Association of genetic polymorphisms of de novo nucleotide biosynthesis with increased CHD susceptibility in the northern Chinese population.


:Congenital heart disease (CHD) is one of most prevalent birth defects in the world. However, the underlying molecular mechanism(s) have not been fully understood. Here we report that increased CHD susceptibility is associated with genetic polymorphisms for de novo nucleotide biosynthesis in northern Chinese population, which has been reported with lower plasma folate levels. Nine tagSNPs of four genes (GART, ATIC, MTHFD1 and SHMT1) in de novo nucleotide biosynthesis were sequenced in 802 sporadic CHD patients and 1093 controls from two Han Chinese populations, located in north China (Shandong) and South China (Shanghai), respectively. Six SNPs were found to be significantly associated with CHDs or septation defects only in the Shandong population dataset, but none displayed significant association with any CHDs in the Shanghai population dataset as well as in the combined dataset. We also showed that the minor A allele of rs7279549 in GART reduced transcriptional activity and displayed lower affinity for unknown transcription factor(s), demonstrating the allele is a functional risk factor for CHD in Shandong population. Our study indicates that dysregulation of de novo nucleotide biosynthesis pathway may conditionally contribute to CHD pathogenesis in northern Chinese.


Clin Genet


Clinical genetics


Jiang YC,Kuang LL,Sun SN,Duan WY,Qiao B,Wang HY




Has Abstract


2017-05-01 00:00:00












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    journal_title:Clinical genetics

    pub_type: 杂志文章


    authors: Silengo M,Lerone M,Seri M,Boffi P

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    journal_title:Clinical genetics

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    authors: Fitzgerald-Butt SM,Bodine A,Fry KM,Ash J,Zaidi AN,Garg V,Gerhardt CA,McBride KL

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  • Catecholamine metabolism in familial amyloid polyneuropathy.

    abstract::In order to evaluate the involvement of the peripheral autonomic nervous system in the pathogenesis of type 1 familial amyloid polyneuropathy, the urinary excretion rates of catecholamines and serum dopamine-beta-hydroxylase (DB/) activity were examined in 22 patients at various clinical stages. Changes in both indice...

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    pub_type: 杂志文章


    authors: Pedersen L

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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