Abstract：
:RNA sequence motifs are not sufficient for association with RBPs. In this issue of Molecular Cell, Taliaferro et al. (2016) demonstrate that, other than sequence motif, RNA secondary structure plays a repressive role on RBP binding, both in vitro and in vivo.
journal_name
Mol Celljournal_title
Molecular cellauthors
Luo Z,Yang Q,Yang Ldoi
10.1016/j.molcel.2016.10.006subject
Has Abstractpub_date
2016-10-20 00:00:00pages
219-220issue
2eissn
1097-2765issn
1097-4164pii
S1097-2765(16)30629-3journal_volume
64pub_type
评论,杂志文章相关文献
MOLECULAR CELL文献大全abstract：:The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(00)80234-8
更新日期：1999-12-01 00:00:00
abstract：:Cellular RNAs can be chemically modified over a hundred different ways. These modifications were once thought to be static, discrete, and utilized to fine-tune RNA structure and function. However, recent studies have revealed that some modifications, like mRNA methylation, can be reversed, and these reversible modific...
journal_title：Molecular cell
pub_type： 杂志文章,评审
doi：10.1016/j.molcel.2014.09.001
更新日期：2014-10-02 00:00:00
abstract：:We have identified human MBT domain-containing protein L3MBTL2 as an integral component of a protein complex that we termed Polycomb repressive complex 1 (PRC1)-like 4 (PRC1L4), given the copresence of PcG proteins RING1, RING2, and PCGF6/MBLR. PRC1L4 also contained E2F6 and CBX3/HP1γ, known to function in transcripti...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2011.04.004
更新日期：2011-05-20 00:00:00
abstract：:Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2) has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the catalytic subunit of PRC2, has been reported as the sole histone methyltransferase that methylates H3K27 and mediates transcriptional silencing. Analysis...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2008.10.016
更新日期：2008-11-21 00:00:00
abstract：:How polycomb group proteins repress gene expression in vivo is not known. While histone-modifying activities of the polycomb repressive complexes (PRCs) have been studied extensively, in vitro data have suggested a direct activity of the PRC1 complex in compacting chromatin. Here, we investigate higher-order chromatin...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2010.02.032
更新日期：2010-05-14 00:00:00
abstract：:When faced with proteotoxic stress, cells mount adaptive responses to eliminate aberrant proteins. Adaptive responses increase the expression of protein folding and degradation factors to enhance the cellular quality control machinery. However, it is unclear whether and how this augmented machinery acquires new activi...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2018.04.027
更新日期：2018-06-21 00:00:00
abstract：:CRISPR-Cas12a (Cpf1) is an RNA-guided DNA-cutting nuclease that has been repurposed for genome editing. Upon target DNA binding, Cas12a cleaves both the target DNA in cis and non-target single-stranded DNAs (ssDNAs) in trans. To elucidate the molecular basis for both DNase cleavage modes, we performed structural and b...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2018.11.021
更新日期：2019-02-07 00:00:00
abstract：:Nine human neurodegenerative diseases are due to expansion of a CAG repeat- encoding glutamine within the open reading frame of the respective genes. Polyglutamine (polyQ) expansion confers dominant toxicity, resulting in neuronal degeneration. MicroRNAs (miRNAs) have been shown to modulate programmed cell death durin...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2006.07.030
更新日期：2006-10-06 00:00:00
abstract：:The tumor suppressor BAP1 interacts with chromatin-associated proteins and regulates cell proliferation, but its mechanism of action and regulation remain poorly defined. We show that the ubiquitin-conjugating enzyme UBE2O multi-monoubiquitinates the nuclear localization signal of BAP1, thereby inducing its cytoplasmi...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2014.03.002
更新日期：2014-05-08 00:00:00
abstract：:Melanoma and other cancers harbor oncogenic mutations in the protein kinase B-Raf, which leads to constitutive activation and dysregulation of MAP kinase signaling. In order to elucidate molecular determinants responsible for B-Raf control of cancer phenotypes, we present a method for phosphoprotein profiling, using n...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2009.03.007
更新日期：2009-04-10 00:00:00
abstract：:The stimulation of fibroblast growth factor receptors (FGFRs) with distinct FGF ligands generates specific cellular responses. However, the mechanisms underlying this paradigm have remained elusive. Here, we show that FGF-7 stimulation leads to FGFR2b degradation and, ultimately, cell proliferation, whereas FGF-10 pro...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2013.08.002
更新日期：2013-09-26 00:00:00
abstract：:In the death receptor induced apoptotic pathway, caspase-8 autocatalytically cleaves itself at specific cleavage sites. To better understand the regulatory mechanisms behind caspase-8 activation, we compared active wild-type caspase-8 (wtC8) and an uncleavable form of procaspase-8 (uncleavable C8). We demonstrate that...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(03)00059-5
更新日期：2003-02-01 00:00:00
abstract：:In this issue of Molecular Cell, Vonk et al. (2020) and Thiruvalluvan et al. (2020) identify key chaperones that confer resistance to protein aggregation in neural stem cells and become reduced upon differentiation. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2020.03.028
更新日期：2020-04-16 00:00:00
abstract：:In bacterial and archaeal CRISPR immune pathways, DNA sequences from invading bacteriophage or plasmids are integrated into CRISPR loci within the host genome, conferring immunity against subsequent infections. The ribonucleoprotein complex Cascade utilizes RNAs generated from these loci to target complementary "nonse...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2012.03.020
更新日期：2012-06-08 00:00:00
abstract：:RNA:DNA hybrids in the genome are constantly being generated as a by-product of transcription; in this issue, two papers, from Helmrich et al. (2011) and Wahba et al. (2011), provide insight into how RNA:DNA hybrids lead to genetic instability. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2011.12.003
更新日期：2011-12-23 00:00:00
abstract：:Elongation factor G (EF-G) catalyzes tRNA translocation on the ribosome. Here a cryo-EM reconstruction of the 70S*EF-G ribosomal complex at 7.3 A resolution and the crystal structure of EF-G-2*GTP, an EF-G homolog, at 2.2 A resolution are presented. EF-G-2*GTP is structurally distinct from previous EF-G structures, an...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2007.01.027
更新日期：2007-03-09 00:00:00
abstract：:Adrenergic stimulation of the heart engages cAMP and phosphoinositide second messenger signaling cascades. Cardiac phosphoinositide 3-kinase p110γ participates in these processes by sustaining β-adrenergic receptor internalization through its catalytic function and by controlling phosphodiesterase 3B (PDE3B) activity ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2011.01.030
更新日期：2011-04-08 00:00:00
abstract：:Transcriptional and posttranslational signals are known mechanisms that promote efficient responses to DNA damage. We have identified Saccharomyces cerevisiae tRNA methyltransferase 9 (Trm9) as an enzyme that prevents cell death via translational enhancement of DNA damage response proteins. Trm9 methylates the uridine...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2007.09.021
更新日期：2007-12-14 00:00:00
abstract：:Dong et al. (2017) establish how the mitochondrial Ca2+ uniporter (MCU) integrates Ca2+ and oxidative stress signals by identifying a cysteine residue that controls MCU channel activity, a mechanism causing mitochondrial Ca2+ overload and cell death during oxidative stress. ...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2017.02.029
更新日期：2017-03-16 00:00:00
abstract：:The recruitment of the TATA box-binding protein (TBP) to promoters in vivo is often rate limiting in gene expression. We present evidence that TBP negatively autoregulates its accessibility to promoter DNA in yeast through dimerization. The crystal structure of TBP dimers was used to design point mutations in the dime...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(01)80004-6
更新日期：1999-06-01 00:00:00
abstract：:Translational control is frequently exerted at the stage of mRNA recruitment to the initiating ribosome. We have reconstituted mRNA recruitment to the 43S preinitiation complex (PIC) using purified S. cerevisiae components. We show that eIF3 and the eIF4 factors not only stabilize binding of mRNA to the PIC, they also...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2010.08.021
更新日期：2010-09-24 00:00:00
abstract：:Structures of intact receptors with single-pass transmembrane domains are essential to understand how extracellular and cytoplasmic domains regulate association and signaling through transmembrane domains. A chemical and computational method to determine structures of the membrane regions of such receptors on the cell...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2009.02.022
更新日期：2009-04-24 00:00:00
abstract：:During X-inactivation, Xist RNA spreads along an entire chromosome to establish silencing. However, the mechanism and functional RNA elements involved in spreading remain undefined. By performing a comprehensive endogenous Xist deletion screen, we identify Repeat B as crucial for spreading Xist and maintaining Polycom...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2019.01.015
更新日期：2019-04-04 00:00:00
abstract：:The heat shock protein 90 (Hsp90) family of heat shock proteins is an abundantly expressed and highly conserved family of ATP-dependent molecular chaperones. Hsp90 facilitates remodeling and activation of hundreds of proteins. In this study, we developed a screen to identify Hsp90-defective mutants in E. coli. The mut...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2012.11.017
更新日期：2013-02-07 00:00:00
abstract：:Loss of endogenous tumor suppression is a critical step on the road to cancer. In a recent paper in Molecular Cell, Wang and colleagues provide evidence that inactivation of the pivotal BRCA1 tumor suppressor disrupts a safeguard gene network that opposes cell proliferation and cell survival. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章
doi：10.1016/j.molcel.2008.10.007
更新日期：2008-10-24 00:00:00
abstract：:In eukaryotes, the 20S proteasome contains two chymotrypsin-like, two trypsin-like, and two active sites shown here to have caspase-like specificity. We report that certain sites allosterically regulate each other's activities. Substrates of a chymotrypsin-like site stimulate dramatically the caspase-like activity and...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(00)80341-x
更新日期：1999-09-01 00:00:00
abstract：:Stress granules (SGs) are condensates of mRNPs that form in response to stress. SGs arise by multivalent protein-protein, protein-RNA, and RNA-RNA interactions. However, the role of RNA-RNA interactions in SG assembly remains understudied. Here, we describe a yeast SG reconstitution system that faithfully recapitulate...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2020.07.017
更新日期：2020-09-17 00:00:00
abstract：:In addition to protein-coding information, mRNAs harbor regulatory sequences necessary for appropriate processing of their precursors. Goren et al. (2006) and Wang et al. (2006) explore the diversity of these signals and the rules by which they function. ...
journal_title：Molecular cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.molcel.2006.07.003
更新日期：2006-07-21 00:00:00
abstract：:Eukaryotic transcription and mRNA processing depend upon the coordinated interactions of many proteins, including Spn1 and Spt6, which are conserved across eukaryotes, are essential for viability, and associate with each other in some of their biologically important contexts. Here we report crystal structures of the S...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/j.molcel.2010.11.014
更新日期：2010-12-10 00:00:00
abstract：:The hairpin ribozyme is a self-cleaving motif found in the negatives strand of the satellite RNA of some plant viruses. In its natural context, the ribozyme comprises four helices, two of which contain conserved formally unpaired loops, that are adjacent arms of a four-way RNA junction. We show that the arms that woul...
journal_title：Molecular cell
pub_type： 杂志文章
doi：10.1016/s1097-2765(00)80086-6
更新日期：1998-05-01 00:00:00
