End Points of Sepsis Resuscitation.

Abstract:

:Resuscitation goals for the patient with sepsis and septic shock are to return the patient to a physiologic state that promotes adequate end-organ perfusion along with matching metabolic supply and demand. Ideal resuscitation end points should assess the adequacy of tissue oxygen delivery and oxygen consumption, and be quantifiable and reproducible. Despite years of research, a single resuscitation end point to assess adequacy of resuscitation has yet to be found. Thus, the clinician must rely on multiple end points to assess the patient's overall response to therapy. This review will discuss the role and limitations of central venous pressure (CVP), mean arterial pressure (MAP), and cardiac output/index as macrocirculatory resuscitation targets along with lactate, central venous oxygen saturation (ScvO2), central venous-arterial CO2 gradient, urine output, and capillary refill time as microcirculatory resuscitation endpoints in patients with sepsis.

authors

Greenwood JC,Orloski CJ

doi

10.1016/j.emc.2016.09.001

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

93-107

issue

1

eissn

0733-8627

issn

1558-0539

pii

S0733-8627(16)30071-2

journal_volume

35

pub_type

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