Abstract:
:The CD4+CD25+ regulatory T cells (Tregs), an innate immunomodulator, suppress cerebral inflammation and maintain immune homeostasis in multiple central nervous system injury, but its role in intracerebral hemorrhage (ICH) has not been fully characterized. This study investigated the effect of Tregs on brain injury using the mouse ICH model, which is established by autologous blood infusion. The results showed that tail intravenous injection of Tregs significantly reduced brain water content and Evans blue dye extravasation of perihematoma at day (1, 3 and 7), and improved short- and long-term neurological deficits following ICH in mouse model. Tregs treatment reduced the content of pro-inflammatory cytokines interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and malondialdehyde, while increasing the superoxide dismutase (SOD) enzymatic activity at day (1, 3 and 7) following ICH. Furthermore, Tregs treatment obviously reduced the number of NF-κB+, IL-6+, TUNEL+ and active caspase-3+ cells at day 3 after ICH. These results indicate that adoptive transfer of Tregs may provide neuroprotection following ICH in mouse models.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Mao LL,Yuan H,Wang WW,Wang YJ,Yang MF,Sun BL,Zhang ZY,Yang XYdoi
10.1007/s10571-016-0429-1subject
Has Abstractpub_date
2017-07-01 00:00:00pages
919-929issue
5eissn
0272-4340issn
1573-6830pii
10.1007/s10571-016-0429-1journal_volume
37pub_type
杂志文章abstract::Anxiety-related disorders are complex illnesses that underlying molecular mechanisms need to be understood. Mitochondria stand as an important link between energy metabolism, oxidative stress, and anxiety. The nuclear factor, erythroid-derived 2,-like 1(Nrf1) is a member of the cap "n" collar subfamily of basic region...
journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
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journal_title:Cellular and molecular neurobiology
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