G-CSF mobilized peripheral blood stem cell collection for allogeneic transplantation in healthy donors: Analysis of factors affecting yield.

Abstract:

:Mobilized PBSC are the main source for allogeneic HSCT. We aimed to evaluate factors that affect CD34+ cell yield including the donor's age, gender, BSA, processed blood volume and the method of G-CSF dose calculation. Data from 170 healthy donors were analyzed. The concentration of CD34+ cells in the peripheral blood (PB) and the processed volume of blood were significantly correlated to CD34+ cells yield (P < .00005 and P < .001, respectively). The G-CSF dose per m2 was significantly correlated to the concentration of CD34+ cells in the PB (P = .0003) and in the product (P = .01). Smaller BSA and less processed volume were found among female donors, who were given lesser G-CSF dose per m2 , and showed lower yield compared to men. However, multivariate analysis of the yield showed that only the concentration of CD34+ cells in the PB and the processed volume remained independent significant.

journal_name

J Clin Apher

authors

Machaczka M,Hägglund H,Staver E,Joks M,Hassan M,Wahlin BE,Axdorph Nygell U

doi

10.1002/jca.21524

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

384-391

issue

6

eissn

0733-2459

issn

1098-1101

journal_volume

32

pub_type

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