Abstract：
:No causal treatment for chemotherapy-induced peripheral neuropathy (CIPN) is known. Therefore, there is an urgent need to develop a therapy for CIPN. Only scarce clinical data are available concerning magnetic field therapy (MFT) in this context. We conducted a unicentric, randomized, double-blind, placebo-controlled phase-III trial of an MFT device versus placebo. In this study, we randomized 44 patients with CIPN to two treatment groups, where 21 patients were treated with MFT (Group 1) and 23 patients received placebo (Group 2). We evaluated the efficacy of MFT at baseline (T1 ), after 3 weeks of study treatment (T2 ), and after 3 months of study treatment (T3 ). The primary endpoint was nerve conduction velocity (NCV), while secondary endpoints were the Common Toxicity Criteria (CTCAE) score and the Pain Detect End Score at T3 . Seventeen of the patients in Group 1 and 14 patients in Group 2 completed the respective study treatment. The primary endpoint, significant improvement of NCV at T3 , was achieved by MFT (P = 0.015), particularly for sensory neurotoxicity of the peroneal nerve. Also, in respect to the secondary endpoints, significant improvement (P = 0.04) was achieved in terms of the patients' subjectively perceived neurotoxicity (CTCAE score), but not of neuropathic pain (P = 0.11). From data in the randomized study presented here, a positive effect on the reduction of neurotoxicity can be assumed for the MFT device. Patients with sensory neurotoxicity in the lower limbs, especially, should therefore be offered this therapy. Bioelectromagnetics. 38:85-94, 2017. © 2016 The Authors. Bioelectromagnetics published by Wiley Periodicals, Inc.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Rick O,von Hehn U,Mikus E,Dertinger H,Geiger Gdoi
10.1002/bem.22005subject
Has Abstractpub_date
2017-02-01 00:00:00pages
85-94issue
2eissn
0197-8462issn
1521-186Xjournal_volume
38pub_type
杂志文章,随机对照试验abstract：:To assess the effect of a magnetic treatment on pain perception, we compared the sensory threshold in 18 healthy volunteers. We determined the threshold by noninvasive electrical stimulation of the tooth pulp and skin before and after exposure to an altered magnetic field of low intensity and to a sham treatment. Five...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.2250160505
更新日期：1995-01-01 00:00:00
abstract：:Measurements have been made of vector current densities induced by vertical, uniform, 60-Hz electric fields in the torsos of homogeneous models of swine and rats. The observed data were a strong function of the five grounding configurations invested: all four feet grounded, only front feet grounded, only rear feet gro...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.2250090102
更新日期：1988-01-01 00:00:00
abstract：:Conductive nanoparticles may enhance tissue heating during radiofrequency (RF) irradiation. Specific absorption rate (SAR) is known to rise with the electrical conductivity of tissue. However, no studies to date have measured the relationship between complex permittivity and nanoparticle concentration in tissue-like s...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.20595
更新日期：2010-12-01 00:00:00
abstract：:A novel exposure system for double-blind human electromagnetic provocation studies has been developed that satisfies the precision, control of fields and potential artifacts, and provides the flexibility to investigate the response of hypotheses-driven electromagnetic field exposure schemes on brain function, ranging ...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.21710
更新日期：2012-09-01 00:00:00
abstract：:A biphasic modulation of responsiveness of spleen lymphocytes to mitogens was observed in mice exposed to 2,450-MHz radiation at power densities of 5-15 mW/cm2 over various periods ranging between one and 17 days. This modulated phenomenon may be explained on the basis of 1) suppression of lymphocyte response to micro...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.2250010108
更新日期：1980-01-01 00:00:00
abstract：:Childhood cancer has been modestly associated with wire codes, an exposure surrogate for power frequency magnetic fields, but less consistently with measured fields. We analyzed data on the population distribution of wire codes and their relationship with several measured magnetic field metrics. In a given geographic ...
journal_title：Bioelectromagnetics
pub_type： 杂志文章,评审
doi：10.1002/(sici)1521-186x(1997)18:2<99::aid-bem2>3.0
更新日期：1997-01-01 00:00:00
abstract：:This study analyzes if an external magnetic stimulus (2 kHz and approximately 0.1 μT applied near frontal cortex) influences working memory, perception, binary decision, motor execution, and sustained attention in humans. A magnetic stimulus and a sham stimulus were applied to both sides of the head (frontal cortex cl...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.21944
更新日期：2016-01-01 00:00:00
abstract：:Mice were exposed in the far field in an anechoic chamber to 2,880-MHz pulsed microwaves 3 to 7.5 h daily, 5 days/week for 60 to 360 h. Three experiments were performed at average power densities of 5 mW/cm2 and six at 10 mW/cm2, corresponding to averaged specific absorption rates (SARs) of 2.25 and 4.50 mW/g, respect...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.2250040409
更新日期：1983-01-01 00:00:00
abstract：:There are public concerns regarding possible carcinogenic or cancer-promoting effects of radiofrequency electromagnetic fields (RF-EMFs) because of the extensive use of wireless mobile phones and other telecommunication devices in daily life. However, so far it is unclear if non-thermal exposure of single EMF exposure...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.20655
更新日期：2011-09-01 00:00:00
abstract：:Daily preexposure and postexposure mass measurements of 65 rats (young males and females, old males) a proprietary pulsed wound healing field, pulsed electromagnetic field, (PEMF), or their control fields for 4 h/day for 21 days. Statistical analysis of mass changes over time showed that young rats exposed to PEMF los...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.92
更新日期：2002-01-01 00:00:00
abstract：:The possible effects of repeated night-time exposure to an extremely low frequency magnetic field (ELF-MF) on melatonin were investigated in nine healthy male subjects aged 23-37 yr. The 16-week experiment consisted of 3 weeks of pre-exposure, 11 weeks of night-time exposure to MF generated from a nonheated electric s...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/1521-186x(200102)22:2<138::aid-bem1017>3.0
更新日期：2001-02-01 00:00:00
abstract：:The MobilEe-study was the first cross-sectional population-based study to investigate possible health effects of mobile communication networks on children using personal dosimetry. Exposure was assessed every second resulting in 86,400 measurements over 24 h for each participant. Therefore, a functional approach to an...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.20477
更新日期：2009-05-01 00:00:00
abstract：:There is extensive literature on possible effects of extremely low-frequency magnetic fields (ELF-MFs) on human cognitive functions. However, due to methodological deficits (e.g., low statistical power, small sample sizes) findings have been inconsistent. In the current study we try to overcome these problems by carry...
journal_title：Bioelectromagnetics
pub_type： 杂志文章,meta分析
doi：10.1002/bem.20543
更新日期：2010-04-01 00:00:00
abstract：:Magnetic targeting is a promising therapeutic strategy for localizing systemically delivered magnetic responsive drugs or cells to target tissue, but excessive aggregation of magnetic particles could result in vascular embolization. To analyze the reason for embolization, the attractive process of magnetic particles i...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.21977
更新日期：2016-07-01 00:00:00
abstract：:We have studied the effect of extremely low frequency electromagnetic fields (ELF-EMF) in the presence of a second stressor (mild heat shock) on the expression of a lacZ reporter gene under the control of hsp16 or hsp70 promoters in two transgenic strains of C. elegans. The expression of the reporter gene was studied ...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/(sici)1521-186x(200002)21:2<100::aid-bem4>
更新日期：2000-02-01 00:00:00
abstract：:We used exposure to microwaves from a global system for mobile communication (GSM) mobile phone (915 MHz, specific absorption rate (SAR) 37 mW/kg) and power frequency magnetic field (50 Hz, 15 muT peak value) to investigate the response of lymphocytes from healthy subjects and from persons reporting hypersensitivity t...
journal_title：Bioelectromagnetics
pub_type： 临床试验,杂志文章
doi：10.1002/bem.20103
更新日期：2005-04-01 00:00:00
abstract：:This study aimed to explore effects of static magnetic fields (SMFs) of moderate intensity (3-50 mT) as biophysical stimulators of proliferation and osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells (MSCs). MSCs were exposed to SMFs of three intensities: 3, 15, and 50 mT. Proliferation w...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.21903
更新日期：2015-04-01 00:00:00
abstract：:An automated blood sampling system was developed for use with tethered baboons (Papio cynocephalus) during concurrent exposure to 60 Hz 30 kV/m electric fields and 0.1 mT (1.0 G) magnetic fields. The system was controlled by a FORTH-based microcomputer, which operated a pump, a fraction collector, and two pinch valves...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.2250160710
更新日期：1995-01-01 00:00:00
abstract：:The use of electronic article surveillance (EAS) systems has become popular in many public sites. As a consequence, concern has risen about infant exposure to magnetic fields (MFs) from this kind of device. To evaluate infant exposure to MFs of an EAS system (operating at 125 kHz and 13.56 MHz), we numerically compare...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.21901
更新日期：2015-04-01 00:00:00
abstract：:This study describes the effects of a static magnetic field (SMF) on cell growth and DNA integrity of human umbilical vein endothelial cells (HUVECs). Fast halo assay was used to investigate nuclear damage; quantitative polymerase chain reaction (QPCR), standard PCR, and real-time PCR were used to evaluate mitochondri...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.20591
更新日期：2010-12-01 00:00:00
abstract：:Radio-frequency electromagnetic radiation (RFR) at 915 and 147 MHz, when sinusoidally amplitude modulated (AM) at 16 Hz, has been shown to enhance release of calcium ions from neuroblastoma cells in culture. The dose-response relation is unusual, consisting of two power-density "windows" in which enhanced efflux occur...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.2250130407
更新日期：1992-01-01 00:00:00
abstract：:Hyperthermia has been used in conjunction with radiation and chemotherapy for cancer treatment. When using electromagnetic heating, applicators are critical components in contact with or in proximity to patients and can be the determining factor for effective and safe treatment. Tissue absorption of electromagnetic en...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.2250130612
更新日期：1992-01-01 00:00:00
abstract：:Laboratory measurements of electric fields have been carried out around examples of smart meter devices used in Great Britain. The aim was to quantify exposure of people to radiofrequency signals emitted from smart meter devices operating at 2.4 GHz, and then to compare this with international (ICNIRP) health-related ...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.22044
更新日期：2017-05-01 00:00:00
abstract：:The impedance spectroscopy technique (IST) was used for studying the effect of a 0.5 T magnetic field on the electrical properties of whole human blood. A Solartron SI 1260 spectrometer was used to measure the impedance spectra of magnetic field exposed blood samples compared to non-exposed samples. An equivalent elec...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.20132
更新日期：2005-10-01 00:00:00
abstract：:Electromagnetic sensibility refers to the ability to perceive the electromagnetic field (EMF) without necessarily developing health symptoms attributed to EMF exposure. A large sample of young healthy adults (n = 84) performed two forced-choice tasks on the perception of the GSM mobile phone EMF (902 MHz pulsed at 217...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.20375
更新日期：2008-02-01 00:00:00
abstract：:Cytostatic-induced polyneuropathy (CIPN) is a common and serious toxicity in tumor patients. Treatment and prophylactic measures are mainly ineffective. Therefore, there is an urgent need to establish a sufficient therapy for pPNP. Between July 2007 and August 2008, 20 patients were treated with low frequency (4-12 Hz...
journal_title：Bioelectromagnetics
pub_type： 信件
doi：10.1002/bem.21897
更新日期：2015-04-01 00:00:00
abstract：:Radiofrequency (5.28 MHz) electromagnetic radiation and low-temperature plasma were applied as short-term (2-15 min) seed treatments to two perennial woody plant species, including Smirnov's rhododendron (Rhododendron smirnowii Trautv.) and black mulberry (Morus nigra L.). Potential effects were evaluated using germin...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.22003
更新日期：2016-12-01 00:00:00
abstract：:The aim of this study was to explore the prevalence, nature and determinants of concerns about mobile phone radiation. We used data from a 2006 telephone survey of 1004 people aged 15+ years in Denmark. Twenty-eight percent of the respondents were concerned about exposure to mobile phone radiation; radiation from mast...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.20484
更新日期：2009-07-01 00:00:00
abstract：:There are large disparities between basic restrictions for exposure to extremely low-frequency (0-3 kHz) Electric and Magnetic Fields set by two major international bodies. Both bodies agree that these basic restrictions should prevent neuro-stimulatory effects: the retinal phosphene at frequencies up to a few hundred...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.20412
更新日期：2008-09-01 00:00:00
abstract：:Fertile eggs of the Coturnix quail were exposed twice a day for 30 min to 2.45-GHz continuous wave radiation at power densities of 25 or 50 mW cm-2 throughout the 17-day incubation period. Other eggs were exposed to 20 degrees C or 24 degrees C temperatures twice daily. Repeated exposures to 20 degrees C, 24 degrees C...
journal_title：Bioelectromagnetics
pub_type： 杂志文章
doi：10.1002/bem.2250060307
更新日期：1985-01-01 00:00:00
