Can contrast-enhanced harmonic endosonography predict malignancy risk in gastrointestinal subepithelial tumors?

Abstract:

BACKGROUND AND OBJECTIVES:Contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) is a novel technology that can identify subepithelial tumors (SETs) by detecting the degree of enhancement, but whether CEH-EUS can predict the malignancy risk of gastrointestinal stromal tumors (GISTs) remains unclear. The aim of our study was to evaluate the diagnostic accuracy of CEH-EUS and its ability to discriminate among SETs and predict the malignancy risk of GISTs. MATERIALS AND METHODS:We retrospectively included patients with suspected subepithelial lesions who underwent CEH-EUS preoperatively. Thirty-five patients with histologically proven GISTs and benign neoplasms were enrolled in the study. The images of CEH-EUS were categorized in accordance with microvasculature, parenchymal perfusion, and nonenhancing spots. The diagnostic performance of CEH-EUS was evaluated by comparing these findings with the histological diagnosis. RESULTS:When we divided the enrolled patients into high- and low-grade malignancy and benign groups, nonenhancing spots on CEH-EUS were found more frequently in the high-grade malignancy group (63.6%), followed by the low-grade malignancy (46.7%) and benign groups (25.7%) (P = 0.022). However, based on the statistical validity of the CEH-EUS findings for the discrimination of SETs, the sensitivity was 53.8% for diagnostic performance and 63.6% for prediction of malignancy risk of GISTs. CONCLUSIONS:From our study results, it is unclear whether CEH-EUS alone has a diagnostic role in the discrimination of SETs and the prediction of malignancy risk of GISTs. Further studies with larger samples from multiple centers and use of other imaging analysis modalities are needed.

journal_name

Endosc Ultrasound

journal_title

Endoscopic ultrasound

authors

Park HY,Jeon SW,Lee HS,Cho CM,Bae HI,Seo AN,Kweon OK

doi

10.4103/2303-9027.195871

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

384-389

issue

6

eissn

2303-9027

issn

2226-7190

pii

EndoscUltrasound_2016_5_6_384_195871

journal_volume

5

pub_type

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