Four birds with one stone? Reparative, neuroplastic, cardiorespiratory, and metabolic benefits of aerobic exercise poststroke.


PURPOSE OF REVIEW:Converging evidence from animal models of stroke and clinical trials suggests that aerobic exercise has effects across multiple targets. RECENT FINDINGS:The subacute phase is characterized by a period of heightened neuroplasticity when aerobic exercise has the potential to optimize recovery. In animals, low intensity aerobic exercise shrinks lesion size and reduces cell death and inflammation, beginning 24 h poststroke. Also in animals, aerobic exercise upregulates brain-derived neurotrophic factor near the lesion and improves learning. In terms of neuroplastic effects, clinical trial results are less convincing and have only examined effects in chronic stroke. Stroke patients demonstrate cardiorespiratory fitness levels below the threshold required to carry out daily activities. This may contribute to a 'neurorehabilitation ceiling' that limits capacity to practice at a high enough frequency and intensity to promote recovery. Aerobic exercise when delivered 2-5 days per week at moderate to high intensity beginning as early as 5 days poststroke improves cardiorespiratory fitness, dyslipidemia, and glucose tolerance. SUMMARY:Based on the evidence discussed and applying principles of periodization commonly used to prepare athletes for competition, we have created a model of aerobic training in subacute stroke in which training is delivered in density blocks (duration × intensity) matched to recovery phases.


Curr Opin Neurol


Ploughman M,Kelly LP




Has Abstract


2016-12-01 00:00:00












  • Genetics of Parkinson's disease.

    abstract:PURPOSE OF REVIEW:Parkinson's disease is the second most common neurodegenerative disorder and affects 2% of the population over the age of 60 years. Due to the increasing proportion of elderly individuals in developed countries, Parkinson's disease and related neurodegenerative disorders represent a growing burden on ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Gasser T

    更新日期:2005-08-01 00:00:00

  • Examining the ocular fundus in neurology.

    abstract:PURPOSE OF REVIEW:The funduscopic examination can be a technically difficult, and often omitted, portion of the neurologic examination, despite its great potential to influence patient care. RECENT FINDINGS:Medical practitioners are often first taught to examine the ocular fundus using a direct ophthalmoscope, however...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Rodenbeck SJ,Mackay DD

    更新日期:2019-02-01 00:00:00

  • Microbiota and neurodegenerative diseases.

    abstract:PURPOSE OF REVIEW:Despite the extensive research carried out in the past decades, the current pathophysiological notions of neurodegenerative disease as well as effective treatments to reduce their progression are largely unknown. Alterations of the human microbiota, the plethora of different microscopic organisms that...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Marizzoni M,Provasi S,Cattaneo A,Frisoni GB

    更新日期:2017-12-01 00:00:00

  • Impact of brain aging and neurodegeneration on cognition: evidence from MRI.

    abstract:PURPOSE OF REVIEW:We present an overview of recent concepts in mechanisms underlying cognitive decline associated with brain aging and neurodegeneration from the perspective of MRI. RECENT FINDINGS:Recent findings challenge the established link between neuroimaging biomarkers of neurodegeneration and age-related or di...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Draganski B,Lutti A,Kherif F

    更新日期:2013-12-01 00:00:00

  • What have we learned from recent twin studies about the etiology of neurodevelopmental disorders?

    abstract:PURPOSE OF REVIEW:The relative influence of genes and environment on the liability to neurodevelopmental disorders (NDDs) can be investigated using a twin design. This review highlights the results of the most recent twin studies of NDDs. RECENT FINDINGS:Recent twin studies have confirmed that NDDs show moderate-to-hi...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Posthuma D,Polderman TJ

    更新日期:2013-04-01 00:00:00

  • Deciphering spreading mechanisms in amyotrophic lateral sclerosis: clinical evidence and potential molecular processes.

    abstract:PURPOSE OF REVIEW:The aim of this review is to refer to recent arguments supporting the existence of specific propagation mechanisms associated with spreading of neuron injury in amyotrophic lateral sclerosis (ALS). RECENT FINDINGS:Misfolded ALS-linked protein accumulation can induce aggregation of their native equiva...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Pradat PF,Kabashi E,Desnuelle C

    更新日期:2015-10-01 00:00:00

  • Functional (psychogenic) movement disorders.

    abstract:PURPOSE OF REVIEW:This review provides an overview of recent developments in diagnosis, pathophysiology, neuroimaging and management of functional (psychogenic) movement disorders (FMD). RECENT FINDINGS:There has been increasing interest to study the underlying pathophysiology of FMD, which has resulted in a broadened...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Czarnecki K,Hallett M

    更新日期:2012-08-01 00:00:00

  • Exotic and emerging viral encephalitides.

    abstract:PURPOSE OF REVIEW:The exotic and emerging viral encephalitides are caused by animal or human viruses and characterised by sudden unexpected outbreaks of neurological disease, usually in tropical and sub-tropical regions, but sometimes spreading to temperate areas. Although a wide range of viruses come within this label...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Solomon T

    更新日期:2003-06-01 00:00:00

  • New drug therapies for multiple sclerosis.

    abstract:PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune and inflammatory disease of the central nervous system (CNS) that causes neurological disability in young adults and that to date has no cure. Until now, expensive and only partially efficacious therapies have become available. For this reason, researchers, cli...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Mangas A,Coveñas R,Geffard M

    更新日期:2010-06-01 00:00:00

  • Neuroimaging of drug resistance in epilepsy.

    abstract:PURPOSE OF REVIEW:Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the fu...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Koepp MJ

    更新日期:2014-04-01 00:00:00

  • Optic neuritis as a phase 2 paradigm for neuroprotection therapies of multiple sclerosis: update on current trials and perspectives.

    abstract:PURPOSE OF REVIEW:In multiple sclerosis as the most common inflammatory demyelinating disease in Western countries, major therapeutic success has been achieved with regard to strategies targeting immunological master switches. These approaches effectively reduce inflammatory disease activity but fail to address ongoing...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Aktas O,Albrecht P,Hartung HP

    更新日期:2016-06-01 00:00:00

  • The pupil.

    abstract:PURPOSE OF REVIEW:To give an overview on topics of pupillary function selected according to their relevance in clinical neurology. Mainly publications of the last 3 years have been considered. RECENT FINDINGS:The discovery of photosensitive retinal ganglion cells not serving vision, but serving circadian rhythm and th...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章


    authors: Wilhelm H

    更新日期:2008-02-01 00:00:00

  • Radiation injury to the nervous system.

    abstract::This article reviews the current knowledge with regard to neurotoxicity of conventional radiation, including recent understanding of the pathophysiology, molecular biology, diagnostic evaluation and clinical presentations, as well as proposed treatment modalities and possible protective agents. ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: New P

    更新日期:2001-12-01 00:00:00

  • Cerebral small vessel diseases: cerebral microangiopathies.

    abstract:PURPOSE OF REVIEW:Small vessel diseases of the brain are still clinically underrecognized whereas their burden is increasing steeply. The most frequent is acquired degenerative small vessel disease. Many hereditary or idiopathic small vessel diseases have also been identified, of which cerebral autosomal-dominant arter...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Ringelstein EB,Nabavi DG

    更新日期:2005-04-01 00:00:00

  • Diabetes, hyperglycemia and the management of cerebrovascular disease.

    abstract:PURPOSE OF REVIEW:Hyperglycemia is frequent in patients with cerebrovascular disease. This review article aims to summarize the recent evidence from observational studies that examined the adverse cerebrovascular effects of dysglycemic states as well as interventional studies assessing intensive management strategies f...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Haratz S,Tanne D

    更新日期:2011-02-01 00:00:00

  • Pseudoprogression and pseudoresponse in the treatment of gliomas.

    abstract:PURPOSE OF REVIEW:Treatment response of brain tumours is typically evaluated with gadolinium-enhanced MRI using the Macdonald criteria. These criteria depend on changes in the area of enhancement. However, gadolinium enhancement of brain tumours primarily reflects impairment of the blood-brain barrier. RECENT FINDINGS...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Brandsma D,van den Bent MJ

    更新日期:2009-12-01 00:00:00

  • Skeletal muscle channelopathies: new insights into the periodic paralyses and nondystrophic myotonias.

    abstract:PURPOSE OF REVIEW:To summarize advances in our understanding of the clinical phenotypes, genetics, and molecular pathophysiology of the periodic paralyses, the nondystrophic myotonias, and other muscle channelopathies. RECENT FINDINGS:The number of pathogenic mutations causing periodic paralysis, nondystrophic myotoni...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Platt D,Griggs R

    更新日期:2009-10-01 00:00:00

  • Stroke mimics and chameleons.

    abstract:PURPOSE OF REVIEW:A stroke mimic is a situation in which a diagnosis of stroke at admission is not confirmed, and a stroke chameleon is a situation in which a stroke is revealed by clinical symptoms that are not usual in stroke. The objective of this review is to identify the most frequent clinical situations in which ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Moulin S,Leys D

    更新日期:2019-02-01 00:00:00

  • Inflammation and ischaemic stroke.

    abstract:PURPOSE OF REVIEW:Inflammation is implicated in ischaemic stroke as a general cardiovascular risk factor, a possible immediate trigger, a component (and possible exacerbating factor) of the response to tissue injury, a marker of future risk, and as a therapeutic target. Each aspect is reviewed. RECENT FINDINGS:Evidenc...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Muir KW,Tyrrell P,Sattar N,Warburton E

    更新日期:2007-06-01 00:00:00

  • Neurorehabilitation in multiple sclerosis: foundations, facts and fiction.

    abstract:PURPOSE OF REVIEW:This review of recent work in the area of neurorehabilitation of multiple sclerosis patients surveys progress and underscores the need for further work to evaluate the effectiveness of treatments. RECENT FINDINGS:Several recent review documents have summarized the current position regarding neuroreha...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Thompson AJ

    更新日期:2005-06-01 00:00:00

  • Neurosteroids and epilepsy.

    abstract:PURPOSE OF REVIEW:Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influe...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Biagini G,Panuccio G,Avoli M

    更新日期:2010-04-01 00:00:00

  • Intra-arterial thrombolysis in acute stroke.

    abstract::A relatively small number of studies were published on the intra-arterial therapy of stroke in the past year. Those reports, however, do offer strong evidence for the feasibility and safety of this therapeutic approach. Partly on the basis of these data it has become evident that the intra-arterial thrombolytic therap...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Abou-Chebl A,Furlan AJ

    更新日期:2000-02-01 00:00:00

  • Developmental perspectives on epilepsy.

    abstract::This paper reviews current knowledge about epileptogenesis in the developing brain. Animal studies indicate that the maturational balance of excitatory and inhibitory neurotransmitter systems should result in an increased susceptibility to seizures. However, the reason for specific age-locked syndromes and the high ra...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Scott RC,Neville BG

    更新日期:1998-04-01 00:00:00

  • Health and well being of adults with cerebral palsy.

    abstract:PURPOSE OF REVIEW:This article reviews what is known about the health and well being of adults with cerebral palsy. It also addresses the factors known to affect the areas identified in the World Health Organization International Classification of Functioning model as being critical for optimal health and well being. ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Liptak GS

    更新日期:2008-04-01 00:00:00

  • Stimulation of N-methyl-D-aspartate receptors by exogenous and endogenous ligands improves outcome of brain injury.

    abstract:PURPOSE OF REVIEW:The failure of N-methyl-D-aspartate receptor (NMDAR) antagonists as a treatment for human traumatic brain injury (TBI) and stroke, along with preclinical findings of a persistent hypofunctional state of these receptors after brain injury, resulted in a new focus on NMDAR agonists, specifically those a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Biegon A,Liraz-Zaltsman S,Shohami E

    更新日期:2018-12-01 00:00:00

  • Visual neglect.

    abstract:PURPOSE OF REVIEW:Left visual neglect is a frequent and dramatic consequence of right hemisphere lesions. Diagnosis is important because behavioural and pharmacological treatments are available. Furthermore, neglect raises important issues concerning the brain mechanisms of consciousness, perception and attention. REC...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Bartolomeo P

    更新日期:2007-08-01 00:00:00

  • Assessing the severity of seizures and epilepsy: which scales are valid?

    abstract::A review of the literature on methods of seizure or epilepsy severity assessments resulted in tabulation of the seizure rating scales known as US Department of Veterans Affairs (VA), Chalfont-National Hospital, Liverpool, Hague, and others. Each of the scales reviewed has some advantages, but none of them appears to b...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Cramer JA

    更新日期:2001-04-01 00:00:00

  • Retrograde amnesia and malingering.

    abstract:PURPOSE OF REVIEW:Malingered anterograde amnesia is a phenomenon that has been exhaustively studied, whereas research on retrograde amnesia has tended to focus upon functional and organic accounts of impairment. The present review explores studies relevant to extending the malingering paradigm to retrograde amnesia. R...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Jenkins KG,Kapur N,Kopelman MD

    更新日期:2009-12-01 00:00:00

  • Cognitive abilities and behaviour of children exposed to antiepileptic drugs in utero.

    abstract:PURPOSE OF REVIEW:The last two decades have witnessed a growing concern over the treatment of epilepsy in women of childbearing age, with an increased risk of major congenital malformations and possible cognitive difficulties associated with certain antiepileptic drugs. The aim here is to review the literature regardin...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Bromley RL,Baker GA,Meador KJ

    更新日期:2009-04-01 00:00:00

  • Prevention and management of medication overuse headache.

    abstract:PURPOSE OF REVIEW:This review provides an update on our knowledge regarding prevention and management of medication overuse headache (MOH). RECENT FINDINGS:The prevalence of MOH is 1-2% in the general population worldwide, and because of the tremendous socio-economic cost, it is likely to be the most costly neurologic...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审


    authors: Russell MB,Lundqvist C

    更新日期:2012-06-01 00:00:00