Abstract:
:Salecan is a water-soluble bacterial polysaccharide consisting of glucopyranosyl units linked by α-1,3 and β-1,3 glycosidic bonds. salecan is suitable for the development of hydrogels for biomedical applications, given its outstanding physicochemical and biological profiles. In this study we designed a new semi-interpenetrating polymer network hydrogel that introduces the salecan polysaccharide into a stimuli-responsive poly(2-acrylamido-2-methylpropanosulfonic acid-co-[2-(methacryloxy)ethyl]trimethylammonium chloride) (PAM) hydrogel matrix for controlled insulin release. We found that salecan not only tunes the structure and pore size of the PAM hydrogels, but also endows them with adjustable water release rates. More importantly, in vitro drug loading/release assays demonstrated that insulin is efficiently loaded into the resulting hydrogels and can be released in an on-demand manner by controlling the pH and salecan dose. Furthermore, cell viability and cell adhesion experiments verified the cell compatibility of these hydrogel carriers. Together, these results make salecan-incorporated PAM hydrogels promising materials for drug delivery.
journal_name
ChemMedChemjournal_title
ChemMedChemauthors
Qi X,Li J,Wei W,Su T,Zuo G,Pan X,Zhang J,Dong Wdoi
10.1002/cmdc.201600570subject
Has Abstractpub_date
2017-01-20 00:00:00pages
120-129issue
2eissn
1860-7179issn
1860-7187journal_volume
12pub_type
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