MALDI IMS and Cancer Tissue Microarrays.

abstract：:Humans are a colonized with trillions of commensal microorganisms which exert a profound effect on normal host physiology and immune function through an abundance of genetic and metabolic by-products. Although the commensal microbiome has beneficial functions to host physiology, perturbations of the composition of the...

journal_title：Advances in cancer research

authors： Buchta Rosean C,Feng TY,Azar FN,Rutkowski MR

更新日期：2019-01-01 00:00:00

abstract：:The significantly higher breast cancer (BCa) mortality rates of African-American (AA) women compared to non-Hispanic (NHW) white women constitute a major US health disparity. Investigations have primarily focused on biological differences in tumors to explain more aggressive forms of BCa in AA women. The biology of tu...

journal_title：Advances in cancer research

authors： Ford ME,Magwood G,Brown ET,Cannady K,Gregoski M,Knight KD,Peterson LL,Kramer R,Evans-Knowell A,Turner DP

更新日期：2017-01-01 00:00:00

abstract：:Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent mutation of the Rb gene, and the functional inactivation of pRb in tumor cells, have spurred interest in the mechanism of pRb action. ...

journal_title：Advances in cancer research

authors： Morris EJ,Dyson NJ

更新日期：2001-01-01 00:00:00

abstract：:The IKK/nuclear factor-kappaB pathway (NF-κB) is critical in proper immune function, cell survival, apoptosis, cellular proliferation, synaptic plasticity, and even memory. While NF-κB is crucial for both innate and adaptive immunity, defective regulation of this master transcriptional regulator is seen in a variety o...

journal_title：Advances in cancer research

authors： Bradford JW,Baldwin AS

更新日期：2014-01-01 00:00:00

abstract：:Follicular lymphoma (FL) and B-cell chronic lymphocytic leukemia (B-CLL) are paradigmatic examples of lymphoid malignancies in which the relevant biological mechanisms are alterations in the control of apoptosis rather than an exaggerated proliferation. This explains why low-grade B-cell neoplasms still fail to be cur...

journal_title：Advances in cancer research

authors： Ghia P,Caligaris-Cappio F

更新日期：2000-01-01 00:00:00

abstract：:Almost three decades ago, we presented a model where the extracellular matrix (ECM) was postulated to influence gene expression and tissue-specificity through the action of ECM receptors and the cytoskeleton. This hypothesis implied that ECM molecules could signal to the nucleus and that the unit of function in higher...

journal_title：Advances in cancer research

authors： Spencer VA,Xu R,Bissell MJ

更新日期：2007-01-01 00:00:00

abstract：:Since their discovery, there has been significant progress in the understanding of dendritic cell (DC) biology. Their capacity for priming an immune response against pathogens and cancers has been exploited clinically. However, the objective responses obtained to date using DC cancer vaccines have been modest. Subopti...

journal_title：Advances in cancer research

authors： Vulink A,Radford KJ,Melief C,Hart DN

更新日期：2008-01-01 00:00:00

abstract：:The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated levels in different forms of cancer and expression often correlates positively with cancer progression and poor prognosis. Different mutant forms of this protein also contribute to cancer heterogeneity. A constitutively active form of EGFR...

journal_title：Advances in cancer research

authors： Talukdar S,Emdad L,Das SK,Fisher PB

更新日期：2020-01-01 00:00:00

abstract：:The hepatocyte growth factor (HGF) and its receptor, the Met receptor tyrosine kinase, form a signaling network promoting cell proliferation, invasion, and survival in normal and cancer cells. Improper regulation of this pathway is attributed to many cancer types through overexpression, activating mutations, or autocr...

journal_title：Advances in cancer research

authors： Hanna JA,Bordeaux J,Rimm DL,Agarwal S

更新日期：2009-01-01 00:00:00

abstract：:The link between evasion of apoptosis and the development of cellular hyperplasia and ultimately cancer is implicitly clear if one considers how many cells are produced each day and, hence, how many cells must die to make room for the new ones (reviewed in Raff, 1996). Furthermore, cells are frequently experiencing no...

journal_title：Advances in cancer research

authors： Kelly GL,Strasser A

更新日期：2011-01-01 00:00:00

abstract：:Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation l...

journal_title：Advances in cancer research

authors： Das S,Thorek DL,Grimm J

更新日期：2014-01-01 00:00:00

abstract：:Histone acetylation and deacetylation are chromatin-modifying processes that have fundamental importance for transcriptional regulation. Transcriptionally active chromatin regions show a high degree of histone acetylation, whereas deacetylation events are generally linked to transcriptional silencing. Many of the acet...

journal_title：Advances in cancer research

authors： Lehrmann H,Pritchard LL,Harel-Bellan A

更新日期：2002-01-01 00:00:00

abstract：:The strong clinical activity of the proteasome inhibitor bortezomib (Velcade) in multiple myeloma and other hematological malignancies has focused considerable attention on its mechanisms of action. Although NFκB inhibition was initially the mechanism in focus, accumulating evidence indicates that misfolded protein ac...

journal_title：Advances in cancer research

authors： McConkey DJ,White M,Yan W

更新日期：2012-01-01 00:00:00

abstract：:The role of clusterin (CLU) in prostate tumorigenesis is probably the most highly controversial, with evidence that CLU expression is increased or decreased in different cancer models. For example, some studies showed that CLU expression is increased in advanced stages of prostate cancer and that suppression of CLU ex...

journal_title：Advances in cancer research

authors： Rizzi F,Bettuzzi S

更新日期：2009-01-01 00:00:00

abstract：:Molecular analyses of tumor virus-host cell interactions have provided key insights into the genes and pathways involved in neoplastic transformation. Recent studies have revealed that the human tumor viruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), human papillomavirus (HPV), hepatiti...

journal_title：Advances in cancer research

authors： D'Agostino DM,Bernardi P,Chieco-Bianchi L,Ciminale V

更新日期：2005-01-01 00:00:00

abstract：:At the cellular level, cancer is a genetic disease; genetic changes in somatic cells are essential events in neoplasia. In a majority of cases these changes involve large enough blocks of genetic material to be visible in the microscope. The chromosome aberrations in neoplastic disorders are probably of three kinds: (...

journal_title：Advances in cancer research

authors： Heim S,Mitelman F

更新日期：1989-01-01 00:00:00

abstract：:The functional relevance of autophagy in tumor formation and progression remains controversial. Autophagy can promote tumor suppression during cancer initiation and protect tumors during progression. Autophagy-associated cell death may act as a tumor suppressor, with several autophagy-related genes deleted in cancers....

journal_title：Advances in cancer research

authors： Bhutia SK,Mukhopadhyay S,Sinha N,Das DN,Panda PK,Patra SK,Maiti TK,Mandal M,Dent P,Wang XY,Das SK,Sarkar D,Fisher PB

更新日期：2013-01-01 00:00:00

abstract：:Multiple epidemiologic studies have linked the development of renal cancer to obesity. In this chapter, we begin with a review of selected population studies, followed by recent mechanistic discoveries that further link lipid deregulation to the RCC development. The upregulation of leptin and downregulation of adipone...

journal_title：Advances in cancer research

authors： Drabkin HA,Gemmill RM

更新日期：2010-01-01 00:00:00

abstract：:Molecular chaperones are essential for guarding proteins that are indispensable for normal cellular functions. Heat shock protein 90 (Hsp90) is a vital molecular chaperone in eukaryotes that participates in stabilizing and activating approximately 200 target proteins, called "clients," many of which are involved in si...

journal_title：Advances in cancer research

authors： Woodford MR,Dunn D,Miller JB,Jamal S,Neckers L,Mollapour M

更新日期：2016-01-01 00:00:00

abstract：:Recent clinical studies document the power of immunotherapy in treating subsets of patients with advanced cancers. In this context and with multiple cancer immunotherapeutics already evaluated in the clinic and a large number in various stages of clinical trials, it is imperative to comprehensively examine genomics da...

journal_title：Advances in cancer research

authors： Bacolod MD,Barany F,Pilones K,Fisher PB,de Castro RJ

更新日期：2019-01-01 00:00:00

abstract：:Stem cell-based therapeutic strategies have emerged as very attractive treatment options over the past decade. Stem cells are now being utilized as delivery vehicles especially in cancer therapy to deliver a number of targeted proteins and viruses. This chapter aims to shed light on numerous studies that have successf...

journal_title：Advances in cancer research

authors： Bhere D,Shah K

更新日期：2015-01-01 00:00:00

abstract：:Clusterin (CLU) has kept many researchers engaged for a long time since its first discovery and characterization in the attempt to unravel its biological role in mammals. Although there is a general consensus on the fact that CLU is supposed to play important roles in nearly all fundamental biological phenomena and in...

journal_title：Advances in cancer research

authors： Rizzi F,Coletta M,Bettuzzi S

更新日期：2009-01-01 00:00:00

abstract：:Liver cancer is the fifth most common cancer, but the second leading cause of cancer death, in the world, with more than 700,000 fatalities annually. The major etiology of liver cancer is infection with an hepatotropic virus such as hepatitis B virus or hepatitis C virus infection. While chronic viral infection remain...

journal_title：Advances in cancer research

authors： Mehta A,Herrera H,Block T

更新日期：2015-01-01 00:00:00

abstract：:TP53 mutations are the most frequent genetic alterations found in human cancer. For more than 20 years, TP53 mutation databases have collected over 30,000 somatic mutations from various types of cancer. Analyses of these mutations have led to many types of studies and have improved our knowledge about the TP53 protein...

journal_title：Advances in cancer research

authors： Soussi T

更新日期：2011-01-01 00:00:00

abstract：:CD8(+) T cells respond to antigen stimulation through a process of activation, division, and differentiation generating a large pool of activated effector cytolytic T lymphocytes (CTLs). Many cancer patients harbor the accordant precursor CTLs capable of responding to various tumor-associated antigens (TAA). In select...

journal_title：Advances in cancer research

authors： Mehrotra S,Mougiakakos D,Johansson CC,Voelkel-Johnson C,Kiessling R

更新日期：2009-01-01 00:00:00

abstract：:Resistance to chemotherapeutic drugs exemplifies the greatest hindrance to effective treatment of cancer patients. The molecular mechanisms responsible have been investigated for over 50 years and have revealed the lack of a single cause, but instead, multiple mechanisms including induced expression of membrane transp...

journal_title：Advances in cancer research

authors： Rosenzweig SA

更新日期：2018-01-01 00:00:00

abstract：:Sphingosine kinase 1 (SK1) is a lipid enzyme with oncogenic properties that converts the proapoptotic lipids ceramide and sphingosine into the antiapoptotic lipid sphingosine-1-phosphate and activates the signal transduction pathways that lead to cell proliferation, migration, the activation of the inflammatory respon...

journal_title：Advances in cancer research

authors： Alshaker H,Sauer L,Monteil D,Ottaviani S,Srivats S,Böhler T,Pchejetski D

更新日期：2013-01-01 00:00:00

abstract：:Autophagy is a lysosomal degradation process crucial for adaptation to stress and cellular homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in tumor initiation and progression. Although genetic evidence corroborates a role for autophagy as a tumor suppressor mechanism during tumor in...

journal_title：Advances in cancer research

authors： Liu J,Debnath J

更新日期：2016-01-01 00:00:00

abstract：:Vascular integrity or the maintenance of blood vessel continuity is a fundamental process regulated by endothelial cell-cell junctions. Defects in endothelial barrier function are an initiating factor in several disease processes including tumor angiogenesis and metastasis. The glycosaminoglycan, hyaluronan (HA), main...

journal_title：Advances in cancer research

authors： Singleton PA

更新日期：2014-01-01 00:00:00

abstract：:Hodgkin's lymphoma (HL) is characterized by typical mononucleated Hodgkin and multinucleated Reed-Sternberg cells, which occur at low frequency in a mixed cellular infiltrate in the tumor tissue. Because of the rarity of these cells and their unusual immunophenotype, which is strikingly different from those of all nor...

journal_title：Advances in cancer research

authors： Küppers R

更新日期：2002-01-01 00:00:00