Abstract:
:No causal treatment for chemotherapy-induced peripheral neuropathy (CIPN) is known. Therefore, there is an urgent need to develop a therapy for CIPN. Only scarce clinical data are available concerning magnetic field therapy (MFT) in this context. We conducted a unicentric, randomized, double-blind, placebo-controlled phase-III trial of an MFT device versus placebo. In this study, we randomized 44 patients with CIPN to two treatment groups, where 21 patients were treated with MFT (Group 1) and 23 patients received placebo (Group 2). We evaluated the efficacy of MFT at baseline (T1 ), after 3 weeks of study treatment (T2 ), and after 3 months of study treatment (T3 ). The primary endpoint was nerve conduction velocity (NCV), while secondary endpoints were the Common Toxicity Criteria (CTCAE) score and the Pain Detect End Score at T3 . Seventeen of the patients in Group 1 and 14 patients in Group 2 completed the respective study treatment. The primary endpoint, significant improvement of NCV at T3 , was achieved by MFT (P = 0.015), particularly for sensory neurotoxicity of the peroneal nerve. Also, in respect to the secondary endpoints, significant improvement (P = 0.04) was achieved in terms of the patients' subjectively perceived neurotoxicity (CTCAE score), but not of neuropathic pain (P = 0.11). From data in the randomized study presented here, a positive effect on the reduction of neurotoxicity can be assumed for the MFT device. Patients with sensory neurotoxicity in the lower limbs, especially, should therefore be offered this therapy. Bioelectromagnetics. 38:85-94, 2017. © 2016 The Authors. Bioelectromagnetics published by Wiley Periodicals, Inc.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Rick O,von Hehn U,Mikus E,Dertinger H,Geiger Gdoi
10.1002/bem.22005subject
Has Abstractpub_date
2017-02-01 00:00:00pages
85-94issue
2eissn
0197-8462issn
1521-186Xjournal_volume
38pub_type
杂志文章,随机对照试验abstract::Electric fields induced in a conductive body by the magnetic field of a current-carrying wire were analyzed theoretically and experimentally to assess the dosimetric importance of highly nonuniform, field-exposure conditions. Experimentation revealed that a 60-Hz magnetic field was inversely proportional to the radius...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250130305
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abstract::Magnetic resonance (MR)-based electrical impedance tomography (MREIT) is a widely used imaging technique that provides high-resolution conductivity images at DC or below the 1 kHz frequency range. Using an MR scanner, this technique injects imaging currents into the human body and measures induced internal magnetic fl...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21852
更新日期:2014-07-01 00:00:00
abstract::The aim of the present study was to investigate the influence of 50 Hz sinusoidal magnetic field on Hsp27, Hsp70, and Hsp90 expression in a model of primary culture of porcine aortic endothelial cells (PAEC). We took into consideration the Hsp profile in terms of mRNA expression, protein expression and protein localiz...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20299
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abstract::This study was undertaken to investigate whether power frequency magnetic fields can affect the kinetics of cell cycle progression in exposed human cells. To achieve this, cultures of normal human fibroblasts were synchronised in the G(0) phase of the cell cycle and exposed to 50 Hz magnetic fields at a range of flux ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::This study analyzes if an external magnetic stimulus (2 kHz and approximately 0.1 μT applied near frontal cortex) influences working memory, perception, binary decision, motor execution, and sustained attention in humans. A magnetic stimulus and a sham stimulus were applied to both sides of the head (frontal cortex cl...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21944
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20331
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abstract::Cytostatic-induced polyneuropathy (CIPN) is a common and serious toxicity in tumor patients. Treatment and prophylactic measures are mainly ineffective. Therefore, there is an urgent need to establish a sufficient therapy for pPNP. Between July 2007 and August 2008, 20 patients were treated with low frequency (4-12 Hz...
journal_title:Bioelectromagnetics
pub_type: 信件
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/(SICI)1521-186X(1996)17:6<436::AID-BEM2>3.
更新日期:1996-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250020105
更新日期:1981-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章,随机对照试验
doi:10.1002/bem.22127
更新日期:2018-07-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20693
更新日期:2012-02-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/(sici)1521-186x(200004)21:3<197::aid-bem7>
更新日期:2000-04-01 00:00:00
abstract::Previously, we have reported that exposure to 50 Hz coherent sinusoidal magnetic fields (MF) for 24 h inhibits gap junction intercellular communication (GJIC) in mammalian cells at an intensity of 0.4 mT and enhances the inhibition effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) at 0.2 mT. In the present study, w...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20207
更新日期:2006-05-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20593
更新日期:2010-10-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250060406
更新日期:1985-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250070206
更新日期:1986-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20507
更新日期:2009-10-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20391
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21977
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journal_title:Bioelectromagnetics
pub_type: 杂志文章,评审
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.10186
更新日期:2004-04-01 00:00:00
abstract::Radiofrequency (5.28 MHz) electromagnetic radiation and low-temperature plasma were applied as short-term (2-15 min) seed treatments to two perennial woody plant species, including Smirnov's rhododendron (Rhododendron smirnowii Trautv.) and black mulberry (Morus nigra L.). Potential effects were evaluated using germin...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.22003
更新日期:2016-12-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20664
更新日期:2011-10-01 00:00:00
abstract::The constant exposure of modern society to extremely low frequency magnetic fields (ELF-MF) has raised considerable concerns about the potential risks to male reproduction. However, the epidemiological and experimental data remain contradictory and inconclusive. In the present study, we investigated the effects of 50 ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21816
更新日期:2014-01-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20316
更新日期:2007-07-01 00:00:00
abstract::Exposures to radiofrequency (RF) energy above 6 GHz are characterized by shallow energy penetration, typically limited to the skin, but the subsequent increase in skin temperature is largely determined by heat transport in subcutaneous layers. A detailed analysis of the energy reflection, absorption, and power density...
journal_title:Bioelectromagnetics
pub_type: 杂志文章,评审
doi:10.1002/bem.22110
更新日期:2018-04-01 00:00:00
abstract::In-vitro studies of biological effects of electromagnetic fields are often conducted with cultured cells either in suspension or grown in a monolayer. In the former case, the exposed medium can be assumed to be homogeneous; however, eventually the cells settle to the bottom of the container forming a two layer system ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250140106
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
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