evidence suggests that an upregulation of the mammalian target of rapamycin (mTOR) pathway may be a ca...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2017.09.012
更新日期:2018-02-01 00:00:00
abstract::Cochlear implantation and cochlear implants (CIs) have a long history filled with innovations that have resulted in the high-performing device's currently available. Several promising technologies have been reviewed in this article, which hold the promise to drive performance even higher. Remote CI programming, totall...
journal_title:Otolaryngologic clinics of North America
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.otc.2015.07.009
更新日期:2015-12-01 00:00:00
abstract::The saddle nose and short nose deformities are challenging surgical problems characterized by significant architectural deficiencies of the nasal framework. These defects produce cosmetic and functional nasal problems. Reconstructive techniques and augmentation materials are reviewed. Case examples illustrate the auth...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章
doi:10.1016/s0030-6665(05)70117-1
更新日期:1999-02-01 00:00:00
abstract::Balloon catheter dilation (BCD) is a treatment paradigm for surgical management of paranasal sinus inflammatory disease. There are few robust clinical trials evaluating the efficacy of balloon technology in chronic rhinosinusitis (CRS). The available database largely comprises retrospective, uncontrolled studies with ...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2012.06.005
更新日期:2012-10-01 00:00:00
abstract::The field of skull base surgery has expanded dramatically the surgical horizons in the treatment of skull base neoplasms, which, previously, were considered inoperable because of their locations and relation to vital structures. This article aims to offer improved understanding of surgical indications and appreciation...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0030-6665(05)70373-x
更新日期:2001-12-01 00:00:00
abstract::Nasal obstruction is one of the most common problems seen by pediatric otolaryngologists. Prompt treatment of nasal obstruction can be critical in newborns and infants because of their obligatory nasal breathing. Older children will typically have more inflammatory, infectious, or traumatic causes of nasal obstruction...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2018.05.005
更新日期:2018-10-01 00:00:00
abstract::After a nearly a century of development, augmentation of laryngeal tissue through injection remains as complex a procedure as it was in the earlier part of the century. Initially, the number of surgeons performing injection laryngoplasty was limited since the technique of injection was thought to be difficult and the ...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2003.12.002
更新日期:2004-02-01 00:00:00
abstract::Endoscopic endonasal skull base surgical techniques, initially developed in adult patients, are being utilized with increasing frequency in pediatric patients to treat sinonasal and skull base lesions. This article reviews the current state of endoscopic endonasal approaches to the skull base to both treat disease and...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2014.09.007
更新日期:2015-02-01 00:00:00
abstract::The use of minimally invasive and endoscopic thyroidectomy techniques has become widespread. However, these procedures all result in a visible neck incision. Several remote access thyroidectomy approaches that place the necessary incision in inconspicuous, noncervical locations have recently been described. Robotic fa...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2014.02.001
更新日期:2014-06-01 00:00:00
abstract::Allergic rhinitis (AR) is a global disease affecting hundreds of millions internationally. Substantial pharmacologic gains have been made in the treatment of allergy, including antihistamines, steroids, and leukotriene inhibitors. Pharmacology and immunotherapy are the 2 primary choices in an otolaryngologist's armame...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2012.12.005
更新日期:2013-06-01 00:00:00
abstract::Meniere's disease can be observed uniquely in revisions of the conservative surgical procedure for endolymphatic sac enhancement, which preserves the labyrinth, unlike destructive procedures. Genetic anatomic abnormalities in patients lead to malabsorption of endolymph and symptoms of Meniere's that are reversed by en...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2006.03.001
更新日期:2006-08-01 00:00:00
abstract::Despite recent, major steps forward in our understanding of tinnitus pathophysiology and improved research methodology, tinnitus remains a clear unmet clinical need. Here, the authors identify current active clinical and preclinical development programs of tinnitus drug candidates using publications, databases, and co...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2020.03.012
更新日期:2020-08-01 00:00:00
abstract::This article summarizes available evidence on various management options for vestibular schwannoma as they relate to the decision-making strategies used in selection. After a brief consideration of individual options, the literature directly comparing two or more management options is examined, noting the level of evi...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2012.01.001
更新日期:2012-04-01 00:00:00
abstract::Surgical navigation technology provides real-time intraoperative localization of surgical instruments within the field. These systems are highly accurate, assist with preoperative planning, and improve surgeon confidence. The industry has recently responded to the growing trend of treatment in ambulatory surgical cent...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章
doi:10.1016/j.otc.2009.07.004
更新日期:2009-10-01 00:00:00
abstract::The transnasal endoscopic resection of ventral skull base lesions represents a safe and effective method for the surgical management of sinonasal and ventral skull base malignancies in carefully selected cases. The goal of surgery is complete removal of all tumor with negative resection margins while maintaining the k...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2016.12.005
更新日期:2017-04-01 00:00:00
abstract::The historical context for quality improvement is provided. Important differences are described between the two overarching types of databases: clinical registries and administrative databases. The pros and cons of each are provided as are examples of their utilization in otolaryngology-head and neck surgery. ...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2018.08.004
更新日期:2019-02-01 00:00:00
abstract::The main issue in the management of glottic squamous cell carcinoma, as for all cancers, is adequate disease control while optimizing functional outcomes and minimizing morbidity. This is true for early-stage disease as for advanced tumors. This article evaluates the current evidence for the diagnostic and pretherapeu...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2012.06.014
更新日期:2012-10-01 00:00:00
abstract::Specific deficits that may be encountered as well as interventional strategies and evidence-based practice are discussed. When discussing the voice, it is important to consider that for many people the voice is not just a tool for communication, but also an identifying feature that allows expression of personality. Ea...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/j.otc.2008.01.018
更新日期:2008-08-01 00:00:00
abstract::This article reviews the evolution of the author's stapedectomy technique from total footplate removal with single loop wire prosthesis and Gelfoam seal to small fenestra stapedectomy with platinum ribbon piston prosthesis and blood seal. The author concludes that the microdrill is effective, safe, and cost effective ...
journal_title:Otolaryngologic clinics of North America
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00