Neck muscle spindle activity in the decerebrate, unparalyzed cat: dynamics and influence of vestibular stimulation.


:1. Using floating electrodes, we recorded from neck-muscle spindle afferents in the C2 dorsal root ganglion of the decerebrate cat. Nerves to dorsal neck muscles were cut so that the afferents presumably originated mainly from ventral and ventrolateral perivertebral muscles and sternocleidomastoid. One goal of our experiments was to study possible vestibular influence exerted on these spindles via the fusimotor system. Unparalyzed preparations were therefore used. 2. Stimuli consisted of sinusoidal rotations in vertical planes. Neck tilt stretched neck muscles, whereas whole-body tilt stimulated vestibular receptors. 3. For each afferent we first determined the most effective direction of neck tilt, then used stimuli oriented close to this direction to study response dynamics, particularly gain of responses to stimuli of different amplitudes (0.5-7.5 degrees). 4. Three-quarters of the afferents failed to respond to 0.5 degrees, 0.2-Hz neck rotations. Stimuli that were effective usually elicited responses that had low gain and were linear over the whole range of amplitudes. Only a few afferents had behavior typical of spindle primary afferents: high-gain responses to small sinusoidal stimuli, gain decreasing as stimulus amplitude increases. This prevalence of static spindle responses in the unparalyzed cat is in striking contrast to results obtained on neck-muscle spindles in paralyzed, decerebrate cats, and on hindlimb extensor muscle spindles in decerebrate, unparalyzed cats. 5. Paralysis produced by injection of Flaxedil changed the behavior of 2/4 spindle afferents tested, causing the appearance of high-gain responses to 0.5 degrees stimuli and of nonlinear behavior.(ABSTRACT TRUNCATED AT 250 WORDS)


J Neurophysiol


Kasper J,Wilson VJ,Yamagata Y,Yates BJ




Has Abstract


1989-10-01 00:00:00












  • Direct physiological evidence for synaptic connectivity between medium-sized spiny neurons in rat nucleus accumbens in situ.

    abstract::Dual whole cell patch-clamp recordings in rat nucleus accumbens, the main component of the ventral striatum, were made to assess the presence of synaptic interconnections between medium-sized spiny neurons, a group of GABAergic and peptidergic neurons that constitute the principal cells of the striatum. Neurons were s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Taverna S,van Dongen YC,Groenewegen HJ,Pennartz CM

    更新日期:2004-03-01 00:00:00

  • Synaptically recruited apical currents are required to initiate axonal and apical spikes in hippocampal pyramidal cells: modulation by inhibition.

    abstract::Dendritic voltage-dependent currents and inhibition modulate the information flow between synaptic and decision areas. Subthreshold and spike currents are sequentially recruited by synaptic potentials in the apical shaft of pyramidal cells, which may also decide cell output. We studied the global role of proximal apic...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Canals S,López-Aguado L,Herreras O

    更新日期:2005-02-01 00:00:00

  • Functional properties of neurons in the primate tongue primary motor cortex during swallowing.

    abstract::Recent studies conducted in our laboratory have suggested that the tongue primary motor cortex (i.e., tongue-MI) plays a critical role in the control of voluntary tongue movements in the primate. However, the possible involvement of tongue-MI in semiautomatic tongue movements, such as those in swallowing, remains unkn...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Martin RE,Murray GM,Kemppainen P,Masuda Y,Sessle BJ

    更新日期:1997-09-01 00:00:00

  • Dorsal root reflexes and cutaneous neurogenic inflammation after intradermal injection of capsaicin in rats.

    abstract::The role of dorsal root reflexes (DRRs) in acute cutaneous neurogenic inflammation induced by intradermal injection of capsaicin (CAP) was examined in anesthetized rats. Changes in cutaneous blood flow (flare) on the plantar surface of the foot were measured using a laser Doppler flowmeter, and neurogenic edema was ex...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Lin Q,Wu J,Willis WD

    更新日期:1999-11-01 00:00:00

  • Cutaneous masking. II. Geometry of excitatory andinhibitory receptive fields of single units in somatosensory cortex of the cat.

    abstract::1. The responses of single neurons in the primary somatosensory cortex of the cat to brief air-pulse stimuli were quantitatively examined. These controlled natural stimuli activated almost exclusively rapidly adapting hair units which, on systematic movement of the stimulus through the receptive field, gave unit-respo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Laskin SE,Spencer WA

    更新日期:1979-07-01 00:00:00

  • Opposing mechanisms underlying differential changes in brain oxygen and temperature induced by intravenous morphine.

    abstract::Morphine remains widely used in clinical settings due to its potent analgesic properties. However, one of the gravest risks of all opioids is their ability to induce respiratory depression and subsequent brain hypoxia that can lead to coma and death. Due to these life-threatening effects, our goal was to examine the e...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Solis E Jr,Afzal A,Kiyatkin EA

    更新日期:2018-11-01 00:00:00

  • The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network.

    abstract::The spinal network coordinating locomotion is comprised of a core of glutamate and glycine interneurons. This network is modulated by several transmitter systems including spinal GABA interneurons. The purpose of this study is to explore the contribution of GABAergic neurons to the regulation of locomotor burst freque...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Schmitt DE,Hill RH,Grillner S

    更新日期:2004-10-01 00:00:00

  • Regulation of excitatory input to inhibitory interneurons of the dentate gyrus during hypoxia.

    abstract::The role of metabotropic glutamate receptors (mGluRs) and adenosine receptors in hypoxia-induced suppression of excitatory synaptic input to interneurons residing at the granule cell-hilus border in the dentate gyrus was investigated with the use of whole cell electrophysiological recording techniques in thin (250 mic...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Doherty J,Dingledine R

    更新日期:1997-01-01 00:00:00

  • GABA-Induced intrinsic light-scattering changes associated with voltage-sensitive dye signals in embryonic brain stem slices: coupling of depolarization and cell shrinkage.

    abstract::We have found new evidence for gamma-aminobutyric acid (GABA)-induced intrinsic optical changes associated with a voltage-sensitive dye signal in the early embryonic chick brain stem slice. The slices were prepared from 8-day-old embryos, and they were stained with a voltage-sensitive dye (NK2761). Pressure ejection o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Momose-Sato Y,Sato K,Hirota A,Kamino K

    更新日期:1998-04-01 00:00:00

  • Large gaze shift generation while standing: the role of the vestibular system.

    abstract::The functional significance of vestibular information for the generation of gaze shifts is controversial and less well established than the vestibular contribution to gaze stability. In this study, we asked seven bilaterally avestibular patients to execute voluntary, whole body pivot turns to visual targets up to 180°...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Anastasopoulos D,Ziavra N,Bronstein AM

    更新日期:2019-11-01 00:00:00

  • Responses of medullary reticulospinal neurons to sinusoidal stimulation of labyrinth receptors in decerebrate cat.

    abstract::The electrical activity of 168 individual neurons located in the medullary reticular formation, namely, in the medial aspects of the nucleus reticularis gigantocellularis, magnocellularis, and ventralis, has been recorded in precollicular decerebrate cats during sinusoidal tilt about the longitudinal axis of the whole...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Manzoni D,Pompeiano O,Stampacchia G,Srivastava UC

    更新日期:1983-11-01 00:00:00

  • Age-related alterations in the neural coding of envelope periodicities.

    abstract::This research was guided by the working hypothesis that the aging auditory system progressively loses its ability to process rapid acoustic transients efficiently, and in elderly listeners, this results in difficulties in speech perception. Neural correlates of age-related deficits in temporal processing were investig...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Walton JP,Simon H,Frisina RD

    更新日期:2002-08-01 00:00:00

  • High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents.

    abstract::Long-term potentiation (LTP) in rat spinal dorsal horn neurons was induced by electrical high-frequency stimulation (HFS) of afferent C fibers. LTP is generally assumed to be a key mechanism of spinal sensitization. To determine the contribution of skin and muscle afferents to LTP induction, the sural nerve (SU, pure ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Zhang J,Hoheisel U,Klein T,Magerl W,Mense S,Treede RD

    更新日期:2016-02-01 00:00:00

  • Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype.

    abstract::Previously, an essential tremor-like phenotype has been noted in animals with a global knockout of the GABAAα1 subunit. Given the hypothesized role of the cerebellum in tremor, including essential tremor, we used transgenic mice to selectively knock out the GABAAα1 subunit from cerebellar Purkinje cells. We examined t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Nietz A,Krook-Magnuson C,Gutierrez H,Klein J,Sauve C,Hoff I,Christenson Wick Z,Krook-Magnuson E

    更新日期:2020-10-01 00:00:00

  • The human brain representation of odor identification.

    abstract::Odor identification (OI) tests are increasingly used clinically as biomarkers for Alzheimer's disease and schizophrenia. The aim of this study was to directly compare the neuronal correlates to identified odors vs. nonidentified odors. Seventeen females with normal olfactory function underwent a functional magnetic re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Kjelvik G,Evensmoen HR,Brezova V,Håberg AK

    更新日期:2012-07-01 00:00:00

  • Processing of interaural temporal disparities in the medial division of the ventral nucleus of the lateral lemniscus.

    abstract::The medial division of the ventral nucleus of the lateral lemniscus (VNLLm) contains a specialized population of neurons that is sensitive to interaural temporal disparities (ITDs), a potent cue for sound localization along the azimuth. Unlike many ITD-sensitive neurons elsewhere in the auditory system, neurons in the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Batra R,Fitzpatrick DC

    更新日期:2002-08-01 00:00:00

  • Context compensation in the vestibuloocular reflex during active head rotations.

    abstract::The vestibuloocular reflex (VOR) needs to modulate its gain depending on target distance to prevent retinal slip during head movements. We investigated gain modulation (context compensation) for binocular gaze stabilization in human subjects during voluntary yaw and pitch head rotations. Movements of each eye were rec...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章


    authors: Medendorp WP,Van Gisbergen JA,Van Pelt S,Gielen CC

    更新日期:2000-12-01 00:00:00

  • Stimulus induced desynchronization of human auditory 40-Hz steady-state responses.

    abstract::The hypothesis that gamma-band oscillations are related to the representation of an environmental scene in the cerebral cortex after binding of corresponding perceptual elements is currently under discussion. One question is how the sensory system reacts to a fast change in the scene if perceptual elements are rigidly...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Ross B,Herdman AT,Pantev C

    更新日期:2005-12-01 00:00:00

  • Influence of instruction, prediction, and afferent sensory information on the postural organization of step initiation.

    abstract::1. Our previous study showed that two distinct postural modifications occurred when subjects were instructed to step, rather than maintain stance, in response to a backward surface translation: 1) the automatic postural responses to the surfaces perturbation were reduced in magnitude and 2) the anticipatory postural a...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burleigh A,Horak F

    更新日期:1996-04-01 00:00:00

  • Cholecystokinin B-type receptors mediate a G-protein-dependent depolarizing action of sulphated cholecystokinin ocatapeptide (CCK-8s) on rodent neonatal spinal ventral horn neurons.

    abstract::Reports of cholecystokinin (CCK) binding and expression of CCK receptors in neonatal rodent spinal cord suggest that CCK may influence neuronal excitability. In patch-clamp recordings from 19/21 ventral horn motoneurons in neonatal (PN 5-12 days) rat spinal cord slices, we noted a slowly rising and prolonged membrane ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Oz M,Yang KH,Shippenberg TS,Renaud LP,O'Donovan MJ

    更新日期:2007-09-01 00:00:00

  • Evoked responses of the dentate gyrus during seizures in developing gerbils with inherited epilepsy.

    abstract::When they are 1-2 mo old, domesticated Mongolian gerbils begin having initially mild seizures which become more severe with age. To evaluate the development of this increasing seizure severity, we obtained field potential responses of the dentate gyrus to paired-pulse stimulation of the perforant path during seizures....

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Buckmaster PS,Wong EH

    更新日期:2002-08-01 00:00:00

  • Long-term, multisite, parallel, in-cell recording and stimulation by an array of extracellular microelectrodes.

    abstract::Here we report on the development of a novel neuroelectronic interface consisting of an array of noninvasive gold-mushroom-shaped microelectrodes (gMmicroEs) that practically provide intracellular recordings and stimulation of many individual neurons, while the electrodes maintain an extracellular position. The develo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Hai A,Shappir J,Spira ME

    更新日期:2010-07-01 00:00:00

  • Fatigue and motor redundancy: adaptive increase in finger force variance in multi-finger tasks.

    abstract::We studied the effects of fatigue of the index finger on indices of force variability in discrete and rhythmic accurate force production tasks performed by the index finger and by all four fingers pressing in parallel. An increase in the variance of the force produced by the fatigued index finger was expected. We hypo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Singh T,Varadhan SK,Zatsiorsky VM,Latash ML

    更新日期:2010-06-01 00:00:00

  • Neuronal activity in primate orbitofrontal cortex reflects the value of time.

    abstract::Neurons in monkey orbitofrontal cortex (OF) are known to respond to reward-predicting cues with a strength that depends on the value of the predicted reward as determined 1) by intrinsic attributes including size and quality and 2) by extrinsic factors including the monkey's state of satiation and awareness of what ot...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Roesch MR,Olson CR

    更新日期:2005-10-01 00:00:00

  • Potassium currents in precursor cells isolated from the anterior subventricular zone of the neonatal rat forebrain.

    abstract::The progenitor cells from the anterior part of the neonatal subventricular zone, the SVZa, are unusual in that, although they undergo division, they have a neuronal phenotype. To characterize the electrophysiological properties of the SVZa precursor cells, recordings were made of potassium and sodium currents from SVZ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Stewart RR,Zigova T,Luskin MB

    更新日期:1999-01-01 00:00:00

  • Identification of two forebrain structures that mediate execution of memorized sequences in the pigeon.

    abstract::The execution of action sequences is the basis of most behavior. However, little is known about the neural foundation of visuomotor sequence execution in birds, although pigeons are a classic model animal to study sequence learning and production. Recently, we identified two structures in the pigeon brain, the nidopal...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Helduser S,Cheng S,Güntürkün O

    更新日期:2013-02-01 00:00:00

  • Three-independent-compartment chamber to study in vitro commissural synapses.

    abstract::We describe a novel chamber in which the two intact neonatal rat hippocampi and the commissural fibers are placed in three independent compartments separated by latex membranes and perfused selectively with different solutions. A set of control tests showed that the compartments are well isolated: 1) methylene blue or...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Khazipov R,Desfreres L,Khalilov I,Ben-Ari Y

    更新日期:1999-02-01 00:00:00

  • Neural correlates of gap detection in three auditory cortical fields in the Cat.

    abstract::Neural correlates of gap detection in three auditory cortical fields in the cat. Mimimum detectable gaps in noise in humans are independent of the position of the gap, whereas in cat primary auditory cortex (AI) they are position dependent. The position dependence in other cortical areas is not known and may resolve t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Eggermont JJ

    更新日期:1999-05-01 00:00:00

  • Discrimination of speech stimuli based on neuronal response phase patterns depends on acoustics but not comprehension.

    abstract::Speech stimuli give rise to neural activity in the listener that can be observed as waveforms using magnetoencephalography. Although waveforms vary greatly from trial to trial due to activity unrelated to the stimulus, it has been demonstrated that spoken sentences can be discriminated based on theta-band (3-7 Hz) pha...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Howard MF,Poeppel D

    更新日期:2010-11-01 00:00:00

  • A novel paraplegia model in awake behaving macaques.

    abstract::Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains a large societal burden. Neurophysiological and neuroprosthetic research have the potential to improve quality of life for these patients; however, the lack of an ethical and sustainable nonhuma...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章


    authors: Krucoff MO,Zhuang K,MacLeod D,Yin A,Byun YW,Manson RJ,Turner DA,Oliveira L,Lebedev MA

    更新日期:2017-09-01 00:00:00