Abstract:
:Relapses may represent a critical hazard in schizophrenia spectrum disorders as they are associated with an increased risk of a clinical and functional deterioration. Preventing relapse after recovering from a first psychotic episode has become a major challenge due to its critical impact on lifelong functionality. This study explored the rate of first and second relapses and the predictors associated with these relapses in a large cohort of non-affective psychosis patients during a period of 3 years after the first break of the illness. From February 2001 to May 2014, sociodemographic and clinical data from an epidemiological cohort of 341 non-affective first-episode psychosis patients at risk of relapse were analysed at a specialized early intervention service. Logistic regression, Cox regression, and Kaplan-Meier survival analyses were performed to compare non-relapsed and relapsed patients. One hundred and sixty-six (48.7%) individuals relapsed at least once. Median time to relapse was 17.0 months in non-adherent patients and 40.0 months in adherent patients (log-rankχ 2: 51.36; p < 0.001). Non-adherence to medication (odds ratio-OR 2.979; p < 0.001), schizophrenia diagnosis (OR 2.173; p = 0.002), and age of onset (OR 1.020; p = 0.033) were the main predictors of the first relapse. Fifty-six subjects experienced a second relapse (33.73%) predicted by diagnosis (OR 1.975; p = 0.074), age of onset (OR 1.078; p = 0.003), and positive symptoms (OR 0.863; p = 0.03), but not adherence. Non-adherence is the main predictive factor of first relapse after a first episode of psychosis. Second relapses were not often and not related to modifiable factors, suggesting that multiple relapsed patients may comprise a subgroup with a higher biological risk.
journal_name
Eur Arch Psychiatry Clin Neurosciauthors
Pelayo-Terán JM,Gajardo Galán VG,de la Ortiz-García de la Foz V,Martínez-García O,Tabarés-Seisdedos R,Crespo-Facorro B,Ayesa-Arriola Rdoi
10.1007/s00406-016-0740-3subject
Has Abstractpub_date
2017-06-01 00:00:00pages
315-323issue
4eissn
0940-1334issn
1433-8491pii
10.1007/s00406-016-0740-3journal_volume
267pub_type
杂志文章abstract::The National Institute on Aging-Alzheimer's Association (NIA-AA) clinical research criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) incorporate the use of biomarkers to classify patients according to the likelihood of the presence of AD pathology. The aim of the study was to compare the ris...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-012-0349-0
更新日期:2013-06-01 00:00:00
abstract::The aim of this study was to reexamine and compare the characteristics of the deficit and nondeficit schizophrenic patients. This cross-sectional study consisted of 62 in- and out-patients, 18-65 years of age, diagnosed with schizophrenia according to DSM-IV. The sociodemographic variables, premorbid adjustment, clini...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-003-0434-5
更新日期:2003-10-01 00:00:00
abstract::Although classical and atypical antipsychotics may have different neurotoxic effects, their underlying mechanisms remain to be elucidated, especially regarding neuroglial function. In the present study, we compared the atypical antipsychotic risperidone (0.01-10 μM) with the typical antipsychotic haloperidol (0.01-10 ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-009-0095-0
更新日期:2010-09-01 00:00:00
abstract::This paper reports on psychiatric case identification by the application of the Structured Clinical Interview for DSM-III-R (SCID) in a sample of 198 Greek migrants repatriated from western europe in a northwestern province of Greece. The current (1 month) prevalence of psychiatric morbidity, based on the total number...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02191542
更新日期:1995-01-01 00:00:00
abstract:AIM:This study examined the extent to which fathers' and infants' interaction behavior were related to children's externalizing behavior problems at age 8 and 11 years. METHODS:In a prospective longitudinal study of children at risk for later psychopathology, 72 fathers and their 3-month-old children were videotaped a...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-006-0642-x
更新日期:2006-09-01 00:00:00
abstract::A study was carried out involving 134 neurotic-depressive inpatients (according to ICD-9) treated with cognitive behaviour therapy and in a subgroup additionally with antidepressants. Using standardized rating instruments, a large set of potential predictor variables was tested. After cross-validation according to the...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02190390
更新日期:1993-01-01 00:00:00
abstract::The role of the brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD) remains to be elucidated. Recent post hoc analyses indicated a potential association of three polymorphisms in the BDNF gene with worse treatment outcome in patients with the subtype of melancholic depres...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,多中心研究
doi:10.1007/s00406-012-0364-1
更新日期:2013-08-01 00:00:00
abstract::Intravascular lymphomatosis (IVL), a rare type of non-Hodgkin's lymphoma, is an uncommon cause of progressive dementia, usually followed by death within a few months of onset of clinical disease. Often this aggressive tumor is only diagnosed at autopsy, because of misleading clinical features mimicking a broad spectru...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-004-0551-9
更新日期:2005-08-01 00:00:00
abstract::The transcription nuclear factor-erythroid factor 2-related factor 2 (Nrf2) plays a key role in inflammation that is involved in depression. We previously reported that Nrf2 knock-out (KO) mice exhibit depression-like phenotypes through systemic inflammation. (R)-ketamine, an enantiomer of ketamine, has rapid-acting a...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-020-01208-w
更新日期:2020-11-12 00:00:00
abstract::Studies addressing the relationship between a history of obstetric complications (OCs) and neurological abnormalities in schizophrenia have produced contradictory findings. Using a pre-posttreatment design in a neuroleptic-naive sample of psychotic patients, we examined the relationship of a history of OC to primary a...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-006-0653-7
更新日期:2006-10-01 00:00:00
abstract::Obesity is highly prevalent worldwide and results in a high disease burden. The efforts to monitor and predict treatment outcome in participants with obesity using functional magnetic resonance imaging (fMRI) depends on the reliability of the investigated task-fMRI brain activation. To date, no study has investigated ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-020-01218-8
更新日期:2020-12-17 00:00:00
abstract::The deficit syndrome is thought to be specific to and a subtype of schizophrenia; however, there are scarce or no data on the prevalence and characteristics of this syndrome in non-schizophrenic psychoses. The aim of this study was to explore the prevalence and correlates of different types of negative symptoms (NegS)...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-004-0464-7
更新日期:2004-06-01 00:00:00
abstract::The aim of this study was to estimate the prevalence and incidence of mood disorders, anxiety disorders, and stress and adjustment disorders in primary health care in Sweden and to analyse the relationship between socioeconomic and demographic factors and incidence of these disorders. Prevalence and incidence data on ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-013-0422-3
更新日期:2014-04-01 00:00:00
abstract::In a recent randomized, double-blind, placebo-controlled trial, we established a robust efficacy (Cohen's d = 2.17) of osmotic release oral system-methylphenidate (OROS-methylphenidate) delivered 72 mg daily for 5 weeks versus placebo on attention deficit hyperactivity disorder (ADHD) symptoms, global severity and glo...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00406-012-0317-8
更新日期:2012-12-01 00:00:00
abstract::Two sisters with muscular dystrophy of Becker-like clinical features presented. Muscle weakness was most prominent in the pelvic girdle, but in the elder sister the distal muscles of the lower extremities were also affected. The progression was different in the siblings: The older sister showed a more pronounced deter...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02191875
更新日期:1995-01-01 00:00:00
abstract::The aim of the study was to evaluate the relationship between social problem solving ability, clinical features and cognitive functions, and determine the predictors of benefit from social problem solving training in 63 patients with schizophrenia. We administered Brief Psychiatric Rating Scale (BPRS), Wisconsin Card ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00406-006-0651-9
更新日期:2006-09-01 00:00:00
abstract::Mental health problems do significantly impact on a person's functioning. In the past, problems with psychosocial functioning were mainly associated with the diagnoses of schizophrenia. However, nowadays it is clear that impaired psychosocial functioning is also a common phenomenon in people suffering from affective d...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-012-0335-6
更新日期:2013-03-01 00:00:00
abstract::Despite the lack of clinical data about the role of the endocannabinoid system (ECS) in affective disorders, preclinical work suggests that the ECS is relevant in both with regard to the etiology of depression as well as the mediation of antidepressant effects. We measured the intraindividual levels of the endocannabi...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-017-0789-7
更新日期:2017-12-01 00:00:00
abstract::The differential diagnosis of obsessive-compulsive disorder (OCD) and schizophrenia-spectrum disorders can be difficult. In the current diagnostic criteria, basic concepts such as obsession and delusion overlap. This study examined lifetime schizophrenia-spectrum psychopathology, including subtle schizotypal symptomat...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-019-01022-z
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Fluoxetine and its active metabolite norfluoxetine have long half-lives. We postulate that, owing to the long elimination half-life and the time to reach steady-state level in plasma is nearly four weeks, patients diagnosed with major depressive disorder might be treated with fluoxetine taken once every third...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00406-003-0445-2
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:The aims of this study are threefold: to depict characteristics of homeless at discharge from a psychiatric hospital; to describe the utilisation of inpatient care and treatment measures during hospitalisation; and to analyse to what extent psychiatric disorders and clinical variables contribute to the risk f...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-005-0616-4
更新日期:2006-04-01 00:00:00
abstract::The aim of the study was to explore whether the individual burden of ADHD is the same in the elderly as in younger ages even though the symptomatological impact of ADHD seems to remain stable over the lifespan. To assess ADHD symptoms and ADHD-associated problems in daily life, standardised questionnaires were conduct...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-015-0644-7
更新日期:2016-06-01 00:00:00
abstract::In recent studies, the glutamate (Glu) level has been quantified using the modified STEAM sequence on 3T MRI. We enrolled 15 healthy volunteers and a group of 51 patients who experienced stroke for the first time and had a good prognosis. The patients with infarction were divided into three groups according to their s...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-011-0209-3
更新日期:2012-02-01 00:00:00
abstract::Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged th...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-018-0924-0
更新日期:2018-12-01 00:00:00
abstract::Theoretical and empirical models of thought disorder (ThD) were tested through Confirmatory factor analysis (CFA). A sample of 253 DSM-III-R acute schizophrenic patients consecutively admitted was studied. A semistructured interview for schizophrenia was used for diagnosis, and ThD was assessed by means of the Thought...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 临床试验,杂志文章
doi:10.1007/s004060050066
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Risk factors, emergence and accumulation of symptoms in the untreated early course were studied as a basis for understanding the relationship between schizophrenia and depression. MATERIALS AND METHODS:130 representative first admissions for schizophrenia were compared retrospectively with 130 individually m...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-005-0584-8
更新日期:2005-06-01 00:00:00
abstract::This study concerns the validation of an instrument, the SAB2, designed to measure child behaviour and to help identify emotional problems which arise because the child has been a victim of child sexual abuse. Clinically disturbed children, mainstream school children and sexually abused youngsters were assessed. Relia...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/BF02916247
更新日期:1997-01-01 00:00:00
abstract::The Trial Criteria in Schizophrenia Working Group was convened in November 2007 to define consensus criteria for clinical trials in patients suffering from acute schizophrenia with special focus on placebo-controlled trials and withdrawal conditions. Clinical trials involving patients give rise to ethical and medico-l...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-011-0225-3
更新日期:2012-03-01 00:00:00
abstract::Cannabinoid receptors and their endogenous ligands have been detected from the earliest stages of embryonic development. The endocannabinoid system appears to play essential roles in these early stages for neuronal development and cell survival, although its detailed involvement in fundamental developmental processes ...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章,评审
doi:10.1007/s00406-009-0026-0
更新日期:2009-10-01 00:00:00
abstract::The objective of this study is to determine whether cannabis influences BDNF levels in patients with psychosis (FEP) and healthy volunteers (HV) to help understand the role of BDNF in psychosis. We assessed the association between BDNF and cannabis in a cohort of FEP antipsychotic-naïve patients and HV, whilst control...
journal_title:European archives of psychiatry and clinical neuroscience
pub_type: 杂志文章
doi:10.1007/s00406-020-01117-y
更新日期:2020-10-01 00:00:00