Particulate matter from indoor environments of classroom induced higher cytotoxicity and leakiness in human microvascular endothelial cells in comparison with those collected from corridor.


:We investigated the physicochemical properties (size, shape, elemental composition, and endotoxin) of size resolved particulate matter (PM) collected from the indoor and corridor environments of classrooms. A comparative hazard profiling of these PM was conducted using human microvascular endothelial cells (HMVEC). Oxidative stress-dependent cytotoxicity responses were assessed using quantitative reverse transcriptase polymerase chain reaction (RT-PCR) and high content screening (HCS), and disruption of monolayer cell integrity was assessed using fluorescence microscopy and transwell assay. Scanning electron microscopy (SEM) coupled with energy-dispersive X-ray spectroscopy (EDX) analysis showed differences in the morphology and elemental composition of PM of different sizes and origins. While the total mass of PM collected from indoor environment was lower in comparison with those collected from the corridor, the endotoxin content was substantially higher in indoor PM (e.g., ninefold higher endotoxin level in indoor PM8.1-20 ). The ability to induce oxidative stress-mediated cytotoxicity and leakiness in cell monolayer were higher for indoor PM compared to those collected from the corridor. In conclusion, this comparative analysis suggested that indoor PM is relatively more hazardous to the endothelial system possibly because of higher endotoxin content.


Indoor Air


Indoor air


Chua ML,Setyawati MI,Li H,Fang CHY,Gurusamy S,Teoh FTL,Leong DT,George S




Has Abstract


2017-05-01 00:00:00












  • Variations of formaldehyde and VOC levels during 3 years in new and older homes.

    abstract:UNLABELLED:Indoor air organic compounds were continuously monitored during 3 years in new and older homes which were voluntarily selected throughout countries. The levels of volatile organic compounds (VOCs) in the new homes decreased markedly after 1 year, and steady emissions of VOCs were obtained in the initial mont...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Park JS,Ikeda K

    更新日期:2006-04-01 00:00:00

  • Molds in floor dust and building-related symptoms among adolescent school children: a problem for boys only?

    abstract:UNLABELLED:In this stratified cross-sectional study in eight 'wet' and seven 'dry' schools, 1024 adolescent school children reported potentially building-related symptoms (BRS) in self-administrated questionnaires. From their classrooms dust samples were collected from floors, ventilation ducts, and air; settled dust w...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Meyer HW,Würtz H,Suadicani P,Valbjørn O,Sigsgaard T,Gyntelberg F,Members of a Working Group under the Danish Mold in Buildings program (DAMIB).

    更新日期:2005-01-01 00:00:00

  • Chemistry in indoor environments: 20 years of research.

    abstract:UNLABELLED:In the two decades since the first issue of Indoor Air, there have been over 250 peer-reviewed publications addressing chemical reactions among indoor pollutants. The present review has assembled and categorized these publications. It begins with a brief account of the state of our knowledge in 1991 regardin...

    journal_title:Indoor air

    pub_type: 杂志文章,评审


    authors: Weschler CJ

    更新日期:2011-06-01 00:00:00

  • A pilot study to investigate the effects of combined dehumidification and HEPA filtration on dew point and airborne mold spore counts in day care centers.

    abstract:UNLABELLED:Meteorological factors such as relative humidity directly correlate with airborne fungal levels outdoors and indoors. While dehumidification alone is effective at reducing moisture necessary for mold growth, it is inadequate as a single intervention as it does not remove viable and non-viable fungal spores t...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Bernstein JA,Levin L,Crandall MS,Perez A,Lanphear B

    更新日期:2005-12-01 00:00:00

  • Simulating the human body's microclimate using automatic coupling of CFD and an advanced thermoregulation model.

    abstract::This study aims to develop an approach to couple a computational fluid dynamics (CFD) solver to the University of California, Berkeley (UCB) thermal comfort model to accurately evaluate thermal comfort. The coupling was made using an iterative JavaScript to automatically transfer data for each individual segment of th...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Voelker C,Alsaad H

    更新日期:2018-05-01 00:00:00

  • Determination of radon exhalation from construction materials using VOC emission test chambers.

    abstract::The inhalation of (222) Rn (radon) decay products is one of the most important reasons for lung cancer after smoking. Stony building materials are an important source of indoor radon. This article describes the determination of the exhalation rate of stony construction materials by the use of commercially available me...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Richter M,Jann O,Kemski J,Schneider U,Krocker C,Hoffmann B

    更新日期:2013-10-01 00:00:00

  • Indoor gaseous air pollutants determinants in office buildings-The OFFICAIR project.

    abstract::The aim of this study was to identify determinants of aldehyde and volatile organic compound (VOC) indoor air concentrations in a sample of more than 140 office rooms, in the framework of the European OFFICAIR research project. A large field campaign was performed, which included (a) the air sampling of aldehydes and ...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Spinazzè A,Campagnolo D,Cattaneo A,Urso P,Sakellaris IA,Saraga DE,Mandin C,Canha N,Mabilia R,Perreca E,Mihucz VG,Szigeti T,Ventura G,de Oliveira Fernandes E,de Kluizenaar Y,Cornelissen E,Hänninen O,Carrer P,Wolkoff P

    更新日期:2020-01-01 00:00:00

  • Indoor visible mold and mold odor are associated with new-onset childhood wheeze in a dose-dependent manner.

    abstract::Evidence is accumulating that indoor dampness and mold are associated with the development of asthma. The underlying mechanisms remain unknown. New Zealand has high rates of both asthma and indoor mold and is ideally placed to investigate this. We conducted an incident case-control study involving 150 children with ne...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Shorter C,Crane J,Pierse N,Barnes P,Kang J,Wickens K,Douwes J,Stanley T,Täubel M,Hyvärinen A,Howden-Chapman P,Wellington Region General Practitioner Research Network.

    更新日期:2018-01-01 00:00:00

  • Spatiotemporally resolved black carbon concentration, schoolchildren's exposure and dose in Barcelona.

    abstract::At city level, personal monitoring is the best way to assess people's exposure. However, it is usually estimated from a few monitoring stations. Our aim was to determine the exposure to black carbon (BC) and BC dose for 45 schoolchildren with portable microaethalometers and to evaluate the relationship between persona...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Rivas I,Donaire-Gonzalez D,Bouso L,Esnaola M,Pandolfi M,de Castro M,Viana M,Àlvarez-Pedrerol M,Nieuwenhuijsen M,Alastuey A,Sunyer J,Querol X

    更新日期:2016-06-01 00:00:00

  • Machine learning and statistical models for predicting indoor air quality.

    abstract::Indoor air quality (IAQ), as determined by the concentrations of indoor air pollutants, can be predicted using either physically based mechanistic models or statistical models that are driven by measured data. In comparison with mechanistic models mostly used in unoccupied or scenario-based environments, statistical m...

    journal_title:Indoor air

    pub_type: 杂志文章,评审


    authors: Wei W,Ramalho O,Malingre L,Sivanantham S,Little JC,Mandin C

    更新日期:2019-09-01 00:00:00

  • Sorptive interactions between VOCs and indoor materials.

    abstract::This study was carried out using various materials (carpet, gypsum board, upholstery, vinyl and wood flooring, acoustic tiles, and fruit) that were exposed to eight gaseous volatile organic compounds (VOCs) (isopropanol, MTBE, cyclohexane, toluene, ethylbenzene, tetrachloroethene, 1,2-dichlorobenzene, and 1,2,4-trichl...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Won D,Corsi RL,Rynes M

    更新日期:2001-12-01 00:00:00

  • Stability of airborne microbes in the Louvre Museum over time.

    abstract::The microbial content of air has as yet been little described, despite its public health implications, and there remains a lack of environmental microbial data on airborne microflora in enclosed spaces. In this context, the aim of this study was to characterize the diversity and dynamics of airborne microorganisms in ...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Gaüzère C,Moletta-Denat M,Blanquart H,Ferreira S,Moularat S,Godon JJ,Robine E

    更新日期:2014-02-01 00:00:00

  • Particle size distributions and concentrations of airborne endotoxin using novel collection methods in homes during the winter and summer seasons.

    abstract:UNLABELLED:A comparison study of novel collection methods for airborne bacteria and endotoxin was performed in an environmentally controlled chamber and in pilot-field studies. Airborne particulate matter was collected in swirling liquid impingers, air-monitoring filter cassettes, and with a micro-orifice uniform depos...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Kujundzic E,Hernandez M,Miller SL

    更新日期:2006-06-01 00:00:00

  • Subjective perceptions, symptom intensity and performance: a comparison of two independent studies, both changing similarly the pollution load in an office.

    abstract::The present paper shows that introducing or removing the same pollution source in an office in two independent investigations, one in Denmark and one in Sweden, using similar experimental methodology, resulted in similar and repeatable effects on subjective assessments of perceived air quality, intensity of sick build...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Wargocki P,Lagercrantz L,Witterseh T,Sundell J,Wyon DP,Fanger PO

    更新日期:2002-06-01 00:00:00

  • Performance evaluation of a novel personalized ventilation-personalized exhaust system for airborne infection control.

    abstract::In the context of airborne infection control, it is critical that the ventilation system is able to extract the contaminated exhaled air within the shortest possible time. To minimize the spread of contaminated air exhaled by occupants efficiently, a novel personalized ventilation (PV)-personalized exhaust (PE) system...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Yang J,Sekhar SC,Cheong KW,Raphael B

    更新日期:2015-04-01 00:00:00

  • Removal of viable bioaerosol particles with a low-efficiency HVAC filter enhanced by continuous emission of unipolar air ions.

    abstract:UNLABELLED:Continuous emission of unipolar ions has been shown to improve the performance of respirators and stationary filters challenged with non-biological particles. In this study, we investigated the ion-induced enhancement effect while challenging a low-efficiency heating, ventilation and air-conditioning (HVAC) ...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Huang R,Agranovski I,Pyankov O,Grinshpun S

    更新日期:2008-04-01 00:00:00

  • Exercise-induced effects on a gym atmosphere.

    abstract::We report results of analysis of a month-long measurement of indoor air and environment quality parameters in one gym during sporting activities such as football, basketball, volleyball, badminton, boxing, and fitness. We have determined an average single person's contribution to the increase of temperature, humidity,...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Žitnik M,Bučar K,Hiti B,Barba Ž,Rupnik Z,Založnik A,Žitnik E,Rodrìguez L,Mihevc I,Žibert J

    更新日期:2016-06-01 00:00:00

  • Formaldehyde as a basis for residential ventilation rates.

    abstract::Traditionally, houses in the US have been ventilated by passive infiltration in combination with active window opening. However in recent years, the construction quality of residential building envelopes has been improved to reduce infiltration, and the use of windows for ventilation also may have decreased due to a n...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Sherman MH,Hodgson AT

    更新日期:2004-02-01 00:00:00

  • Co-occupant's exposure to exhaled pollutants with two types of personalized ventilation strategies under mixing and displacement ventilation systems.

    abstract::Personalized ventilation (PV) system in conjunction with total ventilation system can provide cleaner inhaled air for the user. Concerns still exist about whether the normally protecting PV device, on the other hand, facilitates the dispersion of infectious agents generated by its user. In this article, two types of P...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Li X,Niu J,Gao N

    更新日期:2013-04-01 00:00:00

  • Organic compounds as indicators of air pollution.

    abstract::The most important indoor air pollutants have already been addressed with individual national guidelines or recommendations. However, an international set of guidelines or recommendations for indoor air quality (IAQ) is needed for these pollutants based on general and uniform rules for setting such standards. A major ...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Mølhave L

    更新日期:2003-01-01 00:00:00

  • Personal measurement of exposure to black carbon and ultrafine particles in schoolchildren from PARIS cohort (Paris, France).

    abstract::This study aimed to measure in French children personal exposure concentrations of black carbon (BC) and ultrafine particles (UFP) and to quantify the contribution of different microenvironments (home, school, places of extracurricular activities, transport) to their total exposure. It was conducted on 96 9-year-old c...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Paunescu AC,Attoui M,Bouallala S,Sunyer J,Momas I

    更新日期:2017-07-01 00:00:00

  • Association of size-fractionated indoor particulate matter and black carbon with heart rate variability in healthy elderly women in Beijing.

    abstract::Associations between size-fractionated indoor particulate matter (PM) and black carbon (BC) and heart rate variability (HRV) and heart rate (HR) in elderly women remain unclear. Twenty-nine healthy elderly women were measured for 24-hour HRV/HR indices. Real-time size-fractionated indoor PM and BC were monitored on th...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Dong W,Pan L,Li H,Miller MR,Loh M,Wu S,Xu J,Yang X,Shan J,Chen Y,Deng F,Guo X

    更新日期:2018-05-01 00:00:00

  • Indoor thermal stratification and its statistical distribution.

    abstract::Thermal stratification is established when warmer air rises and cooler air descends under thermal buoyancy. It occurs in indoor environment situations including large warehouse-type buildings, buoyancy-driven ventilated spaces with displacement, underfloor ventilation, and/or natural ventilation, and enclosure fires w...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Wang LL,Zhang X,Qi D

    更新日期:2019-03-01 00:00:00

  • Comparison of two dust collection methods for reservoir indoor allergens and endotoxin on carpets and mattresses.

    abstract::Variable methods of dust collection may lead to uncertainty in the measurement of biomarkers. The purpose of this study was to examine the effect of two different dust collection devices on dust weight, Der p 1, Fel d 1, and endotoxin levels. We compared: (1) a nylon mesh sock inserted between the furniture attachment...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Wickens K,Lane J,Siebers R,Ingham T,Crane J

    更新日期:2004-06-01 00:00:00

  • Indoor environmental control of tuberculosis and other airborne infections.

    abstract::Tuberculosis (TB) remains the airborne infection of global importance, although many environmental interventions to control TB apply to influenza and other infections with airborne potential. This review focuses on the global problem and the current state of available environmental interventions. TB transmission is fa...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Nardell EA

    更新日期:2016-02-01 00:00:00

  • Biomass fuel smoke exposure was associated with adverse cardiac remodeling and left ventricular dysfunction in Peru.

    abstract::While household air pollution from biomass fuel combustion has been linked to cardiovascular disease, the effects on cardiac structure and function have not been well described. We sought to determine the association between biomass fuel smoke exposure and cardiac structure and function by transthoracic echocardiograp...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Burroughs Peña MS,Velazquez EJ,Rivera JD,Alenezi F,Wong C,Grigsby M,Davila-Roman VG,Gilman RH,Miranda JJ,Checkley W

    更新日期:2017-07-01 00:00:00

  • Effects of energy retrofits on Indoor Air Quality in multifamily buildings.

    abstract::We assessed 45 multifamily buildings (240 apartments) from Finland and 20 (96 apartments) from Lithuania, out of which 37 buildings in Finland and 15 buildings in Lithuania underwent energy retrofits. Building characteristics, retrofit activities, and energy consumption data were collected, and Indoor Air Quality (IAQ...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Du L,Leivo V,Prasauskas T,Täubel M,Martuzevicius D,Haverinen-Shaughnessy U

    更新日期:2019-07-01 00:00:00

  • Experimental study of ventilation performance and contaminant distribution of underfloor ventilation systems vs. traditional ceiling-based ventilation system.

    abstract:UNLABELLED:Ventilation performance and pollutant distribution in a traditional ceiling-type ventilation system, a top-return (TR)-type and a floor-return (FR)-type underfloor ventilation systems were performed in a controlled experimental room. Tracer gas method was utilized to determine the age of air and the contamin...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Chao CY,Wan MP

    更新日期:2004-10-01 00:00:00

  • Effectiveness of a portable air cleaner in removing aerosol particles in homes close to highways.

    abstract::Outdoor traffic-related airborne particles can infiltrate a building and adversely affect the indoor air quality. Limited information is available on the effectiveness of high efficiency particulate air (HEPA) filtration of traffic-related particles. Here, we investigated the effectiveness of portable HEPA air cleaner...

    journal_title:Indoor air

    pub_type: 杂志文章,随机对照试验


    authors: Cox J,Isiugo K,Ryan P,Grinshpun SA,Yermakov M,Desmond C,Jandarov R,Vesper S,Ross J,Chillrud S,Dannemiller K,Reponen T

    更新日期:2018-11-01 00:00:00

  • Chamber testing of adsorption of volatile organic compounds (VOCs) on material surfaces.

    abstract::A simple test chamber method to quantify adsorption and desorption of organic compounds on material surfaces is described. Important environmental parameters such as temperature, relative humidity and air velocity were varied and controlled independently around typical indoor values. Experiments were performed with al...

    journal_title:Indoor air

    pub_type: 杂志文章


    authors: Jørgensen RB,Bjørseth O,Malvik B

    更新日期:1999-03-01 00:00:00