Abstract：
:Chronic rhinosinusitis (CRS) is a prevalent condition that is heterogeneous in disease characteristics and multifactorial in cause. Although sinonasal mucosal inflammation in CRS is often either reversible or well-managed medically and surgically, a significant proportion of patients has a refractory form of CRS despite maximal therapy. Two of the several described factors thought to contribute to disease recalcitrance are genetic influences and dysfunction of the host immune system. Current evidence for a genetic basis of CRS is reviewed, as it pertains to putative abnormalities in innate and adaptive immune function. The role of systemic immunodeficiencies in refractory CRS is discussed.
journal_name
Otolaryngol Clin North Amjournal_title
Otolaryngologic clinics of North Americaauthors
Halderman A,Lane APdoi
10.1016/j.otc.2016.08.009subject
Has Abstractpub_date
2017-02-01 00:00:00pages
13-28issue
1eissn
0030-6665issn
1557-8259pii
S0030-6665(16)30167-0journal_volume
50pub_type
杂志文章,评审abstract：:Today interest and enthusiasm regarding facial plastic surgery is burgeoning. Office surgery provides a new, more expedient, comfortable method of delivery of health care while directly responding to the growing concern among the public and government for improved cost containment of medical services. Awareness of imp...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:Diet hypersensitivity may be "allergic," that is, caused by some form of immunologic reaction, or nonallergic. The latter includes chemical pharmacologic, enzymatic, or dietary disorders. Food allergies may be immediate Gell and Coombs type I reactions (5%), or delayed "serum sickness" type reactions (95%). The latter...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1992-02-01 00:00:00
abstract：:The endoscope has transformed the way we observe, understand, and treat chronic ear disease. Improved view, exclusive transcanal techniques, assessment of ventilation routes and mastoid tissue preservation have led to decreased morbidity and functional enhancement of minimally invasive reconstruction of the middle ear...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2016.05.016
更新日期：2016-10-01 00:00:00
abstract：:Endolymphatic sac tumors (ELST) are slow-growing, locally aggressive, low-grade malignancies that originate from the epithelium of the endolymphatic duct and sac. ELST often present with sensorineural hearing loss, tinnitus, and vertigo, which may mimic Meniere disease. Large tumors may present with additional cranial...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2014.12.006
更新日期：2015-04-01 00:00:00
abstract：:This article is a comprehensive overview of tympanic membrane injury and its healing. Its wound healing process is unique from soft tissue because epithelialization occurs before fibrous tissue advancement. Contemporary and future modalities to improve tympanic membrane repair are also discussed in this article. ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：:Petroclival meningiomas are most commonly found in women around 50 years of age and have the general tendency to grow and affect several cranial nerves. At presentation, many patients complain of headaches, gait disturbances and cranial neuropathies. Treatment options include surgery, with a variety of surgical approa...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2015.02.007
更新日期：2015-06-01 00:00:00
abstract：:An overview of the use of rigid internal fixation using the AO method for the repair of complex mandibular injuries is presented. The end result of such an approach is the return of the patient as rapidly as possible to his or her normal status with return to normal alimentation, normal mobility of the mandible, norma...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：:Endoscopic pituitary surgery has been gaining wide acceptance as the first-line treatment of most functional pituitary adenomas. This technique has many advantages over traditional procedures, and growing evidence supports its use for endocrine control of functioning tumors. This article reviews data on the different ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2011.06.019
更新日期：2011-08-01 00:00:00
abstract：:Advances in prenatal imaging in the last 20 years have enabled prenatal diagnosis of obstructive head and neck masses. These advances, coupled with improvements in maternal-fetal anesthesia, have made possible the development of the ex utero intrapartum treatment (EXIT) procedure for management of obstructive head and...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2014.09.013
更新日期：2015-02-01 00:00:00
abstract：:Neurotologic and skull base surgery involves working around important neurovascular and neurotologic structures and can incur unwarranted complications. Knowledge of surgical anatomy, good preoperative planning, intraoperative monitoring, and excellent microsurgical technique contribute to minimizing and avoiding comp...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2007.03.008
更新日期：2007-06-01 00:00:00
abstract：:Blunt, penetrating trauma to the ear, nose, and throat, and related structures are striking. Injuries may range from simple soft tissue wounds to complex injuries of the face, neck, and brain. Proximity of the cervical spine and airway complicate anesthetic management. A multidisciplinary approach is required. Airway ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2019.08.004
更新日期：2019-12-01 00:00:00
abstract：:The field of skull base surgery has expanded dramatically the surgical horizons in the treatment of skull base neoplasms, which, previously, were considered inoperable because of their locations and relation to vital structures. This article aims to offer improved understanding of surgical indications and appreciation...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0030-6665(05)70373-x
更新日期：2001-12-01 00:00:00
abstract：:Fanconi anemia (FA) is a rare disorder inherited in an autosomal recessive fashion, with an estimated incidence of 1:360,000 births. Although hematologic complications are the most common manifestation of this disease, cancers, especially of the head and neck, are also prominent. The chromosomal fragility of patients ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2013.04.002
更新日期：2013-08-01 00:00:00
abstract：:An update regarding the selective application of CT scanning in acute laryngeal trauma is presented for a period encompassing 9 years. A study group of 16 patients from a larger population of 52 patients was identified as having undergone CT scanning as part of their clinical management. A rationale is presented for t...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:For early-stage T1-T2 glottic squamous cell carcinoma, transoral laser microsurgery (TLM) is the main surgical modality, with rates of local control and laryngeal preservation ranging from 85% to 100% and low morbidity. For extensive lesions, open conservation laryngeal surgery may enable wider resections than TLM but...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2015.04.007
更新日期：2015-08-01 00:00:00
abstract：:Advances in management of adult skull base pathologies are increasingly being applied in children. Pediatric patients present special challenges because of their smaller anatomy, but potential gains in reduced morbidity make improvements in skull base approaches well worth pursuing. ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2005.03.001
更新日期：2005-08-01 00:00:00
abstract：:The lacrimal drainage system is a very important functional and anatomic assembly in the orbit and midface. For surgeons who intend to become involved in its repair or reconstruction, it is mandatory to understand the full range of anatomic, physiologic, and diagnostic considerations prior to embarking upon a surgical...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1988-02-01 00:00:00
abstract：:With increases in survivorship for patients with head and neck cancer, attention is turning to quality-of-life issues for survivors. Care for these patients is multifaceted. Dysphagia and issues of voice/speech, airway obstruction, neck and shoulder dysfunction, lymphedema, and pain control are important to address. R...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2017.04.004
更新日期：2017-08-01 00:00:00
abstract：:Reconstruction of craniomaxillofacial defects caused by injury, tumor ablation, or congenital deformities can be accomplished by a variety of methods. Nonvascularized (free), vascularized (pedicled), and revascularized (microvascular) bone grafts have been employed for osseous restoration of the upper, mid, and lower ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1994-10-01 00:00:00
abstract：:The authors review problems associated with prolonged intubation. Laryngeal stenosis and injuries caused by the endotracheal tube itself are described. Postintubation laryngotracheal pathology, including signs and symptoms and the management of specific lesions, is described in detail. Other injuries associated with p...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1990-12-01 00:00:00
abstract：:Congenital choanal atresia is a challenging clinical problem requiring prompt diagnosis and intervention. The method of repair is controversial, with no technique having gained universal acceptance. Proponents of the transnasal repair must acknowledge the variability of results, especially with thick bony plates, and ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-01 00:00:00
abstract：:Neoplasms of the nasopharynx are rare in children, but they threaten the child's life when they do occur. The nasopharynx tends to harbor dysontogenetic neoplasms. After classification into benign and malignant groups, nasopharyngeal neoplasms in children can be further characterized according to the age of the patien...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：
更新日期：1977-02-01 00:00:00
abstract：:This article presents a summary of the current simulation training for otologic skills. There is a wide variety of educational approaches, assessment tools, and simulators in use, including simple low-cost task trainers to complex computer-based virtual reality systems. A systematic approach to otologic skills trainin...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2017.05.005
更新日期：2017-10-01 00:00:00
abstract：:The nasal septum is a structure poorly understood and appreciated by the lay public and the nonotolaryngologist--head and neck surgeon alike. Deviation of the caudal portion of the nasal septum may result in nasal obstruction, a crooked nose, and columellar irregularities. The correction of a severely deviated caudal ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2009.03.005
更新日期：2009-06-01 00:00:00
abstract：UNLABELLED:1. Do not create an emergency obstruction unless you are prepared to handle it. (It may be best to do nothing until the diagnosis is clear.) 2. Support the patient with oxygen, humidity, and positioning and monitor vital signs. 3. Take as brief, concise, and accurate a history as possible. 4. Determine the a...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:Thorough evaluation of a patient presenting with nasal obstruction, including nasal endoscopy and a CT scan when indicated, is recommended to guide proper diagnosis and treatment. The rhinoplasty surgeon should be aware of the differential diagnosis of nasal obstruction and should proceed with thorough evaluation or r...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章
doi：10.1016/j.otc.2009.03.001
更新日期：2009-06-01 00:00:00
abstract：:Meniere disease is one of the most fascinating and most vexing of all clinical conditions encountered by the otolaryngologist. Operationally speaking, a Meniere ear is a fragile ear. In fact, Meniere disease can and should be redefined as a degenerating inner ear that has impairment of one or more homeostatic systems,...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2010.05.003
更新日期：2010-10-01 00:00:00
abstract：:Chronic airway obstruction usually has an insidious onset. It is often difficult to diagnose unless the patient is examined by a physician familiar with the problem and causes. Potential causes can be divided into infectious, inflammatory, traumatic, and neoplastic. Although the precise incidence of each category is u...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-08-01 00:00:00
abstract：:The historical context for quality improvement is provided. Important differences are described between the two overarching types of databases: clinical registries and administrative databases. The pros and cons of each are provided as are examples of their utilization in otolaryngology-head and neck surgery. ...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.otc.2018.08.004
更新日期：2019-02-01 00:00:00
abstract：:This article focuses on the female patient with sleep-disordered breathing. Sleep-disordered breathing has historically been considered a disease seen primarily in men, but it has become increasingly recognized in women. Recent studies of the general population suggest that almost one third of all obstructive sleep ap...
journal_title：Otolaryngologic clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/s0030-6665(02)00181-0
更新日期：2003-06-01 00:00:00
